Tumor Biology

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Delivery of miR-155 to retinal pigment epithelial cells mediated by Burkitt’s lymphoma exosomes
Tumor Biology - Tập 37 - Trang 313-321 - 2015
Changshin Yoon, Jayoung Kim, Gabin Park, Seonghan Kim, Daejin Kim, Dae Young Hur, Bomi Kim, Yeong Seok Kim
Exosomes are extracellularly secreted vesicles ranging from 40 to 100 nm in diameter that are thought to play important roles in intercellular communication. Exosomes contain numerous proteins, RNA, and lipids that can affect the status of recipient cells under various pathological conditions. MicroRNAs (miRNAs) are small non-coding RNAs that play a major role in post-transcriptional gene silencin...... hiện toàn bộ
Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation
Tumor Biology - Tập 36 Số 2 - Trang 655-662 - 2015
Jinlong Shi, Bei Sun, Wei Shi, Houjuan Zuo, Daming Cui, Lei Ni, Jian Chen
Clinical significance of microRNA expressions in diagnosing uterine cancer and predicting lymph node metastasis
Tumor Biology - - 2014
Changlong Hou, Guangming Tan, Shi‐Ting Feng
Survivin mRNA-circulating tumor cells predict treatment efficacy of chemotherapy and survival for advanced non-small cell lung cancer patients
Tumor Biology - Tập 35 Số 5 - Trang 4499-4507 - 2014
Yong-Jie Du, Jian Li, Wen Zhu, Yan Wu, Xinping Tang, Yi Wang, Yutian Hu
Role of ERCC1 variants in response to chemotherapy and clinical outcome of advanced non-small cell lung cancer
Tumor Biology - Tập 35 - Trang 4023-4029 - 2013
Shao-jun Huang, Yu-fei Wang, Zhi-yong Jin, Jia-yang Sun, Zhan-lin Guo
Excision repair cross-complementation group 1 (ERCC1) and xeroderma pigmentosum-F (XPF) in the nucleotide excision repair pathway have been effectively repairing DNA damage induced by chemotherapeutic agents. We conducted a cohort study to assess the associations of ERCC1 and XPF polymorphisms with response to platinum-based chemotherapy and clinical outcome of non-small-cell lung cancer (NSCLC). ...... hiện toàn bộ
Zoledronic acid increases cytotoxicity by inducing apoptosis in hormone and docetaxel-resistant prostate cancer cell lines
Tumor Biology - Tập 36 - Trang 779-786 - 2014
Umut Varol, Mustafa Degirmenci, Burcak Karaca, Harika Atmaca, Asli Kisim, Selim Uzunoglu, Canfeza Sezgin, Ulus Ali Sanli, Ruchan Uslu
Our aim was to investigate the possible synergistic/additive cytotoxic and apoptotic effects of combination of docetaxel and zoledronic acid (ZA), in PC-3 hormone-refractory prostate cancer cells (HRPC), as well as their docetaxel-resistant sublines. We established a docetaxel-resistant cell line (PC-3R) from PC-3 prostate cancer cells, by intermittent exposure to increasing concentrations of doce...... hiện toàn bộ
Diagnostic and prognostic value of serum thioredoxin and DJ-1 in non-small cell lung carcinoma patients
Tumor Biology - Tập 37 - Trang 1949-1958 - 2015
Jinping Fan, Haiying Yu, Ying Lv, Liguo Yin
In response to reactive oxygen species (ROS), thioredoxin and DJ-1 are upregulated to counteract the detrimental effect of ROS under normal condition. However, cancer cells can take advantage of thioredoxin and DJ-1 against ROS-induced cell damage. In several human cancer types, thioredoxin and DJ-1 were found to be overexpressed. The present study aimed to explore the serum levels of thioredoxin ...... hiện toàn bộ
Serum level of HE4 is closely associated with pulmonary adenocarcinoma progression
Tumor Biology - Tập 33 - Trang 2365-2370 - 2012
Shin-ichi Yamashita, Keita Tokuishi, Toshihiko Moroga, Satoshi Yamamoto, Kazuyuki Ohbo, So Miyahara, Yasuhiro Yoshida, Jun Yanagisawa, Daisuke Hamatake, Masafumi Hiratsuka, Yasuteru Yoshinaga, Takeshi Shiraishi, Akinori Iwasaki, Katsunobu Kawahara
The human epididymis 4 (HE4) protein is expressed in the epididymis and respiratory tract. We previously reported that HE4 is also expressed in pulmonary adenocarcinoma. The purpose of this study was to investigate serum levels of HE4 as a biological marker in pulmonary adenocarcinoma. As the trained set, 102 patients with pulmonary adenocarcinoma who underwent surgery in our institute from 2008 t...... hiện toàn bộ
The clinical value of dynamic contrast-enhanced MRI in differential diagnosis of malignant and benign ovarian lesions
Tumor Biology - Tập 36 - Trang 5515-5522 - 2015
Xian Li, Jun-Li Hu, Lai-Min Zhu, Xin-Hai Sun, Hua-Qiang Sheng, Ning Zhai, Xi-Bin Hu, Chu-Ran Sun, Bin Zhao
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used in preoperative diagnosis of various tumors. We investigated the clinical value of DCE-MRI in differential diagnosis of malignant and benign ovarian lesions. The study involved 48 subjects with surgical pathology-confirmed ovarian tumors with solid components. Early dynamic phase enhancement performances of the ovarian l...... hiện toàn bộ
Prognostic value of long noncoding RNA MALAT1 in various carcinomas: evidence from nine studies
Tumor Biology - Tập 37 - Trang 1211-1215 - 2015
Yuan Xue, Yan-Qing Teng, Jian-Dong Zhou, Yong-Jun Rui
RNA-sequencing technology is progressing day by day. Numerous researches have showed that long noncoding RNAs (lncRNAs) play oncogenic or tumor suppressor roles in tumor biological processes. To our knowledge, many studies have identified a lot of lncRNAs with aberrant expression in several types of cancers. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a newly discovered lncRNA...... hiện toàn bộ
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