Viruses
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Virus-like Particles: Measures and Biological Functions
Viruses - Tập 14 Số 2 - Trang 383
Virus-like particles resemble infectious virus particles in size, shape, and
molecular composition; however, they fail to productively infect host cells.
Historically, the presence of virus-like particles has been inferred from total
particle counts by microscopy, and infectious particle counts or
plaque-forming-units (PFUs) by plaque assay; the resulting ratio of
particles-to-PFUs is often greate...
Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?
Viruses - Tập 12 Số 1 - Trang 14
Respiratory viruses infect the human upper respiratory tract, mostly causing
mild diseases. However, in vulnerable populations, such as newborns, infants,
the elderly and immune-compromised individuals, these opportunistic pathogens
can also affect the lower respiratory tract, causing a more severe disease
(e.g., pneumonia). Respiratory viruses can also exacerbate asthma and lead to
various types ...
Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms
Viruses - Tập 11 Số 8 - Trang 762
For a long time, viruses have been shown to modify the clinical picture of
several autoimmune diseases, including type 1 diabetes (T1D), systemic lupus
erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS),
herpetic stromal keratitis (HSK), celiac disease (CD), and multiple sclerosis
(MS). Best examples of viral infections that have been proposed to modulate the
induction and dev...
Preventive Activity against Influenza (H1N1) Virus by Intranasally Delivered RNA-Hydrolyzing Antibody in Respiratory Epithelial Cells of Mice
Viruses - Tập 7 Số 9 - Trang 5133-5144
The antiviral effect of a catalytic RNA-hydrolyzing antibody, 3D8 scFv, for
intranasal administration against avian influenza virus (H1N1) was described.
The recombinant 3D8 scFv protein prevented BALB/c mice against H1N1 influenza
virus infection by degradation of the viral RNA genome through its intrinsic
RNA-hydrolyzing activity. Intranasal administration of 3D8 scFv (50 μg/day) for
five days p...
Historical Perspective, Development and Applications of Next-Generation Sequencing in Plant Virology
Viruses - Tập 6 Số 1 - Trang 106-136
Next-generation high throughput sequencing technologies became available at the
onset of the 21st century. They provide a highly efficient, rapid, and low cost
DNA sequencing platform beyond the reach of the standard and traditional DNA
sequencing technologies developed in the late 1970s. They are continually
improved to become faster, more efficient and cheaper. They have been used in
many fields...
A Rapid Method for Sequencing Double-Stranded RNAs Purified from Yeasts and the Identification of a Potent K1 Killer Toxin Isolated from Saccharomyces cerevisiae
Viruses - Tập 11 Số 1 - Trang 70
Mycoviruses infect a large number of diverse fungal species, but considering
their prevalence, relatively few high-quality genome sequences have been
determined. Many mycoviruses have linear double-stranded RNA genomes, which
makes it technically challenging to ascertain their nucleotide sequence using
conventional sequencing methods. Different specialist methodologies have been
developed for the ...
The Predictive Role of Hepatitis B Biomarkers on HBV Reactivation following Direct-Acting Antiviral Therapy in HBV/HCV Coinfected Patients
Viruses - Tập 14 Số 8 - Trang 1812
Hepatitis B and C (HBV/HCV) coinfected patients have a potential risk of
hepatitis B reactivation (HBVr) after direct-acting antivirals (DAAs) treatment.
The study intends to investigate the predictive role of HBV biomarkers in HBVr.
Forty-six HBV/HCV coinfected patients receiving DAAs were enrolled. All patients
completed treatment and follow-up to the 12th-week post-DAA treatment (P12).
Blood sa...
Human Hepatitis B Virus Core Protein Inhibits IFNα-Induced IFITM1 Expression by Interacting with BAF200
Viruses - Tập 11 Số 5 - Trang 427
Human hepatitis B virus core protein (HBc) is a structural protein of the
hepatitis B virus (HBV) and contributes to HBV regulation of host-cell
transcription. However, the mechanisms of transcriptional regulation remain
poorly characterized. To dissect the function of HBc, a yeast two-hybrid was
performed to identify HBc-binding proteins, and the C-terminal of
BRG1/hBRM-associated factors 200 (BA...
Diagnosis of Dengue Infection Using Conventional and Biosensor Based Techniques
Viruses - Tập 7 Số 10 - Trang 5410-5427
Dengue is an arthropod-borne viral disease caused by four antigenically
different serotypes of dengue virus. This disease is considered as a major
public health concern around the world. Currently, there is no licensed vaccine
or antiviral drug available for the prevention and treatment of dengue disease.
Moreover, clinical features of dengue are indistinguishable from other
infectious diseases su...
Retrospective Analysis Revealed an April Occurrence of Monkeypox in the Czech Republic
Viruses - Tập 14 Số 8 - Trang 1773
Herein, we present our findings of an early appearance of the Monkeypox virus in
Prague, Czech Republic. A retrospective analysis of biological samples, carried
out on the 28th of April, revealed a previously unrecognized case of Monkeypox
virus (MPxV) infection. Subsequent data analysis confirmed that the virus strain
belongs to the ongoing outbreak. Combined with clinical and epidemiological
inv...
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