Toxicological Research
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Toxicologic pathological mechanism of acute lung injury induced by oral administration of benzalkonium chloride in mice
Toxicological Research - Tập 39 - Trang 409-418 - 2023
Benzalkonium chloride (BAC) intoxication causes fatal lung injuries, such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the pathogenesis of ALI/ARDS induced by BAC ingestion is poorly understood. This study aimed to clarify the mechanism of lung toxicity after BAC ingestion in a mouse model. BAC was orally administered to C57BL/6 mice at doses of 100, 250, and...... hiện toàn bộ
Phototoxicity: Its Mechanism and Animal Alternative Test Methods
Toxicological Research - Tập 31 - Trang 97-104 - 2015
The skin exposure to solar irradiation and photoreactive xenobiotics may produce abnormal skin reaction, phototoxicity. Phototoxicity is an acute light-induced response, which occurs when photoreacive chemicals are activated by solar lights and transformed into products cytotoxic against the skin cells. Multifarious symptoms of phototoxicity are identified, skin irritation, erythema, pruritis, and...... hiện toàn bộ
Lipid hydroperoxide-derived insulin resistance and its inhibition by pyridoxamine in skeletal muscle cells
Toxicological Research - Tập 39 - Trang 147-156 - 2022
Oxidative stress is strongly associated with the onset and/or progression of diabetes. Under conditions of oxidative stress, lipid hydroperoxides are decomposed to reactive aldehydes that have been reported to induce insulin resistance by modifying proteins involved in insulin signaling. Pyridoxamine (PM) can inhibit the formation of advanced glycation/lipoxidation end products by scavenging react...... hiện toàn bộ
Assessment of the Dermal and Ocular Irritation Potential of Lomefloxacin by Using In Vitro Methods
Toxicological Research - Tập 26 - Trang 9-14 - 2010
The evaluation of eye and skin irritation potential is essential to ensuring the safety of human in contact with a wide variety of substances. Despite this importance of irritation test, little is known with respect to the irritation potency of lomefloxacin, a fluoroquinolone antibiotic, which has been known to cause phototoxicity with an abnormal reaction of the skin. Thus, to investigate the ten...... hiện toàn bộ
Repeated oral dose toxicity and genotoxicity of a standardized Quisqualis indica extract
Toxicological Research - Tập 38 - Trang 577-589 - 2022
Quisqualis indica L. of Combretaceae family is a traditional medicine that is widely used for various gastrointestinal discomfort including stomach pain, constipation, and digestive problem. In this study, the potential repeated dose toxicity and genotoxicity of a standardized Quisqualis indica L. extract (HU033) were determined under good laboratory practice conditions. For the repeated dose toxi...... hiện toàn bộ
Protection of Saururus Chinensis Extract against Liver Oxidative Stress in Rats of Triton WR-1339-induced Hyperlipidemia
Toxicological Research - Tập 30 - Trang 291-296 - 2014
Saururus chinensis has been reported to contain compounds such as lignans, alkaloids, diterpenes, flavonoids, tannins, steroids, and lipids. Fermentation is commonly used to break down certain undesirable compounds, to induce effective microbial conversion, and to improve the potential nutraceutical values. Previous studies have reported that the fermentation process could modify naturally occurri...... hiện toàn bộ
The Association of Heavy Metal of Blood and Serum in the Alzheimer’s Diseases
Toxicological Research - Tập 28 - Trang 93-98 - 2012
This study has attempted to establish an analysis method through validation against heavy metals in the body (Pb, Cd and Hg) using ICP-MS and Gold amalgamation and find out the relevance between heavy metal and Alzheimer’s disease after analyzing the distribution of heavy metal concentration (Pb, Cd and Hg) and correlations between a control group and Alzheimer’s disease group. In this study, Pb a...... hiện toàn bộ
The effect of methadone on blood glucose, lipids and glucose-modulating hormones in methadone-dependent Wistar rats
Toxicological Research - Tập 36 - Trang 221-226 - 2019
A growing body of evidence indicates that opioids regulate mechanisms activated during the stress response. This study was aimed to investigate the effect of methadone dependency on blood glucose, lipids and glucose-modulating hormones in male and female Wistar rats.This study was performed on 40 Wistar rats weighing 150–350 g, in four methadone exposure and control groups of both males and female...... hiện toàn bộ
Influence of Lead on Repetitive Behavior and Dopamine Metabolism in a Mouse Model of Iron Overload
Toxicological Research - Tập 30 - Trang 267-276 - 2014
Exposures to lead (Pb) are associated with neurological problems including psychiatric disorders and impaired learning and memory. Pb can be absorbed by iron transporters, which are up-regulated in hereditary hemochromatosis, an iron overload disorder in which increased iron deposition in various parenchymal organs promote metal-induced oxidative damage. While dysfunction in HFE (High Fe) gene is ...... hiện toàn bộ
α-Mangostin and Apigenin Induced Cell Cycle Arrest and Programmed Cell Death in SKOV-3 Ovarian Cancer Cells
Toxicological Research - Tập 35 Số 2 - Trang 167-179 - 2019
Ovarian cancer is the fifth main cause of pre-senescent death in women. Although chemotherapy is generally an efficient treatment, its side effects and the occurrence of chemotherapeutic resistance have prompted the need for alternative treatments. In this study, α-mangostin and apigenin were evaluated as possible anticancer alternatives to the chemotherapeutic drug doxorubicin, used herein as a p...... hiện toàn bộ
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