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Beneficial Effects of Rhodiola and Salidroside in Diabetes: Potential Role of AMP-Activated Protein Kinase
Springer Science and Business Media LLC - Tập 23 - Trang 489-498 - 2019
Diabetes mellitus represents a chronic metabolic disorder characterized by impaired lipid homeostasis and carbohydrate metabolism, gradually leading to persistent hyperglycemia. The extracts of Rhodiola species are widely used as herbal medicine or dietary supplement in Asia, Europe and the United States. Salidroside, a p-hydroxyphenethyl-β-glucoside compound, is the main active ingredient of the ...... hiện toàn bộ
Leading RNA Interference Therapeutics Part 2: Silencing Delta-Aminolevulinic Acid Synthase 1, with a Focus on Givosiran
Springer Science and Business Media LLC - Tập 24 - Trang 61-68 - 2019
In November 2019 givosiran became the second small interfering RNA (siRNA)-based drug to receive US Food and Drug Administration (FDA) approval, it has been developed for the treatment of acute intermittent porphyria (AIP), a disorder characterized by life-threatening acute neurovisceral attacks. The porphyrias are a group of disorders in which enzymatic deficiencies in heme production lead to tox...... hiện toàn bộ
Current Outlook on Molecular Pathogenesis and Treatment of Myeloproliferative Neoplasms
Springer Science and Business Media LLC - Tập 16 - Trang 269-283 - 2012
Discovery of the JAK2 V617F mutation in the myeloproliferative neoplasms (MPNs) essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) has stimulated great interest in the underlying molecular mechanisms and treatment of these diseases. Along with acceleration of technologies, novel mutations in genes such as MPL, LNK, and CBL have been discovered that converge on ...... hiện toàn bộ
The Long Non-Coding RNA Landscape of Atherosclerotic Plaques
Springer Science and Business Media LLC - - 2019
Currently, cardiovascular diseases continue to be the leading cause of death worldwide; therefore, atherosclerosis remains one of the most crucial public health problems. This chronic and complex disease is considered to be a result of aberrant lipid homeostasis and inflammation of the inner wall of arteries that leads to plaque development. In recent years, a specific class of non-coding RNAs tha...... hiện toàn bộ
Professor Robert W. Kerwin, MA, PhD, MB BChir, DSc, FRCPsych 1955–2007
Springer Science and Business Media LLC - - 2012
Authors’ Reply to Uguen: “Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma”
Springer Science and Business Media LLC - Tập 21 - Trang 695-696 - 2017
Evaluation of a New High-Throughput Next-Generation Sequencing Method Based on a Custom AmpliSeq™ Library and Ion Torrent PGM™ Sequencing for the Rapid Detection of Genetic Variations in Long QT Syndrome
Springer Science and Business Media LLC - Tập 18 Số 5 - Trang 533-539 - 2014
Inherited long QT syndrome (LQTS) is a cardiac channelopathy associated with a high risk of sudden death. The prevalence has been estimated at close to 1:2,000. Due to large cohorts to investigate and high rate of private mutations, mutational screening must be performed using an extremely sensitive and specific detection method. Mutational screening is crucial as this may have implications for th...... hiện toàn bộ
Tác động của E-cadherin đến dự đoán bệnh ung thư đại tràng: Cập nhật phân tích tổng hợp Dịch bởi AI
Springer Science and Business Media LLC - Tập 26 - Trang 397-409 - 2022
Tác động của E-cadherin đối với ung thư đại tràng vẫn còn gây tranh cãi. Để làm rõ tác động của E-cadherin đối với tiên lượng và các đặc điểm lâm sàng - bệnh lý của ung thư đại tràng, một phân tích tổng hợp đã được thực hiện. Các cơ sở dữ liệu PubMed, Embase và Thư viện Cochrane đã được sử dụng để thu thập tất cả các tài liệu liên quan được công bố trước tháng 11 năm 2021, và dữ liệu tương ứng đã ...... hiện toàn bộ
#E-cadherin #ung thư đại tràng #phân tích tổng hợp #tiên lượng #đặc điểm lâm sàng - bệnh lý
Emerging Landscape of SARS-CoV-2 Variants and Detection Technologies
Springer Science and Business Media LLC - - 2023
Cytosine Deamination Is a Major Cause of Baseline Noise in Next-Generation Sequencing
Springer Science and Business Media LLC - Tập 18 - Trang 587-593 - 2014
As next-generation sequencing (NGS) becomes a major sequencing platform in clinical diagnostic laboratories, it is critical to identify artifacts that constitute baseline noise and may interfere with detection of low-level gene mutations. This is especially critical for applications requiring ultrasensitive detection, such as molecular relapse of solid tumors and early detection of cancer. We rece...... hiện toàn bộ
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