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Current Landscape and Future Directions on Bladder Sparing Approaches to Muscle-Invasive Bladder Cancer
Springer Science and Business Media LLC - Tập 22 - Trang 1-10 - 2020
Although radical cystectomy is considered the gold standard approach for patients with muscle-invasive bladder cancer, tri-modal therapy (TMT) is a well-tolerated and efficacious alternative to radical cystectomy that is underutilized in inoperable patients and rarely offered to cystectomy candidates in the USA. Retrospective data suggest similar outcomes between radical cystectomy and TMT after a...... hiện toàn bộ
The Evolving Treatment Landscape of Medullary Thyroid Cancer
Springer Science and Business Media LLC - Tập 24 - Trang 1815-1832 - 2023
Genetic assessment is crucial to address the correct treatment for advanced medullary thyroid cancer (MTC). Multi tyrosine kinase inhibitors (mTKIs) cabozantinib and vandetanib are good first line options, even vandetanib prescription is currently limited to RET mutated patients. Selective RET inhibitors such as pralsetinib could be a preferred upfront treatment in case of RET mutated MTC presenti...... hiện toàn bộ
Current State of Immunotherapy for Treatment of Glioblastoma
Springer Science and Business Media LLC - Tập 20 - Trang 1-15 - 2019
At this time, there are no FDA-approved immune therapies for glioblastoma (GBM) despite many unique therapies currently in clinical trials. GBM is a highly immunosuppressive tumor and there are limitations to a safe immune response in the central nervous system. To date, there have been several failures of phase 3 immune therapy clinical trials in GBM. These trials have targeted single components ...... hiện toàn bộ
Gastric Cancer Surgery: An American Perspective on the Current Options and Standards
Springer Science and Business Media LLC - Tập 12 - Trang 72-84 - 2011
Gastric cancer is prevalent globally, particularly in Asian countries such as Japan and Korea. While the prevalence of gastric cancer is not nearly as high in the United States (U.S.) as in Asia, the treatment armamentarium differs widely between regions. The role of surgery for gastric cancer in the U.S. has changed drastically over the last decade. While the natural history of gastric cancer see...... hiện toàn bộ
Controversies in the Therapy of Brain Metastases: Shifting Paradigms in an Era of Effective Systemic Therapy and Longer-Term Survivorship
Springer Science and Business Media LLC - Tập 17 Số 9 - 2016
Neoadjuvant Immunotherapy for Locally Advanced Melanoma
Springer Science and Business Media LLC - - 2020
Patients with clinical stage III melanoma, defined as palpable lymph nodes with or without in-transit metastases, have poor prognosis even with recent advances with targeted and checkpoint inhibitor therapy in the adjuvant setting. Neoadjuvant therapy for clinical stage III melanoma is an attractive treatment paradigm as patient outcomes may be improved by earlier introduction to systemic therapy....... hiện toàn bộ
Juvenile myelomonocytic leukemia
Springer Science and Business Media LLC - Tập 4 - Trang 203-210 - 2003
Juvenile myelomonocytic leukemia is an aggressive neoplasia of early childhood. Only allogeneic stem cell transplantation (SCT) offers a long-term cure. In the absence of an HLA-matched family donor, early SCT from an unrelated donor will be the treatment of choice for most children. With clear evidence of a graft-versus-leukemia effect and a high post-transplant relapse rate, outcome of SCT will ...... hiện toàn bộ
Managing Disease and Therapy-Related Complications in Patients with Central Nervous System Tumors
Springer Science and Business Media LLC - Tập 16 Số 8 - 2015
Novel Agents in the Treatment of Thymic Malignancies
Springer Science and Business Media LLC - - 2017
The management of thymic tumours is a paradigm of multidisciplinary collaboration. Chemotherapy may be administered part of curative-intent sequential strategy integrating subsequent surgery or radiotherapy, or as an exclusive treatment if local treatment is not achievable. Recurrences of thymic epithelial tumors should be managed according to the same strategy as newly diagnosed tumors. Given the...... hiện toàn bộ
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