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Evaluating the impact of glucokinase activation on risk of cardiovascular disease: a Mendelian randomisation analysis
Springer Science and Business Media LLC - Tập 21 - Trang 1-10 - 2022
Ke Wang, Mai Shi, Chuiguo Huang, Baoqi Fan, Andrea O. Y. Luk, Alice P. S. Kong, Ronald C. W. Ma, Juliana C. N. Chan, Elaine Chow
Glucokinase activators (GKAs) are an emerging class of glucose lowering drugs that activate the glucose-sensing enzyme glucokinase (GK). Pending formal cardiovascular outcome trials, we applied two-sample Mendelian randomisation (MR) to investigate the impact of GK activation on risk of cardiovascular diseases. We used independent genetic variants in or around the glucokinase gene meanwhile associ...... hiện toàn bộ
Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation
Springer Science and Business Media LLC - Tập 22 - Trang 1-11 - 2023
Chidinma A Okolo, Ei-Phyo Khaing, Valeria Mereacre, Rachel S Wallace, Michelle L Munro, Jeffrey R Erickson, Peter P. Jones
O-GlcNAcylation is the enzymatic addition of a sugar, O-linked β-N-Acetylglucosamine, to the serine and threonine residues of proteins, and is abundant in diabetic conditions. We have previously shown that O-GlcNAcylation can trigger arrhythmias by indirectly increasing pathological Ca2+ leak through the cardiac ryanodine receptor (RyR2) via Ca2+/calmodulin-dependent kinase II (CaMKII). However, R...... hiện toàn bộ
The association of higher levels of within-normal-limits liver enzymes and the prevalence of the metabolic syndrome
Springer Science and Business Media LLC - - 2010
Arie Steinvil, Itzhak Shapira, Orit Kliuk Ben-Bassat, Michael Cohen, Yaffa Vered, Shlomo Berliner, Ori Rogowski
AbstractBackgroundMetabolic syndrome (MetS) is frequently characterized by elevated liver enzymes, including gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT). Our objective was to evaluate the range of prevalence of MetS in apparently healthy individuals whose liver enzyme concentrations were all within-normal-r...... hiện toàn bộ
Liraglutide preserves CD34+ stem cells from dysfunction Induced by high glucose exposure
Springer Science and Business Media LLC - Tập 21 - Trang 1-16 - 2022
Annalisa Sforza, Vera Vigorelli, Erica Rurali, Gianluca Lorenzo Perrucci, Elisa Gambini, Martina Arici, Alessia Metallo, Raffaella Rinaldi, Paolo Fiorina, Andrea Barbuti, Angela Raucci, Elena Sacco, Marcella Rocchetti, Giulio Pompilio, Stefano Genovese, Maria Cristina Vinci
Glucagon like peptide-1 receptor agonists (GLP-1RAs) have shown to reduce mortality and cardiovascular events in patients with type 2 diabetes mellitus (T2DM). Since the impairment in number and function of vasculotrophic circulating CD34+ hematopoietic stem progenitor cells (HSPCs) in T2D has been reported to increase cardiovascular (CV) risk, we hypothesized that one of the mechanisms whereby GL...... hiện toàn bộ
Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis
Springer Science and Business Media LLC - Tập 16 - Trang 1-13 - 2017
Robyn Bruen, Sean Curley, Sarina Kajani, Daniel Crean, Marcella E. O’Reilly, Margaret B. Lucitt, Catherine G. Godson, Fiona C. McGillicuddy, Orina Belton
Macrophages play a pivotal role in atherosclerotic plaque development. Recent evidence has suggested the glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, can attenuate pro-inflammatory responses in macrophages. We hypothesized that liraglutide could limit atherosclerosis progression in vivo via modulation of the inflammatory response. Human THP-1 macrophages and bone marrow-derived ...... hiện toàn bộ
General versus central adiposity as risk factors for cardiovascular-related outcomes in a high-risk population with type 2 diabetes: a post hoc analysis of the REWIND trial
Springer Science and Business Media LLC - Tập 22 Số 1
Edward Franek, Прем Пайс, Jan Basile, Claudia Nicolay, Sohini Raha, Ana Hickey, Nadia Ahmad, Маниге Кониг, Hong Kan, Hertzel C. Gerstein
