<i>Aspergillus flavus</i>: an emerging non‐<i>fumigatus Aspergillus</i> species of significance

Mycoses - Tập 52 Số 3 - Trang 206-222 - 2009
Suganthini Krishnan1, Elias K. Manavathu, Pranatharthi Chandrasekar
1Division of Infectious Diseases, Wayne State University, John D. Dingell VA Medical Center, Detroit, MI 48201, USA. [email protected]

Tóm tắt

SummaryInvasive aspergillosis is rare in immunocompetent people but contributes to significant morbidity and mortality in immunosuppressed patients. The majority (approximately 80%) of invasive Aspergillus infections is caused by Aspergillus fumigatus. The second most frequent (approximately 15–20%) pathogenic species is Aspergillus flavus and to a lesser extent, Aspergillus niger and Aspergillus terreus. Aspergillus flavus has emerged as a predominant pathogen in patients with fungal sinusitis and fungal keratitis in several institutions worldwide. To date, there has not been any publication exclusively reviewing the topic of A. flavus in the literature. This article reviews the microbiology, toxigenicity and epidemiology of A. flavus as well as describes the clinical characteristics, diagnosis and management of infections caused by this organism.

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Tài liệu tham khảo

Corrall CJ, 1982, Aspergillus osteomyelitis in an immunocompetent adolescent: a case report and review of the literature, Pediatrics, 70, 455, 10.1542/peds.70.3.455

10.1016/S1130-1406(05)70043-7

10.1007/BF00443938

10.1016/S0163-4453(98)90303-6

Chakrabarti A, 2000, Paranasal sinus mycoses, Indian J Chest Dis Allied Sci, 42, 293

Chakrabarti A, 1992, Epidemiology and pathogenesis of paranasal sinus mycoses, Otolaryngol Head Neck Surg, 1, 745, 10.1177/019459988910700606.1

10.1016/S0161-6420(03)00861-3

10.1097/00003226-200110000-00009

10.1016/S0002-9394(00)00406-2

10.1097/00003226-200301000-00020

10.1097/01.inf.0000157218.37603.84

Hetherington SV, 1994, Monoclonal antibodies against a 97‐kilodalton antigen from Aspergillus flavus, Clin Diagn Lab Immunol, 1, 63, 10.1128/cdli.1.1.63-67.1994

Sutton DA, 1998, Guide to Clinically Significant Fungi

Sommer NF, 1976, Aflatoxin and sterigmatocystin contamination of pistachio nuts in orchards, Appl Environ Microbiol, 32, 64, 10.1128/aem.32.1.64-67.1976

Desai MR, 2003, Occupational exposure to airborne fungi among rice mill workers with special reference to aflatoxin producing A. flavus strains, Ann Agric Environ Med, 10, 159

10.1016/S0168-1605(02)00539-1

Desai MR, 2003, Aflatoxin related occupational exposure to maize processing workers, Cell Mol Biol (Noisy-le-grand), 49, 529

10.4315/0362-028X-67.1.96

10.4315/0362-028X-67.1.90

10.1016/S0160-4120(03)00103-X

Valenton M, 1996, Wound infection after cataract surgery, Jpn J Ophthalmol, 40, 447

10.1016/j.jhin.2004.02.007

10.1007/BF01259400

10.1001/jama.284.22.2869

Hube B, 1996, Candida albicans secreted aspartyl proteinases, Curr Top Med Mycol, 7, 55

10.1128/MMBR.67.3.400-428.2003

Yang YL, 2003, Virulence factors of Candida albicans, J Microbiol Immunol Infect, 36, 223

10.1016/S1567-1356(03)00205-8

10.1016/j.femsle.2005.02.015

10.1016/0732-8893(90)90081-6

10.1099/jmm.0.05248-0

10.1159/000024205

10.1016/0732-8893(88)90036-3

Ramesh MV, 1994, Isolation, characterization, and cloning of cDNA and the gene for an elastinolytic serine proteinase from Aspergillus flavus, Infect Immun, 62, 79, 10.1128/iai.62.1.79-85.1994

