Toxicological Research

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Determination of Goitrogenic Metabolites in the Serum of Male Wistar Rat Fed Structurally Different Glucosinolates
Toxicological Research - - 2014
Eunji Choi, Ping Zhang, Hoonjeong Kwon
Subcutaneous Four-Week Repeated Dose Toxicity Studies of Rice Cell-Derived Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor in Rats
Toxicological Research - Tập 24 - Trang 315-320 - 2008
Jung Eun Ji, Jung Min Lee, Jong Min Choi, Young Hwa Choi, Eun Kyung Kim, So Jung Chu, Seok Kyun Kim, Kyong Hoon Ahn, Dong Hoon Lee, Ha Hyung Kim, Kyuboem Han, Dae Kyong Kim
Recombinant human granulocyte-macrophage colony stimulating factor (hGM-CSF) is a glycoprotein and hematopoietic growth factors that regulates the proliferation of myeloid precursor cells and activates mature granulocytes and macrophages. In a previous study, we reported that hGM-CSF could be produced in transgenic rice cell suspension culture, termed rhGM-CSF. In the present study, we examined th...... hiện toàn bộ
Subacute Inhalation Toxicity of Cyclohexanone in B6C3F1 Mice
Toxicological Research - - 2018
Yong-Hoon Lee, Yong Hyun Chung, Hyeon-Yeong Kim, Seo Ho Shin, Sang Bae Lee
Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilization
Toxicological Research - Tập 39 - Trang 601-609 - 2023
Ju Young Lee, JuKyung Lee, Sung Ho Lee, Jeong Ho Hwang, Han Na Suh
We investigated the cytotoxic effect of Pelargonium sidoides extract on Madin–Darby canine kidney (MDCK) cells. P. sidoides extract decreased the cell viability in a dose dependent manner (> 0.2%). The extract of P. sidoides decreased the mitochondrial action potential, increased the number of reactive oxygen species (ROS) inside the cell, and caused nicotinamide adenine dinucleotide hydride (NADH...... hiện toàn bộ
Modulation of Apoptosis and Differentiation by the Treatment of Sulfasalazine in Rabbit Articular Chondrocytes
Toxicological Research - Tập 32 - Trang 115-121 - 2016
Won Kil Lee, Jin Seok Kang
This study was conducted to examine the cellular regulatory mechanisms of sulfasalazine (SSZ) in rabbit articular chondrocytes treated with sodium nitroprusside (SNP). Cell phenotype was determined, and the MTT assay, Western blot analysis and immunofluorescence staining of type II collagen was performed in control, SNP-treated and SNP plus SSZ (50~200 µg/mL) rabbit articular chondrocytes. Cellula...... hiện toàn bộ
Bio-Inspired Green Nanoparticles: Synthesis, Mechanism, and Antibacterial Application
Toxicological Research - Tập 32 Số 2 - Trang 95-102 - 2016
Palaniyandi Velusamy, Govindarajan Venkat Kumar, Venkadapathi Jeyanthi, Jayabrata Das, Raman Pachaiappan
Fimbristylis ovata extract and its ability to encounter AGEs-induced neurotoxicity in SH-SY5Y
Toxicological Research - Tập 37 - Trang 355-367 - 2021
Suphasarang Sirirattanakul, Rachana Santiyanont
Advanced glycation end products (AGEs) upon binding to its receptor (receptor for AGEs, RAGE) trigger several pathological processes involving oxidative stress and inflammatory pathway which play a pivotal role in various degenerative diseases including Alzheimer’s disease. Fimbristylis ovata (F. ovata) has long been reported to be used as a traditional herbal medicine; nonetheless, very few studi...... hiện toàn bộ
Grading criteria of histopathological evaluation in BCOP assay by various staining methods
Toxicological Research - Tập 38 - Trang 9-17 - 2021
Mi Kyung Jeong, Bae-Hwan Kim
This study was performed to provide information on classifying eye irritating chemicals using the BCOP assay. After the BCOP assay, bovine corneas were classified by IVIS presented in OECD test guideline 437, and three special staining methods (H&E, MT, and PAS) were performed for histopathological evaluation. Non-irritant chemicals (IVIS ≤ 3), showed intact structures. In the 3 < IVIS ≤ 55 group,...... hiện toàn bộ
Allele Frequencies of the Single Nucleotide Polymorphisms Related to the Body Burden of Heavy Metals in the Korean Population and Their Ethnic Differences
Toxicological Research - Tập 32 - Trang 195-205 - 2016
Sang-Yong Eom, Ji-Ae Lim, Yong-Dae Kim, Byung-Sun Choi, Myung Sil Hwang, Jung-Duck Park, Heon Kim, Ho-Jang Kwon
This study was performed to select single nucleotide polymorphisms (SNPs) related to the body burden of heavy metals in Koreans, to provide Korean allele frequencies of selected SNPs, and to assess the difference in allele frequencies with other ethnicities. The candidate-gene approach method and genome-wide association screening were used to select SNPs related to the body burden of heavy metals....... hiện toàn bộ
Arylquin 1, a potent Par-4 secretagogue, induces lysosomal membrane permeabilization-mediated non-apoptotic cell death in cancer cells
Toxicological Research - Tập 36 - Trang 167-173 - 2019
Kyoung-jin Min, Sk Abrar Shahriyar, Taeg Kyu Kwon
Arylquin 1, a small-molecule prostate-apoptosis-response-4 (Par-4) secretagogue, targets vimentin to induce Par-4 secretion. Secreted Par-4 binds to its receptor, 78-kDa glucose-regulated protein (GRP78), on the cancer cell surface and induces apoptosis. In the present study, we investigated the molecular mechanisms of arylquin 1 in cancer cell death. Arylquin 1 induces morphological changes (cell...... hiện toàn bộ
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