β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during Collagen-Induced Arthritis

McInnes, 2007, Cytokines in the pathogenesis of rheumatoid arthritis, Nat. Rev. Immunol., 7, 429, 10.1038/nri2094

Dekkers, 2004, Elevated sympathetic nervous system activity in patients with recently diagnosed rheumatoid arthritis with active disease, Clin. Exp. Rheumatol., 22, 63

Kuis, 1996, The autonomic nervous system and the immune system in juvenile rheumatoid arthritis, Brain Behav. Immun., 10, 387, 10.1006/brbi.1996.0034

Tanaka, 1996, Biphasic changes in behavioral, endocrine, and sympathetic systems in adjuvant arthritis in Lewis rats, Brain Res. Bull., 39, 33, 10.1016/0361-9230(95)02037-3

Pongratz, 2008, B-cell involvement in the pathogenesis of RA-is there a contribution of the sympathetic nervous system?, Immunol. Res., 40, 148, 10.1007/s12026-007-8002-0

Harle, 2005, An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis, Arthritis Rheum., 52, 1305, 10.1002/art.20987

Miller, 2000, The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages, FASEB J., 14, 2097, 10.1096/fj.99-1082com

Capellino, 2015, Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis, Ann. Rheum. Dis., 74, 444, 10.1136/annrheumdis-2013-203925

Miller, 2002, Norepinephrine from synovial tyrosine hydroxylase positive cells is a strong indicator of synovial inflammation in rheumatoid arthritis, J. Rheumatol., 29, 427

Schorr, 1999, Interactions between the sympathetic nervous system and the immune system, Brain Behav. Immun., 13, 271, 10.1006/brbi.1999.0549

Kim, 2010, Epinephrine-primed murine bone marrow-derived dendritic cells facilitate production of IL-17A and IL-4 but not IFN-gamma by CD4+ T cells, Brain Behav. Immun., 24, 1126, 10.1016/j.bbi.2010.05.003

Felten, 1987, Noradrenergic sympathetic innervation of the spleen: I. Nerve fibers associate with lymphocytes and macrophages in specific compartments of the splenic white pulp, J. Neurosci. Res., 18, 28, 10.1002/jnr.490180107

Straub, 2004, Complexity of the bi-directional neuroimmune junction in the spleen, Trends Pharmacol. Sci., 25, 640, 10.1016/j.tips.2004.10.007

Emeny, 2007, Beta1-adrenergic receptors on immune cells impair innate defenses against Listeria, J. Immunol., 178, 4876, 10.4049/jimmunol.178.8.4876

Esparza, 2018, Isoproterenol-induced beta-2 adrenergic receptor activation negatively regulates interleukin-2 signaling, Biochem. J., 475, 2907, 10.1042/BCJ20180503

Yanagawa, 2010, Enhanced dendritic cell antigen uptake via alpha2 adrenoceptor-mediated PI3K activation following brief exposure to noradrenaline, J. Immunol., 185, 5762, 10.4049/jimmunol.1001899

Hasko, 2001, Receptor-mediated interaction between the sympathetic nervous system and immune system in inflammation, Neurochem. Res., 26, 1039, 10.1023/A:1012305122327

Honke, N., Lowin, T., Opgenoorth, B., Shaabani, N., Lautwein, A., Teijaro, J.R., Schneider, M., and Pongratz, G. (2022). Endogenously produced catecholamines improve the regulatory function of TLR9-activated B cells. PLoS Biol., 20.

Harle, 2008, An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells, Arthritis Rheum., 58, 2347, 10.1002/art.23628

Lorton, 1999, Dual role for noradrenergic innervation of lymphoid tissue and arthritic joints in adjuvant-induced arthritis, Brain Behav. Immun., 13, 315, 10.1006/brbi.1999.0564

Straub, 2008, Neuronally released sympathetic neurotransmitters stimulate splenic interferon-gamma secretion from T cells in early type II collagen-induced arthritis, Arthritis Rheum., 58, 3450, 10.1002/art.24030

Pongratz, 2012, The sympathetic nervous system stimulates anti-inflammatory B cells in collagen-type II-induced arthritis, Ann. Rheum. Dis., 71, 432, 10.1136/ard.2011.153056

Nandakumar, 2004, Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells, Arthritis Res. Ther., 6, R544, 10.1186/ar1217

Mauri, 2003, Prevention of arthritis by interleukin 10-producing B cells, J. Exp. Med., 197, 489, 10.1084/jem.20021293

