β-Adrenergic Receptor Polymorphisms: Cardiovascular Disease Associations and Pharmacogenetics

Pharmaceutical Research - Tập 19 Số 12 - Trang 1779-1787 - 2002
Johnson, Julie A.1, Terra, Steven G.1
1Department of Pharmacy Practice, College of Pharmacy, Center for Pharmacogenomics, University of Florida, Gainesville, USA

Tóm tắt

The β-adrenergic receptors (βAR) play important roles in cardiovascular function and disease, and both agonists and antagonists are widely used in various settings for treatment of cardiovascular disease. Both the β1AR and β2AR genes have several polymorphisms that are common in the population and result in encoding of different amino acids. More importantly, in vitro functional studies suggest that these polymorphisms have functional significance. In this review we summarize the literature on the relationship between the βAR polymorphisms and cardiovascular disease as well as the literature on the impact of these polymorphisms on drug response. Additionally, the polymorphisms in both the β1AR and β2AR genes are in linkage disequilibrium; thus, the relevance of single polymorphism vs. haplotype analysis is discussed. Further study of the βAR genetic polymorphisms is likely to enhance our understanding of cardiovascular disease and improve our use of β-agonists and β-antagonists in treatment of cardiovascular disease.

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citation_journal_title=Can. J. Physiol. Pharmacol.; citation_title=The negative inotropic action of catecholamines: role of beta3-adrenoceptors; citation_author=C. Gauthier, V. Leblais, S. Moniotte, D. Langin, J. L. Balligand; citation_volume=78; citation_publication_date=2000; citation_pages=681-690; citation_id=CR1

citation_journal_title=Circulation; citation_title=ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure): Developed in collaboration with the International Society for Heart and Lung Transplantation; endorsed by the Heart Failure Society of America; citation_author=S. A. Hunt, D. W. Baker, M. H. Chin, M. P. Cinquegrani, A. M. Feldmanmd, G. S. Francis, T. G. Ganiats, S. Goldstein, G. Gregoratos, M. L. Jessup, R. J. Noble, M. Packer, M. A. Silver, L. W. Stevenson, R. J. Gibbons, E. M. Antman, J. S. Alpert, D. P. Faxon, V. Fuster, A. K. Jacobs, L. F. Hiratzka, R. O. Russell, S. C. Smith; citation_volume=104; citation_publication_date=2001; citation_pages=2996-3007; citation_id=CR2

citation_journal_title=[published erratum appears in Arch. Intern. Med.; citation_author=; citation_volume=23; citation_issue=6; citation_publication_date=1998; citation_pages=573-2446; citation_id=CR3

citation_journal_title=Circulation; citation_title=ACC/AHA guidelines for the management of patients with unstable angina and non-STsegment elevation myocardial infarction: executive summary and recommendations: A report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina); citation_author=E. Braunwald, E. M. Antman, J. W. Beasley, R. M. Califf, M. D. Cheitlin, J. S. Hochman, R. H. Jones, D. Kereiakes, J. Kupersmith, T. N. Levin, C. J. Pepine, J. W. Schaeffer, E. E. Smith, D. E. Steward, P. Theroux, R. J. Gibbons, J. S. Alpert, K. A. Eagle, D. P. Faxon, V. Fuster, T. J. Gardner, G. Gregoratos, R. O. Russell, S. C. Smith; citation_volume=102; citation_publication_date=2000; citation_pages=1193-1209; citation_id=CR4

citation_journal_title=Circulation; citation_title=ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: executive summary and recommendations: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients with Chronic Stable Angina); citation_author=R. J. Gibbons, K. Chatterjee, J. Daley, J. S. Douglas, S. D. Fihn, J. M. Gardin, M. A. Grunwald, D. Levy, B. W. Lytle, R. A. O'Rourke, W. P. Schafer, S. V. Williams, J. L. Ritchie, M. D. Cheitlin, K. A. Eagle, T. J. Gardner, A. Garson, R. O. Russell, T. J. Ryan, S. C. Smith; citation_volume=99; citation_publication_date=1999; citation_pages=2829-2848; citation_id=CR5

