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Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells
Springer Science and Business Media LLC - Tập 36 - Trang 1-11 - 2017
Rong Geng, Xin Tan, Zhixiang Zuo, Jiangxue Wu, Zhizhong Pan, Wei Shi, Ranyi Liu, Chen Yao, Gaoyuan Wang, Jiaxin Lin, Lin Qiu, Wenlin Huang, Shuai Chen
The mitogen-activated extracellular signal-regulated kinase 1/2 (MEK1/2) inhibitor trametinib has shown promising therapeutic effects on melanoma, but its efficacy on colorectal cancer (CRC) is limited. Synthetic lethality arises with a combination of two or more separate gene mutations that causes cell death, whereas individual mutations keep cells alive. This study aimed to identify the genes re...... hiện toàn bộ
Expert consensus on maintenance treatment for metastatic colorectal cancer in China
Springer Science and Business Media LLC - Tập 35 Số 1 - 2016
Rui Xu, Lin Shen, Jin Li, Jian Xu, Feng Bi, Yi Ba, Bai Li, Yongqian Shu, Tian Shu Liu, Yu Hong Li, Chun Mei Bai, Xianglin Yuan, Jun Zhang, Gong Chen, Ai-Ping Zhou, Ying Yuan, Xi Jing Wang, Xiao Ping Qian, Yuxin Deng
Primary site and regional lymph node involvement are independent prognostic factors for early-stage extranodal nasal-type natural killer/T cell lymphoma
Springer Science and Business Media LLC - Tập 35 - Trang 1-9 - 2016
Shao-Qing Niu, Yong Yang, Yi-Yang Li, Ge Wen, Liang Wang, Zhi-Ming Li, Han-Yu Wang, Lu-Lu Zhang, Yun-Fei Xia, Yu-Jing Zhang
Nasal-type extranodal natural killer/T-cell lymphoma (ENKTCL) originates primarily in the nasal cavity or extra-nasal sites within the upper aerodigestive tract. However, it is unclear whether the primary site can serve as an independent prognostic factor or whether the varying clinical outcomes observed with different primary sites can be attributed merely to their propensities of regional lymph ...... hiện toàn bộ
Significance of spatial organization of chromosomes in the progression of acute myeloid leukemia
Springer Science and Business Media LLC - - 2017
Xueli Tian, Yanfang Wang, Dieyan Chen, Xiaoyan Ke, Wanyun Ma
Ovarian cancer: a molecularly insidious disease
Springer Science and Business Media LLC - Tập 34 - Trang 1-3 - 2015
Delia Mezzanzanica
In this issue of the Chinese Journal of Cancer, European, American, and Chinese experts review the current management and future perspectives of epithelial ovarian cancer (EOC), the leading cause of gynecological cancer deaths. Although major advances have been made in understanding the cellular and molecular biology of this highly heterogeneous malignancy, the survival rate of women with EOC has ...... hiện toàn bộ
Brain metastasis in children with stage 4 neuroblastoma after multidisciplinary treatment
Springer Science and Business Media LLC - Tập 34 - Trang 1-7 - 2015
Jia Zhu, Juan Wang, Zi-Jun Zhen, Su-Ying Lu, Fei Zhang, Fei-Fei Sun, Peng-Fei Li, Jun-Ting Huang, Rui-Qing Cai, Xiao-Fei Sun
Brain metastasis is common in relapsed neuroblastoma patients, but the characteristics of brain metastasis remain largely unknown. This study aimed to investigate the status of brain metastasis with neuroblastoma in South China. In this retrospective case-based study, 106 patients with stage 4 neuroblastoma from the Department of Pediatric Oncology in Sun Yat-sen University Cancer Center between J...... hiện toàn bộ
Clinical treatment considerations in the intensity-modulated radiotherapy era for patients with N0-category nasopharyngeal carcinoma and enlarged neck lymph nodes
Springer Science and Business Media LLC - Tập 36 Số 1 - Trang 1-9 - 2017
Peng, Hao, Chen, Lei, Guo, Rui, Zhang, Yuan, Li, Wen-Fei, Mao, Yan-Ping, Sun, Ying, Zhang, Fan, Liu, Li-Zhi, Tian, Li, Ma, Jun
Nasopharyngeal carcinoma (NPC) shows a high proportion of lymph node metastasis, and treatment guidelines have been developed for positive nodes. However, no irradiation guidelines have been proposed for patients with enlarged neck lymph nodes (ENLNs) that do not meet the radiological criteria of 10 mm in diameter for positive lymph nodes. This study aimed to determine the prognostic value an...... hiện toàn bộ
Chromatin remodeling factor lymphoid-specific helicase inhibits ferroptosis through lipid metabolic genes in lung cancer progression
Springer Science and Business Media LLC - Tập 36 Số 1 - 2017
Yiqun Jiang, Yuchen He, Shuang Liu, Yongguang Tao
Different dissecting orders of the pulmonary bronchus and vessels during right upper lobectomy are associated with surgical feasibility and postoperative recovery for lung cancer patients
Springer Science and Business Media LLC - - 2017
Hao-Ran Zhai, Xue-Ning Yang, Qiang Nie, Ri-Qiang Liao, Song Dong, Wei Li, Ben-Yuan Jiang, Jin-Ji Yang, Qing Zhou, Hai-Yan Tu, Xu-Chao Zhang, Yi-Long Wu, Wen-Zhao Zhong
Right upper lobectomy (RUL) for lung cancer with different dissecting orders involves the most variable anatomical structures, but no studies have analyzed its effects on postoperative recovery. This study compared the conventional surgical approach, VAB (dissecting pulmonary vessels first, followed by the bronchus), and the alternative surgical approach, aBVA (dissecting the posterior ascending a...... hiện toàn bộ
The 150 most important questions in cancer research and clinical oncology series: questions 6–14
Springer Science and Business Media LLC - Tập 36 Số 1 - 2017
Chinese Journal of Cancer
Tổng số: 192   
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