VNU Journal of Science: Medical and Pharmaceutical Sciences
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Analysis Characteristics of Genetic Alterations in Colorectal Cancer
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 39 Số 2 - 2023
This study aims to evaluate the mutation status of KRAS, BRAF, NRAS, PIK3CA, and AKT and analyze the association of gene mutations with clinicopathological characteristics of colorectal cancer. 151 colorectal cancer patients were diagnosed at Pathology and Molecular Biology Center in National Cancer Hospital K. The research was conducted as a cross-sectional study using methods such as genomic DNA......
A Systematic Review of the Cost-effectiveness of Perampanel in the Treatment of Epilepsy
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 2 - 2022
Objective: Epilepsy is a chronic non-communicable disease that can affect all ages, genders, races, and social classes with large treatment costs that vary widely between countries and regions. Perampanel is a new generation of antiepileptic drugs (AEDs), but cost-effectiveness reports are inconsistent in several countries that have conducted pharmacoeconomic evaluations. Study with the obje......
Protein Drugs
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 3 - 2022
Abstract: To serve health care, up to now, sciences have successfully developed many drugs with different effects. In general, in terms of chemical structure and effect characteristics, medicine can be classified into groups including inorganic drugs, small-molecule organic drugs, protein drugs (macromolecules), and recently a new group of drugs has been formed, separate from the protein drug clas......
Development and Validation of a HPLC Method of Quantification of Caffeine and EGCG in Green Tea (Camellia sinensis L.) Extract
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 36 Số 3 - 2020
A simple high performance liquid chromatography (HPLC) with an isocratic eluent manner for quantification of caffeine and EGCG in green tea extract was established. The seperation system contained a C18-RP column (250 × 4.6 mm, 5 µm), a mobile phase of methanol/phosphoric acid/water (20/0.1/79.9, v/v) and a DAD detector at 280 nm. This validated method is convinient for rapid, routine analysis of ......
Cytotoxicity and Antioxidant Effects of Celastrus hindsii Benth. Leaf Extract
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 36 Số 1 - 2020
Celastrus hindsii Benth et Hook. is known as a herbal medicine for the treatment of cancer. In this study we evaluated the cytotoxic and antioxidant effects of Celastrus hindsii Benth et Hook. leaf extract. Samples of Celastrus hindsii were extracted with 90 % ethanol and subsequently fractionated with n-hexane, ethyl acetate (EtOAc) and n-butanol (n-BuOH) solvents. To evaluate the cytotoxic effec......
Morphological and Microscopical Characteristics of Oxalis corniculata L.
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 37 Số 1 - 2021
A Simplified Method for Simultaneous Extraction and Purification of Stevioside and Rebaudioside A from Stevia Rebaudiana Bert. Applying in Pharmaceutical
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 3 - 2022
Abstract: Steviol glycosides from Stevia rebaudiana Bert., notably stevioside and rebaudioside A, are ingredients with many pharmaceutical applications. In which rebaudioside A has a uniform sweetness with no bitter aftertaste. A simple method for the simultaneous extraction of stevioside and rebaudioside A has been studied with basic steps including extracting medicinal herbs with water, removing......
Clinical, Paraclinical Characteristics and Relative Risk Factors of Severe Degree in Children with COVID-19: Systematic Review
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 1 - 2022
Aim: systematic review of studies in the medical literature of children with COVID – 19 in order to provide evidence of clinical, paraclinical characteristics and relative risk factors of severe degree in children with COVID-19. Research subjects: A systematic review of studies on COVID-19 in children published in the international medical literature. Research methods: the information of research ......
Evaluation of Xanthine Oxidase Inhibitory Activities in vitro of Gomphrena CelosiodesMart
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 33 Số 2 - 2017
Xanthin oxidase (XO) là một enzym có vai trò quan trọng trong tổng hợp acid uric. Enzym XO xúc tác cho phản ứng oxy hóa hypoxanthin thành xanthin và phản ứng oxy hóa xanthin thành acid uric. Đây là hai phản ứng trong giai đoạn cuối cùng của quá trình chuyển hóa các base purin trong cơ thể. Do đó, các chất ức chế enzym XO làm giảm sinh tổng hợp acid uric đã được sử dụng để phòng và điều trị bệnh gú......
OVERVIEW OF THE RESEARCH SYSTEM COST - EFFECTIVENESS OF EMICIZUMAB IN PREVENTING BLEEDING IN PEOPLE WITH HEMOPHILIA A
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 39 Số 4 - 2023
Nghiên cứu tổng quan hệ thống giúp cung cấp thêm các bằng chứng khoa học cho các bác sĩ trong sử dụng thuốc cũng như các nhà hoạch định trong chính sách sử dụng thuốc an toàn – hợp lý - hiệu quả. Emicizumab lần đầu tiên được FDA chấp thuận vào năm 2017 cho bệnh nhân mắc bệnh ưa chảy máu A bẩm sinh sau đó được được phê duyệt trong điều trị dự phòng. Nhưng chi phí điều trị Emicizumab cao là khó khăn......
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