Translational Psychiatry

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Full function of exon junction complex factor, Rbm8a, is critical for interneuron development
Translational Psychiatry - Tập 10 Số 1
Colleen McSweeney, Fengqin Dong, Miranda Chen, Jessica Vitale, Li Xu, Nicole A. Crowley, Bernhard Lüscher, Donghua Zou, Yingwei Mao
AbstractThe formation of the nervous system requires a balance between proliferation, differentiation, and migration of neural progenitors (NPs). Mutations in genes regulating development impede neurogenesis and lead to neuropsychiatric diseases, including autism spectrum disorders (ASDs) and schizophrenia (SZ). Recently, mutations in nonsense-mediated mRNA decay g...... hiện toàn bộ
Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies
Translational Psychiatry - Tập 6 Số 3 - Trang e747-e747
Brittany S. Gluskin, Brian J. Mickey
AbstractThe D2 dopamine receptor mediates neuropsychiatric symptoms and is a target of pharmacotherapy. Inter-individual variation of D2 receptor density is thought to influence disease risk and pharmacological response. Numerous molecular imaging studies have tested whether common genetic variants influence D2 receptor binding potential (BP) in humans, but demonst...... hiện toàn bộ
Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit
Translational Psychiatry - Tập 9 Số 1 - Trang 1-10
Ng, Tommy H., Alloy, Lauren B., Smith, David V.
Many neuroimaging studies have investigated reward processing dysfunction in major depressive disorder. These studies have led to the common idea that major depressive disorder is associated with blunted responses within the reward circuit, particularly in the ventral striatum. Yet, the link between major depressive disorder and reward-related responses in other regions remains inconclusive, thus ...... hiện toàn bộ
Animal models to improve our understanding and treatment of suicidal behavior
Translational Psychiatry - Tập 7 Số 4 - Trang e1092-e1092
T D Gould, Polymnia Georgiou, Lisa A. Brenner, Lena Brundin, Adem Can, Philippe Courtet, Zoe R. Donaldson, Yogesh Dwivedi, Sébastien Guillaume, Irving I. Gottesman, Shami Kanekar, Christopher A. Lowry, Perry F. Renshaw, Dan Rujescu, E. G. Smith, Gustavo Turecki, Panos Zanos, Carlos A. Zarate, Patricia A. Zunszain, Teodor T. Postolache
AbstractWorldwide, suicide is a leading cause of death. Although a sizable proportion of deaths by suicide may be preventable, it is well documented that despite major governmental and international investments in research, education and clinical practice suicide rates have not diminished and are even increasing among several at-risk populations. Although nonhuman ...... hiện toàn bộ
RGS2 expression predicts amyloid-β sensitivity, MCI and Alzheimer’s disease: genome-wide transcriptomic profiling and bioinformatics data mining
Translational Psychiatry - Tập 6 Số 10 - Trang e909-e909
Adva Hadar, Elena Milanesi, Alessio Squassina, Paola Niola, Caterina Chillotti, M Pasmanik-Chor, Orly Yaron, Pavel Martásek, Moshe Rehavi, Daphna Weissglas‐Volkov, Noam Shomron, Illana Gozes, David Gurwitz
AbstractAlzheimer's disease (AD) is the most frequent cause of dementia. Misfolded protein pathological hallmarks of AD are brain deposits of amyloid-β (Aβ) plaques and phosphorylated tau neurofibrillary tangles. However, doubts about the role of Aβ in AD pathology have been raised as Aβ is a common component of extracellular brain deposits found, also by ... hiện toàn bộ
Adversity in childhood and depression: linked through SIRT1
Translational Psychiatry - Tập 5 Số 9 - Trang e629-e629
Luisa Lo Iacono, Federica Visco‐Comandini, Alessandro Valzania, Maria Teresa Viscomi, Mariangela Coviello, Alessio Giampà, L Roscini, Elisa Bisicchia, Alberto Siracusano, Alfonso Troisi, Stefano Puglisi-Allegra, Valeria Carola
AbstractExperiencing an adverse childhood and parental neglect is a risk factor for depression in the adult population. Patients with a history of traumatic childhood develop a subtype of depression that is characterized by earlier onset, poor treatment response and more severe symptoms. The long-lasting molecular mechanisms that are engaged during early traumatic ...... hiện toàn bộ
A role for the extended amygdala in the fear-enhancing effects of acute selective serotonin reuptake inhibitor treatment
Translational Psychiatry - Tập 3 Số 1 - Trang e209-e209
Shilpa Ravinder, Nesha S. Burghardt, RA Brodsky, Erwin Bauer, Sumantra Chattarji
“DNA Methylation signatures in panic disorder”
Translational Psychiatry - Tập 7 Số 12
Stella Iurato, Tania Carrillo‐Roa, Janine Arloth, Darina Czamara, Laura Diener-Hölzl, Jennifer Lange, Bertram Müller‐Myhsok, Elisabeth B. Binder, Angelika Erhardt
AbstractPanic disorder (PD) affects about four million Europeans, with women affected twice as likely as men, causing substantial suffering and high economic costs. The etiopathogenesis of PD remains largely unknown, but both genetic and environmental factors contribute to risk. An epigenome-wide association study (EWAS) was conducted to compare medication-free PD ...... hiện toàn bộ
Lack of parvalbumin in mice leads to behavioral deficits relevant to all human autism core symptoms and related neural morphofunctional abnormalities
Translational Psychiatry - Tập 5 Số 3 - Trang e525-e525
Markus Wöhr, David Orduz, Patricia Gregory, Herman Moreno, Usman Khan, Karl Jakob Vörckel, David P Wolfer, Hans Welzl, David Gall, Serge N. Schiffmann, Beat Schwaller
Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala
Translational Psychiatry - Tập 4 Số 2 - Trang e359-e359
Sergey Sotnikov, Patrick Markt, Victoria A. Malik, N. Yu. Chekmareva, Roshan Ratnakar Naik, Anupam Sah, Nicolas Singewald, Herta Flor, Ludwig Czibere, Rainer Landgraf
Tổng số: 51   
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