Springer Science and Business Media LLC

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Human-to-mouse prion-like propagation of mutant huntingtin protein
Springer Science and Business Media LLC - Tập 132 - Trang 577-592 - 2016
Iksoo Jeon, Francesca Cicchetti, Giulia Cisbani, Suji Lee, Endan Li, Jiwoo Bae, Nayeon Lee, Ling Li, Wooseok Im, Manho Kim, Hyun Sook Kim, Seung-Hun Oh, Tae-Aug Kim, Jung Jae Ko, Benoit Aubé, Abid Oueslati, Yun Joong Kim, Jihwan Song
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder of the central nervous system (CNS) that is defined by a CAG expansion in exon 1 of the huntingtin gene leading to the production of mutant huntingtin (mHtt). To date, the disease pathophysiology has been thought to be primarily driven by cell-autonomous mechanisms, but, here, we demonstrate that fibroblasts derived from...... hiện toàn bộ
Pituitary adenomas: Immunohistology and ultrastructural analysis of 118 tumors
Springer Science and Business Media LLC - Tập 62 - Trang 1-14 - 1983
M. M. Esiri, C. B. T. Adams, C. Burke, R. Underdown
An analysis is presented of the immunohistological and ultrastructural features in a series of 118 surgically removed pituitary adenomas all of which were studied immunohistologically using antisera to growth hormone (GH), prolactin (PRL) ACTH, βFSH, βLH and βTSH, and 75 of which were studied ultrastructurally. Results were analysed according to the mode of presentation of patients. Forty-one (35%...... hiện toàn bộ
Effect of arachidonic acid on cultured cerebromicrovascular endothelium: permeability, lipid peroxidation and membrane “fluidity”
Springer Science and Business Media LLC - Tập 78 - Trang 310-316 - 1989
A. Villacara, M. Spatz, R. F. Dodson, C. Corn, J. Bembry
The relationship of free arachidonic acid (AA) to cellular permeability, lipid peroxidation and physical state “fluidity” of the membrane was investigated in cultured endothelial cells (EC) dissociated from cerebral microvessels of rats. The results demonstrate that AA can induce a reversible alteration of endothelial permeability to trypan blue albumin (TBA). Exposure of EC to AA increases membra...... hiện toàn bộ
Amyloid plaque formation precedes dendritic spine loss
Springer Science and Business Media LLC - Tập 124 Số 6 - Trang 797-807 - 2012
Tobias Bittner, Steffen Burgold, Mario M. Dorostkar, Martin Fuhrmann, Bettina M. Wegenast‐Braun, Boris Schmidt, Hans A. Kretzschmar, Jochen Herms
Immunohistochemical studies on cellular character of microtumors induced by ethylnitrosourea in the rat brain utilizing anti-leu 7 and anti-glial fibrillary acidic protein antibodies
Springer Science and Business Media LLC - - 1985
T. Yoshino, M. Motoi, K. Ogawa
To clarify the chronologic changes in the cellular morphology of ENU-induced rat brain tumors, microtumors in the early stage were examined ummunohistochemically in comparison with macrotumors in the advanced stage. The tumor cells composing microtumors were negative for glial fibrillary acidic protein (GFAP), a specific marker of astrocylic cells, and Leu 7, a marker of oligodendrocytes, while ce...... hiện toàn bộ
Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration
Springer Science and Business Media LLC - - 1987
Maiken Nedergaard, Nils Henrik Diemer
Impacts of massively parallel sequencing for genetic diagnosis of neuromuscular disorders
Springer Science and Business Media LLC - Tập 125 - Trang 173-185 - 2012
Nasim Vasli, Jocelyn Laporte
Neuromuscular disorders (NMD) such as neuropathy or myopathy are rare and often severe inherited disorders, affecting muscle and/or nerves with neonatal, childhood or adulthood onset, with considerable burden for the patients, their families and public health systems. Genetic and clinical heterogeneity, unspecific clinical features, unidentified genes and the implication of large and/or several ge...... hiện toàn bộ
Required techniques and useful molecular markers in the neuropathologic diagnosis of neurodegenerative diseases
Springer Science and Business Media LLC - Tập 109 - Trang 14-24 - 2005
Dennis W. Dickson
Modern neuropathologic methods and molecular biology have lead to increased understanding of neurodegenerative disorders and biologically based classifications of these disorders. The purpose of this review is to discuss neuropathologic methods that are useful in the characterization of neurodegenerative disorders, with emphasis on disorders of late life that present with dementia or movement diso...... hiện toàn bộ
The distribution of amyloid beta precursor protein in canine brain
Springer Science and Business Media LLC - Tập 87 - Trang 161-167 - 1994
R. Okuda, K. Uchida, S. Tateyama, R. Yamaguchi, H. Nakayama, N. Goto
The distribution of amyloid beta precursor protein (APP) in canine brain was investigated. By immunoblot analysis, APP-positive bands corresponding to proteins of 105–120 kilodalton were recognized in all canine brains regardless of the individual age of the dogs. Bands of similar molecular mass were also detected in the meninges, cerebrospinal fluid, and several visceral organs. Immunohistochemic...... hiện toàn bộ
Serial ultrastructural study of experimental Creutzfeldt-Jacob disease in guinea pigs
Springer Science and Business Media LLC - Tập 69 - Trang 81-90 - 1986
J. H. Kim, E. E. Manuelidis
Guinea pigs inoculated with brain homogenate from serially passaged Creutzfeldt-Jakob disease (CJD) were killed biweekly starting at week 2 until terminal illness (about 200 days following inoculation). A mild swelling of postsynaptic dendrites and an increase in the number of glial filaments in astrocytic processes was seen at week 4, followed by increased swelling and lucency of axons and dendri...... hiện toàn bộ
Tổng số: 6,283   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10