Vitamin B12serostatus in Colombian children and adult women: results from a nationally representative survey
Tóm tắt
Vitamin B12deficiency is associated with many adverse health outcomes and is highly prevalent worldwide. The present study assesses the prevalence of vitamin B12deficiency and marginal deficiency in Colombian children and women and examines the sociodemographic correlates of serum vitamin B12concentrations in these groups.
Cross-sectional, nationally representative survey.
Colombia.
Children <18 years old (
The overall prevalence of vitamin B12deficiency (serum vitamin B12<148 pmol/l) and marginal deficiency (serum vitamin B12=148–221 pmol/l) was, respectively, 6·6 % (95 % CI 5·2 %, 8·3 %) and 22·5 % (95 % CI 21·1 %, 23·9 %). Pregnant women had the highest prevalence of deficiency (18·9 %; 95 % CI 16·6 %, 21·5 %) compared with non-pregnant adult women (18·5 %; 95 % CI 4·4 %, 53·1 %) and children (2·8 %; 95 % CI 2·3 % %, 3·3 %). In multivariable analyses among children, mean serum vitamin B12was positively associated with female sex (12 pmol/l higher compared with males;
The prevalence of vitamin B12deficiency and marginal deficiency in Colombian women and children is substantial. The burden falls largely on adult women, those with lowest education and those living in the poorest, most rural regions of the country.
Từ khóa
Tài liệu tham khảo
Brasileiro, 2005, Plasma total homocysteine in Brazilian overweight and non-overweight adolescents: a case–control study, Nutr Hosp, 20, 313
Alvarez, 2006, Validation of a household food security scale in Antioquia, Colombia, Salud Publica Mex, 48, 474
Lindenbaum, 1994, Prevalence of cobalamin deficiency in the Framingham elderly population, Am J Clin Nutr, 60, 2, 10.1093/ajcn/60.1.2
de Onis, 2006, WHO Child Growth Standards based on length/height, weight and age, Acta Paediatr, 95, 76, 10.1111/j.1651-2227.2006.tb02378.x
Casterline, 1997, Vitamin B-12 deficiency is very prevalent in lactating Guatemalan women and their infants at three months postpartum, J Nutr, 127, 1966, 10.1093/jn/127.10.1966
Clarke, 2002, Homocysteine and risk of ischemic heart disease and stroke – a meta-analysis, JAMA, 288, 2015, 10.1001/jama.288.16.2015
Blanco, 2003, Nutritional anemia in nursing women in Costa Rica, Arch Latinoam Nutr, 53, 28
Louwman, 2000, Signs of impaired cognitive function in adolescents with marginal cobalamin status, Am J Clin Nutr, 72, 762, 10.1093/ajcn/72.3.762
1998, Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline
Jones, 2007, Prevalent vitamin B-12 deficiency in twelve-month-old Guatemalan infants is predicted by maternal B-12 deficiency and infant diet, J Nutr, 137, 1307, 10.1093/jn/137.5.1307
Villamor, 2008, Vitamin B-12 status is associated with socioeconomic level and adherence, to an animal food dietary pattern in Colombian school children, J Nutr, 138, 1391, 10.1093/jn/138.7.1391
Baltaci, 2012, Evaluation of vitamin B12 level in middle-aged obese women with metabolic and nonmetabolic syndrome: case–control study, Turk J Med Sci, 42, 802
Duran, 2009, Nutrition status in Argentinean children 6 to 72 months old: results from the National Nutrition and Health Survey (ENNyS), Arch Argent Pediatr, 107, 397
2011, Encuesta Nacional de la Situación Nutricional en Colombia 2010
Rutstein, 2004, The DHS Wealth Index. DHS Comparative Reports
Herbert, 1997, Call for endorsement of a petition to the Food and Drug Administration to always add vitamin B-12 to any folate fortification or supplement, Am J Clin Nutr, 65, 572, 10.1093/ajcn/65.2.572
Morris, 2002, Elevated serum methylmalonic acid concentrations are common among elderly Americans, J Nutr, 132, 2799, 10.1093/jn/132.9.2799
Karatela, 2009, Plasma homocysteine in obese, overweight and normal weight hypertensives and normotensives, Indian Heart J, 61, 156