10.1006/bbrc.1999.1093

Ramesh MV, 1996, Disruption of the serine proteinase gene (sep) in Aspergillus flavus leads to a compensatory increase in the expression of a metalloproteinase gene (mep20), J Bacteriol, 178, 3899, 10.1128/jb.178.13.3899-3907.1996

10.1078/1438-4221-00223

Pavlukova EB, 1998, Extracellular proteolytic enzymes of filamentous fungi, Biochemistry (Mosc), 63, 899

10.1271/bbb.68.2607

10.1006/fgbi.2000.1195

10.1099/mic.0.27058-0

10.1128/IAI.70.1.19-26.2002

10.1128/IAI.63.10.3796-3803.1995

10.1099/00221287-144-8-2355

10.1016/S0378-1119(98)00057-2

10.1007/BF00284683

10.1080/02681219780001131

10.1111/j.1439-0507.1998.tb00588.x

10.3314/jjmm.40.235

10.1128/IAI.43.1.320-325.1984

10.1128/JCM.40.5.1811-1813.2002

10.1128/IAI.60.12.5153-5156.1992

Kolattukudy PE, 1993, Evidence for possible involvement of an elastolytic serine protease in aspergillosis, Infect Immun, 61, 2357, 10.1128/iai.61.6.2357-2368.1993

10.1080/02681219480000301

10.3109/01902149809041532

10.1046/j.1439-0507.2000.00586.x

10.1183/09031936.98.12030607

10.1007/s002849910048

Rhodes JC, 1990, Isolation and characterization of an elastinolytic proteinase from Aspergillus flavus, Infect Immun, 58, 2529, 10.1128/iai.58.8.2529-2534.1990

10.1080/02681219180000641

10.1016/0378-1119(95)00434-8

10.1111/j.1365-280X.1998.00124.x

10.1128/iai.65.12.5110-5117.1997

10.1007/s00284-002-3948-6

10.1016/S0300-483X(99)00023-2

10.1128/JCM.37.4.1221-1223.1999

10.1016/0192-0561(94)90076-0

Bis WA, 1990, Studies of immunological activity of Aspergillus flavus Link III. Presence of antibodies against fungal antigens in the sera of persons from selected groups, Med Dosw Mikrobiol, 42, 156

Bis WA, 1990, Study of immunological activity of Aspergillus flavus Link II. Immunogenicity, antigenic properties and evaluation of cross reactions of Aspergillus flavus antibodies with Aspergillus fumigatus antigens, Med Dosw Mikrobiol, 42, 149

10.1016/0300-483X(89)90076-0

10.1007/BF00409647

Dolezal M, 1977, Level of antibodies to Aspergillus flavus in women and the incidence of various disorders of reproductive functions, Pol Tyg Lek, 32, 1865

Aleksandrowicz J, 1973, Studies on precipitating antibodies for Aspergillus flavus antigens in patients with proliferative diseases, Mater Med Pol, 5, 232

Adamek T, 1971, Searching for antibodies against Aspergillus flavus antigens in patients with systemic prolifrative diseases, Pol Tyg Lek, 26, 1470

Tilden Eb, 1961, Preparation and properties of the endotoxins of Aspergillus fumigatus and Aspergillus flavus, Mycopathologia, 14, 325

International Agency for Research on Cancer (IARC), 1976, Some Naturally Occurring Substances. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans

International Agency for Research on Cancer, 1993, Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines, and Mycotoxins. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans

International Agency for Research on Cancer, 1987, Overall Evaluation of Carcinogenicity. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans

International Agency for Research on Cancer, 2002, Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans

10.1080/01635588309513794

10.1016/j.canlet.2004.08.028

10.1097/00008571-200410000-00007

10.1146/annurev.pa.34.040194.001031

10.1002/mc.2940060209

10.1093/carcin/13.5.891

10.1289/ehp.93101s245

10.2307/3434197

10.2307/3431480

10.1080/15428119791012513

10.1080/15428119891010514

10.1016/S0026-265X(02)00061-9

10.1086/501915

10.1093/infdis/166.6.1379

Narimatsu H, 2003, Systemic infection of Aspergillus flavus in a patient with acute lymphoblastic leukemia, Rinsho Ketsueki, 44, 1026

Nenoff P, 2002, Secondary cutaneous aspergillosis due to Aspergillus flavus in an acute myeloid leukaemia patient following stem cell transplantation, Eur J Dermatol, 12, 93

10.1128/JCM.42.9.4335-4337.2004

10.1111/j.1365-280X.1998.00124.x

10.1067/mai.2002.130179

10.2741/943

10.2741/990

10.1055/s-0028-1104276

10.1385/CRIAI:23:1:087

10.2741/982

10.2741/981

Chiner E, 1990, A pulmonary mycotic sequestrum during invasive aspergillosis, Ann Med Int, 7, 304

10.1007/BF01103062

10.1007/BF00158257

10.1023/A:1026462631716

10.1002/1097-0142(19840501)53:9<1995::AID-CNCR2820530932>3.0.CO;2-S

Chin GN, 1978, Aspergillus flavus keratitis, Ann Ophthalmol, 10, 415

10.1016/S0161-6420(88)33087-3

Center for Disease Control, 1990, Aspergillus endophthalmitis in intravenous‐drug users – Kentucky, MMWR Morb Mortal Wkly Rep, 39, 48

From the Centers for Disease Control, 1990, Aspergillus endophthalmitis in intravenous‐drug users – Kentucky, JAMA, 263

10.1097/00003226-199701000-00006

10.1177/014556130108000821

10.1111/j.1439-0507.1994.tb00302.x

10.1111/j.1439-0507.1996.tb00156.x

Meyohas MC, 1994, Aspergillosis in acquired immunodeficiency syndrome, Pathol Biol (Paris), 42, 647

10.1086/317452

10.1378/chest.114.1.251

10.1378/chest.114.1.131

10.1016/0002-9343(93)90258-Q

10.1093/infdis/167.4.905

10.1093/clinids/17.3.344

Wrzolek MA, 1995, Opportunistic infections of the central nervous system in children with HIV infection: report of 9 autopsy cases and review of literature, Clin Neuropathol, 14, 187

10.1001/archneur.1990.00530020087020

10.1093/clinids/14.1.141

10.1097/00002030-200105250-00020

10.1016/S0190-9622(80)80334-3

10.1111/j.1365-2230.1990.tb02141.x

10.2741/996

10.1056/NEJM198710293171802

10.1016/S0190-9622(85)80042-6

10.1086/598661

10.1046/j.1365-4362.2000.00095-3.x

10.1097/00006534-199309000-00025

10.1111/j.1524-4725.1995.tb00301.x

10.1111/j.1365-4632.2003.01807.x

10.1001/archderm.126.9.1214

10.1007/BF00436515

10.1002/1097-0142(19860715)58:2<366::AID-CNCR2820580228>3.0.CO;2-V

10.1086/513662

10.1177/194589240401800202

10.1016/S0161-6420(97)30054-2

10.1128/JCM.37.5.1532-1535.1999

10.1097/00042737-200012010-00022

10.1086/317527

10.1080/02681219680000201

Faure BT, 1990, Aspergillar osteomyelitis of the acetabulum. A case report and review of the literature, Orthop Rev, 19, 58

Olle JE, 1990, Aspergillus osteomyelitis of the sternum description of a case and review of the literature, Enferm Infecc Microbiol Clin, 8, 94

10.1007/BF01704898

Chi CY, 2003, Aspergillus flavus epidural abscess and osteomyelitis in a diabetic patient, J Microbiol Immunol Infect, 36, 145

