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Effectiveness and safety of the combination of sodium–glucose transport protein 2 inhibitors and glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of observational studies
Springer Science and Business Media LLC - Tập 23 Số 1
Abstract Background Randomized controlled trials and real-world studies suggest
that combination therapy with sodium–glucose transport protein 2 inhibitors
(SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) is associated
with improvement in fasting plasma glucose (FPG), glycated hemoglobin (HbA1c),
systolic blood pressure (SBP), body mass index (BMI), and total cholesterol
levels. ...
Evaluating the impact of glucokinase activation on risk of cardiovascular disease: a Mendelian randomisation analysis
Springer Science and Business Media LLC - Tập 21 - Trang 1-10 - 2022
Glucokinase activators (GKAs) are an emerging class of glucose lowering drugs
that activate the glucose-sensing enzyme glucokinase (GK). Pending formal
cardiovascular outcome trials, we applied two-sample Mendelian randomisation
(MR) to investigate the impact of GK activation on risk of cardiovascular
diseases. We used independent genetic variants in or around the glucokinase gene
meanwhile associ...
Association between triglyceride glucose index and atherosclerotic plaques and Burden: findings from a community-based study
Springer Science and Business Media LLC - Tập 21 - Trang 1-10 - 2022
Insulin resistance is an important cause of cardiovascular events and cerebral
infarction development. We aimed to investigate the association of the
triglyceride glucose (TyG) index with atherosclerotic burden and plaques in
coronary, intra- and extracranial arteries in participants with non-diabetes,
and compared the results with that of the homeostasis model assessment of
insulin resistance (HO...
Impact of type 2 diabetes mellitus in the utilization and in-hospital outcomes of surgical mitral valve replacement in Spain (2001–2015)
Springer Science and Business Media LLC - Tập 18 - Trang 1-13 - 2019
The main aims of this study were to examine the incidence and in-hospital
outcomes of mechanical and bioprosthetic surgical mitral valve replacement
(SMVR) among patients with and without T2DM. We performed a retrospective study
using the Spanish National Hospital Discharge Database from 2001 to 2015. We
included patients with SMVR codified in their discharge report. We grouped
admissions by diabe...
Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation
Springer Science and Business Media LLC - Tập 22 - Trang 1-11 - 2023
O-GlcNAcylation is the enzymatic addition of a sugar, O-linked
β-N-Acetylglucosamine, to the serine and threonine residues of proteins, and is
abundant in diabetic conditions. We have previously shown that O-GlcNAcylation
can trigger arrhythmias by indirectly increasing pathological Ca2+ leak through
the cardiac ryanodine receptor (RyR2) via Ca2+/calmodulin-dependent kinase II
(CaMKII). However, R...
The association of higher levels of within-normal-limits liver enzymes and the prevalence of the metabolic syndrome
Springer Science and Business Media LLC - - 2010
AbstractBackgroundMetabolic syndrome (MetS) is frequently characterized by
elevated liver enzymes, including gamma-glutamyl transferase (GGT) and alanine
aminotransferase (ALT). Our objective was to evaluate the range of prevalence of
MetS in apparently healthy individuals whose liver enzyme concentrations were
all within-normal-range.MethodsWe have performed a cross sectional analysis on
particip...
Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats
Springer Science and Business Media LLC - Tập 15 - Trang 1-21 - 2016
There is a spectacular rise in the global prevalence of type 2 diabetes mellitus
(T2DM) due to the worldwide obesity epidemic. However, a significant proportion
of T2DM patients are non-obese and they also have an increased risk of
cardiovascular diseases. As the Goto-Kakizaki (GK) rat is a well-known model of
non-obese T2DM, the goal of this study was to investigate the effect of
non-obese T2DM o...
Risks of stroke, its subtypes and atrial fibrillation associated with glucagon-like peptide 1 receptor agonists versus sodium-glucose cotransporter 2 inhibitors: a real-world population-based cohort study in Hong Kong
Springer Science and Business Media LLC - - 2023
There are limited data on head-to-head comparative risk of stroke between
sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1
receptor agonists (GLP-1RA). We compared risk of stroke with its subtypes and
incident atrial fibrillation (AF) between them. A population-based,
retrospective cohort of patients with type 2 diabetes between 2008 and 2020 were
identified from the ...
Liraglutide preserves CD34+ stem cells from dysfunction Induced by high glucose exposure
Springer Science and Business Media LLC - Tập 21 - Trang 1-16 - 2022
Glucagon like peptide-1 receptor agonists (GLP-1RAs) have shown to reduce
mortality and cardiovascular events in patients with type 2 diabetes mellitus
(T2DM). Since the impairment in number and function of vasculotrophic
circulating CD34+ hematopoietic stem progenitor cells (HSPCs) in T2D has been
reported to increase cardiovascular (CV) risk, we hypothesized that one of the
mechanisms whereby GL...
Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis
Springer Science and Business Media LLC - Tập 16 - Trang 1-13 - 2017
Macrophages play a pivotal role in atherosclerotic plaque development. Recent
evidence has suggested the glucagon-like peptide-1 receptor (GLP-1R) agonist,
liraglutide, can attenuate pro-inflammatory responses in macrophages. We
hypothesized that liraglutide could limit atherosclerosis progression in vivo
via modulation of the inflammatory response. Human THP-1 macrophages and bone
marrow-derived ...
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