VNU Journal of Science: Medical and Pharmaceutical Sciences

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Nghiên cứu bào chế và đánh giá tác dụng bảo vệ gan của viên nang cứng chứa phytosome quercetin
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 4 - 2022
Pham Thi Minh Hue, Vu Thi Thu Giang, Nguyen Hong Trang
Quercetin is a well-known flavonoid with different biological effects such as anti-inflammatory, antioxidant, etc. However, this active ingredient was not applied broadly in clinical treatment due to the limitation of solubility, stability, and low oral bioavailability. To overcome this limitation, phytosome quercetin was prepared to enhance quercetin's physicochemical properties and permeability....... hiện toàn bộ
Towards Developing Quantitative Structure-activity Relationship Models for the Design of Novel Influenza A Inhibitors Targeting Neuraminidase
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 39 Số 1 - 2023
Ly Cong Thanh
Thuốc chống virus cúm A H1N1 hướng ức chế neuraminidase đã được nghiên cứu và ứng dụng trong hai thập kỷ qua. Trong nghiên cứu này, mô hình liên quan định lượng giữa cấu trúc và hoạt tính (QSAR) của các dẫn xuất oseltamivir hướng ức chế neuraminidase (IN) của virus cúm A đã được phát triển sử dụng phương pháp Monte Carlo dựa trên hàm mục tiêu xác định bởi hệ số tương quan lý tưởng. Kết quả thu đượ...... hiện toàn bộ
In Silico Screening, Design and Synthesis of Novel Inhibitors against Histone Deacetylase (HDAC)
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 34 Số 1 - 2018
Le Thi Thu Huong, Pham The Hai, Nguyen Hai Nam
Finding a new treatment for cancer is one of the most interested fields for pharmaceutical research worldwide. As a member of HDAC class I, histone deacetylase 2 (HDAC2) appears to be an important druggable target. Today, computer-aided drug design is increasingly used in the drug discovery and development processes. In this study, computational methods, including Quantitative Structure-Activity R...... hiện toàn bộ
Analysis Characteristics of Genetic Alterations in Colorectal Cancer
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 39 Số 2 - 2023
Nguyen Ngoc Quang, Vuong Dieu Linh, Chu Hoang Ha
This study aims to evaluate the mutation status of KRAS, BRAF, NRAS, PIK3CA, and AKT and analyze the association of gene mutations with clinicopathological characteristics of colorectal cancer. 151 colorectal cancer patients were diagnosed at Pathology and Molecular Biology Center in National Cancer Hospital K. The research was conducted as a cross-sectional study using methods such as genomic DNA...... hiện toàn bộ
A Systematic Review of the Cost-effectiveness of Perampanel in the Treatment of Epilepsy
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 2 - 2022
Dang Thi Hon, Nguyen Xuan Bach, Tran Tien Dat, Pham Huy Tuan Kiet, Nguyen Doan Duy Linh
 Objective: Epilepsy is a chronic non-communicable disease that can affect all ages, genders, races, and social classes with large treatment costs that vary widely between countries and regions. Perampanel is a new generation of antiepileptic drugs (AEDs), but cost-effectiveness reports are inconsistent in several countries that have conducted pharmacoeconomic evaluations. Study with the obje...... hiện toàn bộ
Protein Drugs
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 3 - 2022
Nguyen Hue Linh, Bui Thanh Tung, Nguyen Thanh Hai, Nguyen Thi Thanh Binh, Pham Thi Minh Hue, Nguyen Thi Hai Yen
Abstract: To serve health care, up to now, sciences have successfully developed many drugs with different effects. In general, in terms of chemical structure and effect characteristics, medicine can be classified into groups including inorganic drugs, small-molecule organic drugs, protein drugs (macromolecules), and recently a new group of drugs has been formed, separate from the protein drug clas...... hiện toàn bộ
Development and Validation of a HPLC Method of Quantification of Caffeine and EGCG in Green Tea (Camellia sinensis L.) Extract
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 36 Số 3 - 2020
Tra Trong Bien, Bui Thi Lan Phuong
A simple high performance liquid chromatography (HPLC) with an isocratic eluent manner for quantification of caffeine and EGCG in green tea extract was established. The seperation system contained a C18-RP column (250 × 4.6 mm, 5 µm), a mobile phase of methanol/phosphoric acid/water (20/0.1/79.9, v/v) and a DAD detector at 280 nm. This validated method is convinient for rapid, routine analysis of ...... hiện toàn bộ
Cytotoxicity and Antioxidant Effects of Celastrus hindsii Benth. Leaf Extract
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 36 Số 1 - 2020
Bui Thanh Tung, Vu Manh Hung, Bui Thi Thanh Duyen
Celastrus hindsii Benth et Hook. is known as a herbal medicine for the treatment of cancer. In this study we evaluated the cytotoxic and antioxidant effects of Celastrus hindsii Benth et Hook. leaf extract. Samples of Celastrus hindsii were extracted with 90 % ethanol and subsequently fractionated with n-hexane, ethyl acetate (EtOAc) and n-butanol (n-BuOH) solvents. To evaluate the cytotoxic effec...... hiện toàn bộ
Preparation of Aspirin Nanosuspension by Antisolvent Precipitation Method
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 37 Số 3 - 2021
Nguyen Van Khanh, Vu Van Thuong, Nguyen Thanh Hai, Hoang Anh Tuan
This study aims to enhance the dissolution rate of a poorly-soluble drug, aspirin, by fabricating aspirin nanosuspensions using the anti-solvent precipitation. The  study investigates the effect of the type of solvents, solvent to anti-solvent ratio, drug concentration, machines, stirring speed, ultrasonication technique and the temperature of solvent on the particle size and polydispersity i...... hiện toàn bộ
Morphological and Microscopical Characteristics of Oxalis corniculata L.
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 37 Số 1 - 2021
Pham Thi Minh Hai, Nguyen Thi Mai, Nguyen Thuc Thu Huong, Le Thi Hong Duong, Vu Duc Loi, Le Thi Nguyet
   
Tổng số: 400   
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