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Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells
Springer Science and Business Media LLC - Tập 36 - Trang 1-11 - 2017
Rong Geng, Xin Tan, Zhixiang Zuo, Jiangxue Wu, Zhizhong Pan, Wei Shi, Ranyi Liu, Chen Yao, Gaoyuan Wang, Jiaxin Lin, Lin Qiu, Wenlin Huang, Shuai Chen
The mitogen-activated extracellular signal-regulated kinase 1/2 (MEK1/2) inhibitor trametinib has shown promising therapeutic effects on melanoma, but its efficacy on colorectal cancer (CRC) is limited. Synthetic lethality arises with a combination of two or more separate gene mutations that causes cell death, whereas individual mutations keep cells alive. This study aimed to identify the genes re...... hiện toàn bộ
Expert consensus on maintenance treatment for metastatic colorectal cancer in China
Springer Science and Business Media LLC - Tập 35 Số 1 - 2016
Rui Xu, Lin Shen, Jin Li, Jian Xu, Feng Bi, Yi Ba, Bai Li, Yongqian Shu, Tian Shu Liu, Yu Hong Li, Chun Mei Bai, Xianglin Yuan, Jun Zhang, Gong Chen, Ai-Ping Zhou, Ying Yuan, Xi Jing Wang, Xiao Ping Qian, Yuxin Deng
Primary site and regional lymph node involvement are independent prognostic factors for early-stage extranodal nasal-type natural killer/T cell lymphoma
Springer Science and Business Media LLC - Tập 35 - Trang 1-9 - 2016
Shao-Qing Niu, Yong Yang, Yi-Yang Li, Ge Wen, Liang Wang, Zhi-Ming Li, Han-Yu Wang, Lu-Lu Zhang, Yun-Fei Xia, Yu-Jing Zhang
Nasal-type extranodal natural killer/T-cell lymphoma (ENKTCL) originates primarily in the nasal cavity or extra-nasal sites within the upper aerodigestive tract. However, it is unclear whether the primary site can serve as an independent prognostic factor or whether the varying clinical outcomes observed with different primary sites can be attributed merely to their propensities of regional lymph ...... hiện toàn bộ
Significance of spatial organization of chromosomes in the progression of acute myeloid leukemia
Springer Science and Business Media LLC - - 2017
Xueli Tian, Yanfang Wang, Dieyan Chen, Xiaoyan Ke, Wanyun Ma
Clinical treatment considerations in the intensity-modulated radiotherapy era for patients with N0-category nasopharyngeal carcinoma and enlarged neck lymph nodes
Springer Science and Business Media LLC - Tập 36 Số 1 - Trang 1-9 - 2017
Peng, Hao, Chen, Lei, Guo, Rui, Zhang, Yuan, Li, Wen-Fei, Mao, Yan-Ping, Sun, Ying, Zhang, Fan, Liu, Li-Zhi, Tian, Li, Ma, Jun
Nasopharyngeal carcinoma (NPC) shows a high proportion of lymph node metastasis, and treatment guidelines have been developed for positive nodes. However, no irradiation guidelines have been proposed for patients with enlarged neck lymph nodes (ENLNs) that do not meet the radiological criteria of 10 mm in diameter for positive lymph nodes. This study aimed to determine the prognostic value an...... hiện toàn bộ
Cell-free circulating tumor DNA in cancer
Springer Science and Business Media LLC - Tập 35 - Trang 1-9 - 2016
Zhen Qin, Vladimir A. Ljubimov, Cuiqi Zhou, Yunguang Tong, Jimin Liang
Cancer is a common cause of death worldwide. Despite significant advances in cancer treatments, the morbidity and mortality are still enormous. Tumor heterogeneity, especially intratumoral heterogeneity, is a significant reason underlying difficulties in tumor treatment and failure of a number of current therapeutic modalities, even of molecularly targeted therapies. The development of a virtually...... hiện toàn bộ
Cytokine-induced killer (CIK) cells: from basic research to clinical translation
Springer Science and Business Media LLC - Tập 34 - Trang 1-9 - 2015
Yelei Guo, Weidong Han
The accumulation of basic researches and clinical studies related to cytokine-induced killer (CIK) cells has confirmed their safety and feasibility in treating malignant diseases. This review summarizes the available published literature related to the biological characteristics and clinical applications of CIK cells in recent years. A number of clinical trials with CIK cells have been implemented...... hiện toàn bộ
Twenty years after: the beautiful hypothesis and the ugly facts
Springer Science and Business Media LLC - Tập 35 - Trang 1-3 - 2016
Francesco Pezzella, Kevin Gatter, Chao-Nan Qian
The limited clinical benefits from current antiangiogenic therapy for cancer patients have triggered some critical thoughts and insightful investigations aiming to further elucidate the relationship between vessels and cancer. Tumors need blood perfusion but there are mounting evidences that angiogenesis alone does not explain it in all the neoplasms. In this editorial, for a special issue on tumo...... hiện toàn bộ
Kết quả lâm sàng của điều trị EGFR-TKI và tính dị hình di truyền ở bệnh nhân ung thư phổi tuyến có đột biến EGFR trên exon 19 và 21 Dịch bởi AI
Springer Science and Business Media LLC - Tập 35 - Trang 1-10 - 2016
Jiang-Yong Yu, Si-Fan Yu, Shu-Hang Wang, Hua Bai, Jun Zhao, Tong-Tong An, Jian-Chun Duan, Jie Wang
Đột biến thụ thể yếu tố tăng trưởng biểu bì (EGFR), bao gồm một đột biến biết đến là xóa exon 19 (19 del) và đột biến điểm L858R trên exon 21 (đột biến L858R), là những yếu tố dự đoán mạnh mẽ về phản ứng điều trị bằng chất ức chế kinase tyrosine EGFR (EGFR-TKI) trong ung thư phổi tuyến. Tuy nhiên, việc liệu các bệnh nhân mang đột biến EGFR 19 del và L858R có biểu hiện khả năng đáp ứng khác nhau đố...... hiện toàn bộ
#EGFR #đột biến #ung thư phổi tuyến #điều trị EGFR-TKI #tính dị hình di truyền
Fertility preservation in female cancer patients: a single center experience
Springer Science and Business Media LLC - - 2015
Cristina Sigismondi, Enrico Papaleo, Paola Viganò, Simona Vailati, Massimo Candiani, Jessica Ottolina, Valentina Elisabetta Di Mattei, Giorgia Mangili
Tổng số: 192   
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