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Getting personalized cancer genome analysis into the clinic: the challenges in bioinformatics
Springer Science and Business Media LLC - Tập 4 - Trang 1-17 - 2012
Progress in genomics has raised expectations in many fields, and particularly in personalized cancer research. The new technologies available make it possible to combine information about potential disease markers, altered function and accessible drug targets, which, coupled with pathological and medical information, will help produce more appropriate clinical decisions. The accessibility of such ...... hiện toàn bộ
Mass spectrometry for translational proteomics: progress and clinical implications
Springer Science and Business Media LLC - Tập 4 - Trang 1-11 - 2012
The utility of mass spectrometry (MS)-based proteomic analyses and their clinical applications have been increasingly recognized over the past decade due to their high sensitivity, specificity and throughput. MS-based proteomic measurements have been used in a wide range of biological and biomedical investigations, including analysis of cellular responses and disease-specific post-translational mo...... hiện toàn bộ
Obesity genomics: assessing the transferability of susceptibility loci across diverse populations
Springer Science and Business Media LLC - Tập 5 - Trang 1-14 - 2013
The prevalence of obesity has nearly doubled worldwide over the past three decades, but substantial differences exist between nations. Although these differences are partly due to the degree of westernization, genetic factors also contribute. To date, little is known about whether the same genes contribute to obesity-susceptibility in populations of different ancestry. We review the transferabilit...... hiện toàn bộ
Nghiên cứu đa chiều về dịch não tủy để khám phá và theo dõi phản ứng miễn dịch của hệ thần kinh trung ương Dịch bởi AI
Springer Science and Business Media LLC - Tập 14 - Trang 1-12 - 2022
Dịch não tủy (CSF) có thành phần tế bào miễn dịch độc đáo và luôn tiếp xúc với các ranh giới của não, do đó cho phép cung cấp thông tin về não nhằm chẩn đoán và theo dõi các bệnh lý. Gần đây, màng não, nơi chứa đựng CSF, được xác định là một giao diện thần kinh miễn dịch, làm nổi bật tiềm năng khám phá miễn dịch của hệ thần kinh trung ương (CNS) thông qua việc nghiên cứu các khu vực biên giới của ...... hiện toàn bộ
#dịch não tủy #miễn dịch hệ thần kinh trung ương #tế bào đơn bào #bệnh thần kinh #đa xơ cứng
The circadian clock system’s influence in health and disease
Springer Science and Business Media LLC - Tập 9 - Trang 1-5 - 2017
Joseph T. Bass discusses recent developments in circadian clock research and reflects on the future of the field and its potential applications to clinical medicine.
Automated prioritization of sick newborns for whole genome sequencing using clinical natural language processing and machine learning
Springer Science and Business Media LLC - Tập 15 - Trang 1-9 - 2023
Rapidly and efficiently identifying critically ill infants for whole genome sequencing (WGS) is a costly and challenging task currently performed by scarce, highly trained experts and is a major bottleneck for application of WGS in the NICU. There is a dire need for automated means to prioritize patients for WGS. Institutional databases of electronic health records (EHRs) are logical starting poin...... hiện toàn bộ
Rare subclonal sequencing of breast cancers indicates putative metastatic driver mutations are predominately acquired after dissemination
Springer Science and Business Media LLC - Tập 16 - Trang 1-19 - 2024
Evolutionary models of breast cancer progression differ on the extent to which metastatic potential is pre-encoded within primary tumors. Although metastatic recurrences often harbor putative driver mutations that are not detected in their antecedent primary tumor using standard sequencing technologies, whether these mutations were acquired before or after dissemination remains unclear. To ascerta...... hiện toàn bộ
Erratum to: Colorectal cancer screening: will non-invasive procedures triumph?
Springer Science and Business Media LLC - Tập 7 - Trang 1-1 - 2015
Clinical trial design in the era of precision medicine
Springer Science and Business Media LLC - Tập 14 - Trang 1-27 - 2022
Recent rapid biotechnological breakthroughs have led to the identification of complex and unique molecular features that drive malignancies. Precision medicine has exploited next-generation sequencing and matched targeted therapy/immunotherapy deployment to successfully transform the outlook for several fatal cancers. Tumor and liquid biopsy genomic profiling and transcriptomic, immunomic, and pro...... hiện toàn bộ
Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
Springer Science and Business Media LLC - Tập 10 - Trang 1-3 - 2018
Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing cur...... hiện toàn bộ
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