Analysis Characteristics of Genetic Alterations in Colorectal Cancer
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 39 Số 2 - 2023
Nguyen Ngoc Quang, Vuong Dieu Linh, Chu Hoang Ha
This study aims to evaluate the mutation status of KRAS, BRAF, NRAS, PIK3CA, and AKT and analyze the association of gene mutations with clinicopathological characteristics of colorectal cancer. 151 colorectal cancer patients were diagnosed at Pathology and Molecular Biology Center in National Cancer Hospital K. The research was conducted as a cross-sectional study using methods such as genomic DNA...... hiện toàn bộ
A Systematic Review of the Cost-effectiveness of Perampanel in the Treatment of Epilepsy
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 2 - 2022
Dang Thi Hon, Nguyen Xuan Bach, Tran Tien Dat, Pham Huy Tuan Kiet, Nguyen Doan Duy Linh
Objective: Epilepsy is a chronic non-communicable disease that can affect all ages, genders, races, and social classes with large treatment costs that vary widely between countries and regions. Perampanel is a new generation of antiepileptic drugs (AEDs), but cost-effectiveness reports are inconsistent in several countries that have conducted pharmacoeconomic evaluations. Study with the obje...... hiện toàn bộ
Protein Drugs
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 3 - 2022
Nguyen Hue Linh, Bui Thanh Tung, Nguyen Thanh Hai, Nguyen Thi Thanh Binh, Pham Thi Minh Hue, Nguyen Thi Hai Yen
Abstract: To serve health care, up to now, sciences have successfully developed many drugs with different effects. In general, in terms of chemical structure and effect characteristics, medicine can be classified into groups including inorganic drugs, small-molecule organic drugs, protein drugs (macromolecules), and recently a new group of drugs has been formed, separate from the protein drug clas...... hiện toàn bộ
Development and Validation of a HPLC Method of Quantification of Caffeine and EGCG in Green Tea (Camellia sinensis L.) Extract
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 36 Số 3 - 2020
Tra Trong Bien, Bui Thi Lan Phuong
A simple high performance liquid chromatography (HPLC) with an isocratic eluent manner for quantification of caffeine and EGCG in green tea extract was established. The seperation system contained a C18-RP column (250 × 4.6 mm, 5 µm), a mobile phase of methanol/phosphoric acid/water (20/0.1/79.9, v/v) and a DAD detector at 280 nm. This validated method is convinient for rapid, routine analysis of ...... hiện toàn bộ
Cytotoxicity and Antioxidant Effects of Celastrus hindsii Benth. Leaf Extract
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 36 Số 1 - 2020
Bui Thanh Tung, Vu Manh Hung, Bui Thi Thanh Duyen
Celastrus hindsii Benth et Hook. is known as a herbal medicine for the treatment of cancer. In this study we evaluated the cytotoxic and antioxidant effects of Celastrus hindsii Benth et Hook. leaf extract. Samples of Celastrus hindsii were extracted with 90 % ethanol and subsequently fractionated with n-hexane, ethyl acetate (EtOAc) and n-butanol (n-BuOH) solvents. To evaluate the cytotoxic effec...... hiện toàn bộ
A Simplified Method for Simultaneous Extraction and Purification of Stevioside and Rebaudioside A from Stevia Rebaudiana Bert. Applying in Pharmaceutical
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 3 - 2022
Tran Trong Bien, Nguyen Van Han
Abstract: Steviol glycosides from Stevia rebaudiana Bert., notably stevioside and rebaudioside A, are ingredients with many pharmaceutical applications. In which rebaudioside A has a uniform sweetness with no bitter aftertaste. A simple method for the simultaneous extraction of stevioside and rebaudioside A has been studied with basic steps including extracting medicinal herbs with water, removing...... hiện toàn bộ
Clinical, Paraclinical Characteristics and Relative Risk Factors of Severe Degree in Children with COVID-19: Systematic Review
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 1 - 2022
Pham Van Dem, Tran Minh Dien, Nguyen Thanh Nam, Pham Quang Tue, Pham Trung Kien, Nguyen Thu Huong, Nguyen Thanh Trung
Aim: systematic review of studies in the medical literature of children with COVID – 19 in order to provide evidence of clinical, paraclinical characteristics and relative risk factors of severe degree in children with COVID-19. Research subjects: A systematic review of studies on COVID-19 in children published in the international medical literature. Research methods: the information of research ...... hiện toàn bộ
Evaluation of Xanthine Oxidase Inhibitory Activities in vitro of Gomphrena CelosiodesMart
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 33 Số 2 - 2017
Chu Ngoc Khanh, Vu Thi Hoa, Bui Thanh Tung, Dang Kim Thu
Xanthin oxidase (XO) là một enzym có vai trò quan trọng trong tổng hợp acid uric. Enzym XO xúc tác cho phản ứng oxy hóa hypoxanthin thành xanthin và phản ứng oxy hóa xanthin thành acid uric. Đây là hai phản ứng trong giai đoạn cuối cùng của quá trình chuyển hóa các base purin trong cơ thể. Do đó, các chất ức chế enzym XO làm giảm sinh tổng hợp acid uric đã được sử dụng để phòng và điều trị bệnh gú...... hiện toàn bộ
Analyze the Influencing Factors and Predictability of Metabolic Syndrome in Schizophrenic Patients Treated with Olanzapine through Decision Tree Model
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 38 Số 3 - 2022
Nguyen Huu Chien, Pham Thu Huong, Kieu Mai Anh, Nguyen Thanh Tuyen, Nguyen Thanh Hai, Nguyen Chi Thanh, Nguyen Xuan Bach
Abstract: Olanzapine is a typical antipsychotic that has demonstrated efficacy for the treatment of schizophrenia, but the patients treated with olanzapine usually appear it’s specific adverse events such as metabolism. It shows some factors that may affect metabolism such as age, BMI, high-dose antipsychotics, etc. Up to now the main predictors for metabolism in a patient with schizophrenia have ...... hiện toàn bộ
Effects of Carbonyl-cyanide m-chlorophenylhydrazone on Mitochondrial Function of H9C2 Cells
VNU Journal of Science: Medical and Pharmaceutical Sciences - Tập 33 Số 2 - 2017
Ngo Thi Hai Yen, Pham Thi Bich, Vu Thao Hien, Bui Thi Van Khanh, To Thanh Thuy, Dang Thi Ha Trang, Vu Thi Thu
We examined the effects of carbonyl-cyanide m-chlorophenylhydrazone (CCCP) on mitochondrial function of H9C2 cells. Composition of mitochondrial membrane lipids (cardiolipin) and mitochondrial membrane potential was analyzed by fluorescence intensity change of tetramethl rhodamine ethyl ester (TMRE) and 10-nonyl acridine orange (NAO) using the LSM800 confocal microscope. Our results showed that CC...... hiện toàn bộ