Toxicological Research

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Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of ε-Acetamidocaproic Acid in Rat Plasma
Toxicological Research - Tập 29 - Trang 203-209 - 2013
Tae Hyun Kim, Yong Seok Choi, Young Hee Choi, Yoon Gyoon Kim
A simple and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of ε-acetamidocaproic acid (AACA), the primary metabolite of zinc acexamate (ZAC), in rat plasma by using normetanephrine as an internal standard. Sample preparation involved protein precipitation using methanol. Separation was achieved on a Gemini-NX C18 column (1... hiện toàn bộ
Determination of Goitrogenic Metabolites in the Serum of Male Wistar Rat Fed Structurally Different Glucosinolates
Toxicological Research - - 2014
Eunji Choi, Ping Zhang, Hoonjeong Kwon
Highly Active Antiretroviral Therapy Alters Sperm Parameters and Testicular Antioxidant Status in Diet-Induced Obese Rats
Toxicological Research - - 2018
Ibukun P. Oyeyipo, Bongekile T. Skosana, Frans P. Everson, Hans Strijdom, Stefan S. du Plessis
The efficacy of highly active antiretroviral therapy (HAART) has led to an increase demand for therapeutic use, thereby necessitating investigation into drug toxicity. This study was designed to investigate the in vivo effects of HAART on sperm parameters and testicular oxidative stress in lean and obese rats. Wistar rats (males, n = 40, weighing 180∼200 g) were assigned randomly into 4 groups and... hiện toàn bộ
Subcutaneous Four-Week Repeated Dose Toxicity Studies of Rice Cell-Derived Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor in Rats
Toxicological Research - Tập 24 - Trang 315-320 - 2008
Jung Eun Ji, Jung Min Lee, Jong Min Choi, Young Hwa Choi, Eun Kyung Kim, So Jung Chu, Seok Kyun Kim, Kyong Hoon Ahn, Dong Hoon Lee, Ha Hyung Kim, Kyuboem Han, Dae Kyong Kim
Recombinant human granulocyte-macrophage colony stimulating factor (hGM-CSF) is a glycoprotein and hematopoietic growth factors that regulates the proliferation of myeloid precursor cells and activates mature granulocytes and macrophages. In a previous study, we reported that hGM-CSF could be produced in transgenic rice cell suspension culture, termed rhGM-CSF. In the present study, we examined th... hiện toàn bộ
28-Day Oral Toxicity of Cadmium Selenide in Sprague-Dawley Rats
Toxicological Research - Tập 25 - Trang 140-146 - 2009
Yong Soon Kim, Moon Yong Song, Jin Sik Kim, Dae Sik Rha, Yong Joon Jeon, Ji Eun Kim, Hyeon Yeol Ryu, Il Je Yu, Kyung Seuk Song
This study was performed to evaluate the toxicity of cadmium selenide for a period of 28 days in Sprague-Dawley rats. Each of 10 healthy male and females rats per group received daily oral administration for 28-day period at dosage levels 30, 300 and 1,000 mg/kg of body weight. Mortality and clinical signs were checked, and body weight, water intake and food consumption were also recorded weekly. ... hiện toàn bộ
Subacute Inhalation Toxicity of Cyclohexanone in B6C3F1 Mice
Toxicological Research - - 2018
Yong-Hoon Lee, Yong Hyun Chung, Hyeon-Yeong Kim, Seo Ho Shin, Sang Bae Lee
Evaluation of the Effect of Pentoxifylline on Cisplatin-Induced Testicular Toxicity in Rats
Toxicological Research - Tập 33 - Trang 255-263 - 2017
Ali Reza Fallahzadeh, Zohreh Rezaei, Hamid Reza Rahimi, Mehrazd Jafari Barmak, Hossein Sadeghi, Sadrollah Mehrabi, Seyed Mohammadreza Rabani, Iraj Ragerdi Kashani, Vahid Barati, Reza Mahmoudi
Chemotherapy is associated with male infertility. Cisplatin (cis-diamminedichloro-platinum (II) (CDDP) as a chemotherapy medication used to treat a number of cancers has been reported to most likely induce testicular toxicity. Administration of antioxidants, such as pentoxifylline (PTX) may reduce some Adverse Drug Reactions (ADRs) of CDDR Therefore, this study investigated the potentially protect... hiện toàn bộ
Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilization
Toxicological Research - Tập 39 - Trang 601-609 - 2023
Ju Young Lee, JuKyung Lee, Sung Ho Lee, Jeong Ho Hwang, Han Na Suh
We investigated the cytotoxic effect of Pelargonium sidoides extract on Madin–Darby canine kidney (MDCK) cells. P. sidoides extract decreased the cell viability in a dose dependent manner (> 0.2%). The extract of P. sidoides decreased the mitochondrial action potential, increased the number of reactive oxygen species (ROS) inside the cell, and caused nicotinamide adenine dinucleotide hydride (NADH... hiện toàn bộ
Phosphoinositides Signaling and Epithelial-to-Mesenchymal Transition: Putative Topic for Basic Toxicological Research
Toxicological Research - Tập 24 - Trang 1-9 - 2008
Chang Ho Lee
Ptdlns(4,5)P2 is a key cellular phosphoinositide that localizes in separate and distinctive pools in subcellular membrane and vesicular compartments. In membranes, Ptdlns(4,5)P2 acts as a precursor to second messengers and is itself a main signaling and targeting molecule. Specific subcellular localization of type I PIP kinases directed by interacting with specific targeting module differentiates ... hiện toàn bộ
Modulation of Apoptosis and Differentiation by the Treatment of Sulfasalazine in Rabbit Articular Chondrocytes
Toxicological Research - Tập 32 - Trang 115-121 - 2016
Won Kil Lee, Jin Seok Kang
This study was conducted to examine the cellular regulatory mechanisms of sulfasalazine (SSZ) in rabbit articular chondrocytes treated with sodium nitroprusside (SNP). Cell phenotype was determined, and the MTT assay, Western blot analysis and immunofluorescence staining of type II collagen was performed in control, SNP-treated and SNP plus SSZ (50~200 µg/mL) rabbit articular chondrocytes. Cellula... hiện toàn bộ
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