Viruses

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Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?
Viruses - Tập 12 Số 1 - Trang 14
Marc Desforges, Alain Le Coupanec, Philippe Dubeau, Andréanne Bourgouin, Louise Lajoie, Mathieu Dubé, Pierre J. Talbot
Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, causing a more severe disease (e.g., pneumonia). Respiratory viruses can also exacerbate asthma and lead to variou...... hiện toàn bộ
The Predictive Role of Hepatitis B Biomarkers on HBV Reactivation following Direct-Acting Antiviral Therapy in HBV/HCV Coinfected Patients
Viruses - Tập 14 Số 8 - Trang 1812
Chih‐Wei Tseng, Wen‐Chun Liu, Ping‐Hung Ko, Yen‐Chun Chen, Kuo‐Chih Tseng, Ting‐Tsung Chang
Hepatitis B and C (HBV/HCV) coinfected patients have a potential risk of hepatitis B reactivation (HBVr) after direct-acting antivirals (DAAs) treatment. The study intends to investigate the predictive role of HBV biomarkers in HBVr. Forty-six HBV/HCV coinfected patients receiving DAAs were enrolled. All patients completed treatment and follow-up to the 12th-week post-DAA treatment (P12). ...... hiện toàn bộ
Human Hepatitis B Virus Core Protein Inhibits IFNα-Induced IFITM1 Expression by Interacting with BAF200
Viruses - Tập 11 Số 5 - Trang 427
Tongya Li, Zunlong Ke, Weiyong Liu, Ying Xiong, Ying Zhu, Yingle Liu
Human hepatitis B virus core protein (HBc) is a structural protein of the hepatitis B virus (HBV) and contributes to HBV regulation of host-cell transcription. However, the mechanisms of transcriptional regulation remain poorly characterized. To dissect the function of HBc, a yeast two-hybrid was performed to identify HBc-binding proteins, and the C-terminal of BRG1/hBRM-associated factors...... hiện toàn bộ
Retrospective Analysis Revealed an April Occurrence of Monkeypox in the Czech Republic
Viruses - Tập 14 Số 8 - Trang 1773
Martin Chmel, Oldřich Bartoš, Hana Kabíčková, Petr Pajer, Pavla Kubíčková, Iva Novotná, Zofia Bartovská, Milan Zlámal, Anna Burantová, Michal Holub, Helena Jiřincová, A. Nagy, Lenka Černíková, Hana Zákoucká, Jiří Dresler
Herein, we present our findings of an early appearance of the Monkeypox virus in Prague, Czech Republic. A retrospective analysis of biological samples, carried out on the 28th of April, revealed a previously unrecognized case of Monkeypox virus (MPxV) infection. Subsequent data analysis confirmed that the virus strain belongs to the ongoing outbreak. Combined with clinical and epidemiolog...... hiện toàn bộ
Development and Validation of a Microtiter Plate-Based Assay for Determination of Bacteriophage Host Range and Virulence
Viruses - Tập 10 Số 4 - Trang 189
Yicheng Xie, Laith Wahab, Jason J. Gill
Bacteriophages, which are the natural predators of bacteria, have re-emerged as an attractive alternative to combat antibiotic resistant bacteria. Phages are highly specific at the species and strain level and measurement of the phage host range plays an important role in utilizing the phage as antimicrobials. The most common method for phage host range determination has been to spot phage...... hiện toàn bộ
Ion Channels as Therapeutic Targets for Viral Infections: Further Discoveries and Future Perspectives
Viruses - Tập 12 Số 8 - Trang 844
Frank Charlton, Hugh A. Pearson, Samantha Hover, Jonathan D. Lippiat, Juan Fontana, John N. Barr, Jamel Mankouri
Ion channels play key roles in almost all facets of cellular physiology and have emerged as key host cell factors for a multitude of viral infections. A catalogue of ion channel-blocking drugs have been shown to possess antiviral activity, some of which are in widespread human usage for ion channel-related diseases, highlighting new potential for drug repurposing. The emergence of ion chan...... hiện toàn bộ
Structure, Function and Dynamics in Adenovirus Maturation
Viruses - Tập 6 Số 11 - Trang 4536-4570
Walter F. Mangel, Carmen San Martı́n
Here we review the current knowledge on maturation of adenovirus, a non-enveloped icosahedral eukaryotic virus. The adenovirus dsDNA genome fills the capsid in complex with a large amount of histone-like viral proteins, forming the core. Maturation involves proteolytic cleavage of several capsid and core precursor proteins by the viral protease (AVP). AVP uses a peptide cleaved from one o...... hiện toàn bộ
The Main Molecular and Serological Methods for Diagnosing COVID-19: An Overview Based on the Literature
Viruses - Tập 13 Số 1 - Trang 40
Bruna Aparecida Souza Machado, Katharine Valéria Saraiva Hodel, Valdir Barbosa-Júnior, Milena Botelho Pereira Soares, Roberto Badaró
Diagnostic tests have been considered as the main alternative for the control of coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as a correct diagnosis allows for decision making when facing the disease, particularly as there is a lack of effective therapeutic protocols and vaccines. Thus, in this review, we summarized the main di...... hiện toàn bộ
Genome-Wide Transcriptomic Analysis Reveals Insights into the Response to Citrus bark cracking viroid (CBCVd) in Hop (Humulus lupulus L.)
Viruses - Tập 10 Số 10 - Trang 570
Ajay Kumar Mishra, Atul Kumar, Deepti Mishra, Vishnu Sukumari Nath, Jernej Jakše, Tomáš Kocábek, Uday Kumar Killi, Filis Morina, Jaroslav Matoušek
Viroids are smallest known pathogen that consist of non-capsidated, single-stranded non-coding RNA replicons and they exploits host factors for their replication and propagation. The severe stunting disease caused by Citrus bark cracking viroid (CBCVd) is a serious threat, which spreads rapidly within hop gardens. In this study, we employed comprehensive transcriptome analyses to dissect h...... hiện toàn bộ
Revisiting the Role of Transcription Factors in Coordinating the Defense Response Against Citrus Bark Cracking Viroid Infection in Commercial Hop (Humulus Lupulus L.)
Viruses - Tập 11 Số 5 - Trang 419
Vishnu Sukumari Nath, Ajay Kumar Mishra, Atul Kumar, Jaroslav Matoušek, Jernej Jakše
Transcription factors (TFs) play a major role in controlling gene expression by intricately regulating diverse biological processes such as growth and development, the response to external stimuli and the activation of defense responses. The systematic identification and classification of TF genes are essential to gain insight into their evolutionary history, biological roles, and regulato...... hiện toàn bộ
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