DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
Tóm tắt
About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tumors had homozygous deletions at 18q21.1, a site that excludes
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Tài liệu tham khảo
ALEXANDROW G. M., TRANSFORMING GROWTH-FACTOR-BETA AND CELL-CYCLE REGULATION, CANCER RESEARCH 55, 1452 (1995).
ALMOGUERA C, MOST HUMAN CARCINOMAS OF THE EXOCRINE PANCREAS CONTAIN MUTANT C-K-RAS GENES, CELL 53, 549 (1988).
CALDAS C, FREQUENT SOMATIC MUTATIONS AND HOMOZYGOUS DELETIONS OF THE P16 (MTS1) GENE IN PANCREATIC ADENOCARCINOMA, NATURE GENETICS 8, 27 (1994).
CHO R. K., THE DCC GENE - STRUCTURAL-ANALYSIS AND MUTATIONS IN COLORECTAL CARCINOMAS, GENOMICS 19, 525 (1994).
DRYJA P. T., MOLECULAR-DETECTION OF DELETIONS INVOLVING BAND Q14 OF CHROMOSOME-13 IN RETINOBLASTOMAS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83, 7391 (1986).
FRANCKE U, A RADIATION HYBRID MAP OF HUMAN CHROMOSOME-18, CYTOGENETICS AND CELL GENETICS 66, 196 (1994).
GOYETTE C. M., PROGRESSION OF COLORECTAL-CANCER IS ASSOCIATED WITH MULTIPLE TUMOR SUPPRESSOR GENE DEFECTS BUT INHIBITION OF TUMORIGENICITY IS ACCOMPLISHED BY CORRECTION OF ANY SINGLE DEFECT VIA CHROMOSOME TRANSFER, MOLECULAR AND CELLULAR BIOLOGY 12, 1387 (1992).
HAHN A. S., ALLELOTYPE OF PANCREATIC ADENOCARCINOMA USING XENOGRAFT ENRICHMENT, CANCER RESEARCH 55, 4670 (1995).
HAHN A. S., IN PRESS CANCER RES .
HAHN A. S. unpublished data.
HANNON J. G., P15(INK4B) IS A POTENTIAL EFFECTOR OF TGF-BETA-INDUCED CELL-CYCLE ARREST, NATURE 371, 257 (1994).
HRUBAN H. R., K-RAS ONCOGENE ACTIVATION IN ADENOCARCINOMA OF THE HUMAN PANCREAS - A STUDY OF 82 CARCINOMAS USING A COMBINATION OF MUTANT-ENRICHED POLYMERASE CHAIN-REACTION ANALYSIS AND ALLELE-SPECIFIC OLIGONUCLEOTIDE HYBRIDIZATION, AMERICAN JOURNAL OF PATHOLOGY 143, 545 (1993).
HURSH A. D., CROSS-REGULATION OF DECAPENTAPLEGIC AND ULTRABITHORAX TRANSCRIPTION IN THE EMBRYONIC VISCERAL MESODERM OF DROSOPHILA, DEVELOPMENT 117, 1211 (1993).
KNUDSON G. A., HEREDITARY CANCER, ONCOGENES, AND ANTIONCOGENES, CANCER RESEARCH 45, 1437 (1985).
LEACH S. F., COMMUNICATION .
LIU G. Y., THERMAL ASYMMETRIC INTERLACED PCR - AUTOMATABLE AMPLIFICATION AND SEQUENCING OF INSERT END FRAGMENTS FROM P1 AND YAC CLONES FOR CHROMOSOME WALKING, GENOMICS 25, 674 (1995).
POWELL M. S., MOLECULAR DIAGNOSIS OF FAMILIAL ADENOMATOUS POLYPOSIS, NEW ENGLAND JOURNAL OF MEDICINE 329, 1982 (1993).
REDSTON S. M., P53 MUTATIONS IN PANCREATIC-CARCINOMA AND EVIDENCE OF COMMON INVOLVEMENT OF HOMOCOPOLYMER TRACTS IN DNA MICRODELETIONS, CANCER RESEARCH 54, 3025 (1994).
SCHUTTE M, IDENTIFICATION BY REPRESENTATIONAL DIFFERENCE ANALYSIS OF A HOMOZYGOUS DELETION IN PANCREATIC-CARCINOMA THAT LIES WITHIN THE BRCA2 REGION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92, 5950 (1995).
SEKELSKY J. J., GENETIC-CHARACTERIZATION AND CLONING OF MOTHERS AGAINST DPP, A GENE REQUIRED FOR DECAPENTAPLEGIC FUNCTION IN DROSOPHILA-MELANOGASTER, GENETICS 139, 1347 (1995).
SILVERMAN A. G., ISOLATING VECTOR-INSERT JUNCTIONS FROM YEAST ARTIFICIAL CHROMOSOMES, PCR-METHODS AND APPLICATIONS 3, 141 (1993).