citation_journal_title=Circulation; citation_title=1999 Update: ACC/AHA guidelines for the management of patients with acute myocardial infarction: executive summary and recommendations: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction); citation_author=T. J. Ryan, E. M. Antman, N. H. Brooks, R. M. Califf, L. D. Hillis, L. F. Hiratzka, E. Rapaport, B. Riegel, R. O. Russell, E. E. Smith, W. D. Weaver, R. J. Gibbons, J. S. Alpert, K. A. Eagle, T. J. Gardner, A. Garson, G. Gregoratos, S. C. Smith; citation_volume=100; citation_publication_date=1999; citation_pages=1016-1030; citation_id=CR6

citation_journal_title=Circulation; citation_title=ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients with Atrial Fibrillation) developed in collaboration with the North American Society of Pacing and Electrophysiology; citation_author=V. Fuster, L. E. Ryden, R. W. Asinger, D. S. Cannom, H. J. Crijns, R. L. Frye, J. L. Halperin, G. N. Kay, W. W. Klein, S. Levy, R. L. McNamara, E. N. Prystowsky, L. S. Wann, D. G. Wyse, R. J. Gibbons, E. M. Antman, J. S. Alpert, D. P. Faxon, G. Gregoratos, L. F. Hiratzka, A. K. Jacobs, R. O. Russell, S. C. Smith, A. Alonso-Garcia, C. Blomstrom-Lundqvist, G. de Backer, M. Flather, J. Hradec, A. Oto, A. Parkhomenko, S. Silber, A. Torbicki; citation_volume=104; citation_publication_date=2001; citation_pages=2118-2150; citation_id=CR7

citation_journal_title=Am. J. Respir. Cell. Mol. Biol.; citation_title=Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects; citation_author=E. Reihsaus, M. Innis, N. MacIntyre, S. B. Liggett; citation_volume=8; citation_publication_date=1993; citation_pages=334-339; citation_id=CR8

citation_journal_title=Lancet; citation_title=Common polymorphisms of beta1-adrenoceptor: identification and rapid screening assay [letter]; citation_author=A. Maqbool, A. S. Hall, S. G. Ball, A. J. Balmforth; citation_volume=353; citation_publication_date=1999; citation_pages=897; citation_id=CR9

citation_journal_title=J. Mol. Med.; citation_title=Beta1-adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?; citation_author=S. Podlowski, K. Wenzel, H. P. Luther, J. Muller, P. Bramlage, G. Baumann, S. B. Felix, A. Speer, R. Hetzer, K. Kopke, M. R. Hoehe, G. Wallukat; citation_volume=78; citation_publication_date=2000; citation_pages=87-93; citation_id=CR10

citation_journal_title=Clin. Pharmacol. Ther.; citation_title=Linkage disequilibrium of common beta1-adrenergic receptor polymorphisms; citation_author=S. Terra, S. McGorray, M. Wallace, L. Picoult-Newberg, C. Pepine, J. Johnson; citation_volume=71; citation_publication_date=2002; citation_pages=70; citation_id=CR11

citation_journal_title=J. Cardiovasc. Pharmacol.; citation_title=Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking; citation_author=D. A. Rathz, K. M. Brown, L. A. Kramer, S. B. Liggett; citation_volume=39; citation_publication_date=2002; citation_pages=155-160; citation_id=CR12

citation_journal_title=J. Biol. Chem.; citation_title=A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor; citation_author=D. A. Mason, J. D. Moore, S. A. Green, S. B. Liggett; citation_volume=274; citation_publication_date=1999; citation_pages=12670-12674; citation_id=CR13

citation_journal_title=Circulation; citation_title=Polymorphism in the ?1-adrenergic receptor gene and hypertension; citation_author=K. Bengtsson, O. Melander, M. Orho-Melander, U. Lindblad, J. Ranstam, L. Rastam, L. Groop; citation_volume=104; citation_publication_date=2001; citation_pages=187-190; citation_id=CR14

citation_journal_title=Am. J. Cardiol.; citation_title=Effects of beta1-adrenoceptor genetic polymorphisms on resting hemodynamics in patients undergoing diagnostic testing for ischemia; citation_author=L. M. Humma, B. J. Puckett, H. E. Richardson, S. G. Terra, T. E. Andrisin, B. L. Lejeune, M. R. Wallace, J. F. Lewis, D. M. McNamara, L. Picoult-Newberg, C. J. Pepine, J. A. Johnson; citation_volume=88; citation_publication_date=2001; citation_pages=1034-1037; citation_id=CR15

