VNU Journal of Science: Medical and Pharmaceutical Sciences
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In Silico Screening, Design and Synthesis of Novel Inhibitors against Histone Deacetylase (HDAC)
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 34 Số 1 - 2018
Finding a new treatment for cancer is one of the most interested fields for pharmaceutical research worldwide. As a member of HDAC class I, histone deacetylase 2 (HDAC2) appears to be an important druggable target. Today, computer-aided drug design is increasingly used in the drug discovery and development processes. In this study, computational methods, including Quantitative Structure-Activity R......
Analysis Characteristics of Genetic Alterations in Colorectal Cancer
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 39 Số 2 - 2023
This study aims to evaluate the mutation status of KRAS, BRAF, NRAS, PIK3CA, and AKT and analyze the association of gene mutations with clinicopathological characteristics of colorectal cancer. 151 colorectal cancer patients were diagnosed at Pathology and Molecular Biology Center in National Cancer Hospital K. The research was conducted as a cross-sectional study using methods such as genomic DNA......
A Systematic Review of the Cost-effectiveness of Perampanel in the Treatment of Epilepsy
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 2 - 2022
Objective: Epilepsy is a chronic non-communicable disease that can affect all ages, genders, races, and social classes with large treatment costs that vary widely between countries and regions. Perampanel is a new generation of antiepileptic drugs (AEDs), but cost-effectiveness reports are inconsistent in several countries that have conducted pharmacoeconomic evaluations. Study with the obje......
Protein Drugs
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 3 - 2022
Abstract: To serve health care, up to now, sciences have successfully developed many drugs with different effects. In general, in terms of chemical structure and effect characteristics, medicine can be classified into groups including inorganic drugs, small-molecule organic drugs, protein drugs (macromolecules), and recently a new group of drugs has been formed, separate from the protein drug clas......
Development and Validation of a HPLC Method of Quantification of Caffeine and EGCG in Green Tea (Camellia sinensis L.) Extract
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 36 Số 3 - 2020
A simple high performance liquid chromatography (HPLC) with an isocratic eluent manner for quantification of caffeine and EGCG in green tea extract was established. The seperation system contained a C18-RP column (250 × 4.6 mm, 5 µm), a mobile phase of methanol/phosphoric acid/water (20/0.1/79.9, v/v) and a DAD detector at 280 nm. This validated method is convinient for rapid, routine analysis of ......
Cytotoxicity and Antioxidant Effects of Celastrus hindsii Benth. Leaf Extract
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 36 Số 1 - 2020
Celastrus hindsii Benth et Hook. is known as a herbal medicine for the treatment of cancer. In this study we evaluated the cytotoxic and antioxidant effects of Celastrus hindsii Benth et Hook. leaf extract. Samples of Celastrus hindsii were extracted with 90 % ethanol and subsequently fractionated with n-hexane, ethyl acetate (EtOAc) and n-butanol (n-BuOH) solvents. To evaluate the cytotoxic effec......
Preparation of Aspirin Nanosuspension by Antisolvent Precipitation Method
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 37 Số 3 - 2021
This study aims to enhance the dissolution rate of a poorly-soluble drug, aspirin, by fabricating aspirin nanosuspensions using the anti-solvent precipitation. The study investigates the effect of the type of solvents, solvent to anti-solvent ratio, drug concentration, machines, stirring speed, ultrasonication technique and the temperature of solvent on the particle size and polydispersity i......
Morphological and Microscopical Characteristics of Oxalis corniculata L.
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 37 Số 1 - 2021
Terpenenoid Compounds Isolated from the Leaf of Dicliptera Chinensis (L.) Nees.
VNU Journal of Science: Medical and Pharmaceutical Sciences - - 2017
From the ethanol extract of the leaf of Dicliptera chinensis (L.) Nees. collected in Nam Dinh province, two compounds (1-2) were isolated by chromatographic methods. These compounds were identified as: 3β-hydroxylup-20 (29)-20(29)-ene (1), stigmast-5,22-dien-3-β-ol (2). Their structures were elucidated by spectroscopic methods, including MS and NMR. These compounds were isolated from th......
A Simplified Method for Simultaneous Extraction and Purification of Stevioside and Rebaudioside A from Stevia Rebaudiana Bert. Applying in Pharmaceutical
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 3 - 2022
Abstract: Steviol glycosides from Stevia rebaudiana Bert., notably stevioside and rebaudioside A, are ingredients with many pharmaceutical applications. In which rebaudioside A has a uniform sweetness with no bitter aftertaste. A simple method for the simultaneous extraction of stevioside and rebaudioside A has been studied with basic steps including extracting medicinal herbs with water, removing......
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