“Clinical features of women with gout arthritis.” A systematic review

Clinical Rheumatology - 2010
KJM Jansen Dirken-Heukensfeldt1, TAM Teunissen1, EH van de Lisdonk1, ALM Lagro-Janssen1
1Department Primary Care, 229-HAG, General Practice/Women’s Studies in Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

Tóm tắt

Clinically, gout is generally considered as a preferential male disease. However, it definitely does not occur exclusively in males. Our aim was to assess differences in the clinical features of gout arthritis between female and male patients. Five electronic databases were searched to identify relevant original studies published between 1977 and 2007. The included studies had to focus on adult patients with primary gout arthritis and on sex differences in clinical features. Two reviewers independently assessed eligibility and quality of the studies. Out of 355 articles, 14 were selected. Nine fulfilled the quality and score criteria. We identified the following sex differences in the clinical features of gout in women compared to men: the onset of gout occurs at a higher age, more comorbidity with hypertension or renal insufficiency, more often use of diuretics, less likely to drink alcohol, less often podagra but more often involvement of other joints, less frequent recurrent attacks. We found interesting sex differences regarding the clinical features of patients with gout arthritis. To diagnose gout in women, knowledge of these differences is essential, and more research is needed to understand and explain the differences , especially in the general population.

Từ khóa


Tài liệu tham khảo

Bieber JD, Terkeltaub RA (2004) Gout: on the brink of novel therapeutic options for an ancient disease. Arthritis Rheum 50(8):2400–2414

Arromdee E, Michet CJ, Crowson CS, O'Fallon WM, Gabriel SE (2002) Epidemiology of gout: is the incidence rising? J Rheumatol 29(11):2403–2406

Janssens HJ, van de Lisdonk EH, Bor H, van den Hoogen HJ, Janssen M (2003) Gout, just a nasty event or a cardiovascular signal? A study from primary care. Fam Pract 20(4):413–416

Janssens HJ, van de Lisdonk EH, Janssen M, van den Hoogen HJ, Verbeek AL (2006) Gout, not induced by diuretics? A case–control study from primary care. Ann Rheum Dis 65(8):1080–1083

Saag KG, Choi H (2006) Epidemiology, risk factors, and lifestyle modifications for gout. Arthritis Res Ther 8(Suppl 1):S2

Wallace KL, Riedel AA, Joseph-Ridge N, Wortmann R (2004) Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population. J Rheumatol 31(8):1582–1587

Kim KY, Schumacher HR, Hunsche E, Wertheimer A, Kong S (2003) A literature review of epidemiology and treatment in acute gout. Clin Ther 25:1593–1617

Bero LA, Grilli R, Grimshaw JM, Hervey E, Oxman AD, Thomson MA (1998) Closing the gap between research and practice: an overview of systematic reviews of interventions to promote the implementation of research findings. The Cochrane effective practice and organization of care review group. BMJ 317(7156):465–468

Keuken DG, Haafkens JA, Moerman CJ, Klazinga NS, ter Riet G (2007) Attention to sex-related factors in the development of clinical practice guidelines. J Womens Health 16(1):82–92

Wallace SL, Robinsom H, Masi AT, Decker JL, McCarty DL, Yu FT (1977) Preliminary criteria for the classification of the acute arthritis of primary gout. Arthritis Rheum 20(3):895–900

Currie WJ (1978) The gout patient in general practice. Rheumatol Rehabil 17(4):205–217

ter Borg EJ, Rasker JJ (1987) Gout in the elderly, a separate entity? Ann Rheum Dis 46(1):72–76

Cassim B, Mody GM, Deenadayalu VK, Hammond MG (1994) Gout in black South Africans: a clinical and genetic study. Ann Rheum Dis 53(11):59–62

Kowalec JK, Krey PR (1978) Gout in an urban setting. J Med Soc N J 75(9):617–620

Macfarlane DG, Dieppe PA (1985) Diuretic-induced gout in elderly women. Br J Rheumatol 24(2):155–157

Lally EV, Ho G, Kaplan SR (1986) The clinical spectrum of gouty arthritis in women. Arch Intern Med 146(11):2221–2225

Gallerani M, Govoni M, Mucinelli M, Bigoni M, Trotta F, Manfredinil R (1999) Seasonal variation in the onset of acute microcrystalline arthritis. Rheumatology (Oxford) 38(10):1003–1006

Puig JG, Michan AD, Jimenez ML, Perez de Ayala C, Mateos FA, Capitan CF et al (1991) Female gout. Clinical spectrum and uric acid metabolism*2ws KT in. Arch Intern Med 51(4):726–732

Harrold LR, Yood RA, Mikuls TR, Andrade SE, Davis J, Fuller J et al (2006) Sex differences in gout epidemiology, evaluation and treatment. Ann Rheum Dis 65:1368–1372

Meyers OL, Monteagudo FS (1986) A comparison of gout in men and women*2. A 10-year experience. S Afr Med J 70(12):721–723

De Souza AW, Fernandes V, Ferrari AJ (2005) Female gout: clinical and laboratory features. J Rheumatol 32(11):2186–2188

Tikly M et al (1998) Risk factors for gout: a hospital-based study in urban black South Africans. Rev Rhum Engl Ed 65(4):225–231

Deesomchok U, Tumrasvin T (1989) A clinical comparison of females and males with gouty arthritis. J Med Assoc Thai 72(9):510–515

Chang SJ, Chen CJ, Hung HP, Ou TT, Ko YC (2004) Community-based study in Taiwan aborigines concerning renal dysfunction in gout patients. Scand J Rheumatol 33(4):233–238

Hak AE, Curhan G, Grodstein FD, Choi HK (2009) Menopause, postmenopausal hormone use and risk of incident gout. Ann Rheum Dis. doi:ard.2009.109884v1

Cappuccio FP, Stazzullo P, Farinaro E, Trevisan M (1993) Uric acid metabolism and tubular sodium handling: results from a population based study. JAMA 270:354–359

Malik A, Schumacher R, Dinnella JE, Clayburne GM (2009) Clinical diagnostic criteria for gout. Comparison with the gold standard of synovial fluid crystal analysis. J Clin Rheumalog 15:22–24

Thông tin
Thông tin xuất bản

Clinical Rheumatology

Thông tin tác giả