citation_journal_title=Am. J. Hum. Genet.; citation_title=A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate; citation_author=K. Ranade, E. Jorgenson, W. H. Sheu, D. Pei, C. A. Hsiung, F. T. Chiang, Y. D. Chen, R. Pratt, R. A. Olshen, D. Curb, D. R. Cox, D. Botstein, N. Risch; citation_volume=70; citation_publication_date=2002; citation_pages=935-942; citation_id=CR16

citation_journal_title=Pharmacogenetics; citation_title=Arg389Gly beta 1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo; citation_author=H. G. Xie, V. Dishy, G. Sofowora, R. B. Kim, R. Landau, R. M. Smiley, H. H. Zhou, A. J. Wood, P. Harris, C. M. Stein; citation_volume=11; citation_publication_date=2001; citation_pages=191-197; citation_id=CR17

citation_journal_title=Pharmacogenetics; citation_title= In-vivo studies do not support a major functional role for the Gly389Arg beta 1-adrenoceptor polymorphism in humans; citation_author=R. Buscher, H. Belger, K. J. Eilmes, R. Tellkamp, J. Radke, S. Dhein, P. F. Hoyer, M. C. Michel, P. A. Insel, O. E. Brodde; citation_volume=11; citation_publication_date=2001; citation_pages=199-205; citation_id=CR18

citation_journal_title=Eur. Heart J.; citation_title=A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure; citation_author=M. Borjesson, Y. Magnusson, A. Hjalmarson, B. Andersson; citation_volume=21; citation_publication_date=2000; citation_pages=1853-1858; citation_id=CR19

citation_journal_title=J. Mol. Cell. Cardiol.; citation_title=Characterization of a unique genetic variant in the beta1-adrenoceptor gene and evaluation of its role in idiopathic dilated cardiomyopathy. CARDIGENE Group; citation_author=F. Tesson, P. Charron, M. Peuchmaurd, V. Nicaud, F. Cambien, L. Tiret, O. Poirier, M. Desnos, Y. Jullieres, P. Amouyel, G. Roizes, R. Dorent, K. Schwartz, M. Komajda; citation_volume=31; citation_publication_date=1999; citation_pages=1025-1032; citation_id=CR20

citation_journal_title=Clin. Pharmacol. Ther.; citation_title=Betaadrenergic receptor polymorphisms and antihypertensive response to beta-blocker therapy; citation_author=B. J. Puckett, D. F. Pauly, I. Zineh, J. A. Johnson; citation_volume=71; citation_publication_date=2002; citation_pages=2; citation_id=CR21

citation_journal_title=Clin Sci (Colch); citation_title=The gain-of-function G389R variant of the beta1-adrenoceptor does not influence blood pressure or heart rate response to beta-blockade in hypertensive subjects; citation_author=M. O'Shaughnessy, K. B. Fu, C. Dickerson, D. Thurston, M. J. Brown; citation_volume=99; citation_publication_date=2000; citation_pages=233-238; citation_id=CR22

citation_journal_title=N. Engl. J. Med.; citation_title=Seminars in medicine of the Beth Israel Hospital, Boston. Adrenergic receptors-evolving concepts and clinical implications; citation_author=P. A. Insel; citation_volume=334; citation_publication_date=1996; citation_pages=580-585; citation_id=CR23

citation_journal_title=J. Biol. Chem.; citation_title=PKA-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi: Demonstration in a reconstituted system; citation_author=A. M. Zamah, M. Delahunty, L. M. Luttrell, R. J. Lefkowitz; citation_volume=12; citation_publication_date=2002; citation_pages=31249-31256; citation_id=CR24

citation_journal_title=Am. J. Respir. Crit. Care Med.; citation_title=Polymorphisms of the beta2-adrenergic receptor and asthma; citation_author=S. B. Liggett; citation_volume=156; citation_publication_date=1997; citation_pages=S156-S162; citation_id=CR25

