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BEYOND KRAS: Other Markers and Potential Treatment Strategies for KRAS Mutant and Wild-type Patients
Springer Science and Business Media LLC - Tập 12 - Trang 126-135 - 2011
Despite the advances and new drug discoveries, the best drug in metastatic colorectal cancer (mcrc) is 5-fluorouracil. This drug is the backbone of FOLFOX and FOLFIRI which are the standard first line cytotoxic regimens in the metastatic setting. The efficacies of these two regimens are equivalent, and the selection of one over the other is largely based on the side effect profile. Bevacizumab is ......
Tailoring Treatment for Patients with Inflammatory Breast Cancer
Springer Science and Business Media LLC - Tập 24 - Trang 580-593 - 2023
Inflammatory breast cancer (IBC) is a rare but aggressive subtype of breast cancer that has a propensity for locoregional recurrence and distant metastasis and is associated with a disproportionately high percentage of breast cancer deaths. IBC is not resectable at initial diagnosis and trimodality therapy is considered the standard treatment for IBC. This includes systemic therapy upfront, follow......
Novel Surgical Strategies in the Treatment of Gynecological Malignancies
Springer Science and Business Media LLC - Tập 19 - Trang 1-16 - 2018
The main advancement in the surgical treatment of early cervical cancer has been a de-escalation in the radical surgical approach of early stage disease. Similarly, sentinel lymph node detection with cervical tracer injection can be performed alone in microscopic tumors (stage IA) while additional lymphadenectomy is still performed in macroscopic tumors (IB1 and IIA). Parametrial resection has bee......
Fertility Sparing Strategies in Patients Affected by Placental Site Trophoblastic Tumor
Springer Science and Business Media LLC - Tập 18 - Trang 1-9 - 2017
Placental site trophoblastic tumor (PSTT) is the least common and the most ambiguous gestational trophoblastic tumor. Presentation of PSTT may occur in the course of gestation or from 1 week to 14 years after a normal or an abnormal pregnancy (mole, ectopic pregnancy, abortion). The indicators of aggressive behavior for this tumor are not well established. Due to the rarity of this disease that us......
Diagnosis and management of ductal carcinoma in situ
Springer Science and Business Media LLC - Tập 5 - Trang 131-144 - 2004
Ductal carcinoma in situ (DCIS) is a preinvasive form of breast cancer that has increased in incidence over the past 25 years, primarily as a result of mammographically detected microcalcifications. Inadequately treated DCIS carries a risk for evolving into the malignant phenotype; however, the magnitude and timeline for this risk are poorly defined. Treatment options include lumpectomy with or wi......
Reconstruction for lower extremity limb salvage in soft tissue carcinoma
Springer Science and Business Media LLC - Tập 4 Số 6 - Trang 465-475 - 2003
Limb salvage procedures for the lower extremity have a 95% success rate and have essentially supplanted primary amputation as the primary treatment for limb-threatening malignancies. En bloc tumor resection involving major neural and vascular structures that once led to amputation are now successfully reconstructed using free-tissue transfer in combination with neoadjuvant and adjuvant chemoradiat......
Nutritional Considerations After Gastrectomy and Esophagectomy for Malignancy
Springer Science and Business Media LLC - Tập 12 - Trang 85-95 - 2011
This article reviews various methods of assessing and managing post-gastrectomy or esophagectomy patients from a nutritional standpoint, by examining recent research focusing on assessment models, components of enteral feeding, timing of feeding, safety of enteral nutrition (EN) vs total parenteral nutrition (TPN), appetite stimulants, alternative treatments, and long-term care. Pre-, peri-, and p......
Salvage therapy for locally recurrent prostate cancer after external beam radiotherapy
Springer Science and Business Media LLC - Tập 5 - Trang 357-365 - 2004
The greatest obstacle in the cure of patients with locally recurrent prostate cancer after radiation therapy is the lack of early detection markers. The majority of patients who are candidates for local salvage therapy have locally advanced disease, precluding successful salvage therapy. A low pretreatment prostate specific antigen (PSA) has shown to be a favorable prognostic variable for disease ......
Which Second-Line Tyrosine Kinase Inhibitor(s) for Chronic Myeloid Leukemia?
Springer Science and Business Media LLC - Tập 24 - Trang 757-769 - 2023
In patients with chronic myeloid leukemia who require second-line tyrosine kinase inhibitor therapy, many options exist. These treatments include alternate generation tyrosine kinase inhibitors and in some cases consideration of allogeneic transplant. Although efficacious, each tyrosine kinase inhibitor possesses distinct side effects and pharmacological profiles that prevent a generalizable treat......
Management of the Axilla after Neoadjuvant Systemic Therapy
Springer Science and Business Media LLC - Tập 21 - Trang 1-11 - 2020
As the use of neoadjuvant systemic therapy (NAST) increases, the optimal management of the axilla has become increasingly complex. Consensus among professional organizations is that those patients with clinically negative axillary nodes who are being considered for NAST should undergo a sentinel lymph node (SLN) biopsy following NAST. If a positive SLN is subsequently identified, an axillary lymph......
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