Tumor Biology
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Genetic variation in vitamin D-related genes and risk of breast cancer among women of European and East Asian descent
Tumor Biology - Tập 37 - Trang 6379-6387 - 2015
Studies of vitamin D-related genetic variants and breast cancer have been inconsistent. This study aimed to investigate associations of vitamin D-related polymorphisms and breast cancer risk among European and East Asian women and potential interactions with menopausal status and breast tumour subtypes. Data from a case–control study of breast cancer (1037 cases and 1050 controls) were used to ass......
The role of liver transplantation or resection for patients with early hepatocellular carcinoma
Tumor Biology - Tập 37 - Trang 4193-4201 - 2015
Liver resection (LR) and liver transplantation (LT) are curative treatments for early hepatocellular carcinoma (HCC), although their performance remains debated. We compared the survival of patients with HCC conforming to the Milan criteria (MC) after LT and LR and analyzed factors affecting clinical outcomes. Between January 2006 and January 2013, 65 and 184 patients received LT and LR for HCCs f......
miR-16 induction after CDK4 knockdown is mediated by c-Myc suppression and inhibits cell growth as well as sensitizes nasopharyngeal carcinoma cells to chemotherapy
Tumor Biology - Tập 37 - Trang 2425-2433 - 2015
Cyclin-dependent kinase 4 (CDK4) is a member of cyclin-dependent kinase family which regulates G1 to S cell cycle transition. CDK4 activity is increased in many tumor types. Here, we report a negative automodulatory feedback loop between CDK4 and miR-16 that regulates cell cycle progression in nasopharyngeal carcinoma (NPC). By miRNA array and real-time PCR, we identified upregulation of tumor sup......
MicroRNA-486-5p targeting PIM-1 suppresses cell proliferation in breast cancer cells
Tumor Biology - Tập 35 Số 11 - Trang 11137-11145 - 2014
Delivery of miR-155 to retinal pigment epithelial cells mediated by Burkitt’s lymphoma exosomes
Tumor Biology - Tập 37 - Trang 313-321 - 2015
Exosomes are extracellularly secreted vesicles ranging from 40 to 100 nm in diameter that are thought to play important roles in intercellular communication. Exosomes contain numerous proteins, RNA, and lipids that can affect the status of recipient cells under various pathological conditions. MicroRNAs (miRNAs) are small non-coding RNAs that play a major role in post-transcriptional gene silencin......
MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma
Tumor Biology - Tập 34 - Trang 481-491 - 2012
Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney accounting for about 3 % of adult malignancies. MicroRNAs (miRNAs) are a class of naturally occurring, short non-coding RNAs that regulate gene expression at the post-transcriptional level. We determined global miRNA expression profiles of RCC and parallel renal parenchyma tissues by using quantitative reverse transcriptase-pol......
RNA không mã hóa dài LINC01296 là một dấu ấn sinh học tiềm năng trong dự đoán tiên lượng ở bệnh nhân ung thư đại trực tràng Dịch bởi AI
Tumor Biology - Tập 36 - Trang 7175-7183 - 2015
Ung thư đại trực tràng (CRC), một trong những loại ung thư ác tính nhất, hiện đang là nguyên nhân gây tử vong vì ung thư đứng thứ tư trên toàn thế giới. Các nghiên cứu gần đây đã chỉ ra rằng RNA không mã hóa dài (lncRNAs) có thể là những dấu ấn sinh học phân tích tiên lượng mạnh mẽ, có khả năng cải thiện hệ thống giai đoạn khối u-nút-di căn thông thường để dự đoán kết quả cho bệnh nhân CRC. Trong ......
#ung thư đại trực tràng #RNA không mã hóa dài #LINC01296 #dấu ấn sinh học #tiên lượng
Interleukin 10 gene −1082A/G polymorphism is associated with osteosarcoma risk and poor outcomes in the Chinese population
Tumor Biology - Tập 37 - Trang 4517-4522 - 2015
Interleukin-10 (IL-10) is a multifunctional cytokine that participates in the development and progression of various malignant tumors. However, data regarding the role of IL-10 polymorphisms in osteosarcoma development are not available. A case–control study was conducted in 260 patients with osteosarcoma and 260 healthy controls to investigate the possible association between IL-10 polymorphisms ......
Systematic review of high-dose and standard-dose chemotherapies in the treatment of primary well-differentiated osteosarcoma
Tumor Biology - - 2014
The objective of this study is to evaluate whether high-dose chemotherapy is more efficacious than standard-dose chemotherapy in the treatment of primary well-differentiated osteosarcoma. The Cochrane systematic evaluation method was adopted. A database search was conducted in MEDLINE, Embase, OVID, the Cochrane Central Register of Controlled Trials database and the Chinese Biomedical Literature C......
CXCR4, CXCL12 and the relative CXCL12-CXCR4 expression as prognostic factors in colon cancer
Tumor Biology - Tập 37 Số 6 - Trang 7441-7452 - 2016
The CXCL12-CXCR4 axis is proposed to mediate metastasis formation. In this study, we examined CXCL12, CXCR4 and the relative CXCL12-CXCR4 expression as prognostic factors in two cohorts of colon cancer patients. Immunohistochemistry (IHC) and in situ hybridization (ISH) were used to study CXCR4, CXCL12 and relative CXCL12-CXCR4 expression in tissue microarrays. Our study included totally 596 patie......
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