citation_journal_title=Pharmacology; citation_title=Pharmacogenetics of beta-1-and beta-2-adrenergic receptors; citation_author=S. B. Liggett; citation_volume=61; citation_publication_date=2000; citation_pages=167-173; citation_id=CR26

citation_journal_title=Proc. Natl. Acad. Sci. USA; citation_title=Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness; citation_author=C. M. Drysdale, D. W. McGraw, C. B. Stack, J. C. Stephens, R. S. Judson, K. Nandabalan, K. Arnold, G. Ruano, S. B. Liggett; citation_volume=97; citation_publication_date=2000; citation_pages=10483-10488; citation_id=CR27

citation_journal_title=Am. J. Pharmacogenomics; citation_title=Determination of human beta(2)-adrenoceptor haplotypes by denaturation selective amplification and subtractive genotyping; citation_author=J. Wang, E. B. Mougey, C. J. David, L. M. Humma, J. A. Johnson, J. J. Lima, J. E. Sylvester; citation_volume=1; citation_publication_date=2001; citation_pages=315-322; citation_id=CR28

citation_journal_title=Biochemistry; citation_title=Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties; citation_author=S. A. Green, J. Turki, M. Innis, S. B. Liggett; citation_volume=33; citation_publication_date=1994; citation_pages=9414-9419; citation_id=CR29

citation_journal_title=Am. J. Respir. Cell Mol. Biol.; citation_title=Influence of beta 2-adrenergic receptor genotypes on signal Johnson and Terra 1786 transduction in human airway smooth muscle cells; citation_author=S. A. Green, J. Turki, P. Bejarano, I. P. Hall, S. B. Liggett; citation_volume=13; citation_publication_date=1995; citation_pages=25-33; citation_id=CR30

citation_journal_title=Pharmacogenetics; citation_title=Influence of genetic polymorphisms in the beta2-adrenoceptor on desensitization in human lung mast cells; citation_author=L. K. Chong, J. Chowdry, P. Ghahramani, P. T. Peachell; citation_volume=10; citation_publication_date=2000; citation_pages=153-162; citation_id=CR31

citation_journal_title=Clin. Exp. Allergy; citation_title=Beta2-adrenoceptor polymorphisms are in linkage disequilibrium, but are not associated with asthma in an adult population; citation_author=J. C. Dewar, A. P. Wheatley, A. Venn, J. F. Morrison, J. Britton, I. P. Hall; citation_volume=28; citation_publication_date=1998; citation_pages=442-448; citation_id=CR32

citation_journal_title=Pharmacogenetics; citation_title=Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals; citation_author=H. G. Xie, C. M. Stein, R. B. Kim, Z. S. Xiao, N. He, H. H. Zhou, J. V. Gainer, N. J. Brown, J. L. Haines, A. J. Wood; citation_volume=9; citation_publication_date=1999; citation_pages=511-516; citation_id=CR33

citation_journal_title=J. Biol. Chem.; citation_title=A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor; citation_author=S. A. Green, G. Cole, M. Jacinto, M. Innis, S. B. Liggett; citation_volume=268; citation_publication_date=1993; citation_pages=23116-23121; citation_id=CR34

citation_journal_title=J. Clin. Invest.; citation_title=Polymorphisms of the 5? leader cistron of the human beta2-adrenergic receptor regulate receptor expression; citation_author=D. W. McGraw, S. L. Forbes, L. A. Kramer, S. B. Liggett; citation_volume=102; citation_publication_date=1998; citation_pages=1927-1932; citation_id=CR35

citation_journal_title=Am. J. Respir. Crit. Care Med.; citation_title=The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma; citation_author=E. Israel, J. M. Drazen, S. B. Liggett, H. A. Boushey, R. M. Cherniack, V. M. Chinchilli, D. M. Cooper, J. V. Fahy, J. E. Fish, J. G. Ford, M. Kraft, S. Kunselman, S. C. Lazarus, R. F. Lemanske, R. J. Martin, D. E. McLean, S. P. Peters, E. K. Silverman, C. A. Sorkness, S. J. Szefler, S. T. Weiss, C. N. Yandava; citation_volume=162; citation_publication_date=2000; citation_pages=75-80; citation_id=CR36

