Serotonin transporter (SERT) and translocator protein (TSPO) expression in the obese ob/ob mouseSpringer Science and Business Media LLC - Tập 12 - Trang 1-8 - 2011
Gino Giannaccini, Laura Betti, Lionella Palego, Andrea Pirone, Lara Schmid, Mario Lanza, Laura Fabbrini, Caterina Pelosini, Margherita Maffei, Ferruccio Santini, Aldo Pinchera, Antonio Lucacchini
An ever growing body of evidences is emerging concerning metabolism hormones, neurotransmitters or stress-related biomarkers as effective modulators of eating behavior and body weight in mammals. The present study sought at examining the density and affinity of two proteins related to neurotransmission and cell metabolism, the serotonin transporter SERT and the cholesterol import-benzodiazepine si...... hiện toàn bộ
Inhibition of cytosolic Phospholipase A2prevents prion peptide-induced neuronal damage and co-localisation with Beta III TubulinSpringer Science and Business Media LLC - Tập 13 - Trang 1-13 - 2012
Victoria Last, Alun Williams, Dirk Werling
Activation of phospholipase A2 (PLA2) and the subsequent metabolism of arachidonic acid (AA) to prostaglandins have been shown to play an important role in neuronal death in neurodegenerative disease. Here we report the effects of the prion peptide fragment HuPrP106-126 on the PLA2 cascade in primary cortical neurons and translocation of cPLA2 to neurites. Exposure of primary cortical neurons to H...... hiện toàn bộ
Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient miceSpringer Science and Business Media LLC - - 2008
Ying Sun, Li Jia, Michael T Williams, Matt Zamzow, Huimin Ran, Brian Quinn, Bruce J Aronow, Charles V Vorhees, David P Witte, Gregory A Grabowski
Prosaposin encodes, in tandem, four small acidic activator proteins (saposins) with specificities for glycosphingolipid (GSL) hydrolases in lysosomes. Extensive GSL storage occurs in various central nervous system regions in mammalian prosaposin deficiencies. Our hypomorphic prosaposin deficient mouse, PS-NA, exhibited 45% WT levels of brain saposins and showed neuropathology that included neurona...... hiện toàn bộ