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Lamivudine
Springer Science and Business Media LLC - Tập 4 - Trang 687-694 - 2012
▲ Lamivudine, the negative enantiomer of 2′-deoxy-3′-thiacytidine, is a dideoxynucleoside analog that prevents hepatitis B virus (HBV) DNA synthesis by competitively inhibiting the viral reverse transcriptase and DNA polymerase stages of HBV replication and by terminating proviral DNA chain extension. ▲ A dose-ranging study established that once daily oral lamivudine 3 mg/kg up to a maximum of 100...... hiện toàn bộ
Sevoflurane in Paediatric Anaesthesia
Springer Science and Business Media LLC - Tập 1 - Trang 127-153 - 2012
Sevoflurane is an ether inhalation anaesthetic agent with low pungency, a non-irritant odour and a low blood: gas partition coefficient. It can be rapidly and conveniently administered without discomfort, and its low solubility facilitates precise control over the depth of anaesthesia and a rapid and smooth induction of, and emergence from, general anaesthesia. As an induction and maintenance agen...... hiện toàn bộ
Medications That Can Be Fatal For a Toddler with One Tablet or Teaspoonful
Springer Science and Business Media LLC - Tập 6 - Trang 123-126 - 2012
Objective: To provide an updated list of the highly toxic medications in North America that can kill a 10kg toddler upon ingestion of 1–2 dose units.
Methods: All drugs available in North America were reviewed and their reported lethal doses in children or adults (where no pediatric data existed) were identified. The dose units of drugs available in North America ...... hiện toàn bộ
CD19 CAR T Cells for the Treatment of Pediatric Pre-B Cell Acute Lymphoblastic Leukemia
Springer Science and Business Media LLC - Tập 22 - Trang 1-11 - 2019
The development of cluster of differentiation (CD)-19-targeted chimeric antigen receptor (CAR) T cells for the treatment of pre-B-cell acute lymphoblastic leukemia (B-ALL) is an exciting new advancement in the field of pediatric oncology. Tisagenlecleucel and axicabtagene ciloleucel are the first US FDA-approved CD19-targeted CAR T cells. While various different CD19 CAR T cells are in development...... hiện toàn bộ
Measuring the Patient Health, Societal and Economic Benefits of US Pediatric Therapeutics Legislation
Springer Science and Business Media LLC - Tập 14 - Trang 283-294 - 2012
Through at least the mid-1990s, children were often referred to as ‘therapeutic orphans’ for whom many treatments were administered without the benefit of appropriate studies to guide drug labeling for dosing and other critical therapeutic decisions. At that time, there were no incentives for manufacturers to pursue such work, nor regulatory requirements to compel these studies. Congress addressed...... hiện toàn bộ
Neonatal Sepsis
Springer Science and Business Media LLC - Tập 5 - Trang 723-740 - 2012
Neonatal sepsis is uncommon (2–4 per 1000 live births in developed countries), but the rate increases dramatically in premature newborns and those born to mothers with infections or prolonged rupture of the fetal membranes. While infections caused by organisms contracted from the mother at birth have decreased in the past two decades, there has been an increase in nosocomial infections. Today, mos...... hiện toàn bộ
Ranibizumab: A Review in Retinopathy of Prematurity
Springer Science and Business Media LLC - Tập 23 - Trang 111-117 - 2021
Ranibizumab (Lucentis®) is a monoclonal antibody fragment targeted against VEGF-A that is the first approved anti-VEGF agent for the treatment of retinopathy of prematurity (ROP). In the pivotal, randomized, phase III RAINBOW trial in infants with ROP, the majority of intravitreal ranibizumab recipients experienced treatment success at 24 weeks, with a numerically greater treatment success rate in...... hiện toàn bộ
Training Clinicians in Maternal-Fetal Pharmacology
Springer Science and Business Media LLC - Tập 11 Số 1 - Trang 72-73 - 2009
Effects of Antipsychotics on the Unborn Child
Springer Science and Business Media LLC - Tập 2 - Trang 83-90 - 2012
The onset of psychosis during pregnancy presents difficult management decisions. A complete and thorough physical and obstetric examination is always warranted to look for possible physiological precipitants. The treatment of pregnant patients with psychotic symptomatology requires close contacts between family members, non-physician professionals involved in the patient’s care (e.g. social worker...... hiện toàn bộ
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