Translational Psychiatry

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Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac
Translational Psychiatry - Tập 6 Số 9 - Trang e881-e881
Li Zhou, Suk Ling, Pan Yeung, Yung Hou Wong, Karl Wah Keung Tsim, KF So, Linda Lam, Sookja Kim Chung
AbstractIntracellular cAMP and serotonin are important modulators of anxiety and depression. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA)...... hiện toàn bộ
The DNA methylome in panic disorder: a case-control and longitudinal psychotherapy-epigenetic study
Translational Psychiatry - Tập 9 Số 1
Christiane Ziegler, Franziska Grundner-Culemann, Miriam A. Schiele, Pascal Schlosser, Leonie Kollert, Marina Mahr, Agnieszka Gajewska, Klaus‐Peter Lesch, Jürgen Deckert, Anna Köttgen, Katharina Domschke
AbstractIn panic disorder (PD), epigenetic mechanisms such as DNA methylation of candidate genes have been suggested to play a key role at the intersection of genetic and environmental factors. On an epigenome-wide level, however, only two studies in PD patients have been published so far, while to date no study has intra-individually analyzed dynamic epigenetic co...... hiện toàn bộ
Full function of exon junction complex factor, Rbm8a, is critical for interneuron development
Translational Psychiatry - Tập 10 Số 1
Colleen McSweeney, Fengqin Dong, Miranda Chen, Jessica Vitale, Li Xu, Nicole A. Crowley, Bernhard Lüscher, Donghua Zou, Yingwei Mao
AbstractThe formation of the nervous system requires a balance between proliferation, differentiation, and migration of neural progenitors (NPs). Mutations in genes regulating development impede neurogenesis and lead to neuropsychiatric diseases, including autism spectrum disorders (ASDs) and schizophrenia (SZ). Recently, mutations in nonsense-mediated mRNA decay g...... hiện toàn bộ
Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies
Translational Psychiatry - Tập 6 Số 3 - Trang e747-e747
Brittany S. Gluskin, Brian J. Mickey
AbstractThe D2 dopamine receptor mediates neuropsychiatric symptoms and is a target of pharmacotherapy. Inter-individual variation of D2 receptor density is thought to influence disease risk and pharmacological response. Numerous molecular imaging studies have tested whether common genetic variants influence D2 receptor binding potential (BP) in humans, but demonst...... hiện toàn bộ
Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit
Translational Psychiatry - Tập 9 Số 1 - Trang 1-10
Ng, Tommy H., Alloy, Lauren B., Smith, David V.
Many neuroimaging studies have investigated reward processing dysfunction in major depressive disorder. These studies have led to the common idea that major depressive disorder is associated with blunted responses within the reward circuit, particularly in the ventral striatum. Yet, the link between major depressive disorder and reward-related responses in other regions remains inconclusive, thus ...... hiện toàn bộ
Animal models to improve our understanding and treatment of suicidal behavior
Translational Psychiatry - Tập 7 Số 4 - Trang e1092-e1092
T D Gould, Polymnia Georgiou, Lisa A. Brenner, Lena Brundin, Adem Can, Philippe Courtet, Zoe R. Donaldson, Yogesh Dwivedi, Sébastien Guillaume, Irving I. Gottesman, Shami Kanekar, Christopher A. Lowry, Perry F. Renshaw, Dan Rujescu, E. G. Smith, Gustavo Turecki, Panos Zanos, Carlos A. Zarate, Patricia A. Zunszain, Teodor T. Postolache
AbstractWorldwide, suicide is a leading cause of death. Although a sizable proportion of deaths by suicide may be preventable, it is well documented that despite major governmental and international investments in research, education and clinical practice suicide rates have not diminished and are even increasing among several at-risk populations. Although nonhuman ...... hiện toàn bộ
RGS2 expression predicts amyloid-β sensitivity, MCI and Alzheimer’s disease: genome-wide transcriptomic profiling and bioinformatics data mining
Translational Psychiatry - Tập 6 Số 10 - Trang e909-e909
Adva Hadar, Elena Milanesi, Alessio Squassina, Paola Niola, Caterina Chillotti, M Pasmanik-Chor, Orly Yaron, Pavel Martásek, Moshe Rehavi, Daphna Weissglas‐Volkov, Noam Shomron, Illana Gozes, David Gurwitz
AbstractAlzheimer's disease (AD) is the most frequent cause of dementia. Misfolded protein pathological hallmarks of AD are brain deposits of amyloid-β (Aβ) plaques and phosphorylated tau neurofibrillary tangles. However, doubts about the role of Aβ in AD pathology have been raised as Aβ is a common component of extracellular brain deposits found, also by ... hiện toàn bộ
Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates
Translational Psychiatry - Tập 4 Số 12 - Trang e486-e486
Ming Guo, X-Y Lu
Adversity in childhood and depression: linked through SIRT1
Translational Psychiatry - Tập 5 Số 9 - Trang e629-e629
Luisa Lo Iacono, Federica Visco‐Comandini, Alessandro Valzania, Maria Teresa Viscomi, Mariangela Coviello, Alessio Giampà, L Roscini, Elisa Bisicchia, Alberto Siracusano, Alfonso Troisi, Stefano Puglisi-Allegra, Valeria Carola
AbstractExperiencing an adverse childhood and parental neglect is a risk factor for depression in the adult population. Patients with a history of traumatic childhood develop a subtype of depression that is characterized by earlier onset, poor treatment response and more severe symptoms. The long-lasting molecular mechanisms that are engaged during early traumatic ...... hiện toàn bộ
Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach
Translational Psychiatry - Tập 9 Số 1
Azadeh Kushki, Evdokia Anagnostou, Christopher Hammill, Pierre Duez, Jessica Brian, Alana Iaboni, Russell A. Barkley, Jennifer Crosbie, Paul Arnold, Jason P. Lerch
AbstractThe validity of diagnostic labels of autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive compulsive disorder (OCD) is an open question given the mounting evidence that these categories may not correspond to conditions with distinct etiologies, biologies, or phenotypes. The objective of this study was to determine t...... hiện toàn bộ
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