VNU Journal of Science: Medical and Pharmaceutical Sciences
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Analysis Characteristics of Genetic Alterations in Colorectal Cancer
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 39 Số 2 - 2023
This study aims to evaluate the mutation status of KRAS, BRAF, NRAS, PIK3CA, and AKT and analyze the association of gene mutations with clinicopathological characteristics of colorectal cancer. 151 colorectal cancer patients were diagnosed at Pathology and Molecular Biology Center in National Cancer Hospital K. The research was conducted as a cross-sectional study using methods such as genomic DNA......
A Systematic Review of the Cost-effectiveness of Perampanel in the Treatment of Epilepsy
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 2 - 2022
Objective: Epilepsy is a chronic non-communicable disease that can affect all ages, genders, races, and social classes with large treatment costs that vary widely between countries and regions. Perampanel is a new generation of antiepileptic drugs (AEDs), but cost-effectiveness reports are inconsistent in several countries that have conducted pharmacoeconomic evaluations. Study with the obje......
Protein Drugs
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 3 - 2022
Abstract: To serve health care, up to now, sciences have successfully developed many drugs with different effects. In general, in terms of chemical structure and effect characteristics, medicine can be classified into groups including inorganic drugs, small-molecule organic drugs, protein drugs (macromolecules), and recently a new group of drugs has been formed, separate from the protein drug clas......
Development and Validation of a HPLC Method of Quantification of Caffeine and EGCG in Green Tea (Camellia sinensis L.) Extract
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 36 Số 3 - 2020
A simple high performance liquid chromatography (HPLC) with an isocratic eluent manner for quantification of caffeine and EGCG in green tea extract was established. The seperation system contained a C18-RP column (250 × 4.6 mm, 5 µm), a mobile phase of methanol/phosphoric acid/water (20/0.1/79.9, v/v) and a DAD detector at 280 nm. This validated method is convinient for rapid, routine analysis of ......
Cytotoxicity and Antioxidant Effects of Celastrus hindsii Benth. Leaf Extract
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 36 Số 1 - 2020
Celastrus hindsii Benth et Hook. is known as a herbal medicine for the treatment of cancer. In this study we evaluated the cytotoxic and antioxidant effects of Celastrus hindsii Benth et Hook. leaf extract. Samples of Celastrus hindsii were extracted with 90 % ethanol and subsequently fractionated with n-hexane, ethyl acetate (EtOAc) and n-butanol (n-BuOH) solvents. To evaluate the cytotoxic effec......
Terpenenoid Compounds Isolated from the Leaf of Dicliptera Chinensis (L.) Nees.
From the ethanol extract of the leaf of Dicliptera chinensis (L.) Nees. collected in Nam Dinh province, two compounds (1-2) were isolated by chromatographic methods. These compounds were identified as: 3β-hydroxylup-20 (29)-20(29)-ene (1), stigmast-5,22-dien-3-β-ol (2). Their structures were elucidated by spectroscopic methods, including MS and NMR. These compounds were isolated from th......
Hypolipidemic effect of ethanol extract from Mesona chinensis Benth. in high fat diet-induced obesity mice
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 35 Số 1 - 2019
Mesona chiensis Benth. is a natural and safe pharmaceutical ingredient with many nutrients and special medical functions. The aim of this study was to investigate the prevention and treatment effect of ethanol extract from Mesona chiensis Benth. on the plasma lipid concentration of high fat diet-induced obesity mice. Male white mice (Mus musculus) 5 - 6 weeks of age were fed a high-fat diet includ......
Two Alkaloid Compounds Isolated from Tinospora sinensis (Lour.) Merr) Growing in Vinh Phuc Province, Vietnam
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 33 Số 2 - 2017
Cây dây đau xương (Tinospora sinensis (Lour.) Merr) được trồngở Vĩnh phúc là một trong những cây thuốc phổ biến và có giá trị sử dụng cao trong đời sống. Trong chương trình nghiên cứu và phát triển dược liệu, trên cơ sở sử dụng các phương pháp sắc kí đã phân lập được hai hợp chất từ cây dây đau xương thu hái ở Vĩnh Phúc. Câu trúc hóa học của hai hợp chất này được xác định làdecarin (1) và iwamid (......
OVERVIEW OF THE RESEARCH SYSTEM COST - EFFECTIVENESS OF EMICIZUMAB IN PREVENTING BLEEDING IN PEOPLE WITH HEMOPHILIA A
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 39 Số 4 - 2023
Nghiên cứu tổng quan hệ thống giúp cung cấp thêm các bằng chứng khoa học cho các bác sĩ trong sử dụng thuốc cũng như các nhà hoạch định trong chính sách sử dụng thuốc an toàn – hợp lý - hiệu quả. Emicizumab lần đầu tiên được FDA chấp thuận vào năm 2017 cho bệnh nhân mắc bệnh ưa chảy máu A bẩm sinh sau đó được được phê duyệt trong điều trị dự phòng. Nhưng chi phí điều trị Emicizumab cao là khó khăn......
Determination of Pinoresinol 4-O-beta-D-glucopyranoside and Vladinol F as Markers in Pandanus tonkinensis Fruits by High-Performance Liquid Chromatography
According to the traditional know-how, the Northern wild pineapple (Pandanus tonkinensis) has been used efficiently as a major component of oriental remedies for liver protection. Based on the experimentally found chemical composition of Pandanus tonkinensis and their obtained biological activities in terms of the hepatoprotection purpose, two structure-elucidated compounds pinoresinol 4-O-beta-D-......
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