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Lack of association between stavudine exposure and lipoatrophy, dysglycaemia, hyperlactataemia and hypertriglyceridaemia: a prospective cross sectional study
Springer Science and Business Media LLC - Tập 7 - Trang 1-6 - 2010
Phumla Z Sinxadi, Jan-Stefan van der Walt, Helen M McIlleron, Motasim Badri, Peter J Smith, Joel A Dave, Naomi S Levitt, Gary Maartens
Stavudine continues to be widely used in resource poor settings despite its toxicity. Our objective was to determine association between plasma stavudine concentrations and lipoatrophy, concentrations of glucose, lactate and triglycerides. Participants were enrolled in a cross-sectional study with lipoatrophy assessment, oral glucose tolerance test, fasting triglycerides, finger prick lactate, and...... hiện toàn bộ
Morning free and total testosterone in HIV-infected men: implications for the assessment of hypogonadism
Springer Science and Business Media LLC - - 2014
Anne Monroe, Adrian S. Dobs, Frank J. Palella, Lawrence A. Kingsley, Mallory D. Witt, Todd T. Brown
HIV-1 subtype C predicted co-receptor tropism in Africa: an individual sequence level meta-analysis
Springer Science and Business Media LLC - Tập 17 - Trang 1-16 - 2020
Nontokozo D. Matume, Denis M. Tebit, Pascal O. Bessong
Entry inhibitors, such as Maraviroc, hold promise as components of HIV treatment and/or pre-exposure prophylaxis in Africa. Maraviroc inhibits the interaction between HIV Envelope gp120 V3-loop and CCR5 coreceptor. HIV-1 subtype C (HIV-1-C) is predominant in Southern Africa and preferably uses CCR5 co-receptor. Therefore, a significant proportion of HIV-1-C CXCR4 utilizing viruses (X4) may comprom...... hiện toàn bộ
Detection of HIV-1 RNA/DNA and CD4 mRNA in feces and urine from chronic HIV-1 infected subjects with and without anti-retroviral therapy
Springer Science and Business Media LLC - Tập 6 Số 1 - 2009
Ayan K. Chakrabarti, Lori Caruso, Ming Ding, Chengli Shen, William Buchanan, Phalguni Gupta, Charles R. Rinaldo, Yue Chen
AbstractHIV-1 infects gut associated lymphoid tissues (GALT) very early after transmission by multiple routes. The infected GALT consequently serves as the major reservoir for HIV-1 infection and could constantly shed HIV-1 and CD4+T cells into the intestinal lumen. To examine this hypothesis, we monitored HIV-1 RNA/DNA and CD4 mRNA in fecal sa...... hiện toàn bộ
The adult prevalence of HIV in Zambia: results from a population based mobile testing survey conducted in 2013–2014
Springer Science and Business Media LLC - Tập 13 - Trang 1-9 - 2016
Pascalina Chanda-Kapata, Nathan Kapata, Eveline Klinkenberg, Ngosa William, Liwewe Mazyanga, Katoba Musukwa, Elizabeth Chizema Kawesha, Felix Masiye, Peter Mwaba
To estimate the adult prevalence of HIV among the adult population in Zambia and determine whether demographic characteristics were associated with being HIV positive. A cross sectional population based survey to asses HIV status among participants aged 15 years and above in a national tuberculosis prevalence survey. Counselling was offered to participants who tested for HIV. The prevalence was es...... hiện toàn bộ
A structural equation modeling approach to investigate HIV testing willingness for men who have sex with men in China
Springer Science and Business Media LLC - Tập 20 - Trang 1-5 - 2023
Han Jiang, Wei He, Haiying Pan, Xiaoni Zhong
A substantial risk of contracting Human immunodeficiency virus (HIV) exists among men who have sex with men (MSM), and HIV infection rates have been rising. This study aimed to analyze the factors influencing the Chinese MSM population’s intention to test for HIV. Nonprobability sampling techniques were employed in June 2022 to recruit MSM in Chongqing and Sichuan, China. The data were analyzed us...... hiện toàn bộ
The role of the glycosyl moiety of myricetin derivatives in anti-HIV-1 activity in vitro
Springer Science and Business Media LLC - Tập 14 Số 1 - 2017
Joseph T. Ortega, Alírica I. Suárez, María Luisa Serrano, Jani Baptista, Flor H. Pujol, Héctor R. Rangel
Use of taste-masking product, FLAVORx, to assist Thai children to ingest generic antiretrovirals
Springer Science and Business Media LLC - Tập 3 - Trang 1-5 - 2006
Torsak Bunupuradah, Siripan Wannachai, Arpa Chuamchaitrakool, Jintana Intasan, Thantip Nuchapong, Woodie Neiss, Kenny Kramm, Chitsanu Pancharoen, David Burger, Jintanat Ananworanich
We evaluated whether FLAVORx helped thirty Thai children take opened capsule, crushed tablets and liquid generic ARVs with more ease. All children had excellent adherence, evaluated by PACTG Standard International Questionnaire and interviewing, before and after one month of FLAVORx. Eighty percent took ARV with more ease and wish to continue FLAVORx. Strawberry was the most popular flavor.
Uptake of retroviral pre-exposure prophylaxis and its associated factors among female sex workers, Northwest Ethiopia
Springer Science and Business Media LLC - Tập 20 - Trang 1-5 - 2023
Belayneh Fentahun Shibesh, Aragaw Bitew Admas, Amarech Wondie Lake, Samuel Befekadu Getu, Daniel Tarekegn Worede
Pre-exposure prophylaxis is the use of antiretroviral medications by HIV-negative individuals to prevent infection before exposure. Ethiopia has made progress in reducing new HIV infections, but the burden remains high with ongoing challenges in prevention uptake. This study examined the utilization and factors associated with pre-exposure prophylaxis among female sex workers. A community-based cr...... hiện toàn bộ
Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo
Springer Science and Business Media LLC - Tập 6 - Trang 1-10 - 2009
Miriam C Poirier, Ofelia A Olivero, Andrew W Hardy, Genoveffa Franchini, Jennifer P Borojerdi, Vernon E Walker, Dale M Walker, Gene M Shearer
WR1065 is the free-thiol metabolite of the cytoprotective aminothiol amifostine, which is used clinically at very high doses to protect patients against toxicity induced by radiation and chemotherapy. In an earlier study we briefly reported that the aminothiol WR1065 also inhibits HIV-1 replication in phytohemagglutinin (PHA)-stimulated human T-cell blasts (TCBs) infected in culture for 2 hr befor...... hiện toàn bộ
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