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Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension
Springer Science and Business Media LLC - - 2022
Hidenori Yasuhara, Tokuyuki Yoshida, Kiyomi Sasaki, Satoshi Obika, Takao Inoué
Genetic Determinants of Childhood Obesity
Springer Science and Business Media LLC - Tập 24 Số 6 - Trang 653-663 - 2020
Sheridan H. Littleton, Robert I. Berkowitz, Struan F.A. Grant
The Road Traveled and Journey Ahead for the Genetics and Genomics of Tinnitus
Springer Science and Business Media LLC - Tập 26 - Trang 129-136 - 2022
Barbara Vona
The feasibility to unravel genetic and genomic signatures for disorders affecting the auditory system has accelerated since arriving in the post-genomics era roughly 20 years ago. Newly emerging studies have provided initial landmarks signaling heritability and thus, a genetic link, to severe tinnitus. Tinnitus, the phantom perception of ringing in the ears, is experienced by at least 15% of the a...... hiện toàn bộ
Evaluation of the Suitability of RNAscope as a Technique to Measure Gene Expression in Clinical Diagnostics: A Systematic Review
Springer Science and Business Media LLC - - 2022
Sameeha Atout, Shaymaa Shurrab, Carolyn J. Loveridge
Significance of Plasma Osteopontin Levels in Patients with Bladder Urothelial Carcinomas
Springer Science and Business Media LLC - Tập 16 - Trang 311-316 - 2012
Li Zhao, Yalin Wang, Nan Qu, Chen Huang, Lijun Chen
Previous studies have suggested that the plasma level of osteopontin may be a biomarker for cancer metastases and clinical prognosis; however, its role in bladder urothelial carcinoma (BUC) remains unknown. The purpose of this study was to explore the significance of plasma osteopontin levels in evaluating the pathologic features of BUC and its potential as a prognostic marker in BUC patients. A t...... hiện toàn bộ
Response to Rituximab and Timeframe to Relapse in Rheumatoid Arthritis Patients
Springer Science and Business Media LLC - Tập 14 - Trang 43-48 - 2012
Athina Pyrpasopoulou, Stella Douma, Areti Triantafyllou, Elisavet Simoulidou, Magda Samara, Efthymia Parapanisiou, Spyros Aslanidis
Objective: Rituximab is used to deplete B cells and control disease activity, mainly in patients with rheumatoid arthritis (RA) who have not responded to anti-tumor necrosis factor (TNF) therapy. Response rates and time to relapse vary significantly among treated individuals. The objective of this study was to monitor the response of seropositive and seronegative RA patients to ri...... hiện toàn bộ
Bioinformatic Methods and Bridging of Assay Results for Reliable Tumor Mutational Burden Assessment in Non-Small-Cell Lung Cancer
Springer Science and Business Media LLC - Tập 23 - Trang 507-520 - 2019
Han Chang, Ariella Sasson, Sujaya Srinivasan, Ryan Golhar, Danielle M. Greenawalt, William J. Geese, George Green, Kim Zerba, Stefan Kirov, Joseph Szustakowski
Tumor mutational burden (TMB) has emerged as a clinically relevant biomarker that may be associated with immune checkpoint inhibitor efficacy. Standardization of TMB measurement is essential for implementing diagnostic tools to guide treatment. Here we describe the in-depth evaluation of bioinformatic TMB analysis by whole exome sequencing (WES) in formalin-fixed, paraffin-embedded samples from a ...... hiện toàn bộ
Response to Methadone Maintenance Treatment is Associated with the MYOCD and GRM6 Genes
Springer Science and Business Media LLC - Tập 14 - Trang 171-178 - 2012
Francina Fonseca, Mònica Gratacòs, Geòrgia Escaramís, Rafael De Cid, Rocío Martín-Santos, Emilio Fernández-Espejo, Xavier Estivill, Marta Torrens
Background: There is increasing interest in the pharmacogenetic basis for explaining differences between patients in treatment outcome among methadone-treated subjects. Most studies have focused on genetic polymorphisms related to methadone pharmacokinetics and, to a lesser extent, those genes implicated in the pharmacodynamics of methadone. Objective: This study ...... hiện toàn bộ
Beneficial Effects of Rhodiola and Salidroside in Diabetes: Potential Role of AMP-Activated Protein Kinase
Springer Science and Business Media LLC - Tập 23 - Trang 489-498 - 2019
Tao Zheng, Fang Bian, Li Chen, Qibin Wang, Si Jin
Diabetes mellitus represents a chronic metabolic disorder characterized by impaired lipid homeostasis and carbohydrate metabolism, gradually leading to persistent hyperglycemia. The extracts of Rhodiola species are widely used as herbal medicine or dietary supplement in Asia, Europe and the United States. Salidroside, a p-hydroxyphenethyl-β-glucoside compound, is the main active ingredient of the ...... hiện toàn bộ
Evaluation of a Tuberculosis Whole-Blood Interferon-γ Chemiluminescent Immunoassay among Chinese Military Recruits
Springer Science and Business Media LLC - - 2011
Xueqiong Wu, Ying Hou, Yan Liang, Junxian Zhang, Yourong Yang, Lan Wang, Chuiying Zhang
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