Tumor Biology
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Genetic variation in vitamin D-related genes and risk of breast cancer among women of European and East Asian descent
Tumor Biology - Tập 37 - Trang 6379-6387 - 2015
Studies of vitamin D-related genetic variants and breast cancer have been
inconsistent. This study aimed to investigate associations of vitamin D-related
polymorphisms and breast cancer risk among European and East Asian women and
potential interactions with menopausal status and breast tumour subtypes. Data
from a case–control study of breast cancer (1037 cases and 1050 controls) were
used to ass...
The role of liver transplantation or resection for patients with early hepatocellular carcinoma
Tumor Biology - Tập 37 - Trang 4193-4201 - 2015
Liver resection (LR) and liver transplantation (LT) are curative treatments for
early hepatocellular carcinoma (HCC), although their performance remains
debated. We compared the survival of patients with HCC conforming to the Milan
criteria (MC) after LT and LR and analyzed factors affecting clinical outcomes.
Between January 2006 and January 2013, 65 and 184 patients received LT and LR
for HCCs f...
miR-16 induction after CDK4 knockdown is mediated by c-Myc suppression and inhibits cell growth as well as sensitizes nasopharyngeal carcinoma cells to chemotherapy
Tumor Biology - Tập 37 - Trang 2425-2433 - 2015
Cyclin-dependent kinase 4 (CDK4) is a member of cyclin-dependent kinase family
which regulates G1 to S cell cycle transition. CDK4 activity is increased in
many tumor types. Here, we report a negative automodulatory feedback loop
between CDK4 and miR-16 that regulates cell cycle progression in nasopharyngeal
carcinoma (NPC). By miRNA array and real-time PCR, we identified upregulation of
tumor sup...
MicroRNA-486-5p targeting PIM-1 suppresses cell proliferation in breast cancer cells
Tumor Biology - Tập 35 Số 11 - Trang 11137-11145 - 2014
Clinical significance of histone deacetylase (HDAC)-1, HDAC-2, HDAC-4, and HDAC-6 expression in human malignant and benign thyroid lesions
Tumor Biology - Tập 35 - Trang 61-71 - 2013
Histone deacetylases (HDACs) have been associated with human malignant tumor
development and progression, and HDAC inhibitors are currently being explored as
anticancer agents in clinical trials. The present study aimed to evaluate the
clinical significance of HDAC-1, HDAC-2, HDAC-4, and HDAC-6 proteins' expression
in human malignant and benign thyroid lesions. HDAC-1, HDAC-2, HDAC-4, and
HDAC-6 p...
Delivery of miR-155 to retinal pigment epithelial cells mediated by Burkitt’s lymphoma exosomes
Tumor Biology - Tập 37 - Trang 313-321 - 2015
Exosomes are extracellularly secreted vesicles ranging from 40 to 100 nm in
diameter that are thought to play important roles in intercellular
communication. Exosomes contain numerous proteins, RNA, and lipids that can
affect the status of recipient cells under various pathological conditions.
MicroRNAs (miRNAs) are small non-coding RNAs that play a major role in
post-transcriptional gene silencin...
MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma
Tumor Biology - Tập 34 - Trang 481-491 - 2012
Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney
accounting for about 3 % of adult malignancies. MicroRNAs (miRNAs) are a class
of naturally occurring, short non-coding RNAs that regulate gene expression at
the post-transcriptional level. We determined global miRNA expression profiles
of RCC and parallel renal parenchyma tissues by using quantitative reverse
transcriptase-pol...
RNA không mã hóa dài LINC01296 là một dấu ấn sinh học tiềm năng trong dự đoán tiên lượng ở bệnh nhân ung thư đại trực tràng Dịch bởi AI
Tumor Biology - Tập 36 - Trang 7175-7183 - 2015
Ung thư đại trực tràng (CRC), một trong những loại ung thư ác tính nhất, hiện
đang là nguyên nhân gây tử vong vì ung thư đứng thứ tư trên toàn thế giới. Các
nghiên cứu gần đây đã chỉ ra rằng RNA không mã hóa dài (lncRNAs) có thể là những
dấu ấn sinh học phân tích tiên lượng mạnh mẽ, có khả năng cải thiện hệ thống
giai đoạn khối u-nút-di căn thông thường để dự đoán kết quả cho bệnh nhân CRC.
Trong ...
#ung thư đại trực tràng #RNA không mã hóa dài #LINC01296 #dấu ấn sinh học #tiên lượng
Interleukin 10 gene −1082A/G polymorphism is associated with osteosarcoma risk and poor outcomes in the Chinese population
Tumor Biology - Tập 37 - Trang 4517-4522 - 2015
Interleukin-10 (IL-10) is a multifunctional cytokine that participates in the
development and progression of various malignant tumors. However, data regarding
the role of IL-10 polymorphisms in osteosarcoma development are not available. A
case–control study was conducted in 260 patients with osteosarcoma and 260
healthy controls to investigate the possible association between IL-10
polymorphisms ...
Systematic review of high-dose and standard-dose chemotherapies in the treatment of primary well-differentiated osteosarcoma
Tumor Biology - - 2014
The objective of this study is to evaluate whether high-dose chemotherapy is
more efficacious than standard-dose chemotherapy in the treatment of primary
well-differentiated osteosarcoma. The Cochrane systematic evaluation method was
adopted. A database search was conducted in MEDLINE, Embase, OVID, the Cochrane
Central Register of Controlled Trials database and the Chinese Biomedical
Literature C...
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