Fillatreau, 2002, B cells regulate autoimmunity by provision of IL-10, Nat. Immunol., 3, 944, 10.1038/ni833

Fassold, 2009, Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis, Arthritis Rheum., 60, 2892, 10.1002/art.24860

Candando, 2014, B10 cell regulation of health and disease, Immunol. Rev., 259, 259, 10.1111/imr.12176

Sanders, 2012, The beta2-adrenergic receptor on T and B lymphocytes: Do we understand it yet?, Brain Behav. Immun., 26, 195, 10.1016/j.bbi.2011.08.001

Agac, 2018, The beta2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion, Brain Behav. Immun., 74, 176, 10.1016/j.bbi.2018.09.004

Kleibeuker, 2008, Physiological changes in GRK2 regulate CCL2-induced signaling to ERK1/2 and Akt but not to MEK1/2 and calcium, J. Neurochem., 104, 979, 10.1111/j.1471-4159.2007.05023.x

DeWire, 2007, Beta-arrestins and cell signaling, Annu. Rev. Physiol., 69, 483, 10.1146/annurev.physiol.69.022405.154749

Reiter, 2006, GRKs and beta-arrestins: Roles in receptor silencing, trafficking and signaling, Trends Endocrinol. Metab., 17, 159, 10.1016/j.tem.2006.03.008

Shenoy, 2006, beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor, J. Biol. Chem., 281, 1261, 10.1074/jbc.M506576200

Banko, 2017, Induction and Differentiation of IL-10-Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients, J. Immunol., 198, 1512, 10.4049/jimmunol.1600218

Rosser, 2015, Regulatory B cells: Origin, phenotype, and function, Immunity, 42, 607, 10.1016/j.immuni.2015.04.005

Mauri, 2012, Immune regulatory function of B cells, Annu. Rev. Immunol., 30, 221, 10.1146/annurev-immunol-020711-074934

Pongratz, 2013, Role of peripheral nerve fibres in acute and chronic inflammation in arthritis, Nat. Rev. Rheumatol., 9, 117, 10.1038/nrrheum.2012.181

Kohm, 2001, Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo, Pharmacol. Rev., 53, 487

Vazquez, 1991, Modulation of IL-2- and IL-4-dependent human B cell proliferation by cyclic AMP, J. Immunol., 146, 4222, 10.4049/jimmunol.146.12.4222

Kavelaars, 2002, Regulated expression of alpha-1 adrenergic receptors in the immune system, Brain Behav. Immun., 16, 799, 10.1016/S0889-1591(02)00033-8

Heijnen, 2002, Cytokines regulate alpha(1)-adrenergic receptor mRNA expression in human monocytic cells and endothelial cells, J. Neuroimmunol., 125, 66, 10.1016/S0165-5728(02)00034-6

Lubahn, 2014, Targeting alpha- and beta-Adrenergic Receptors Differentially Shifts Th1, Th2, and Inflammatory Cytokine Profiles in Immune Organs to Attenuate Adjuvant Arthritis, Front. Immunol., 5, 346, 10.3389/fimmu.2014.00346

Pongratz, 2010, The B cell, arthritis, and the sympathetic nervous system, Brain Behav. Immun., 24, 186, 10.1016/j.bbi.2009.07.002

Platzer, 1995, Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs, Int. Immunol., 7, 517, 10.1093/intimm/7.4.517

Platzer, 1999, Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells, Eur. J. Immunol., 29, 3098, 10.1002/(SICI)1521-4141(199910)29:10<3098::AID-IMMU3098>3.0.CO;2-H

Laukova, 2013, Catecholamine production is differently regulated in splenic T- and B-cells following stress exposure, Immunobiology, 218, 780, 10.1016/j.imbio.2012.08.279

Capellino, 2012, First appearance and location of catecholaminergic cells during experimental arthritis and elimination by chemical sympathectomy, Arthritis Rheum., 64, 1110, 10.1002/art.33431

Lombardi, 2001, Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system, J. Immunol., 166, 1635, 10.4049/jimmunol.166.3.1635

Lombardi, 1999, Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis, FASEB J., 13, 715, 10.1096/fasebj.13.6.715

Lorton, 2015, Molecular mechanisms underlying beta-adrenergic receptor-mediated cross-talk between sympathetic neurons and immune cells, Int. J. Mol. Sci., 16, 5635, 10.3390/ijms16035635

Benovic, 2002, Novel beta2-adrenergic receptor signaling pathways, J. Allergy Clin. Immunol., 110, S229, 10.1067/mai.2002.129370

