Subcutaneous Four-Week Repeated Dose Toxicity Studies of Rice Cell-Derived Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor in RatsToxicological Research - Tập 24 - Trang 315-320 - 2008
Jung Eun Ji, Jung Min Lee, Jong Min Choi, Young Hwa Choi, Eun Kyung Kim, So Jung Chu, Seok Kyun Kim, Kyong Hoon Ahn, Dong Hoon Lee, Ha Hyung Kim, Kyuboem Han, Dae Kyong Kim
Recombinant human granulocyte-macrophage colony stimulating factor (hGM-CSF) is a glycoprotein and hematopoietic growth factors that regulates the proliferation of myeloid precursor cells and activates mature granulocytes and macrophages. In a previous study, we reported that hGM-CSF could be produced in transgenic rice cell suspension culture, termed rhGM-CSF. In the present study, we examined th...... hiện toàn bộ
Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilizationToxicological Research - Tập 39 - Trang 601-609 - 2023
Ju Young Lee, JuKyung Lee, Sung Ho Lee, Jeong Ho Hwang, Han Na Suh
We investigated the cytotoxic effect of Pelargonium sidoides extract on Madin–Darby canine kidney (MDCK) cells. P. sidoides extract decreased the cell viability in a dose dependent manner (> 0.2%). The extract of P. sidoides decreased the mitochondrial action potential, increased the number of reactive oxygen species (ROS) inside the cell, and caused nicotinamide adenine dinucleotide hydride (NADH...... hiện toàn bộ
Modulation of Apoptosis and Differentiation by the Treatment of Sulfasalazine in Rabbit Articular ChondrocytesToxicological Research - Tập 32 - Trang 115-121 - 2016
Won Kil Lee, Jin Seok Kang
This study was conducted to examine the cellular regulatory mechanisms of sulfasalazine (SSZ) in rabbit articular chondrocytes treated with sodium nitroprusside (SNP). Cell phenotype was determined, and the MTT assay, Western blot analysis and immunofluorescence staining of type II collagen was performed in control, SNP-treated and SNP plus SSZ (50~200 µg/mL) rabbit articular chondrocytes. Cellula...... hiện toàn bộ
Fimbristylis ovata extract and its ability to encounter AGEs-induced neurotoxicity in SH-SY5YToxicological Research - Tập 37 - Trang 355-367 - 2021
Suphasarang Sirirattanakul, Rachana Santiyanont
Advanced glycation end products (AGEs) upon binding to its receptor (receptor for AGEs, RAGE) trigger several pathological processes involving oxidative stress and inflammatory pathway which play a pivotal role in various degenerative diseases including Alzheimer’s disease. Fimbristylis ovata (F. ovata) has long been reported to be used as a traditional herbal medicine; nonetheless, very few studi...... hiện toàn bộ
Grading criteria of histopathological evaluation in BCOP assay by various staining methodsToxicological Research - Tập 38 - Trang 9-17 - 2021
Mi Kyung Jeong, Bae-Hwan Kim
This study was performed to provide information on classifying eye irritating chemicals using the BCOP assay. After the BCOP assay, bovine corneas were classified by IVIS presented in OECD test guideline 437, and three special staining methods (H&E, MT, and PAS) were performed for histopathological evaluation. Non-irritant chemicals (IVIS ≤ 3), showed intact structures. In the 3 < IVIS ≤ 55 group,...... hiện toàn bộ