citation_journal_title=Thorax.; citation_title=Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism; citation_author=D. R. Taylor, J. M. Drazen, G. P. Herbison, C. N. Yandava, R. J. Hancox, G. I. Town; citation_volume=55; citation_publication_date=2000; citation_pages=762-767; citation_id=CR37

citation_title=Familial aggregation and genetic epidemiology of blood pressure; citation_inbook_title=Hypertension: Pathophysiology, Diagnosis and Management; citation_publication_date=1995; citation_pages=67-88; citation_id=CR38; citation_author=R. Ward; citation_publisher=Raven Press

citation_journal_title=J. Clin. Invest.; citation_title=Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension; citation_author=C. M. Stein, R. Nelson, R. Deegan, H. He, M. Wood, A. J. Wood; citation_volume=96; citation_publication_date=1995; citation_pages=579-585; citation_id=CR39

citation_journal_title=Hypertension; citation_title=Beta-2 adrenergic receptor gene variations, blood pressure, and heart size in normal twins; citation_author=A. Busjahn, G. H. Li, H. D. Faulhaber, M. Rosenthal, A. Becker, E. Jeschke, H. Schuster, B. Timmermann, M. R. Hoehe, F. C. Luft; citation_volume=35; citation_publication_date=2000; citation_pages=555-560; citation_id=CR40

citation_journal_title=Hypertension; citation_title=Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes; citation_author=K. Bengtsson, M. Orho-Melander, O. Melander, U. Lindblad, J. Ranstam, L. Rastam, L. Groop; citation_volume=37; citation_publication_date=2001; citation_pages=1303-1308; citation_id=CR41

citation_journal_title=Kidney Int.; citation_title=Beta-2 adrenoceptor genetic variation is associated with genetic predisposition to essential hypertension: The Bergen Blood Pressure Study; citation_author=B. Timmermann, R. Mo, F. C. Luft, E. Gerdts, A. Busjahn, P. Omvik, G. H. Li, H. Schuster, T. F. Wienker, M. R. Hoehe, P. Lund-Johansen; citation_volume=53; citation_publication_date=1998; citation_pages=1455-1460; citation_id=CR42

citation_journal_title=Hypertension; citation_title=Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor; citation_author=P. Kotanko, A. Binder, J. Tasker, P. DeFreitas, S. Kamdar, A. J. Clark, F. Skrabal, M. Caulfield; citation_volume=30; citation_publication_date=1997; citation_pages=773-776; citation_id=CR43

citation_journal_title=J. Intern. Med.; citation_title=Polymorphisms of the beta2-adrenergic receptor gene (ADRB2) in relation to cardiovascular risk factors in men; citation_author=R. Rosmond, O. Ukkola, M. Chagnon, C. Bouchard, P. Bjorntorp; citation_volume=248; citation_publication_date=2000; citation_pages=239-244; citation_id=CR44

citation_journal_title=Hypertension; citation_title=Beta-2 adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult Caucasians; citation_author=G. Gratze, J. Fortin, R. Labugger, A. Binder, P. Kotanko, B. Timmermann, F. C. Luft, M. R. Hoehe, F. Skrabal; citation_volume=33; citation_publication_date=1999; citation_pages=1425-1430; citation_id=CR45

citation_journal_title=J. Hypertens.; citation_title=Polymorphisms of the beta2-adrenoceptor (ADRB2) gene and essential hypertension: the ECTIM and PEGASE studies; citation_author=S. M. Herrmann, V. Nicaud, L. Tiret, A. Evans, F. Kee, J. B. Ruidavets, D. Arveiler, G. Luc, C. Morrison, M. R. Hoehe, M. Paul, F. Cambien; citation_volume=20; citation_publication_date=2002; citation_pages=229-235; citation_id=CR46

citation_journal_title=Hypertension; citation_title=Association analysis of beta(2)-adrenergic receptor polymorphisms with hypertension in Japanese; citation_author=N. Kato, T. Sugiyama, H. Morita, H. Kurihara, T. Sato, Y. Yamori, Y. Yazaki; citation_volume=37; citation_publication_date=2001; citation_pages=286-292; citation_id=CR47

