Statistical Methods in Medical Research
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Extension of the modified Poisson regression model to prospective studies with correlated binary data The Poisson regression model using a sandwich variance estimator has become a viable alternative to the logistic regression model for the analysis of prospective studies with independent binary outcomes. The primary advantage of this approach is that it readily provides covariate-adjusted risk ratios and associated standard errors. In this article, the model is extended to studies with co... ... hiện toàn bộ
Statistical Methods in Medical Research - Tập 22 Số 6 - Trang 661-670 - 2013
Shrinkage observed-to-expected ratios for robust and transparent large-scale pattern discovery Large observational data sets are a great asset to better understand the effects of medicines in clinical practice and, ultimately, improve patient care. For an empirical pattern in observational data to be of practical relevance, it should represent a substantial deviation from the null model. For the purpose of identifying such deviations, statistical significance tests are inadequate, ... ... hiện toàn bộ
Statistical Methods in Medical Research - Tập 22 Số 1 - Trang 57-69 - 2013
Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range The era of big data is coming, and evidence-based medicine is attracting increasing attention to improve decision making in medical practice via integrating evidence from well designed and conducted clinical research. Meta-analysis is a statistical technique widely used in evidence-based medicine for analytically combining the findings from independent clinical trials to provide an overal... ... hiện toàn bộ
Statistical Methods in Medical Research - Tập 27 Số 6 - Trang 1785-1805 - 2018
Measurement reliability and agreement in psychiatry
Statistical Methods in Medical Research - Tập 7 Số 3 - Trang 301-317 - 1998
Group-based multi-trajectory modeling Identifying and monitoring multiple disease biomarkers and other clinically important factors affecting the course of a disease, behavior or health status is of great clinical relevance. Yet conventional statistical practice generally falls far short of taking full advantage of the information available in multivariate longitudinal data for tracking the course of the outcome of interest. ... ... hiện toàn bộ
Statistical Methods in Medical Research - Tập 27 Số 7 - Trang 2015-2023 - 2018
Review of inverse probability weighting for dealing with missing data The simplest approach to dealing with missing data is to restrict the analysis to complete cases, i.e. individuals with no missing values. This can induce bias, however. Inverse probability weighting (IPW) is a commonly used method to correct this bias. It is also used to adjust for unequal sampling fractions in sample surveys. This article is a review of the use of IPW in epidemiological... ... hiện toàn bộ
Statistical Methods in Medical Research - Tập 22 Số 3 - Trang 278-295 - 2013
Probabilistic sensitivity analysis in health economics Health economic evaluations have recently become an important part of the clinical and medical research process and have built upon more advanced statistical decision-theoretic foundations. In some contexts, it is officially required that uncertainty about both parameters and observable variables be properly taken into account, increasingly often by means of Bayesian methods. Among these,... ... hiện toàn bộ
Statistical Methods in Medical Research - Tập 24 Số 6 - Trang 615-634 - 2015
Statistical methods for multivariate meta-analysis of diagnostic tests: An overview and tutorial In this article, we present an overview and tutorial of statistical methods for meta-analysis of diagnostic tests under two scenarios: (1) when the reference test can be considered a gold standard and (2) when the reference test cannot be considered a gold standard. In the first scenario, we first review the conventional summary receiver operating characteristics approach and a bivariate ... ... hiện toàn bộ
Statistical Methods in Medical Research - Tập 25 Số 4 - Trang 1596-1619 - 2016
ANOVA model for network meta-analysis of diagnostic test accuracy dataProcedures combining and summarising direct and indirect evidence from independent studies assessing the diagnostic accuracy of different tests for the same disease are referred to network meta-analysis. Network meta-analysis provides a unified inference framework and uses the data more efficiently. Nonetheless, handling the inherent correlation between sensitivity and specificity continue... ... hiện toàn bộ
Statistical Methods in Medical Research - Tập 27 Số 6 - Trang 1766-1784 - 2018
Meta-analysis for the comparison of two diagnostic tests to a common gold standard: A generalized linear mixed model approach Meta-analysis of diagnostic studies is still a rapidly developing area of biostatistical research. Especially, there is an increasing interest in methods to compare different diagnostic tests to a common gold standard. Restricting to the case of two diagnostic tests, in these meta-analyses the parameters of interest are the differences of sensitivities and specificities (with their corres... ... hiện toàn bộ
Statistical Methods in Medical Research - Tập 27 Số 5 - Trang 1410-1421 - 2018
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