Treatments in Respiratory Medicine
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Respimat?? Soft Mist??? Inhaler versus Hydrofluoroalkane Metered Dose Inhaler
Treatments in Respiratory Medicine - Tập 4 Số 1 - Trang 53-61 - 2005
Pathogenesis and Management of Aspirin-Intolerant Asthma
Treatments in Respiratory Medicine - Tập 4 - Trang 325-336 - 2012
In 2–23% of adults with asthma, and rarely in children with asthma, aspirin
(acetylsalicylic acid) and non-steroidal anti-inflammatory drugs (NSAIDs) cause
asthma exacerbations. Within 3 hours of ingestion of aspirin/NSAIDs, individuals
with aspirin-intolerant asthma (AIA) develop bronchoconstriction, often
accompanied by rhinorrhea, conjunctival irritation, and scarlet flush. In severe
cases, a s...
Matrix Metalloproteinases in the Pathogenesis of Asthma and COPD
Treatments in Respiratory Medicine - Tập 3 - Trang 17-27 - 2012
While asthma is an inflammatory disorder of the airways involving mediators
released from mast cells and eosinophils, inflammation alone is insufficient to
explain the chronic nature of the disease. Recent progress in the understanding
of disease pathogenesis has revealed that airway remodeling, which is at least
in part due to an excess of extracellular matrix (ECM) deposition in the airway
wall,...
The Novolizer®: A Multidose Dry Powder Inhaler
Treatments in Respiratory Medicine - Tập 4 - Trang 70-70 - 2012
The Role of Antihistamines in Asthma Management
Treatments in Respiratory Medicine - - 2012
Histamine is an important mediator in airway inflammation. It is elevated in the
airways of asthmatic patients and is responsible for many of the
pathophysiological features in asthma. Antihistamines block the actions of
histamine and also have effects on inflammation which is independent of
histamine-H1-receptor antagonism. Antihistamines have been shown to have
bronchodilatory effects, effects o...
Lucinactant
Treatments in Respiratory Medicine - Tập 4 - Trang 139-145 - 2012
▲ Lucinactant, formerly known as KL4 surfactant, is a novel synthetic lung
surfactant containing phospholipids and an engineered peptide, sinapultide,
which is designed to mimic the actions of human surfactant protein B. It has
been developed for use in the prevention or treatment of respiratory distress
syndrome (RDS), a common problem in premature infants, which results from a
deficiency or degr...
Monotherapy versus Combination Therapy in Patients Hospitalized with Community-Acquired Pneumonia
Treatments in Respiratory Medicine - Tập 5 - Trang 371-383 - 2012
Current international guidelines for the management of community acquired
pneumonia (CAP) recommend therapy with a β-lactam plus a macrolide or a
‘respiratory’ fluoroquinolone alone in patients hospitalized in a medical ward,
and combination therapy with a β-lactam plus a macrolide or a fluoroquinolone in
patients hospitalized in the intensive care unit. However, which of the
available options sho...
Spotlight on Cefditoren Pivoxil in Bacterial Infections
Treatments in Respiratory Medicine - Tập 4 - Trang 149-152 - 2012
Cefditoren pivoxil (Spectracef®, Meiact®) is a third-generation oral
cephalosporin with a broad spectrum of activity against pathogens, including
both Gram-positive and -negative bacteria, and is stable to hydrolysis by many
common β-lactamases. Cefditoren pivoxil is approved for use in the treatment of
acute exacerbations of chronic bronchitis (AECB), mild-to-moderate
community-acquired pneumonia...
Modeling and Remodeling of the Lung in Neonatal Chronic Lung Disease
Treatments in Respiratory Medicine - Tập 4 - Trang 347-359 - 2012
Neonatal chronic lung disease (CLD) is the major long-term pulmonary
complication of preterm birth affecting about 20% of infants who need mechanical
ventilation. CLD is the result of abnormal repair processes following
inflammatory lung injury that lead to remodeling of the lung. Inflammation may
be initiated by a variety of stimuli including mechanical ventilation, oxygen
toxicity and infection....
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