Abstract Background In clinical practice, anthropometric measures other than BMI are rarely assessed yet may be more predictive of cardiovascular (CV) risk. We analyzed the placebo group of the REWIND CV Outcomes Trial to compare several anthropometric measures as baseline risk factors for cardiovas...... hiện toàn bộ
Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study
Springer Science and Business Media LLC - Tập 21 Số 1
Jacopo Sabbatinelli, Stefania Castiglione, Federica Macrì, Angelica Giuliani, Deborah Ramini, Maria Vinci, Elena Tortato, Anna Rita Bonfigli, Fabiola Olivieri, Angela Raucci
Abstract Background Advanced glycation end-products (AGEs) and their interaction with the receptor for advanced glycation end-products (RAGE) play a pivotal role in the development and progression of type 2 diabetes. In this retrospective cohort study, we explored the association of circulating leve...... hiện toàn bộ
Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II)
Springer Science and Business Media LLC - Tập 19 Số 1 - 2020
Ernesto Maddaloni, Luca D’Onofrio, Francesco Alessandri, Carmen Mignogna, Gaetano Leto, Giuseppe Porcellini, Ivano Mezzaroma, Miriam Lichtner, Paolo Pozzilli, Felice Eugenio Agrò, Monica Rocco, Francesco Pugliese, Andrea Lenzi, Rury R. Holman, Claudio Maria Mastroianni, Raffaella Buzzetti, Camilla Ajassa, Alban Rugova, Federica Alessi, Raissa Aronica, Valeria Belvisi, Matteo Candy, Alessandra Caputi, Anna Carrara, Elena Casali, Eugenio Nelson Cavallari, Giancarlo Ceccarelli, Luigi Celani, Maria Rosa Ciardi, Lucia Coraggio, Ambrogio Curtolo, Claudia D’Agostino, Gabriella d’Ettorre, Francesca De Giorgi, Gabriella De Girolamo, Valeria Filippi, Lucio Gnessi, Cecilia Luordi, Chiara Moretti, Gregorio Egidio Recchia, Marco Ridolfi, Francesco Eugenio Romani, Gianluca Russo, Franco Ruberto, Giulia Savelloni, Guido Siccardi, Antonio Siena, Sara Sterpetti, Serena Valeri, Vera Mauro, Lorenzo Volpicelli, Mikiko Watanabe, Massimo Aiuti, Giuseppe Campagna, Cosmo Del Borgo, Laura Fondaco, Blerta Kertusha, Frida Leonetti, Raffaella Marocco, Renato Masala, Paola Zuccalà, Giulia Nonnis, Alessandra Rigoli, Alessandro Strumia, Daniela Alampi
Abstract Background Cardiometabolic disorders may worsen Covid-19 outcomes. We investigated features and Covid-19 outcomes for patients with or without diabetes, and with or without cardiometabolic multimorbidity. Methods We collected and compared data retrospectively...... hiện toàn bộ
High HbA1c levels correlate with reduced plaque regression during statin treatment in patients with stable coronary artery disease: Results of the coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS)
Springer Science and Business Media LLC - Tập 11 - Trang 1-10 - 2012
Hiroyuki Daida, Tadateru Takayama, Takafumi Hiro, Masakazu Yamagishi, Atsushi Hirayama, Satoshi Saito, Tetsu Yamaguchi, Masunori Matsuzaki
The incidence of cardiac events is higher in patients with diabetes than in people without diabetes. The Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects (COSMOS) demonstrated significant plaque regression in Japanese patients with chronic coronary disease after 76 weeks of rosuvastatin (2.5 mg once daily, up-titrated to a maximum...... hiện toàn bộ
Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity
Springer Science and Business Media LLC - Tập 19 Số 1 - 2020
Cole D. Bendor, Aya Bardugo, Orit Pinhas‐Hamiel, Arnon Afek, Gilad Twig
AbstractSevere obesity among children and adolescents is a significant global public health concern. The prevalence has markedly increased over the last decades, becoming common in many countries. Overwhelming rates of obesity among youth have prompted efforts to identify an evidence-based immediate- and long-term cardiometabolic risk factor profile in childhood-on...... hiện toàn bộ
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