citation_journal_title=Clin. Pharmacol. Ther.; citation_title=Human beta2-adrenergic receptor polymorphisms: no association with essential hypertension in black or white Americans; citation_author=H. G. Xie, C. M. Stein, R. B. Kim, J. V. Gainer, G. Sofowora, V. Dishy, N. J. Brown, R. E. Goree, J. L. Haines, A. J. Wood; citation_volume=67; citation_publication_date=2000; citation_pages=670-675; citation_id=CR48

citation_journal_title=Circulation; citation_title=Positional genomic analysis identifies the beta(2)-adrenergic receptor gene as a susceptibility locus for human hypertension; citation_author=M. S. Bray, J. Krushkal, L. Li, R. Ferrell, S. Kardia, C. F. Sing, S. T. Turner, E. Boerwinkle; citation_volume=101; citation_publication_date=2000; citation_pages=2877-2882; citation_id=CR49

citation_journal_title=Circulation; citation_title=Beta-adrenergic receptor blockade in chronic heart failure; citation_author=M. R. Bristow; citation_volume=101; citation_publication_date=2000; citation_pages=558-569; citation_id=CR50

citation_journal_title=J. Clin. Invest.; citation_title=The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure; citation_author=S. B. Liggett, L. E. Wagoner, L. L. Craft, R. W. Hornung, B. D. Hoit, T. C. McIntosh, R. A. Walsh; citation_volume=102; citation_publication_date=1998; citation_pages=1534-1539; citation_id=CR51

citation_journal_title=Circ. Res.; citation_title=Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure; citation_author=L. E. Wagoner, L. L. Craft, B. Singh, D. P. Suresh, P. W. Zengel, N. McGuire, W. T. Abraham, T. C. Chenier, G. W. Dorn ii, S. B. Liggett; citation_volume=86; citation_publication_date=2000; citation_pages=834-840; citation_id=CR52

citation_journal_title=Am. Heart J.; citation_title=Beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals; citation_author=B. D. Hoit, D. P. Suresh, L. Craft, R. A. Walsh, S. B. Liggett; citation_volume=139; citation_publication_date=2000; citation_pages=537-542; citation_id=CR53

citation_journal_title=Hypertension; citation_title=Beta(2)-adrenoceptor polymorphism determines vascular reactivity in humans; citation_author=J. R. Cockcroft, A. G. Gazis, D. J. Cross, A. Wheatley, J. Dewar, I. P. Hall, J. P. Noon; citation_volume=36; citation_publication_date=2000; citation_pages=371-375; citation_id=CR54

citation_journal_title=J. Clin. Invest.; citation_title=Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing; citation_author=F. D. Martinez, P. E. Graves, M. Baldini, S. Solomon, R. Erickson; citation_volume=100; citation_publication_date=1997; citation_pages=3184-3188; citation_id=CR55

citation_journal_title=N. Engl. J. Med.; citation_title=The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization; citation_author=V. Dishy, G. G. Sofowora, H. G. Xie, R. B. Kim, D. W. Byrne, C. M. Stein, A. J. Wood; citation_volume=345; citation_publication_date=2001; citation_pages=1030-1035; citation_id=CR56

citation_journal_title=Circulation; citation_title=Blunted cardiac responses to receptor activation in subjects with Thr164Ile beta(2)-adrenoceptors; citation_author=O. E. Brodde, R. Buscher, R. Tellkamp, J. Radke, S. Dhein, P. A. Insel; citation_volume=103; citation_publication_date=2001; citation_pages=1048-1050; citation_id=CR57

citation_journal_title=Hum. Mutat.; citation_title=Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C; citation_author=J. D. Moore, D. A. Mason, S. A. Green, J. Hsu, S. B. Liggett; citation_volume=14; citation_publication_date=1999; citation_pages=271; citation_id=CR58

citation_journal_title=Am. J. Hypertens.; citation_title=Beta2-adrenergic receptor polymorphisms at codon 16, cardiovascular phenotypes and essential hypertension in whites and African Americans; citation_author=V. Herrmann, R. Buscher, M. M. Go, K. M. Ring, J. K. Hofer, M. T. Kailasam, D. T. O'Connor, R. J. Parmer, P. A. Insel; citation_volume=13; citation_publication_date=2000; citation_pages=1021-1026; citation_id=CR59

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