Evaluating the impact of glucokinase activation on risk of cardiovascular disease: a Mendelian randomisation analysisSpringer Science and Business Media LLC - Tập 21 - Trang 1-10 - 2022
Ke Wang, Mai Shi, Chuiguo Huang, Baoqi Fan, Andrea O. Y. Luk, Alice P. S. Kong, Ronald C. W. Ma, Juliana C. N. Chan, Elaine Chow
Glucokinase activators (GKAs) are an emerging class of glucose lowering drugs that activate the glucose-sensing enzyme glucokinase (GK). Pending formal cardiovascular outcome trials, we applied two-sample Mendelian randomisation (MR) to investigate the impact of GK activation on risk of cardiovascular diseases. We used independent genetic variants in or around the glucokinase gene meanwhile associ...... hiện toàn bộ
Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylationSpringer Science and Business Media LLC - Tập 22 - Trang 1-11 - 2023
Chidinma A Okolo, Ei-Phyo Khaing, Valeria Mereacre, Rachel S Wallace, Michelle L Munro, Jeffrey R Erickson, Peter P. Jones
O-GlcNAcylation is the enzymatic addition of a sugar, O-linked β-N-Acetylglucosamine, to the serine and threonine residues of proteins, and is abundant in diabetic conditions. We have previously shown that O-GlcNAcylation can trigger arrhythmias by indirectly increasing pathological Ca2+ leak through the cardiac ryanodine receptor (RyR2) via Ca2+/calmodulin-dependent kinase II (CaMKII). However, R...... hiện toàn bộ
Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesitySpringer Science and Business Media LLC - Tập 19 Số 1 - 2020
Cole D. Bendor, Aya Bardugo, Orit Pinhas‐Hamiel, Arnon Afek, Gilad Twig
AbstractSevere obesity among children and adolescents is a significant global public health concern. The prevalence has markedly increased over the last decades, becoming common in many countries. Overwhelming rates of obesity among youth have prompted efforts to identify an evidence-based immediate- and long-term cardiometabolic risk factor profile in childhood-on...... hiện toàn bộ
Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese peopleSpringer Science and Business Media LLC - Tập 11 - Trang 1-8 - 2012
Ying Huang, Zhen Yang, Zi Ye, Qin Li, Jie Wen, Xiaoming Tao, Lili Chen, Min He, Xuanchun Wang, Bin Lu, Zhaoyun Zhang, Weiwei Zhang, Shen Qu, Renming Hu
Lipocalin-2 is a novel adipokine with connection to insulin resistance. In this study, we aimed to investigate the association of serum lipocalin-2 with glucose metabolism and other metabolic phenotype in a large-scale Chinese population. We evaluated serum lipocalin-2 in a cross-sectional sample of 2519 Chinese aged from 50 to 82 year in a Shanghai downtown district by ELISA. Glucose, insulin, li...... hiện toàn bộ
Pericoronary fat inflammation and Major Adverse Cardiac Events (MACE) in prediabetic patients with acute myocardial infarction: effects of metforminSpringer Science and Business Media LLC - Tập 18 - Trang 1-11 - 2019
Celestino Sardu, Nunzia D’Onofrio, Michele Torella, Michele Portoghese, Francesco Loreni, Simone Mureddu, Giuseppe Signoriello, Lucia Scisciola, Michelangela Barbieri, Maria Rosaria Rizzo, Marilena Galdiero, Marisa De Feo, Maria Luisa Balestrieri, Giuseppe Paolisso, Raffaele Marfella
Pericoronary adipose tissue inflammation might lead to the development and destabilization of coronary plaques in prediabetic patients. Here, we evaluated inflammation and leptin to adiponectin ratio in pericoronary fat from patients subjected to coronary artery bypass grafting (CABG) for acute myocardial infarction (AMI). Furthermore, we compared the 12-month prognosis of prediabetic patients com...... hiện toàn bộ
Lack of effects of pioglitazone on cardiac function in patients with type 2 diabetes and evidence of left ventricular diastolic dysfunction: a tissue doppler imaging studySpringer Science and Business Media LLC - Tập 9 - Trang 1-9 - 2010
Katerina K Naka, Konstantinos Pappas, Katerina Papathanassiou, Nikolaos D Papamichael, Nikolaos Kazakos, Chryssanthi Kanioglou, Demetrios Makriyiannis, Christos S Katsouras, Kostas Liveris, Agathocles Tsatsoulis, Lampros K Michalis
Thiazolidinediones, used for the treatment of patients with type 2 diabetes mellitus (DM2), are associated with an increased incidence of heart failure. We sought to investigate the effects of pioglitazone on novel echocardiographic indices of left ventricular (LV) diastolic function in DM2 patients with LV diastolic dysfunction (LVDD). Eighty-eight asymptomatic DM2 patients on metformin and/or su...... hiện toàn bộ
Increased serum myeloid-related protein 8/14 level is associated with atherosclerosis in type 2 diabetic patientsSpringer Science and Business Media LLC - Tập 10 - Trang 1-7 - 2011
Wen Hui Peng, Wei Xia Jian, Hai Ling Li, Lei Hou, Yi Dong Wei, Wei Ming Li, Ya Wei Xu
Myeloid-related protein 8/14 (MRP8/14) is a stable heterodimer formed by two different calcium-binding proteins (MRP8 and MRP14). Studies have identified that MRP8/14 regulates vascular inflammation and serves as a novel marker of acute coronary syndrome. In this study, we evaluated the correlation between serum levels of MRP8/14, hsCRP, endogenous secretory receptor for advanced glycation end-pro...... hiện toàn bộ
Stress hyperglycemia ratio as a prognostic indicator for long-term adverse outcomes in heart failure with preserved ejection fractionSpringer Science and Business Media LLC - Tập 23 - Trang 1-11 - 2024
Abdul-Quddus Mohammed, Yongqiang Luo, Kaitao Wang, Yang Su, Lu Liu, Guoqing Yin, Wen Zhang, J Jiasuer. Alifu, Redhwan M. Mareai, Ayman A. Mohammed, Yawei Xu, Fuad A. Abdu, Wenliang Che
Recent studies highlighted that stress hyperglycemia ratio (SHR) is a potential predictor for future risk in heart failure (HF) patients. However, its implications specifically in HF with preserved ejection fraction (HFpEF) are not yet fully elucidated. We aimed to investigate the association between SHR and long-term clinical outcomes in HFpEF patients. HFpEF patients enrolled between 2015 and 20...... hiện toàn bộ