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Natural firing patterns reduce sensitivity of synaptic plasticity to spike-timing
Springer Science and Business Media LLC - Tập 14 - Trang 1-1 - 2013
Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides
Springer Science and Business Media LLC - Tập 13 - Trang 1-12 - 2012
β-amyloid (Aβ) accumulation is described as a hallmark of Alzheimer’s disease (AD). Aβ perturbs a number of synaptic components including nicotinic acetylcholine receptors containing α7 subunits (α7-nAChRs), which are abundantly expressed in the hippocampus and found on GABAergic interneurons. We have previously demonstrated the existence of a novel, heteromeric α7β2-nAChR in basal forebrain choli...... hiện toàn bộ
Neural correlations code for stimulus variance
Springer Science and Business Media LLC - Tập 14 - Trang 1-2 - 2013
Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology
Springer Science and Business Media LLC - Tập 19 - Trang 1-24 - 2018
Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid progression of disease and lack of biomarkers. Magnetic resonance imaging (MRI) has demonstrated its potential for detecting the pathological signature and tracking disease progression in ALS. However, the microstructural and molecular path...... hiện toàn bộ
Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function
Springer Science and Business Media LLC - Tập 7 - Trang 1-14 - 2006
Neurodegeneration in Alzheimer's disease is associated with increased apoptosis and parallels increased levels of amyloid beta, which can induce neuronal apoptosis. Estrogen exposure prior to neurotoxic insult of hippocampal neurons promotes neuronal defence and survival against neurodegenerative insults including amyloid beta. Although all underlying molecular mechanisms of amyloid beta neurotoxi...... hiện toàn bộ
Modulation of hippocampal gamma oscillations by acetylcholine: insights from mathematical and in vitro optogenetic models
Springer Science and Business Media LLC - Tập 16 - Trang 1-2 - 2015
Pattern formation in a mean field model of electrocortical activity
Springer Science and Business Media LLC - Tập 14 - Trang 1-2 - 2013
Does physical exercise improve or deteriorate treatment of multiple sclerosis with mitoxantrone? Experimental autoimmune encephalomyelitis study in ratsAbstract
Background
Mitoxantrone has proved efficacy in treatment of multiple sclerosis (MS). The fact that physical exercise could slow down the progression of disease and improve performance is still a debatable issue, hence; we aimed at studying whether combining mitoxantrone with exercise is of ... ... hiện toàn bộ
Springer Science and Business Media LLC - Tập 23 Số 1 - 2022
Self-generated neural activity: models and perspective
Springer Science and Business Media LLC - Tập 10 - Trang 1-2 - 2009
Effects of gestational inflammation on age-related cognitive decline and hippocampal Gdnf-GFRα1 levels in F1 and F2 generations of CD-1 MiceAbstract
Background
It has been reported that age-associated cognitive decline (AACD) accelerated by maternal lipopolysaccharide (LPS) insult during late pregnancy can be transmitted to the second generation in a sex-specificity manner. In turn, recent studies indicated that glial cell line‐derived ... ... hiện toàn bộ
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