Creatine kinase B deficient neurons exhibit an increased fraction of motile mitochondriaSpringer Science and Business Media LLC - Tập 9 - Trang 1-10 - 2008
Jan WP Kuiper, Frank TJJ Oerlemans, Jack AM Fransen, Bé Wieringa
Neurons require an elaborate system of intracellular transport to distribute cargo throughout axonal and dendritic projections. Active anterograde and retrograde transport of mitochondria serves in local energy distribution, but at the same time also requires input of ATP. Here we studied whether brain-type creatine kinase (CK-B), a key enzyme for high-energy phosphoryl transfer between ATP and Cr...... hiện toàn bộ
Serotonin transporter (SERT) and translocator protein (TSPO) expression in the obese ob/ob mouseSpringer Science and Business Media LLC - Tập 12 - Trang 1-8 - 2011
Gino Giannaccini, Laura Betti, Lionella Palego, Andrea Pirone, Lara Schmid, Mario Lanza, Laura Fabbrini, Caterina Pelosini, Margherita Maffei, Ferruccio Santini, Aldo Pinchera, Antonio Lucacchini
An ever growing body of evidences is emerging concerning metabolism hormones, neurotransmitters or stress-related biomarkers as effective modulators of eating behavior and body weight in mammals. The present study sought at examining the density and affinity of two proteins related to neurotransmission and cell metabolism, the serotonin transporter SERT and the cholesterol import-benzodiazepine si...... hiện toàn bộ
Inhibition of cytosolic Phospholipase A2prevents prion peptide-induced neuronal damage and co-localisation with Beta III TubulinSpringer Science and Business Media LLC - Tập 13 - Trang 1-13 - 2012
Victoria Last, Alun Williams, Dirk Werling
Activation of phospholipase A2 (PLA2) and the subsequent metabolism of arachidonic acid (AA) to prostaglandins have been shown to play an important role in neuronal death in neurodegenerative disease. Here we report the effects of the prion peptide fragment HuPrP106-126 on the PLA2 cascade in primary cortical neurons and translocation of cPLA2 to neurites. Exposure of primary cortical neurons to H...... hiện toàn bộ