‘Smoking’ mephedrone: The identification of the pyrolysis products of 4‐methylmethcathinone hydrochloride

Drug Testing and Analysis - Tập 5 Số 5 - Trang 291-305 - 2013
Pierce V. Kavanagh1, John E. O’Brien2, John D. Power3, Brian Talbot4, Seán D. McDermott3
1Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland
2School of Chemistry, Trinity College, Dublin 2, Ireland
3Forensic Science Laboratory, Garda HQ, Dublin 8, Ireland
4School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin 2, Ireland

Tóm tắt

The ring‐substituted cathinone – mephedrone – has gained popularity among recreational drug users over the past several years. It is generally consumed orally or by snorting but reports indicate that it is also ingested by vaporization/inhalation. This study examines the pyrolysis products produced by heating mephedrone under using simulated ‘meth pipe’ conditions. Thirteen pyrolysis products were identified, the major ones being iso‐mephedrone, 4‐methylpropiophenone, 4‐methylphenylacetone, two pyrazine derivatives formed by dimerization of mephedrone, N‐methylated mephedrone (N,N,4‐trimethylcatinone), two hydroxylated oxidation products and a diketone. Other minor products formed were identified as 4‐methylacetophenone, two α‐chloro ketones and N‐methylated iso‐mephedrone. Copyright © 2012 John Wiley & Sons, Ltd.

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Drug Testing and Analysis

Tập 5 Số 5

291-305

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