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LIM homeobox transcription factor 1B is associated with pro-fibrotic components and apoptosis in hypoxia/reoxygenation renal tubular epithelial cells
Springer Science and Business Media LLC - Tập 19 - Trang 594-602 - 2013
Tian-Biao Zhou, Hui-Ling Xu, Yuan-Han Qin, Feng-Ying Lei, Wei-Fang Huang, Gregor P. C. Drummen
LIM homeobox transcription factor 1B (LMX1B) is a transcription factor of the LIM-homeodomain type, which plays an important role in foetal development during formation of the extremities, kidneys, eyes, and the brain. Furthermore, LMX1B has been implicated in nail-patella syndrome, which is predominantly characterized by malformation of limbs and nails, and in 30 % of patients, nephropathy, inclu...... hiện toàn bộ
Caspase-independent killing of Burkitt lymphoma cell lines by rituximab
Springer Science and Business Media LLC - Tập 11 - Trang 1013-1023 - 2006
I. Daniels, A. M. Abulayha, B. J. Thomson, A. P. Haynes
Caspase-independent cell death may have a critical role to play in the therapeutic destruction of tumours. Recently it has been suggested that one of the mechanisms by which rituximab, a therapeutic anti-CD20 antibody, kills B cells is caspase-independent. In this study we show that rituximab can induce death in a variety of Burkitt lymphoma derived cell lines. Rituximab-treated cells show leakage...... hiện toàn bộ
N-(3-oxo-acyl) homoserine lactone induced germ cell apoptosis and suppressed the over-activated RAS/MAPK tumorigenesis via mitochondrial-dependent ROS in C. elegans
Springer Science and Business Media LLC - Tập 23 - Trang 626-640 - 2018
Bin Chen, Xianbin Cao, Huayi Lu, Pengbo Wen, Xiaojing Qi, Shaopeng Chen, Lijun Wu, Chi Li, An Xu, Guoping Zhao
As a quorum-sensing molecule for bacteria–bacteria communication, N-(3-oxododecanoyl)-homoserine lactone (C12) has been found to possess pro-apoptotic activities in various cell culture models. However, the detailed mechanism of how this important signaling molecule function in the cells of live animals still remains largely unclear. In this study, we systematically investigated the mechanism for ...... hiện toàn bộ
N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner
Springer Science and Business Media LLC - - Trang 1-12 - 2023
Yibing Wang, Peng Jin, Xia Wang
Increasing data and literature have illustrated that tumor immune escape represents a major source of tumor formation and recrudesce. Besides, novel findings also indicate that RNA N6-methyladenosine (m6A) participates in the human cancer immune escape. Here, our study investigated the functions of m6A reader YTHDF1 in prostate cancer (PCa) immune response and explored the functional mechanism. Re...... hiện toàn bộ
An investigation of a possible role for mitochondrial nuclease in apoptosis
Springer Science and Business Media LLC - Tập 3 - Trang 395-405 - 1998
X. W. Meng, M. J. Fraser, C. M. Ireland, J. M. Feller, J. B. Ziegler
Since mitochondrial factors have been implicated in apoptosis, experiments were designed to assess whether or not the potent mitochondrial nuclease could be one of these factors. Nuclei isolated by two different methods were found to contain mitochondrial nuclease in masked form. This nuclease was released by treatment with the non-ionic detergent NP-40 and rendered trypsin-sensitive. It was not r...... hiện toàn bộ
DDI2 promotes tumor metastasis and resists antineoplastic drugs-induced apoptosis in colorectal cancer
Springer Science and Business Media LLC - Tập 28 - Trang 458-470 - 2022
Lei Lei, Qing Cao, Guoyan An, Yuejiao Lv, Juan Tang, Jin Yang
The normal colorectal mucosa undergoes precancerous lesions that can develop over time into colorectal cancer (CRC). In the stage of precancerous lesions, DNA replication stress may lead to genome instability. We have performed whole-exome sequencing on genomic DNA obtained from three cases of CRC tissues and identified a novel frameshift mutation of DNA damage inducible 1 homolog 2 gene (DDI2, c....... hiện toàn bộ
cDNA Cloning of Human DNase γ: Chromosomal Localization of Its Gene and Enzymatic Properties of Recombinant Protein
Springer Science and Business Media LLC - Tập 3 - Trang 89-95 - 1998
D. Shiokawa, M. Hirai, S. Tanuma
We report here on the nucleotide sequence of the cDNA encoding human DNase γ, which is a candidate for an apoptotic endonuclease. The cDNA clone isolated from a human spleen cDNA library is composed of a 918 bp open reading frame encoding a 305 amino acid precursor protein for DNase γ. Northern blot analysis reveals that the expression of a single transcript of 1.5 kb DNase γ mRNA is detected in t...... hiện toàn bộ
Regulation of survivin by retinoic acid and its role in paclitaxel-mediated cytotoxicity in MCF-7 breast cancer cells
Springer Science and Business Media LLC - - 2006
M.A. Christine Pratt, Min-Ying Niu, L. Isabel Renart
NVP-BEZ235, a dual PI3K/mTOR inhibitor, induces cell death through alternate routes in prostate cancer cells depending on the PTEN genotype
Springer Science and Business Media LLC - - 2014
Seung Woo Hong, Ji Sun Shin, Jung Hwan Moon, Ye Seul Kim, Jooyoung Lee, Eun Kyoung Choi, Seung Hee Ha, Dong Hoon Lee, Ha Na Chung, Jeong Eun Kim, Kyu Pyo Kim, Yong Sang Hong, Jae‐Lyun Lee, Wang Jae Lee, Eun Kyung Choi, Jung Shin Lee, Dong Hoon Jin, Tae Won Kim
2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway
Springer Science and Business Media LLC - Tập 22 - Trang 118-134 - 2016
V. Lakshma Nayak, Narayana Nagesh, A. Ravikumar, Chandrakant Bagul, M. V. P. S. Vishnuvardhan, Vunnam Srinivasulu, Ahmed Kamal
Apoptosis is a representative form of programmed cell death, which has been assumed to be critical for cancer prevention. Thus, any agent that can induce apoptosis may be useful for cancer treatment and apoptosis induction is arguably the most potent defense against cancer promotion. In our previous studies, 2-aryl benzimidazole conjugates were synthesized and evaluated for their antiproliferative...... hiện toàn bộ
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