Aeromonas salmonicidaToxin AexT Has a Rho Family GTPase-Activating Protein Domain

Journal of Bacteriology - Tập 189 Số 6 - Trang 2558-2560 - 2007
Yael Litvak1, Zvi Selinger1
1Department of Biological Chemistry and the Kuhne Minerva Center, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

Tóm tắt

ABSTRACTThe N terminus of theAeromonas salmonicidaADP-ribosylating toxin AexT displays in vitro GTPase-activating protein (GAP) activity for Rac1, CDC42, and RhoA. HeLa cells transfected with the AexT N terminus exhibit rounding and actin disordering. We propose that theAeromonas salmonicidaAexT toxin is a novel member of the growing family of bacterial RhoGAPs.

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