α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

American Association for the Advancement of Science (AAAS) - Tập 329 Số 5999 - Trang 1663-1667 - 2010
Jacqueline Burré1, Manu Sharma1, Theodoros Tsetsenis1, Vladimir L. Buchman2, Mark R. Etherton1, Thomas C. Südhof1,3
1Department of Molecular and Cellular Physiology, and Howard Hughes Medical Institute, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304–5543, USA.
2School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK
3Howard Hughes Medical Institute, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304–5543, USA.

Tóm tắt

α-Synuclein and Aging Transgenic α-synuclein can reverse the otherwise lethal neurodegeneration of cysteine string protein-α knockout mice via changes in SNARE proteins, which mediate synaptic vesicle release. Using experiments with purified recombinant proteins, triple αβγ-synuclein knockout mice, and studies of mouse aging, Burré et al. (p. 1663 , published online 26 August) now demonstrate that α-synuclein directly interacts with the SNARE protein synaptobrevin and functions as a catalyst for SNARE-complex assembly. The role of synucleins is fully dispensable in young animals, but becomes essential late in life, which suggests that α-synuclein maintains normal synaptic function during aging.

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American Association for the Advancement of Science (AAAS)

Tập 329 Số 5999

1663-1667

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