Tumor Biology

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Proto-oncogene Wip1, a member of a new family of proliferative genes in NSCLC and its clinical significance
Tumor Biology - Tập 35 - Trang 2975-2981 - 2013
Zhanzhao Fu, Guogui Sun, Tao Gu
This study aimed to analyze the expression, clinical significance of proto-oncogene in non small cell lung cancer (NSCLC), and the biological effect in its cell line by siRNA targeting wild-type p53-induced phosphatase 1 (Wip1). Immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR) were, respectively, used to analyze Wip1 protein expression in 75 cases of NSCLC and norm...... hiện toàn bộ
DNA methylation as a promising landscape: A simple blood test for breast cancer prediction
Tumor Biology - Tập 36 - Trang 4905-4912 - 2015
Golnaz Khakpour, Arash Pooladi, Pantea Izadi, Mehrdad Noruzinia, Javad Tavakkoly Bazzaz
Breast cancer is the most common malignancy among women worldwide. Risk assessment is one of the main services delivered by cancer clinics. Biomarker analysis on different tissues including the peripheral blood can provide crucial information. One of the potential epigenetic biomarkers (epimarkers) is introduced as the peripheral blood DNA methylation pattern. This study was conducted to evaluate ...... hiện toàn bộ
Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP
Tumor Biology - - 2016
Yavuz Dodurga, Canan Eroğlu, Mücahit Seçme, Levent Elmas, Çığır Biray Avcı, N. Lale Şatıroğlu-Tufan
Plasma miRNAs in predicting radiosensitivity in non-small cell lung cancer
Tumor Biology - Tập 37 Số 9 - Trang 11927-11936 - 2016
Cheng Xu, Yanjun Xu, Xian Liao, Rongxia Liao, Luping Zhang, Kai Niu, Tao Li, Dezhi Li, Zhengtang Chen, Yu-zhong Duan, Jianping Sun
The EGF signaling pathway influences cell migration and the secretion of metalloproteinases by myoepithelial cells in pleomorphic adenoma
Tumor Biology - Tập 36 - Trang 205-211 - 2014
Natalia Festugatto Navarini, Vera Cavalcanti de Araújo, Amy Louise Brown, Fabrício Passador-Santos, Isabela Fernandes de Souza, Marcelo Henrique Napimoga, Ney Soares Araújo, Elizabeth Ferreira Martinez
During tumor development, benign neoplastic cells are influenced by the expression of cytokines, growth factors, and proteases present in the tumor microenvironment. Epidermal growth factor (EGF) is the most studied growth factor and is considered important for cell proliferation and migration. Metalloproteinases (MMPs) are also involved in tumor progression. The present study aimed to analyze the...... hiện toàn bộ
Association of SOX4 regulated by tumor suppressor miR-30a with poor prognosis in low-grade chondrosarcoma
Tumor Biology - - 2015
Ning Lü, Tao Lin, Lin Wang, Mei Qi, Zhiyan Liu, Hongyan Dong, Xiying Zhang, Chunyan Zhai, Yan Wang, Long Liu, Lei Xiang, Lei Qi, Bo Han, Jinsong Li
The plasma lncRNA acting as fingerprint in non-small-cell lung cancer
Tumor Biology - Tập 37 - Trang 3497-3504 - 2015
Xiaodong Hu, Jitao Bao, Zhen Wang, Zigang Zhang, Peijie Gu, Feng Tao, Di Cui, Weilong Jiang
Recent studies have indicated that long non-coding RNAs (lncRNAs) could act as non-invasive tumor markers in both diagnosis and predicting the prognosis. In this study, we focused to determine the expression of circulating lncRNAs in patients suffering from non-small-cell lung cancer (NSCLC), aiming to found the potential lncRNA as predictor. Twenty-one lncRNAs which previously identified were sel...... hiện toàn bộ
Endocan reduces the malign grade of gastric cancer cells by regulating associated protein expression
Tumor Biology - Tập 37 - Trang 14915-14921 - 2016
Zhang Sumei, Chen Shaolong, Wei Xiang, Qi Yinliang, Zhou Qing, Wang Yuan
Endocan, which has been identified to be low expressed in gastric cancer, was found to be positively related to the differentiation level of gastric cancer in vivo and in vitro. In the present study, we aimed to investigate the role of endocan in gastric adenocarcinoma cell line SGC7901 by artificially upregualting or downregulating endocan expression using endocan recombinant vector or specific s...... hiện toàn bộ
DNA repair pathways to regulate response to chemoradiotherapy in patients with locally advanced head and neck cancer
Tumor Biology - Tập 37 - Trang 13435-13443 - 2016
B. Cirauqui, M. Margelí, V. Quiroga, A. Quer, N. Karachaliou, I. Chaib, J. L. Ramírez, A. Muñoz, C. Pollán, I. Planas, A. Drozdowsky, R. Rosell
Platinum-based chemoradiotherapy (CRT) is a preferred standard of care for locally advanced head and neck cancer (HNC). However, survival benefit is small, with substantial toxicity and biomarkers of CRT resistance that could guide treatment selection and spare morbidity. Increased DNA repair in solid tumors may contribute to cancer cells’ ability to survive in genotoxic stress environments afford...... hiện toàn bộ
Polymorphisms in three obesity-related genes (LEP, LEPR, and PON1) and breast cancer risk: a meta-analysis
Tumor Biology - Tập 32 - Trang 1233-1240 - 2011
Chibo Liu, Liu Liu
Common genetic variations in the leptin (LEP), leptin receptor (LEPR), and paraoxonase 1 (PON1) genes have been considered to be implicated in the development of breast cancer. However, the results were inconsistent. In this study, a meta-analysis was performed to assess the associations of five polymorphisms, including LEP G2548A, LEPR Q223R, LEPR Lys109Arg, PON1 L55M, and PON1 Q192R polymorphism...... hiện toàn bộ
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