Evron, 2012, GRK2: Multiple roles beyond G protein-coupled receptor desensitization, Trends Pharmacol. Sci., 33, 154, 10.1016/j.tips.2011.12.003

Lefkowitz, 2005, Transduction of receptor signals by beta-arrestins, Science, 308, 512, 10.1126/science.1109237

Gurevich, 2019, GPCR Signaling Regulation: The Role of GRKs and Arrestins, Front. Pharmacol., 10, 125, 10.3389/fphar.2019.00125

Lorton, 2005, Changes in the density and distribution of sympathetic nerves in spleens from Lewis rats with adjuvant-induced arthritis suggest that an injury and sprouting response occurs, J. Comp. Neurol., 489, 260, 10.1002/cne.20640

Lorton, 1997, Norepinephrine content in primary and secondary lymphoid organs is altered in rats with adjuvant-induced arthritis, Mech. Ageing Dev., 94, 145, 10.1016/S0047-6374(96)01859-3

Han, 2016, Regulatory effects of GRK2 on GPCRs and non-GPCRs and possible use as a drug target (Review), Int. J. Mol. Med., 38, 987, 10.3892/ijmm.2016.2720

Han, 2021, Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats, Acta Pharm. Sin. B, 11, 1835, 10.1016/j.apsb.2021.01.015

Li, 2011, Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: Isoform specific regulation of inflammation, Mol. Immunol., 49, 64, 10.1016/j.molimm.2011.07.021

Li, 2014, beta-Arrestin 2 negatively regulates Toll-like receptor 4 (TLR4)-triggered inflammatory signaling via targeting p38 MAPK and interleukin 10, J. Biol. Chem., 289, 23075, 10.1074/jbc.M114.591495

Gaffal, 2014, beta-arrestin 2 inhibits proinflammatory chemokine production and attenuates contact allergic inflammation in the skin, J. Investig. Derm., 134, 2131, 10.1038/jid.2014.117

Fan, 2014, beta-Arrestins 1 and 2 are critical regulators of inflammation, Innate Immun., 20, 451, 10.1177/1753425913501098

Seregin, 2010, beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: Differential regulation by beta-arrestin-1 and beta-arrestin-2, Virus Res., 147, 123, 10.1016/j.virusres.2009.10.023

Wang, 2016, Anti-inflammatory activities of fenoterol through beta-arrestin-2 and inhibition of AMPK and NF-kappaB activation in AICAR-induced THP-1 cells, Biomed. Pharmacother., 84, 185, 10.1016/j.biopha.2016.09.044

Luttrell, 2002, The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals, J. Cell Sci., 115, 455, 10.1242/jcs.115.3.455

Capellino, 2010, Catecholamine-producing cells in the synovial tissue during arthritis: Modulation of sympathetic neurotransmitters as new therapeutic target, Ann. Rheum. Dis., 69, 1853, 10.1136/ard.2009.119701

Brenner, 2003, cAMP-induced Interleukin-10 promoter activation depends on CCAAT/enhancer-binding protein expression and monocytic differentiation, J. Biol. Chem., 278, 5597, 10.1074/jbc.M207448200

Chung, 2007, Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1, Immunity, 27, 952, 10.1016/j.immuni.2007.11.014

Ma, 2001, The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages, J. Biol. Chem., 276, 13664, 10.1074/jbc.M011157200

Carlezon, 2005, The many faces of CREB, Trends Neurosci., 28, 436, 10.1016/j.tins.2005.06.005

Steven, 2020, What turns CREB on? And off? And why does it matter?, Cell. Mol. Life Sci., 77, 4049, 10.1007/s00018-020-03525-8

Baratki, 2019, Inflammatory signal induced IL-10 production of marginal zone B-cells depends on CREB, Immunol. Lett., 212, 14, 10.1016/j.imlet.2019.06.004

Krutzik, 2004, Analysis of protein phosphorylation and cellular signaling events by flow cytometry: Techniques and clinical applications, Clin. Immunol., 110, 206, 10.1016/j.clim.2003.11.009

Haas, 2008, Intracellular Phospho-Flow cytometry reveals novel insights into TCR proximal signaling events. A comparison with Western blot, Cytom. Part A, 73, 799, 10.1002/cyto.a.20598

Krutzik, 2011, Phospho flow cytometry methods for the analysis of kinase signaling in cell lines and primary human blood samples, Methods Mol. Biol., 699, 179, 10.1007/978-1-61737-950-5_9