Endosomal accumulation of APP in wobbler motor neurons reflects impaired vesicle trafficking: Implications for human motor neuron diseaseSpringer Science and Business Media LLC - Tập 12 - Trang 1-10 - 2011
Ralf Palmisano, Panagiota Golfi, Peter Heimann, Christopher Shaw, Claire Troakes, Thomas Schmitt-John, Jörg W Bartsch
The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown but
hypotheses about disease mechanisms include oxidative stress, defective axonal
transport, mitochondrial dysfunction and disrupted RNA processing. Whereas
familial ALS is well represented by transgenic mutant SOD1 mouse models, the
mouse mutant wobbler (WR) develops progressive motor neuron degeneration due to
a point ... hiện toàn bộ
Creatine kinase B deficient neurons exhibit an increased fraction of motile mitochondriaSpringer Science and Business Media LLC - Tập 9 - Trang 1-10 - 2008
Jan WP Kuiper, Frank TJJ Oerlemans, Jack AM Fransen, Bé Wieringa
Neurons require an elaborate system of intracellular transport to distribute
cargo throughout axonal and dendritic projections. Active anterograde and
retrograde transport of mitochondria serves in local energy distribution, but at
the same time also requires input of ATP. Here we studied whether brain-type
creatine kinase (CK-B), a key enzyme for high-energy phosphoryl transfer between
ATP and Cr... hiện toàn bộ
Hysteresis of haptic vertical and straight ahead in healthy human subjectsSpringer Science and Business Media LLC - Tập 13 - Trang 1-12 - 2012
Alexander A Tarnutzer, Jeanine R Schuler, Christopher J Bockisch, Dominik Straumann
The subjective haptic vertical (SHV) task requires subjects to adjust the roll
orientation of an object, mostly in the roll plane, in such a way that it is
parallel to perceived direction of gravity. Previously we found a tendency for
clockwise rod rotations to deviate counter-clockwise and vice versa, indicating
hysteresis. However, the contributing factors remained unclear. To clarify this
we ch... hiện toàn bộ