Springer Science and Business Media LLC

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Âm nhạc và cảm xúc trong bệnh Alzheimer Dịch bởi AI
Springer Science and Business Media LLC - Tập 11 - Trang 1-11 - 2019
Eva M. Arroyo-Anlló, Stéphanie Dauphin, M. Noelle Fargeau, Pierre Ingrand, Roger Gil
Bệnh Alzheimer có thể ảnh hưởng đến nhiều năng lực âm nhạc, tuy nhiên, dữ liệu rõ ràng về vấn đề này còn thiếu trong tài liệu khoa học. Hơn nữa, âm nhạc có khả năng truyền tải những cảm xúc cơ bản, nhưng còn rất ít điều được biết đến về khía cạnh cảm xúc của âm nhạc ở bệnh nhân Alzheimer. Chúng tôi trình bày một cuộc điều tra hệ thống về việc xử lý âm nhạc liên quan đến các kỹ năng ngoài âm nhạc, ... hiện toàn bộ
#bệnh Alzheimer #âm nhạc #cảm xúc #năng lực âm nhạc #rối loạn trí tuệ
Conversion of mild cognitive impairment patients in Alzheimer’s disease: prognostic value of Alpha3/Alpha2 electroencephalographic rhythms power ratio
Springer Science and Business Media LLC - Tập 7 - Trang 1-14 - 2015
D. V. Moretti
The increase in electroencephalogram (EEG) alpha3/alpha2 frequency power ratio has been demonstrated as a biomarker characteristic of subjects with mild cognitive impairment (MCI) who will develop Alzheimer’s disease (AD). Seventy-four adult subjects with MCI underwent clinical and neuropsychological evaluation, EEG recording, and high-resolution 3D magnetic resonance imaging (MRI). This group has... hiện toàn bộ
Pharmacological recommendations for the symptomatic treatment of dementia: the Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012
Springer Science and Business Media LLC - Tập 5 - Trang 1-12 - 2013
Nathan Herrmann, Krista L Lanctôt, David B Hogan
While there have been no new medications approved for the treatment of Alzheimer's disease (AD) or other dementias in Canada since 2004, the Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD) reviewed and updated the clinical practice guidelines on the pharmacological management of dementia that were published previously. This review focused on the literature for the... hiện toàn bộ
Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer’s disease
Springer Science and Business Media LLC - Tập 10 - Trang 1-11 - 2018
Hua Zhang, Joseph Therriault, Min Su Kang, Kok Pin Ng, Tharick A. Pascoal, Pedro Rosa-Neto, Serge Gauthier
There is accumulating evidence that synaptic loss precedes neuronal loss and correlates best with impaired memory formation in Alzheimer’s disease (AD). Cerebrospinal fluid (CSF) synaptosomal-associated protein 25 (SNAP-25) is a newly discovered marker indicating synaptic damage. We here test CSF SNAP-25 and SNAP-25/amyloid-β42 (Aβ42) ratio as a diagnostic marker for predicting cognitive decline a... hiện toàn bộ
Alpha-synuclein: a pathological factor with Aβ and tau and biomarker in Alzheimer’s disease
Springer Science and Business Media LLC - Tập 14 - Trang 1-14 - 2022
Kyu Hwan Shim, Min Ju Kang, Young Chul Youn, Seong Soo A. An, SangYun Kim
Alpha-synuclein (α-syn) is considered the main pathophysiological protein component of Lewy bodies in synucleinopathies. α-Syn is an intrinsically disordered protein (IDP), and several types of structural conformations have been reported, depending on environmental factors. Since IDPs may have distinctive functions depending on their structures, α-syn can play different roles and interact with sev... hiện toàn bộ
Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice
Springer Science and Business Media LLC - Tập 13 - Trang 1-20 - 2021
Gowoon Son, Seung-Jun Yoo, Shinwoo Kang, Ameer Rasheed, Da Hae Jung, Hyunjun Park, Bongki Cho, Harry W. M. Steinbusch, Keun-A Chang, Yoo-Hun Suh, Cheil Moon
Hyposmia in Alzheimer’s disease (AD) is a typical early symptom according to numerous previous clinical studies. Although amyloid-β (Aβ), which is one of the toxic factors upregulated early in AD, has been identified in many studies, even in the peripheral areas of the olfactory system, the pathology involving olfactory sensory neurons (OSNs) remains poorly understood. Here, we focused on peripher... hiện toàn bộ
Introduction of an assessment toolkit associated with increased rate of DLB diagnosis
Springer Science and Business Media LLC - Tập 13 - Trang 1-8 - 2021
A. Surendranathan, J. Kane, A. Bentley, S. Barker, R. McNally, C. Bamford, J.-P. Taylor, A. Thomas, I. McKeith, D. Burn, J. T. O’Brien
Dementia with Lewy bodies (DLB) and dementia in Parkinson’s disease (PDD) are recognised to be under-recognised in clinical practice in the UK, with only one third to a half of expected cases diagnosed. We aimed to assess whether clinical diagnostic rates could be increased by the introduction of a structured assessment toolkit for clinicians. We established baseline diagnostic rates for DLB and P... hiện toàn bộ
In vivo cortical diffusion imaging relates to Alzheimer’s disease neuropathology
Springer Science and Business Media LLC - Tập 15 - Trang 1-15 - 2023
Mario Torso, Gerard R. Ridgway, Michele Valotti, Ian Hardingham, Steven A. Chance
There has been increasing interest in cortical microstructure as a complementary and earlier measure of neurodegeneration than macrostructural atrophy, but few papers have related cortical diffusion imaging to post-mortem neuropathology. This study aimed to characterise the associations between the main Alzheimer’s disease (AD) neuropathological hallmarks and multiple cortical microstructural meas... hiện toàn bộ
Sex differences in neuropsychiatric symptoms in Alzheimer’s disease dementia: a meta-analysis
Springer Science and Business Media LLC - Tập 14 - Trang 1-13 - 2022
Willem S. Eikelboom, Michel Pan, Rik Ossenkoppele, Michiel Coesmans, Jennifer R. Gatchel, Zahinoor Ismail, Krista L. Lanctôt, Corinne E. Fischer, Moyra E. Mortby, Esther van den Berg, Janne M. Papma
Neuropsychiatric symptoms (NPS) are common in individuals with Alzheimer’s disease (AD) dementia, but substantial heterogeneity exists in the manifestation of NPS. Sex differences may explain this clinical variability. We aimed to investigate the sex differences in the prevalence and severity of NPS in AD dementia. Literature searches were conducted in Embase, MEDLINE/PubMed, Web of Science Core C... hiện toàn bộ
PERK: a novel therapeutic target for neurodegenerative diseases?
Springer Science and Business Media LLC - Tập 6 - Trang 1-3 - 2014
Tao Ma, Eric Klann
Identification of therapeutic targets based on novel mechanistic studies is urgently needed for neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and prion disease. Multiple lines of evidence have emerged to suggest that inhibition of the stress-induced endoplasmic reticulum kinase PERK (protein kinase RNA-like endoplasmic reticulum kinase) is a potential therapeutic str... hiện toàn bộ
Tổng số: 1,092   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10