Translational Psychiatry

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Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac
Translational Psychiatry - Tập 6 Số 9 - Trang e881-e881
Li Zhou, Suk Ling, Pan Yeung, Yung Hou Wong, Karl Wah Keung Tsim, KF So, Linda Lam, Sookja Kim Chung
AbstractIntracellular cAMP and serotonin are important modulators of anxiety and depression. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA)...... hiện toàn bộ
The DNA methylome in panic disorder: a case-control and longitudinal psychotherapy-epigenetic study
Translational Psychiatry - Tập 9 Số 1
Christiane Ziegler, Franziska Grundner-Culemann, Miriam A. Schiele, Pascal Schlosser, Leonie Kollert, Marina Mahr, Agnieszka Gajewska, Klaus‐Peter Lesch, Jürgen Deckert, Anna Köttgen, Katharina Domschke
AbstractIn panic disorder (PD), epigenetic mechanisms such as DNA methylation of candidate genes have been suggested to play a key role at the intersection of genetic and environmental factors. On an epigenome-wide level, however, only two studies in PD patients have been published so far, while to date no study has intra-individually analyzed dynamic epigenetic co...... hiện toàn bộ
Full function of exon junction complex factor, Rbm8a, is critical for interneuron development
Translational Psychiatry - Tập 10 Số 1
Colleen McSweeney, Fengqin Dong, Miranda Chen, Jessica Vitale, Li Xu, Nicole A. Crowley, Bernhard Lüscher, Donghua Zou, Yingwei Mao
AbstractThe formation of the nervous system requires a balance between proliferation, differentiation, and migration of neural progenitors (NPs). Mutations in genes regulating development impede neurogenesis and lead to neuropsychiatric diseases, including autism spectrum disorders (ASDs) and schizophrenia (SZ). Recently, mutations in nonsense-mediated mRNA decay g...... hiện toàn bộ
Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies
Translational Psychiatry - Tập 6 Số 3 - Trang e747-e747
Brittany S. Gluskin, Brian J. Mickey
AbstractThe D2 dopamine receptor mediates neuropsychiatric symptoms and is a target of pharmacotherapy. Inter-individual variation of D2 receptor density is thought to influence disease risk and pharmacological response. Numerous molecular imaging studies have tested whether common genetic variants influence D2 receptor binding potential (BP) in humans, but demonst...... hiện toàn bộ
Progressive loss of cortical gray matter in schizophrenia: a meta-analysis and meta-regression of longitudinal MRI studies
Translational Psychiatry - Tập 2 Số 11 - Trang e190-e190
Antonio Vita, Luca De Peri, Giacomo Deste, Emilio Sacchetti
Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit
Translational Psychiatry - Tập 9 Số 1 - Trang 1-10
Ng, Tommy H., Alloy, Lauren B., Smith, David V.
Many neuroimaging studies have investigated reward processing dysfunction in major depressive disorder. These studies have led to the common idea that major depressive disorder is associated with blunted responses within the reward circuit, particularly in the ventral striatum. Yet, the link between major depressive disorder and reward-related responses in other regions remains inconclusive, thus ...... hiện toàn bộ
Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds
Translational Psychiatry - Tập 4 Số 1 - Trang e346-e346
Elisabetta C. del Re, Sarah E. Bergen, R I Mesholam-Gately, Margaret Niznikiewicz, Jill M. Goldstein, T.U.W. Woo, Martha E. Shenton, Larry J. Seidman, Robert W. McCarley, Tracey L. Petryshen
Animal models to improve our understanding and treatment of suicidal behavior
Translational Psychiatry - Tập 7 Số 4 - Trang e1092-e1092
T D Gould, Polymnia Georgiou, Lisa A. Brenner, Lena Brundin, Adem Can, Philippe Courtet, Zoe R. Donaldson, Yogesh Dwivedi, Sébastien Guillaume, Irving I. Gottesman, Shami Kanekar, Christopher A. Lowry, Perry F. Renshaw, Dan Rujescu, E. G. Smith, Gustavo Turecki, Panos Zanos, Carlos A. Zarate, Patricia A. Zunszain, Teodor T. Postolache
AbstractWorldwide, suicide is a leading cause of death. Although a sizable proportion of deaths by suicide may be preventable, it is well documented that despite major governmental and international investments in research, education and clinical practice suicide rates have not diminished and are even increasing among several at-risk populations. Although nonhuman ...... hiện toàn bộ
Prefrontal cortex markers of suicidal vulnerability in mood disorders: a model-based structural neuroimaging study with a translational perspective
Translational Psychiatry - Tập 5 Số 2 - Trang e516-e516
Yang Ding, Natalia Lawrence, Émilie Olié, Fabienne Cyprien, Emmanuelle Le Bars, Alain Bonafé, Mary L. Phillips, P. Courtet, Fabrice Jollant
Hippocampal metabolic differences implicate distinctions between physical and psychological stress in four rat models of depression
Translational Psychiatry - Tập 8 Số 1
Lanxiang Liu, Xinyu Zhou, Yuqing Zhang, Juncai Pu, Lining Yang, Shuai Yuan, Libo Zhao, Chanjun Zhou, Shouxin Zhang, Peng Xie
AbstractMajor depressive disorder (MDD) is a heterogeneous and multi-factorial disorder, and the underlying molecular mechanisms remain largely unknown. However, many studies have indicated that the molecular mechanisms underlying depression in response to different stress may differ. After screening, 28–30 rats were included in each model of depression (chronic un...... hiện toàn bộ
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