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Pituitary adenomas: Immunohistology and ultrastructural analysis of 118 tumors
Springer Science and Business Media LLC - Tập 62 - Trang 1-14 - 1983
M. M. Esiri, C. B. T. Adams, C. Burke, R. Underdown
An analysis is presented of the immunohistological and ultrastructural features in a series of 118 surgically removed pituitary adenomas all of which were studied immunohistologically using antisera to growth hormone (GH), prolactin (PRL) ACTH, βFSH, βLH and βTSH, and 75 of which were studied ultrastructurally. Results were analysed according to the mode of presentation of patients. Forty-one (35%...... hiện toàn bộ
Amyloid plaque formation precedes dendritic spine loss
Springer Science and Business Media LLC - Tập 124 Số 6 - Trang 797-807 - 2012
Tobias Bittner, Steffen Burgold, Mario M. Dorostkar, Martin Fuhrmann, Bettina M. Wegenast‐Braun, Boris Schmidt, Hans A. Kretzschmar, Jochen Herms
Impacts of massively parallel sequencing for genetic diagnosis of neuromuscular disorders
Springer Science and Business Media LLC - Tập 125 - Trang 173-185 - 2012
Nasim Vasli, Jocelyn Laporte
Neuromuscular disorders (NMD) such as neuropathy or myopathy are rare and often severe inherited disorders, affecting muscle and/or nerves with neonatal, childhood or adulthood onset, with considerable burden for the patients, their families and public health systems. Genetic and clinical heterogeneity, unspecific clinical features, unidentified genes and the implication of large and/or several ge...... hiện toàn bộ
Required techniques and useful molecular markers in the neuropathologic diagnosis of neurodegenerative diseases
Springer Science and Business Media LLC - Tập 109 - Trang 14-24 - 2005
Dennis W. Dickson
Modern neuropathologic methods and molecular biology have lead to increased understanding of neurodegenerative disorders and biologically based classifications of these disorders. The purpose of this review is to discuss neuropathologic methods that are useful in the characterization of neurodegenerative disorders, with emphasis on disorders of late life that present with dementia or movement diso...... hiện toàn bộ
The distribution of amyloid beta precursor protein in canine brain
Springer Science and Business Media LLC - Tập 87 - Trang 161-167 - 1994
R. Okuda, K. Uchida, S. Tateyama, R. Yamaguchi, H. Nakayama, N. Goto
The distribution of amyloid beta precursor protein (APP) in canine brain was investigated. By immunoblot analysis, APP-positive bands corresponding to proteins of 105–120 kilodalton were recognized in all canine brains regardless of the individual age of the dogs. Bands of similar molecular mass were also detected in the meninges, cerebrospinal fluid, and several visceral organs. Immunohistochemic...... hiện toàn bộ
Serial ultrastructural study of experimental Creutzfeldt-Jacob disease in guinea pigs
Springer Science and Business Media LLC - Tập 69 - Trang 81-90 - 1986
J. H. Kim, E. E. Manuelidis
Guinea pigs inoculated with brain homogenate from serially passaged Creutzfeldt-Jakob disease (CJD) were killed biweekly starting at week 2 until terminal illness (about 200 days following inoculation). A mild swelling of postsynaptic dendrites and an increase in the number of glial filaments in astrocytic processes was seen at week 4, followed by increased swelling and lucency of axons and dendri...... hiện toàn bộ
Neuropathologically defined subtypes of Alzheimer’s disease differ significantly from neurofibrillary tangle-predominant dementia
Springer Science and Business Media LLC - Tập 124 - Trang 681-692 - 2012
Nicholas J. Janocko, Kevin A. Brodersen, Alexandra I. Soto-Ortolaza, Owen A. Ross, Amanda M. Liesinger, Ranjan Duara, Neill R. Graff-Radford, Dennis W. Dickson, Melissa E. Murray
Alzheimer’s disease (AD) can be classified based on the relative density of neurofibrillary tangles (NFTs) in the hippocampus and association cortices into three subtypes: typical AD, hippocampal-sparing AD (HpSp AD), and limbic-predominant AD (LP AD). AD subtypes not only have pathologic, but also demographic, clinical, and genetic differences. Neurofibrillary tangle-predominant dementia (NFTD), ...... hiện toàn bộ
Modulation of simian immunodeficiency virus neuropathology by dopaminergic drugs
Springer Science and Business Media LLC - Tập 107 Số 3 - Trang 216-226 - 2004
Stefanie Czub, Markus Czub, Eleni Koutsilieri, Sieghart Sopper, François Villinger, Justus Müller, Christiane Stahl–Hennig∥, Peter Riederer, Volker ter Meulen, Georg Gosztonyi
Immunohistochemical study of kuru plaques using antibodies against synthetic prion protein peptides
Springer Science and Business Media LLC - - 1992
Katsufumi Hashimoto, Toru Mannen, Nobuyuki Nukina
Pediatric low-grade gliomas can be molecularly stratified for risk
Springer Science and Business Media LLC - Tập 136 - Trang 641-655 - 2018
Rui Ryan Yang, Abudumijiti Aibaidula, Wei-wei Wang, Aden Ka-Yin Chan, Zhi-feng Shi, Zhen-yu Zhang, Danny Tat Ming Chan, Wai Sang Poon, Xian-zhi Liu, Wen-cai Li, Rui-qi Zhang, Yan-Xi Li, Nellie Yuk-Fei Chung, Hong Chen, Jingsong Wu, Liangfu Zhou, Kay Ka-Wai Li, Ho-Keung Ng
Pediatric low-grade gliomas (PLGGs) consist of a number of entities with overlapping histological features. PLGGs have much better prognosis than the adult counterparts, but a significant proportion of PLGGs suffers from tumor progression and recurrence. It has been shown that pediatric and adult low-grade gliomas are molecularly distinct. Yet the clinical significance of some of newer biomarkers...... hiện toàn bộ
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