In vivo Preservation of the Hybrid Layer by Chlorhexidine

SAGE Publications - Tập 86 Số 6 - Trang 529-533 - 2007
Marcela Rocha de Oliveira Carrilho1,2,3,4,5, Saulo Geraldeli1,2,3,4,5, Franklin R. Tay1,2,3,4,5, Mário Fernando de Góes1,2,3,4,5, Ricardo M. Carvalho1,2,3,4,5, Leo Tjäderhane1,2,3,4,6, André Figueiredo Reis1,2,3,4,5, Josimeri Hebling1,2,3,4,5, Annalisa Mazzoni1,2,3,4,5, Lorenzo Breschi1,2,3,4,5, David H. Pashley1,2,3,4,5
1Department of Endodontics, School of Dentistry, Medical College of Georgia, Augusta, GA 30912-1129, USA
2Department of Operative Dentistry, School of Dentistry, University of Iowa, Iowa City, IA, USA;
3Department of Oral Biology and Maxillofacial Pathology,
4Department of Prosthodontics, University of São Paulo, Bauru School of Dentistry, Bauru/SP, Brazil;
5Department of Restorative Dentistry, Dental Materials Area, University of Campinas, Piracicaba School of Dentistry, Piracicaba/SP, Brazil;
6Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital (HUCU), Helsinki, Finland

Tóm tắt

Host-derived proteases have been reported to degrade the collagen matrix of incompletely-resin-infiltrated dentin. This study tested the hypothesis that interfacial degradation of resin-dentin bonds may be prevented or delayed by the application of chlorhexidine (CHX), a matrix metalloproteinase inhibitor, to dentin after phosphoric acid-etching. Contralateral pairs of resin-bonded Class I restorations in non-carious third molars were kept under intra-oral function for 14 months. Preservation of resin-dentin bonds was assessed by microtensile bond strength tests and TEM examination. In vivo bond strength remained stable in the CHX-treated specimens, while bond strength decreased significantly in control teeth. Resin-infiltrated dentin in CHX-treated specimens exhibited normal structural integrity of the collagen network. Conversely, progressive disintegration of the fibrillar network was identified in control specimens. Auto-degradation of collagen matrices can occur in resin-infiltrated dentin, but may be prevented by the application of a synthetic protease inhibitor, such as chlorhexidine.

Từ khóa


Tài liệu tham khảo

10.1074/jbc.270.11.5872

Armstrong SR, Jessop JL, Vargas MA, Zou Y, Qian F, Campbell JA, et al. (2006). Effects of exogenous collagenase and cholesterol esterase on the durability of the resin-dentin bond. J Adhes Dent 8:151–160.

10.1902/jop.1993.64.5s.474

Carrilho MR, Carvalho RM, Tay FR, Yiu CK, Pashley DH (2005). Durability of resin-dentin bonds related to water and oil storage. Am J Dent 18:315–319.

10.1177/154405910708600115

10.1177/154405910608500104

10.1177/154405910308200212

10.1177/154405910508400412

10.1128/CDLI.6.3.437-439.1999

10.1177/00220345000790060601

Hashimoto M, Tay FR, Ohno H, Sano H, Kaga M, Yiu C, et al. (2003). SEM and TEM analysis of water degradation of human dentinal collagen. J Biomed Mater Res B Appl Biomater 66:287–298.

10.1177/154405910508400811

10.1016/j.biomaterials.2005.04.052

10.1111/j.1600-0722.2004.00141.x

10.1016/j.biomaterials.2004.11.001

10.1016/j.dental.2005.11.020

10.1016/S0003-9969(00)00052-2

10.1016/j.biomaterials.2006.01.040

10.1111/j.1600-0722.2006.00342.x

10.1177/154405910408300306

10.1111/j.1601-0825.2004.01038.x

10.1177/00220345010800061301

10.1016/j.archoralbio.2006.08.009

Tay FR, Pashley DH, Suh BI, Hiraishi N, Yiu CK (2005). Water treeing in simplified dentin adhesives—déjà vu? Oper Dent 30:561–579.

10.1016/j.joen.2006.04.005

Toledano M, Osorio R, Osorio E, Aguillera F, Yamauti M, Pashley DH, et al. (2007). Effect of bacterial collagenase on resin-dentin bond degradation. J Mater Sci Mater Med (in press).

10.1016/j.biomaterials.2004.01.026

Thông tin
Thông tin xuất bản

SAGE Publications

Tập 86 Số 6

529-533

Thông tin tác giả