Garcinia mangostana L.: a phytochemical and pharmacological review

Phytotherapy Research - Tập 23 Số 8 - Trang 1047-1065 - 2009
Dmitriy Obolskiy1, Ivo Pischel2, Nisarat Siriwatanametanon1, Michael Heinrich1
1Center for Pharmacognosy and Phytotherapy, The School of Pharmacy (University of London), 29-39 Brunswick Square, London WC1N 1AX, UK.
2Phytolab GmbH & Co. KG, Dutendorfer Str. 5–7, D‐91487 Vestenbergsgreuth, Germany

Tóm tắt

Abstract

Garcinia mangostana L. (mangosteen, Clusiaceae) has a long history of use as a medical plant, mostly in Southeast Asia. This is a review of the phytochemistry and pharmacology of mangosteen. Traditionally mangosteen is famous for its antiinflammatory properties and is used in the treatment of skin infections and wounds. Other applications include the therapy of various conditions such as dysentery, different urinary disorders, cystitis and gonorrhoea. This review highlights the development of this botanical drug into a widely used nutraceutical. Products derived from G. mangostana are now distributed increasingly all over the world. This has given rise to a concomitant increase in research on the phytochemical constituents and biological activity of mangosteen. Central to the biological activity of the species are xanthones which are reviewed in detail. A comprehensive assessment of the biological activities of individual xanthones as well as extracts of G. mangostana is included. In addition, its potential in terms of developing novel drug leads is assessed. Products containing its fruits are now sold widely as ‘liquid botanical supplements’, but evidence for the health benefits of these products is still lacking. As shown here, a serious weakness in our knowledge is the lack of clinical data and it is not yet clear to what extent the findings about pharmacological activities are of potential clinical relevance. Copyright © 2009 John Wiley & Sons, Ltd.

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Tài liệu tham khảo

10.1016/0031-9422(95)00042-6

10.1055/s-2006-957943

10.1007/PL00005134

10.1038/sj.bjp.0701695

10.1016/S0031-9422(96)00410-4

Chanarat P, 1997, Immunopharmacological activity of polysaccharide from the pericarp of Mangosteen garcinia: phagocytic intracellular killing activities, J Med Assoc Thai, 80, S149

Chanprechakul A, 2000, Research Reports. Thai Traditional Medicine and Future Prospective, 109

10.1055/s-2006-957916

10.1016/j.fct.2007.09.096

10.1016/j.phytochem.2007.09.023

10.1016/j.jep.2005.04.038

10.1016/j.fitote.2007.02.019

Corner EJH, 1988, Wayside Trees of Malaya.

10.1016/j.cell.2007.08.021

10.1080/14786410500463114

10.1016/0277-9536(82)90167-8

Etkin NL, 1996, Joint Meeting of the Society for Economic Botany and the International Society for Ethnopharmacology ‘Plants for Food and Medicine’, 3

Farnsworth RN, 1992, Thai Medicinal Plants, 160

10.2174/092986705774370727

10.1021/np970165u

Gritsanapan W, 1983, A preliminary study of antidiarrheal plants and antibacterial activity, Mahidol Univ J Pharm Sci, 10, 119

10.1016/S0031-9422(02)00142-5

10.1159/000095205

10.1016/j.arr.2007.08.002

10.1055/s-2002-35668

http://www.fda.gov/foi/warning_letters/archive/g6031d.htm (September 20 2006). ‘Warning letter’.

http://www.health‐report.co.uk/mangosteen.html (accessed May 8 2008).

http://www.xango.co.jp/pressrelease/archive/060324_en.html (March 3 2006). ‘State of the category 2006’.

10.1021/np000583q

10.1111/j.2042-7158.1996.tb03988.x

10.1016/j.jpba.2006.10.018

10.1021/jf052649z

Lim AH, 1984, The embryology of Garcinia mangostana L. (Clusiaceae), Gard Bull Sing, 37, 93

10.1080/10715760000301161

10.1021/np50051a021

10.1023/A:1009591300361

10.1021/np020546u

10.1016/j.bmc.2005.06.065

10.1016/j.bmc.2004.08.034

10.1016/j.jep.2003.09.048

10.1016/j.fitote.2004.01.010

Nabandith V, 2004, Inhibitory effects of crude alpha‐mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2‐dimethylhydrazine in the rat, Asian Pac J Cancer Prev, 5, 433

10.1248/bpb.25.1137

10.1016/S0006-2952(01)00810-3

10.1124/mol.104.002626

NBJ's Supplement Business Report. October, 2007, Nutrition Business Journal.

10.1016/S0031-9422(00)00303-4

10.2174/092986705774370691

10.17660/ActaHortic.2005.680.18

Puripattanavong JKW, 2006, Improved isolation of a‐mangostin from the fruit hull of Garcinia mangostana and its antioxidant and antifungal activity, Planta Med, 72, 1078, 10.1055/s-2006-950128

10.1023/B:EUPH.0000019456.06040.eb

Rapport L, 2002, Nutraceuticals

10.2174/092986705774370709

10.1016/j.phymed.2003.09.012

Saralamp P, 1996, Medical Plants in Thailand

10.1254/jphs.95.33

Shankaranarayan D, 1979, Pharmacological profile of mangostin and its derivatives, Arch Int Pharmacodyn Ther, 239, 257

Sintersmuk J, 1989, Effects of Garcinia mangostana peel extract on dysenteric bacteria and intestinal normal flora, Bull Dept Med Serv, 14, 421

Sornprasit A, 1987, Preliminary toxicological study of mangosteen, Songklanakarin J Sci Technol, 9, 51

Sripanichkulchai B, 1995, Research Reports

10.1021/np010566g

10.1248/cpb.51.857

10.1248/cpb.54.301

Sutabhaha B, 1997, The inhibitory activities of mangosteen's pericarp extract on methicillin‐resistant Staphylococcus aureus., Bull Chiang Mai Assoc Med Sci, 30, 40

10.1002/ptr.2231

10.2174/092986705774370682

10.1055/s-2006-957384

10.1111/j.1469-0691.2005.01104.x

10.1002/jssc.200700024

Wieble JEKC, 1992, Mangosteen (Garcinia mangostana L.) – A potential crop for Northern Australia, Acta Hortic, 321, 132, 10.17660/ActaHortic.1992.321.12

10.3109/10715769509064030

10.1016/j.foodchem.2006.11.018

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Phytotherapy Research

Tập 23 Số 8

1047-1065

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