From Simple Cyclic 1,3-Ketoamides to Complex Spirolactams by Supported Heterogeneous Organocatalysis with PS-BEMPSynthesis - Tập 48 Số 19 - Trang 3217-3231 - 2016
Aouicha Benmaati, Hadjira Habib Zahmani, Salih Hacini, J. Carlos Menéndez, Xavier Bugaut, Jean Rodriguez, Thierry Constantieux
The reaction between cyclic 1,3-ketoamides and Michael acceptors in the presence of a catalytic amount of a polymer-supported organobase PS-BEMP has been developed for a direct access to spirocyclic 1,3-ketolactams through a domino Michael addition/hemiacetalization sequence. The products could be isolated in high chemical yields and purities after simple filtration, and the catalyst could...... hiện toàn bộ