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Bronchogenic carcinoma in solid organ transplant recipients
Springer Science and Business Media LLC - - 2006
Yanis Bellil, Martin J. Edelman
Controversy and Consensus on the Management of Patients With Pseudomyxoma Peritonei
Springer Science and Business Media LLC - Tập 14 - Trang 365-373 - 2013
Jason E. Faris, David P. Ryan
Pseudomyxoma peritonei and peritoneal carcinomatosis derived from appendiceal epithelial tumors are controversial entities from classification to treatment. For the former entity, multiple classification systems have been attempted to distinguish indolent from more aggressive subtypes. The treatment of the low grade variants is managed with serial cytoreduction surgery, with data indicating possib...... hiện toàn bộ
Central Nervous System Prophylaxis and Treatment in Acute Leukemias
Springer Science and Business Media LLC - Tập 23 - Trang 1829-1844 - 2022
Susan Y. Wu, Nicholas J. Short, Lewis Nasr, Bouthaina S. Dabaja, Penny Q. Fang
Improvements in systemic therapy in the treatment of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) have improved patient outcomes and reduced the incidence of CNS relapse. However, management of patients with CNS disease remains challenging, and relapses in the CNS can be difficult to salvage. In addition to treatment with CNS-penetrant systemic therapy (high-dose methotrexat...... hiện toàn bộ
Therapeutic Advances in the Management of Patients with Advanced RET Fusion-Positive Non-Small Cell Lung Cancer
Springer Science and Business Media LLC - Tập 22 - Trang 1-20 - 2021
Fangdi Sun, Caroline E. McCoach
Screening for activating driver gene alterations at the time of diagnosis is the standard of care for advanced non-small cell lung cancer (NSCLC). Activating RET fusions are identified in approximately 1–2% of NSCLCs and have emerged as a targetable driver alteration. Selpercatinib and pralsetinib are RET-selective tyrosine kinase inhibitors (TKIs) with encouraging efficacy, intracranial activity,...... hiện toàn bộ
The Management of Nausea and Vomiting Not Related to Anticancer Therapy in Patients with Cancer
Springer Science and Business Media LLC - Tập 22 - Trang 1-14 - 2021
Janet Hardy, Mellar P Davis
In cancer patients, the management of nausea and vomiting that is not directly related to treatment is challenging. Much current practice is based on expert opinion and anecdote. Fortunately, over recent years, a number of quality trials have been undertaken to strengthen the evidence base that guides the care of our patients with these distressing symptoms. Much is still unknown however. In this ...... hiện toàn bộ
BEYOND KRAS: Other Markers and Potential Treatment Strategies for KRAS Mutant and Wild-type Patients
Springer Science and Business Media LLC - Tập 12 - Trang 126-135 - 2011
Andrea Cercek, Leonard Saltz
Despite the advances and new drug discoveries, the best drug in metastatic colorectal cancer (mcrc) is 5-fluorouracil. This drug is the backbone of FOLFOX and FOLFIRI which are the standard first line cytotoxic regimens in the metastatic setting. The efficacies of these two regimens are equivalent, and the selection of one over the other is largely based on the side effect profile. Bevacizumab is ...... hiện toàn bộ
Management of Myelofibrosis: from Diagnosis to New Target Therapies
Springer Science and Business Media LLC - Tập 21 - Trang 1-14 - 2020
Alessandra Iurlo, Daniele Cattaneo, Cristina Bucelli
Myelofibrosis (MF) is a clonal disorder of the pluripotent hematopoietic stem cell, whose clinical manifestations can be extremely heterogeneous, including cytopenias, organomegaly, constitutional symptoms, and cachexia. Median survival ranges from approximately 3.5 to 5.5 years; while the most frequent cause of death is the evolution to acute myeloid leukemia, also other conditions such as progre...... hiện toàn bộ
Treatment of relapsed and refractory multiple myeloma
Springer Science and Business Media LLC - Tập 4 - Trang 229-237 - 2003
Seema Singhal, Jayesh Mehta
The definition of relapsed and refractory myeloma was straightforward when melphalanprednisone constituted the mainstay of treatment and high-dose therapy with transplantation was rarely used in myeloma. However, several advances have occurred in the treatment of myeloma over the past decade. Most notably, high-dose therapy and transplantation have become broadly applicable, thalidomide has become...... hiện toàn bộ
Update on the Treatment of Early-Stage Triple-Negative Breast Cancer
Springer Science and Business Media LLC - Tập 19 - Trang 1-19 - 2018
Priyanka Sharma
Triple-negative breast cancer (TNBC) accounts for 15% of all breast cancers and is associated with poor long-term outcomes compared to other breast cancer subtypes. Currently, chemotherapy remains the main modality of treatment for early-stage TNBC, as there is no approved targeted therapy for this subtype. The biologic heterogeneity of TNBC has hindered the development and evaluation of novel age...... hiện toàn bộ
Tailoring Treatment for Patients with Inflammatory Breast Cancer
Springer Science and Business Media LLC - Tập 24 - Trang 580-593 - 2023
Alexandra B. Newman, Filipa Lynce
Inflammatory breast cancer (IBC) is a rare but aggressive subtype of breast cancer that has a propensity for locoregional recurrence and distant metastasis and is associated with a disproportionately high percentage of breast cancer deaths. IBC is not resectable at initial diagnosis and trimodality therapy is considered the standard treatment for IBC. This includes systemic therapy upfront, follow...... hiện toàn bộ
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