Enantioselective synthesis of cis-7-methoxy-calamenene via Claisen rearrangement of an enzymatically resolved allyl alcoholTetrahedron: Asymmetry - Tập 15 - Trang 335 - 2004
Fuganti Claudio, Dei Negri Claudia, Serra Stefano, Gatti Francesco G., Brenna Elisabetta
An enantioselective synthesis of cis-7-methoxy-calamenene 1 has been
accomplished through the following key-steps: (i) enzymatic resolution of the
racemic allyl alcohol 3 to furnish the (R)-enantiomer (ee>99%); (ii)
Claisen-orthoester rearrangement of 4 to introduce the isopropyl unit on the
benzylic position (99% ee); (iii) diastereoselective reduction of
dihydronaphthalene derivative 11 to give ... hiện toàn bộ