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The prevalence of Apo E4 genotype and its relationship to bone mineral density in Hong Kong Chinese
Springer Science and Business Media LLC - Tập 23 - Trang 261-265 - 2005
Apolipoprotein E (Apo E) polymorphism has been implicated in many chronic diseases, including Alzheimer disease and osteoporosis. Significant association of the Apo E4 allele to low bone mineral density (BMD) has been repeatedly reported. We here examined the Apo E genotype frequencies in the Chinese population (n = 692) and its relationship to BMD. A significantly lower frequency (a prevalence of...... hiện toàn bộ
The effects of carbonate and Mg on in vitro mineralization of demineralized dentin
Springer Science and Business Media LLC - Tập 6 - Trang 59-66 - 1988
The demineralized sections of dentins of rats were mineralized in vitro. The sections were observed with contact microradiography (CMR) and their mineral contents were determined with micro-photometry of CMR films. In the mineralizing solution containing no carbonate, mineral appeared to adhere only on the surface of the demineralized dentins, regardless of their structure or their chemical nature...... hiện toàn bộ
The relationship between chronic kidney disease and denosumab-induced hypocalcemia in high-age osteoporotic patients
Springer Science and Business Media LLC - Tập 40 - Trang 670-676 - 2022
A few studies have reported the safety of the treatment of elderly osteoporotic patients with chronic kidney disease (CKD) and the possibility of hypocalcemia. The aim of the present study was to examine the relationship between the incidence of hypocalcemia and the CKD stage in elderly osteoporotic patients treated with denosumab. This study was designed as a parallel-group comparison study betwe...... hiện toàn bộ
Treatment of experimental osteonecrosis of the hip in adult rabbits with a single local injection of recombinant human FGF-2 microspheres
Springer Science and Business Media LLC - Tập 28 Số 6 - Trang 608-616 - 2010
THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis
Springer Science and Business Media LLC - Tập 36 - Trang 410-419 - 2017
Sex-determining region Y (Sry)-box (Sox)9 is required for chondrogenesis as a transcriptional activator of genes related to chondrocyte proliferation, differentiation, and cartilage-specific extracellular matrix. Although there have been studies investigating the Sox9-dependent transcriptional complexes, not all their components have been identified. In the present study, we demonstrated that thyr...... hiện toàn bộ
RANKL as the master regulator of osteoclast differentiation
Springer Science and Business Media LLC - Tập 39 - Trang 13-18 - 2021
RANKL, the essential cue for osteoclast differentiation, is the membrane-bound factor expressed by osteoclastogenesis-supporting cells such as osteoblasts and osteocytes. In vivo evidence indicates that RANKL functions as the indispensable and irreplaceable in the program of osteoclast differentiation. The reason why RANKL plays a critical role in osteoclastogenesis is discussed from the viewpoint...... hiện toàn bộ
Efficacy and safety of eldecalcitol, a new active vitamin D3 analog, in the bone metabolism of postmenopausal women receiving maintenance hemodialysis
Springer Science and Business Media LLC - Tập 33 - Trang 213-220 - 2014
Eldecalcitol (ELD), a new active vitamin D3 analog developed in Japan, has attracted attention as an effective osteoporotic therapeutic drug. However, because ELD leads to greater calcium absorption than does conventional active vitamin D3, it has yet to be used in patients with renal insufficiency. Therefore, we evaluated the efficacy and safety of ELD treatment in 27 postmenopausal women receivi...... hiện toàn bộ
Efficacy and safety of romosozumab among Japanese postmenopausal women with osteoporosis and mild-to-moderate chronic kidney disease
Springer Science and Business Media LLC - Tập 40 - Trang 677-687 - 2022
This post hoc analysis of the placebo-controlled phase 3 FRAME study assessed the efficacy and safety of romosozumab in a subpopulation of Japanese postmenopausal women with osteoporosis and chronic kidney disease (CKD). Data were analyzed by baseline estimated glomerular filtration rate (eGFR), where < 90 mL/min/1.73 m2 denoted CKD and ≥ 90 mL/min/1.73 m2 indicated normal renal function. Efficacy...... hiện toàn bộ
Characteristics of bone turnover markers in rapidly destructive coxopathy
Springer Science and Business Media LLC - Tập 35 - Trang 412-418 - 2016
The purpose of this study was to clarify bone turnover marker levels in rapidly destructive coxopathy (RDC). Twenty patients with RDC (mean age, 72 ± 11 years; 3 men, 17 postmenopausal women), 111 with osteoarthritis (OA) (age, 60 ± 10 years; 15 men, 13 premenopausal women, 83 postmenopausal women), and 18 with osteonecrosis of femoral head (ON) (55 ± 14 years; 11 men, 3 premenopausal women, 4 pos...... hiện toàn bộ
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