Evaluating the impact of glucokinase activation on risk of cardiovascular disease: a Mendelian randomisation analysisSpringer Science and Business Media LLC - Tập 21 - Trang 1-10 - 2022
Ke Wang, Mai Shi, Chuiguo Huang, Baoqi Fan, Andrea O. Y. Luk, Alice P. S. Kong, Ronald C. W. Ma, Juliana C. N. Chan, Elaine Chow
Glucokinase activators (GKAs) are an emerging class of glucose lowering drugs that activate the glucose-sensing enzyme glucokinase (GK). Pending formal cardiovascular outcome trials, we applied two-sample Mendelian randomisation (MR) to investigate the impact of GK activation on risk of cardiovascular diseases. We used independent genetic variants in or around the glucokinase gene meanwhile associ...... hiện toàn bộ
Association between triglyceride glucose index and atherosclerotic plaques and Burden: findings from a community-based studySpringer Science and Business Media LLC - Tập 21 - Trang 1-10 - 2022
Mengxing Wang, Lerong Mei, Aoming Jin, Xueli Cai, Jing Jing, Suying Wang, Xia Meng, Shan Li, Tiemin Wei, Yongjun Wang, Yuesong Pan
Insulin resistance is an important cause of cardiovascular events and cerebral infarction development. We aimed to investigate the association of the triglyceride glucose (TyG) index with atherosclerotic burden and plaques in coronary, intra- and extracranial arteries in participants with non-diabetes, and compared the results with that of the homeostasis model assessment of insulin resistance (HO...... hiện toàn bộ
Impact of type 2 diabetes mellitus in the utilization and in-hospital outcomes of surgical mitral valve replacement in Spain (2001–2015)Springer Science and Business Media LLC - Tập 18 - Trang 1-13 - 2019
Ana López-de-Andrés, Javier de Miguel-Díez, Nuria Muñoz-Rivas, Valentín Hernández-Barrera, Manuel Méndez-Bailón, José M. de Miguel-Yanes, Rodrigo Jiménez-García
The main aims of this study were to examine the incidence and in-hospital outcomes of mechanical and bioprosthetic surgical mitral valve replacement (SMVR) among patients with and without T2DM. We performed a retrospective study using the Spanish National Hospital Discharge Database from 2001 to 2015. We included patients with SMVR codified in their discharge report. We grouped admissions by diabe...... hiện toàn bộ
Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylationSpringer Science and Business Media LLC - Tập 22 - Trang 1-11 - 2023
Chidinma A Okolo, Ei-Phyo Khaing, Valeria Mereacre, Rachel S Wallace, Michelle L Munro, Jeffrey R Erickson, Peter P. Jones
O-GlcNAcylation is the enzymatic addition of a sugar, O-linked β-N-Acetylglucosamine, to the serine and threonine residues of proteins, and is abundant in diabetic conditions. We have previously shown that O-GlcNAcylation can trigger arrhythmias by indirectly increasing pathological Ca2+ leak through the cardiac ryanodine receptor (RyR2) via Ca2+/calmodulin-dependent kinase II (CaMKII). However, R...... hiện toàn bộ
The association of higher levels of within-normal-limits liver enzymes and the prevalence of the metabolic syndromeSpringer Science and Business Media LLC - - 2010
Arie Steinvil, Itzhak Shapira, Orit Kliuk Ben-Bassat, Michael Cohen, Yaffa Vered, Shlomo Berliner, Ori Rogowski
AbstractBackgroundMetabolic syndrome (MetS) is frequently characterized by elevated liver enzymes, including gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT). Our objective was to evaluate the range of prevalence of MetS in apparently healthy individuals whose liver enzyme concentrations were all within-normal-r...... hiện toàn bộ
Liraglutide preserves CD34+ stem cells from dysfunction Induced by high glucose exposureSpringer Science and Business Media LLC - Tập 21 - Trang 1-16 - 2022
Annalisa Sforza, Vera Vigorelli, Erica Rurali, Gianluca Lorenzo Perrucci, Elisa Gambini, Martina Arici, Alessia Metallo, Raffaella Rinaldi, Paolo Fiorina, Andrea Barbuti, Angela Raucci, Elena Sacco, Marcella Rocchetti, Giulio Pompilio, Stefano Genovese, Maria Cristina Vinci
Glucagon like peptide-1 receptor agonists (GLP-1RAs) have shown to reduce mortality and cardiovascular events in patients with type 2 diabetes mellitus (T2DM). Since the impairment in number and function of vasculotrophic circulating CD34+ hematopoietic stem progenitor cells (HSPCs) in T2D has been reported to increase cardiovascular (CV) risk, we hypothesized that one of the mechanisms whereby GL...... hiện toàn bộ
Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosisSpringer Science and Business Media LLC - Tập 16 - Trang 1-13 - 2017
Robyn Bruen, Sean Curley, Sarina Kajani, Daniel Crean, Marcella E. O’Reilly, Margaret B. Lucitt, Catherine G. Godson, Fiona C. McGillicuddy, Orina Belton
Macrophages play a pivotal role in atherosclerotic plaque development. Recent evidence has suggested the glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, can attenuate pro-inflammatory responses in macrophages. We hypothesized that liraglutide could limit atherosclerosis progression in vivo via modulation of the inflammatory response. Human THP-1 macrophages and bone marrow-derived ...... hiện toàn bộ
General versus central adiposity as risk factors for cardiovascular-related outcomes in a high-risk population with type 2 diabetes: a post hoc analysis of the REWIND trialSpringer Science and Business Media LLC - Tập 22 Số 1
Edward Franek, Прем Пайс, Jan Basile, Claudia Nicolay, Sohini Raha, Ana Hickey, Nadia Ahmad, Маниге Кониг, Hong Kan, Hertzel C. Gerstein
Abstract
Background
In clinical practice, anthropometric measures other than BMI are rarely assessed yet may be more predictive of cardiovascular (CV) risk. We analyzed the placebo group of the REWIND CV Outcomes Trial to compare several anthropometric measures as baseline risk factors for cardiovas...... hiện toàn bộ