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Comparison of cardiovascular outcomes between SGLT2 inhibitors in diabetes mellitus
Springer Science and Business Media LLC - Tập 21 - Trang 1-9 - 2022
Yuta Suzuki, Hidehiro Kaneko, Akira Okada, Hidetaka Itoh, Satoshi Matsuoka, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Kentaro Kamiya, Atsuhiko Matsunaga, Junya Ako, Koichi Node, Hideo Yasunaga, Issei Komuro
There have been scarce data comparing cardiovascular outcomes between individual sodium-glucose cotransporter-2 (SGLT2) inhibitors. We aimed to compare the subsequent cardiovascular risk between individual SGLT2 inhibitors. We analyzed 25,315 patients with diabetes mellitus (DM) newly taking SGLT2 inhibitors (empagliflozin: 5302, dapagliflozin: 4681, canagliflozin: 4411, other SGLT2 inhibitors: 10...... hiện toàn bộ
Huyết áp và tỷ lệ tử vong ở bệnh nhân tiểu đường loại 2 có sự kiện tim mạch gần đây trong thử nghiệm ELIXA Dịch bởi AI
Springer Science and Business Media LLC - Tập 19 - Trang 1-11 - 2020
Magnus O. Wijkman, Brian Claggett, Rafael Diaz, Hertzel C. Gerstein, Lars Køber, Eldrin Lewis, Aldo P. Maggioni, Emil Wolsk, David Aguilar, Rhonda Bentley-Lewis, John J. McMurray, Jeffrey Probstfield, Matthew Riddle, Jean-Claude Tardif, Scott D. Solomon, Marc A. Pfeffer
Mối quan hệ giữa huyết áp và tỷ lệ tử vong ở bệnh tiểu đường loại 2 (T2DM) là một vấn đề gây tranh cãi, với lo ngại về nguy cơ gia tăng liên quan đến huyết áp giảm quá mức. Chúng tôi đánh giá liệu bệnh tim mạch trước đó (CVD) có làm thay đổi mối quan hệ giữa huyết áp ban đầu và tỷ lệ tử vong do mọi nguyên nhân ở 5852 bệnh nhân T2DM có hội chứng vành cấp tính gần đây (ACS) tham gia thử nghiệm ELIXA...... hiện toàn bộ
Ciprofibrate therapy in patients with hypertriglyceridemia and low high density lipoprotein (HDL)-cholesterol: greater reduction of non-HDL cholesterol in subjects with excess body weight (The CIPROAMLAT study)
Springer Science and Business Media LLC - Tập 3 - Trang 1-6 - 2004
Carlos A Aguilar-Salinas, Andréia Assis-Luores-Vale, Benjamín Stockins, Hector Mario Rengifo, José Dondici Filho, Abrahão Afiune Neto, Lísia Marcílio Rabelo, Kerginaldo Paulo Torres, José Egídio Paulo de Oliveira, Carlos Alberto Machado, Eliana Reyes, Victor Saavedra, Fernando Florenzano, Ma Victoria Hernández, Sergio Hernandez Jiménez, Erika Ramírez, Cuauhtémoc Vazquez, Saul Salinas, Ismael Hernández, Octavio Medel, Ricardo Moreno, Paula Lugo, Ricardo Alvarado, Roopa Mehta, Victor Gutierrez, Francisco J Gómez Pérez
Hypertriglyceridemia in combination with low HDL cholesterol levels is a risk factor for cardiovascular disease. Our objective was to evaluate the efficacy of ciprofibrate for the treatment of this form of dyslipidemia and to identify factors associated with better treatment response. Multicenter, international, open-label study. Four hundred and thirty seven patients were included. The plasma lip...... hiện toàn bộ
CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease
Springer Science and Business Media LLC -
Ting‐Ting Chang, Ching Chen, Jaw-Wen Chen
AbstractChemokines are key components in the pathology of chronic diseases. Chemokine CC motif ligand 7 (CCL7) is believed to be associated with cardiovascular disease, diabetes mellitus, and kidney disease. CCL7 may play a role in inflammatory events by attracting macrophages and monocytes to further amplify inflammatory processes and contribute to disease progres...... hiện toàn bộ
Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: a 5-year follow-up study
Springer Science and Business Media LLC - - 2016
Tove Lekva, Annika Elisabeth Michelsen, Jens Bollerslev, Errol R. Norwitz, Pål Aukrust, Tore Henriksen, Thor Ueland
Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life. Pentraxin 3 (PTX3) is an essential component of innate immunity and independently associated with the risk of developing vascular events. The aim of the study was to examine the relationships between GDM, cardiovascular risk, and plasma PTX3 in pregnancy and at 5 years after the index p...... hiện toàn bộ
Evaluating the impact of glucokinase activation on risk of cardiovascular disease: a Mendelian randomisation analysis
Springer Science and Business Media LLC - Tập 21 - Trang 1-10 - 2022
Ke Wang, Mai Shi, Chuiguo Huang, Baoqi Fan, Andrea O. Y. Luk, Alice P. S. Kong, Ronald C. W. Ma, Juliana C. N. Chan, Elaine Chow
Glucokinase activators (GKAs) are an emerging class of glucose lowering drugs that activate the glucose-sensing enzyme glucokinase (GK). Pending formal cardiovascular outcome trials, we applied two-sample Mendelian randomisation (MR) to investigate the impact of GK activation on risk of cardiovascular diseases. We used independent genetic variants in or around the glucokinase gene meanwhile associ...... hiện toàn bộ
Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin
Springer Science and Business Media LLC - Tập 12 - Trang 1-10 - 2013
Latt S Mansor, Eileen R Gonzalez, Mark A Cole, Damian J Tyler, Jessica H Beeson, Kieran Clarke, Carolyn A Carr, Lisa C Heather
To study the pathogenesis of diabetic cardiomyopathy, reliable animal models of type 2 diabetes are required. Physiologically relevant rodent models are needed, which not only replicate the human pathology but also mimic the disease process. Here we characterised cardiac metabolic abnormalities, and investigated the optimal experimental approach for inducing disease, in a new model of type 2 diabe...... hiện toàn bộ
Postchallenge responses of nitrotyrosine and TNF-alpha during 75-g oral glucose tolerance test are associated with the presence of coronary artery diseases in patients with prediabetes
Springer Science and Business Media LLC - Tập 11 - Trang 1-11 - 2012
Chih-Sheng Chu, Kun-Tai Lee, Kai-Hong Cheng, Min-Yi Lee, Hsuan-Fu Kuo, Tsung-Hsien Lin, Ho-Ming Su, Wen-Chol Voon, Sheng-Hsiung Sheu, Wen-Ter Lai
Meta-analysis has demonstrated an exponential relationship between 2-hr postchallenge hyperglycemia and coronary artery disease (CAD). Pulsatile hyperglycemia can acutely increase proinflammatory cytokines by oxidative stress. We hypothesized that postchallenge proinflammatory and nitrosative responses after 75 g oral glucose tolerance tests (75 g-OGTT) might be associated with CAD in patients wit...... hiện toàn bộ
Association of obesity and long-term mortality in patients with acute myocardial infarction with and without diabetes mellitus: results from the MONICA/KORA myocardial infarction registry
Springer Science and Business Media LLC - Tập 14 Số 1 - 2015
Miriam Giovanna Colombo, Christa Meisinger, Ute Amann, Margit Heier, Wolfgang von Scheidt, Bernhard Kuch, Annette Peters, Inge Kirchberger
Sodium-glucose cotransporter 2 inhibitor may not prevent atrial fibrillation in patients with heart failure: a systematic review
Springer Science and Business Media LLC - Tập 22 - Trang 1-10 - 2023
Xiaolan Ouyang, Jiafu Wang, Qian Chen, Long Peng, Suhua Li, Xixiang Tang
Atrial fibrillation (AF) and heart failure (HF) frequently coexist because of their similar pathological basis. However, whether sodium-glucose cotransporter 2 inhibitor (SGLT2i), a novel class of anti-HF medication, decreases the risk of AF in HF patients remains unclear. The aim of this study was to assess the relationship between SGLT2i and AF in HF patients. A meta-analysis of randomized contr...... hiện toàn bộ
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