In vitro anti‐hepatoma activity of fifteen natural medicines from Canada

Phytotherapy Research - Tập 16 Số 5 - Trang 440-444 - 2002
Liang Lin1, Li‐Teh Liu2, Lien‐Chai Chiang2, Chun‐Ching Lin3
1Department of Microbiology & Immunology, McGill University, Canada
2Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
3Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Taiwan

Tóm tắt

AbstractFifteen crude drugs, Stellaria media Cyrill. (Caryophyllaceae), Calendula officinalis L. (Compositae), Achillea millefolium L. (Compositae), Verbascum thapsus L. (Scrophulariaceae), Plantago major L. (Plantaginaceae), Borago officinalis L. (Boraginaceae), Satureja hortensis L. (Labiatae), Coptis groenlandica Salisb. (Ranunculaceae), Cassia angustifolia Vahl. (Leguminosae), Origanum majorana L. (Labiatae), Centella asiatica L. (Umbelliferae), Caulophyllum thalictroides Mich. (Berberidaceae), Picea rubens Sargent. (Pinaceae), Rhamnus purshiana D.C. (Rhamnaceae) and Hibiscus sabdariffa L. (Malvaceae), which have been used as folk medicine in Canada, were evaluated for their anti‐hepatoma activity on five human liver‐cancer cell lines, i.e. HepG2/C3A, SK‐HEP‐1, HA22T/VGH, Hep3B and PLC/PRF/5. The samples were examined by in vitro evaluation for their cytotoxicity. The results showed that the effects of crude drugs on hepatitis B virus genome‐containing cell lines were different from those against non hepatitis B virus genome‐containing cell lines. C. groenlandica was observed to be the most effective against the growth of all five cell lines and its chemotherapeutic values will be of interest for further studies. Copyright © 2002 John Wiley & Sons, Ltd.

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Phytotherapy Research

Tập 16 Số 5

440-444

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