<i>Benzo fur</i>y: A new trend in the drug misuse scene

Journal of Applied Toxicology - Tập 39 Số 8 - Trang 1083-1095 - 2019
Rita Roque Bravo1, Helena Carmo1, Félix Carvalho1, Maria de Lourdes Bastos1, Diana Dias da Silva1
1UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy University of Porto Rua Jorge Viterbo Ferreira, 228 Porto 4050-313 Portugal

Tóm tắt

AbstractBenzofurans, also known by users as benzo fury or benzofury, are synthetic phenethylamines and constitute the third most prominent group of new psychoactive substances (NPS). As the use of these substances has been spread as an alternative to the classic illicit psychostimulants, such as amphetamines, their legal status was reviewed, resulting in an utter prohibition of these NPS in many countries worldwide. Herein, the prevalence of abuse, chemistry, biological effects, metabolism, and the potential harms and risky behaviors associated with the abuse of benzofurans are reviewed. The congeners of this group are mainly consumed recreationally at electronic dance music parties, in polydrug abuse settings. Benzofurans preferentially act by disturbing the functioning of serotonergic circuits, which induces their entactogenic and stimulant effects and is the reason behind the considerable number of recent benzo fury‐related deaths. The slight interaction of these drugs with the dopaminergic system justifies the rewarding effects of these drugs. To date, published evidence on the mechanisms of toxicity of benzo fury is very limited but a body of research is now beginning to emerge revealing an alarming public health threat regarding the abuse of these NPS.

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Journal of Applied Toxicology

Tập 39 Số 8

1083-1095

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