cPKCγ-Modulated Autophagy in Neurons Alleviates Ischemic Injury in Brain of Mice with Ischemic Stroke Through Akt-mTOR PathwayTranslational Stroke Research - Tập 7 - Trang 497-511 - 2016
Haiping Wei, Yun Li, Song Han, Shuiqiao Liu, Nan Zhang, Li Zhao, Shujuan Li, Junfa Li
We have reported that neuron-specific conventional protein kinase C (cPKC)γ is involved in the development of cerebral hypoxic preconditioning (HPC) and the neuroprotection against ischemic injuries, but its molecular mechanism is unclear. In this study, the adult and postnatal 24 h C57BL/6J wild-type (cPKCγ+/+) and cPKCγ knockout (cPKCγ−/−) mice were respectively used to establish the models of m...... hiện toàn bộ
Intracerebral Hemorrhage–Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2Translational Stroke Research - Tập 11 - Trang 288-295 - 2019
Liheng Bian, Jingwei Zhang, Ming Wang, Richard F. Keep, Guohua Xi, Ya Hua
Red blood cell (RBC) lysis within the hematoma causes brain injury following intracerebral hemorrhage. Peroxiredoxin 2 (PRX-2) is the third most abundant protein in RBCs and this study examined the potential role of PRX-2 in inducing brain injury in rats. First, adult male Sprague-Dawley rats had an intracaudate injection of lysed RBCs or saline. Brains were harvested at 1 h to measure PRX-2 level...... hiện toàn bộ
Sedentary Behaviour and Stroke: Foundational Knowledge is CrucialTranslational Stroke Research - Tập 6 - Trang 9-12 - 2014
Olaf Verschuren, Gillian Mead, Anne Visser-Meily
Physical activity is important for people’s health. The emphasis over the last two decades has been on moderate to vigorous exercise when designing activity and exercise programmes for adults with stroke. Emerging evidence suggests that sedentary behaviour is distinctly different from a lack of moderate to vigorous physical activity and has independent and different physiological mechanisms. The c...... hiện toàn bộ
Predictors and Outcomes of Neurological Deterioration in Intracerebral Hemorrhage: Results from the TICH-2 Randomized Controlled TrialTranslational Stroke Research - - 2020
Zhe Kang Law, Rob Dineen, Timothy J England, Lesley Cala, Amit K Mistri, Jason P Appleton, Serefnur Ozturk, Daniel Bereczki, Alfonso Ciccone, Philip M Bath, Nikola Sprigg
Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological deterioration and whether tranexamic acid reduced the risk of neurological deterioration. Data from the Tranexamic acid in IntraCerebral Hemorrhage-2 (TICH-2) randomized controlled trial were analyzed. Neurological deterioration was defined as an increase in Na...... hiện toàn bộ
Disruptions of Anaerobic Gut Bacteria Are Associated with Stroke and Post-stroke Infection: a Prospective Case–Control StudyTranslational Stroke Research - Tập 12 Số 4 - Trang 581-592 - 2021
Haak, Bastiaan W., Westendorp, Willeke F., van Engelen, Tjitske S. R., Brands, Xanthe, Brouwer, Matthijs C., Vermeij, Jan-Dirk, Hugenholtz, Floor, Verhoeven, Aswin, Derks, Rico J., Giera, Martin, Nederkoorn, Paul J., de Vos, Willem M., van de Beek, Diederik, Wiersinga, W. Joost
In recent years, preclinical studies have illustrated the potential role of intestinal bacterial composition in the risk of stroke and post-stroke infections. The results of these studies suggest that bacteria capable of producing volatile metabolites, including trimethylamine-N-oxide (TMAO) and butyrate, play opposing, yet important roles in the cascade of events leading to stroke. However, no la...... hiện toàn bộ
Iodinated Contrast Agents Reduce the Efficacy of Intravenous Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients: a Multicenter Cohort StudyTranslational Stroke Research - - 2021
Zhicai Chen, Chao Xu, Wansi Zhong, Xiaoxian Gong, Haitao Hu, Xuting Zhang, Yi Chen, Qingqing Li, Zhongyu Luo, Zhuojian Chen, Min Lou
Protective Effects of ShcA Protein Silencing for Photothrombotic Cerebral InfarctionTranslational Stroke Research - Tập 12 - Trang 866-878 - 2020
Jeong-Ah Hwang, Nara Shin, Hyo Jung Shin, Yuhua Yin, Hyeok Hee Kwon, Hyewon Park, Juhee Shin, Song I Kim, Dong Woon Kim, Hee-Jung Song
Reactive oxygen species (ROS) exacerbate stroke-induced cell damage. We found that ShcA, a protein that regulates ROS, is highly expressed in a Rose Bengal photothrombosis model. We investigated whether ShcA is essential for mitophagy in ROS-induced cellular damage and determined whether ROS exacerbate mitochondrial dysfunction via ShcA protein expression. Ischemic stroke was generated by Rose Ben...... hiện toàn bộ