Physiology of Iron Metabolism Tập 41 Số 3 - Trang 213-221 - 2014
Sophie Waldvogel‐Abramowski, Gérard Waeber, Christoph Gassner, Andreas Buser, Beat M. Frey, Bernard Favrat, Jean‐Daniel Tissot
A revolution occurred during the last decade in the comprehension of the physiology as well as in the physiopathology of iron metabolism. The purpose of this review is to summarize the recent knowledge that has accumulated, allowing a better comprehension of the mechanisms implicated in iron homeostasis. Iron metabolism is very fine tuned. The free molecule is very toxic; therefore, comple...... hiện toàn bộ
Platelet Interaction with Innate Immune Cells Tập 43 Số 2 - Trang 78-88 - 2016
Julia B. Kral‐Pointner, Waltraud C. Schrottmaier, Manuel Salzmann, Alice Assinger
Beyond their traditional role in haemostasis and thrombosis, platelets are increasingly recognised as immune modulatory cells. Activated platelets and platelet-derived microparticles can bind to leukocytes, which stimulates mutual activation and results in rapid, local release of platelet-derived cytokines. Thereby platelets modulate leukocyte effector functions and contribute to inflammat...... hiện toàn bộ
The Rhesus Site Tập 41 Số 5 - Trang 357-363 - 2014
Franz F. Wagner, Willy A. Flegel
The Rhesus Site is a resource for information of the ‘Rhesus' blood group. It is intended for specialists and non-specialists. The website details research in the field relevant for transfusion medicine, immunohematology, and molecular research. Link areas guide to important publications and to methodological resources for Rhesus. Many data originally presented at The Rhesus Site have been...... hiện toàn bộ
Physiology and Pharmacology of Plerixafor Tập 40 Số 4 - Trang 237-245 - 2013
Simon P. Fricker
Autologous hematopoietic stem cell (HSC) transplantation is an important therapeutic option for patients with non-Hodgkin's lymphoma and multiple myeloma. The primary source of HSC is from the peripheral blood which requires mobilization from the bone marrow. Current mobilization regimens include cytokines such as G-CSF and/or chemotherapy. However not all patients mobilize enough HSC to p...... hiện toàn bộ
Transfusion-Related Acute Lung Injury: The Work of DAMPs* Tập 40 Số 1 - Trang 3-13 - 2013
W. Land
Current notions in immunology hold that not only pathogen-mediated tissue injury but any injury activates the innate immune system. In principle, this evolutionarily highly conserved, rapid first-line defense system responds to pathogen-induced injury with the creation of infectious inflammation, and non-pathogen-induced tissue injury with ‘sterile’ tissue inflammation. In this review, evi...... hiện toàn bộ