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Tailoring Treatment for Patients with Inflammatory Breast Cancer
Springer Science and Business Media LLC - Tập 24 - Trang 580-593 - 2023
Inflammatory breast cancer (IBC) is a rare but aggressive subtype of breast cancer that has a propensity for locoregional recurrence and distant metastasis and is associated with a disproportionately high percentage of breast cancer deaths. IBC is not resectable at initial diagnosis and trimodality therapy is considered the standard treatment for IBC. This includes systemic therapy upfront, follow......
Fertility Sparing Strategies in Patients Affected by Placental Site Trophoblastic Tumor
Springer Science and Business Media LLC - Tập 18 - Trang 1-9 - 2017
Placental site trophoblastic tumor (PSTT) is the least common and the most ambiguous gestational trophoblastic tumor. Presentation of PSTT may occur in the course of gestation or from 1 week to 14 years after a normal or an abnormal pregnancy (mole, ectopic pregnancy, abortion). The indicators of aggressive behavior for this tumor are not well established. Due to the rarity of this disease that us......
Nutritional Considerations After Gastrectomy and Esophagectomy for Malignancy
Springer Science and Business Media LLC - Tập 12 - Trang 85-95 - 2011
This article reviews various methods of assessing and managing post-gastrectomy or esophagectomy patients from a nutritional standpoint, by examining recent research focusing on assessment models, components of enteral feeding, timing of feeding, safety of enteral nutrition (EN) vs total parenteral nutrition (TPN), appetite stimulants, alternative treatments, and long-term care. Pre-, peri-, and p......
Salvage therapy for locally recurrent prostate cancer after external beam radiotherapy
Springer Science and Business Media LLC - Tập 5 - Trang 357-365 - 2004
The greatest obstacle in the cure of patients with locally recurrent prostate cancer after radiation therapy is the lack of early detection markers. The majority of patients who are candidates for local salvage therapy have locally advanced disease, precluding successful salvage therapy. A low pretreatment prostate specific antigen (PSA) has shown to be a favorable prognostic variable for disease ......
Which Second-Line Tyrosine Kinase Inhibitor(s) for Chronic Myeloid Leukemia?
Springer Science and Business Media LLC - Tập 24 - Trang 757-769 - 2023
In patients with chronic myeloid leukemia who require second-line tyrosine kinase inhibitor therapy, many options exist. These treatments include alternate generation tyrosine kinase inhibitors and in some cases consideration of allogeneic transplant. Although efficacious, each tyrosine kinase inhibitor possesses distinct side effects and pharmacological profiles that prevent a generalizable treat......
Management of the Axilla after Neoadjuvant Systemic Therapy
Springer Science and Business Media LLC - Tập 21 - Trang 1-11 - 2020
As the use of neoadjuvant systemic therapy (NAST) increases, the optimal management of the axilla has become increasingly complex. Consensus among professional organizations is that those patients with clinically negative axillary nodes who are being considered for NAST should undergo a sentinel lymph node (SLN) biopsy following NAST. If a positive SLN is subsequently identified, an axillary lymph......
Chemotherapy in the Treatment of Metastatic Gastric Cancer: Is There a Global Standard?
Springer Science and Business Media LLC - Tập 12 - Trang 96-106 - 2011
Gastric cancer remains one of the leading causes of cancer mortality worldwide even though its incidence has been decreasing in recent years. Despite remarkable advancements in chemotherapy, advanced gastric cancer has remained a therapeutic challenge for physicians as well as for patients. While early chemotherapeutic regimens succeeded in showing a modest but definite improvement over best suppo......
The Role of Advanced Brain Tumor Imaging in the Care of Patients with Central Nervous System Malignancies
Springer Science and Business Media LLC - Tập 19 - Trang 1-19 - 2018
T1-weighted post-contrast and T2-weighted fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) constitute the gold standard for diagnosis and response assessment in neuro-oncologic patients but are limited in their ability to accurately reflect tumor biology and metabolism, particularly over the course of a patient’s treatment. Advanced MR imaging methods are sensitized to ......
Angiogenesis Inhibitors in the Treatment of Epithelial Ovarian Cancer
Springer Science and Business Media LLC - Tập 14 - Trang 22-33 - 2013
Treatment of epithelial ovarian cancer involves surgical management with staging or debulking surgery and chemotherapy with a platinum and taxane-containing regimen. Despite achieving a 70–80 % complete remission, patients often will recur. Novel therapies are needed to improve the treatment of ovarian cancers. Tumor angiogenesis is a critical process involved in the growth and metastasis of ovari......
The Potential of Immune Checkpoint Blockade in Cervical Cancer: Can Combinatorial Regimens Maximize Response? A Review of the Literature
Springer Science and Business Media LLC - Tập 21 - Trang 1-21 - 2020
Cervical cancer (CC) is most often caused by the human papillomavirus (HPV). In principle, these ties to the virus should make HPV tumors a relatively easy target for clearance by the immune system. However, these HPV-associated tumors have evolved strategies to escape immune attack. Checkpoint inhibition immunotherapy, which has had remarkable success in cancer treatment, has the potential to ove......
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