Cortet B, 1994, Aspergillus spondylodiscitis: successful conservative treatment in 9 cases, J Rheumatol, 21, 1287

10.1086/342699

10.1309/EXBVYAUPENBM285Y

10.1001/archinte.144.7.1462

10.1136/jcp.49.10.798

Chumpitazi BF, 2000, Aspergillus fumigatus antigen detection in sera from patients at risk for invasive aspergillosis, J Clin Microbiol, 38, 438, 10.1128/JCM.38.1.438-443.2000

10.1128/JCM.35.9.2206-2209.1997

10.1128/JCM.40.11.4382-4387.2002

10.1053/jinf.2001.0883

10.1128/JCM.40.6.2224-2227.2002

10.1007/s11046-005-4996-9

10.1128/JCM.43.1.299-305.2005

10.1128/JCM.38.4.1510-1515.2000

10.1097/00019606-199710000-00002

10.1128/JCM.38.11.4186-4192.2000

10.1128/JCM.42.8.3495-3504.2004

Martin C, 2000, Development of a PCR‐based line probe assay for identification of fungal pathogens, J Clin Microbiol, 38, 3735, 10.1128/JCM.38.10.3735-3742.2000

James MJ, 2000, Use of repetitive DNA probe to type clinical and environmental isolates of Aspergillus flavus from a cluster of cutaneous infections in neonatal intensive care unit, J Clin Microbiol, 38, 3612, 10.1128/JCM.38.10.3612-3618.2000

10.1099/jmm.0.45856-0

10.1128/JCM.42.8.3495-3504.2004

10.1080/13693780310001656786

10.1093/jac/42.6.741

10.1016/0002-9343(89)90475-0

10.1067/mjd.2002.120627

10.1093/jac/dkg434

10.1128/AAC.44.8.2017-2022.2000

10.1128/AAC.48.10.3690-3696.2004

10.1016/j.drup.2006.01.001

10.1053/jinf.2000.0747

Varanasi NL, 2001, In Vitro Susceptibility and Azole Resistance Among Clinical and Laboratory‐Selected Isolates of Aspergillus Flavus Obtained From Three Continents

10.1128/AAC.49.2.512-517.2005

10.1093/jac/dkg434

10.1067/mjd.2002.120627

10.1016/S0732-8893(98)00102-3

10.1093/jac/46.2.229

10.1111/j.1348-0421.1999.tb01231.x

Rose HD, 1979, Filtering hospital air decreases Aspergillus spore counts, Am Rev Respir Dis, 119, 511

Sarubbi FA, 1982, Increased recovery of Aspergillus flavus from respiratory specimens during hospital construction, Am Rev Respir Dis, 125, 33

10.1086/502101

10.1016/j.jhin.2006.02.014

10.1128/JCM.38.6.2419-2422.2000

10.1128/JCM.38.10.3612-3618.2000

10.1128/jcm.34.2.345-351.1996

10.1007/s10295-005-0226-1

10.1093/clinids/21.1.210

10.3109/02688699409002390

10.1136/jnnp.56.2.188

10.1053/jinf.2000.0786

10.1128/JCM.42.2.665-669.2004

10.3314/jjmm.39.167

10.1111/j.1439-0507.2004.00980.x

10.1053/jinf.2000.0637

Demaria RG, 2000, Aspergillus flavus mitral valve endocarditis after lung abscess, J Heart Valve Dis, 9, 786

10.1067/mjd.2001.107776

10.1055/s-2007-1013214

10.1093/clinids/20.4.1052

Drakos PE, 1993, Invasive fungal sinusitis in patients undergoing bone marrow transplantation, Bone Marrow Transplant, 12, 203

10.3109/08880019309016552

10.1016/S0190-9622(08)81879-8

10.1078/1438-4221-00196

10.1099/jmm.0.05421-0

10.1016/S1087-1845(02)00526-1