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Cellular and biomolecular responses of human ovarian cancer cells to cytostatic dinuclear platinum(II) complexes
Springer Science and Business Media LLC - Tập 16 - Trang 288-300 - 2010
Miaoxin Lin, Xiaoyong Wang, Jianhui Zhu, Damin Fan, Yangmiao Zhang, Junfeng Zhang, Zijian Guo
Polynuclear platinum(II) complexes represent a class of potential anticancer agents that have shown promising pharmacological properties in preclinical studies. The nature of cellular responses induced by these complexes, however, is poorly understood. In this research, the cellular responses of human ovarian cancer COC1 cells to dinuclear platinum(II) complexes {[cis-Pt(NH3)2Cl]2L1}(NO3)2 (1) and...... hiện toàn bộ
p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
Springer Science and Business Media LLC - - 2005
Marcus Saunders, Mazen B. Eldeen, Luis Del Valle, Krzysztof Reiss, Francesca Peruzzi, Giuseppe Mameli, Benjamin B. Gelman, Kamel Khalili, Shohreh Amini, Bassel E. Sawaya
Smac/DIABLO is required for effector caspase activation during apoptosis in human cells
Springer Science and Business Media LLC - Tập 12 - Trang 1503-1510 - 2007
Krishnaraj Rajalingam, Monique Oswald, Kathleen Gottschalk, Thomas Rudel
Mitochondria play a pivotal role during stress-induced apoptosis as several proapoptotic proteins are released to the cytosol to activate caspases. Smac/DIABLO is one of the proapoptotic proteins released from the mitochondria and has been shown to inactivate IAPs. However, gene knockout studies in mice revealed a redundant role for Smac during development and cell death. By applying RNA interfere...... hiện toàn bộ
A novel diquinolonium displays preclinical anti-cancer activity and induces caspase-independent cell death
Springer Science and Business Media LLC - Tập 13 - Trang 748-755 - 2008
Rose Hurren, Reza Beheshti Zavareh, Shadi Dalili, Tabitha Wood, David Rose, Hong Chang, Nazir Jamal, Hans Messner, Robert A. Batey, Aaron D. Schimmer
Quinolines are a class of chemical compounds with emerging anti-cancer properties. Here, we tested the activity of series of quinolines and quinoline-like molecules for anti-cancer activity and identified a novel diquinoline, 1-methyl-2-[3-(1-methyl-1,2-dihydroquinolin-2-yliden)prop-1-enyl]quinolinium iodide (Q2). Q2 induced cell death in leukemia, myeloma, and solid tumor cell lines with LD50s in...... hiện toàn bộ
International Symposium: Apoptosis and its role in immunity Warsaw, Poland, 20 October 1996 session I
Springer Science and Business Media LLC - Tập 1 - Trang 252-261 - 1996
Elevated cytokeratin-19 expression associated with apoptotic resistance and malignant progression of human cervical carcinoma
Springer Science and Business Media LLC - Tập 3 - Trang 161-169 - 1998
C-C. Yuan, T-S. Huang, H-T Ng, R-S. Liu, M-W. Hung, L-C. Tsai
Cytokeratin-19 is an intermediate filament protein associated with the integrity of cell structure, and its elevated expression has been reported to correlate with the disease progression of oesophagus and lung cancers. In this study, we examined the level of cytokeratin-19 in five cervical cancer cell lines by immunobinding and Western blotting analyses. Compared with two control cell lines, FS-4...... hiện toàn bộ
Juglanthraquinone C, a novel natural compound derived from Juglans mandshurica Maxim, induces S phase arrest and apoptosis in HepG2 cells
Springer Science and Business Media LLC - Tập 17 Số 8 - Trang 832-841 - 2012
Yao Yao, Yu-Wei Zhang, Luguo Sun, Biao Liu, Yongli Bao, Hua Lin, Yu Zhang, Lihua Zheng, Yu Sun, Chunlei Yu, Yin Wu, Guan‐Nan Wang, Yuxin Li
Decrease of apoptosis markers during adipogenic differentiation of mesenchymal stem cells from human adipose tissue
Springer Science and Business Media LLC - Tập 18 - Trang 578-588 - 2013
Debora Lo Furno, Adriana C. E. Graziano, Silvia Caggia, Rosario E. Perrotta, Maria Stella Tarico, Rosario Giuffrida, Venera Cardile
Although the proliferation and differentiation of mesenchymal stem cells (MSCs) from adipose tissue (AT) have been widely studied, relatively little information is available on the underlying mechanism of apoptosis during the adipogenic differentiation. Thus, the aim of this study was to analyze how the expression of some apoptotic markers is affected by in vitro expansion during adipogenic differ...... hiện toàn bộ
Sensitizing effect of juglone is mediated by down regulation of Notch1 signaling pathway in trastuzumab-resistant SKBR3 cells
Springer Science and Business Media LLC - Tập 22 - Trang 135-144 - 2016
Soraya Sajadimajd, Razieh Yazdanparast
Trastuzumab (Herceptin) monoclonal antibody directed against HER2 receptor has been administered as a treatment for metastatic HER2 positive breast cancer. The problematic issue in treatment of HER2 positive breast cancer cells is commonly the induction of resistance to trastuzumab which might be due to modulation of some vital signaling elements such as Notch1 and Pin1. In this study, we were aim...... hiện toàn bộ
Effect of burn injury on apoptosis and expression of apoptosis-related genes/proteins in skeletal muscles of rats
Springer Science and Business Media LLC - Tập 14 - Trang 52-65 - 2008
Hongjie Duan, Jiake Chai, Zhiyong Sheng, Yongming Yao, Huinan Yin, Liming Liang, Chuanan Shen, Jing Lin
The purpose of this study was to investigate the occurrence and possible mechanisms of apoptosis in skeletal muscles after burn injury. After a 40% body surface area burn to rats, TA muscles were examined for apoptosis at varying times by TEM, TUNEL and cell death ELISA assay. Thermal injury was found to induce apoptosis in skeletal muscle on the first day and maximal apoptosis appeared 4 days pos...... hiện toàn bộ
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