VNU Journal of Science: Medical and Pharmaceutical Sciences
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Initial evaluation of the relationship between CYP2C19 polymorphisms and platelet aggregation in patients with acute myocardial infraction in some hospitals in Hanoi
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 33 Số 2 - 2017
CYP2C19 is one of the pricipal enzymes involed in the antiplatelet prodrug in patients with acute myocardial infraction. Different genotypes can cause various responses to platelet aggregation inhibitors. Therefore, we conduct research to evaluate the relationship between CYP2C19 polymorphisms and platelet aggregation in patients with acute myocardial infraction. The study was processed with a cro...... hiện toàn bộ
Effectiveness and Tolerance of Neoadjuvant Chemotherapy for Treatment of Locally Advanced Gastric Cancer
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 37 Số 4 - 2021
This study aims to assess effectiveness and tolerance with neoadjuvant chemotherapy in patients with locally advanced gastric cancer in the period of 2018-2020. The study used the descriptive cross-sectional method to investigate 70 patients diagnosed with locally advanced gastric cancer, assigned to ECX/ECF or FLOT neoadjuvant chemotherapy regimens at Vietnam National Cancer Hospital. The results...... hiện toàn bộ
BK Polyomavirus Genotypes in Renal Transplant Recipients in Northern Vietnam
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 34 Số 1 - 2018
BK polyomavirus (BKV), a ubiquitous opportunistic infection among humans, causes BKV-associated nephropathy (BKVN) after renal transplantation. BKV strains worldwide are classified into 4 genotypes (I-IV), among which genotype I and IV are subdivided into 4 and 6 subtypes, respectively. Based on 580 bp-long VP1 sequences, this study analyzed the genotypes of 6 BKV strains from 20 specimens includi...... hiện toàn bộ
Development of a Novel Cytochrome b Real-Time PCR Assay for Identification of Plasmodium malariae
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 36 Số 3 - 2020
This article aims to establish a novel cytochrome b real-time PCR assay using Taqman probe for identification of P. malariae and its discrimination from other Plasmodium human infecting species. The optimization of real-time PCR assay with 1X QuantiTect Probe PCR Master Mix, primers and probe used at concentrations of 0.4 μM and 0.1 μM, respectively; and 2.5 mM MgCl2, 5 μl...... hiện toàn bộ
Possible Correlation between Knee Osteoarthritis and Osteoporosis in Postmenopausal Women
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 33 Số 2 - 2017
Thoái hóa khớp gối là bệnh khớp rất thường gặp phụ nữ sau mãn kinh, do béo phì và tăng phì đại xương và mọc gai xương ở khớp gối. Trái lại, loãng xương là hiện tượng mất xương dần dần sau mãn kinh. Tuy nhiên, trên lâm sàng hai bệnh thường phối hợp với nhau. Mục tiêu nghiên cứu: Xác định tỷ lệ bệnh nhân nữ thoái hóa khớp gối phối hợp loãng xương và tìm hiểu một số yếu tố ảnh hưởng loãng xương ở bện...... hiện toàn bộ
Berberine: A Perspective Compound in the Development of New Medicines
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 4 - 2022
Berberine (BBR) is a plant-origin alkaloid with a long history, commonly used for treating infectious diarrhea. In recent years, BBR has been found with many pharmacological effects such as lowering blood glucose, anti-hyperlipidemia, liver protection, kidney protection, anti-atherosclerosis, antioxidants, etc. However, several studies revealed that the oral bioavailability of BBR was very low. Th...... hiện toàn bộ
APOC3-rs2854116 polymorphism related to hypercholesterolemia in primary school children in Hanoi
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 35 Số 2 - 2019
Apolipoprotein C3 (APOC3) plays an important role in regulating lipid levels. This study aimed to assess whether the polymorphism APOC3-rs2854116 is associated with lipid profiles in primary school children in Hanoi. A case-control study was designed including 161 cases with dyslipidemia and 406 controls without dyslipidemia. Genotype for APOC3-rs2854116 polymorphism was determined by the po...... hiện toàn bộ
Effects of Citric Acid and Sodium Alginate on the Stability and Dissolution of Clarithromycin Extended-Release Tablet
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 39 Số 3 - 2023
The pharmacokinetics of clarithromycin (CLR) conventional tablets (T1/2: 5-7 h) demand 2 or 3 doses per day, which is inconvenient for patients. Therefore, a sustained-release CLR tablet is necessary. Based on Klacid MR tablets (AbbVie) composed of citric acid and sodium alginate (Na-ALG), we developed a 24-hour extended-release CLR tablet. Although citric acid had a significant effect on the CLR ...... hiện toàn bộ
Preparation of 24 - hrs Sustained Release Tablets of Nicotinic Acid
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 33 Số 1 - 2017
Niacin (nicotinic acid) is a highly water-soluble vitamin, which has been used as a lipid-lowering agent. Sustained release (SR) niacin tablet was developed in oder to maintain a constant drug concentration for a specific period of time with minimum side effects. In this study, the once daily extended release matrix tablets of niacin using a hydrophilic polymer of HPMC K100M as matrix excipi...... hiện toàn bộ
Preparation of Nano Niosomes Loaded with Rutin and Aloe Gel Extract
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 36 Số 1 - 2020
Rutin is a natural flavonoid that has many effects on human health and beauty. However, rutin has low solubility and bioavailability. Niosomes are drug delivery system that enhance drug permeation of drug through the skin. Aloe is widly used in cosmetic preparations due to its anti-aging, moisturizing and essential skin nutrients. Therefore, the aim of study is preparation of nano niosomes, loaded...... hiện toàn bộ
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