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Pharmacokinetic and metabolomic analyses of Mangiferin calcium salt in rat models of type 2 diabetes and non-alcoholic fatty liver disease
Springer Science and Business Media LLC - - 2020
He Lin, Houlei Teng, Wei Wu, Yong Li, Guangfu Lv, Xiaowei Huang, Wenhao Yan, Zhe Lin
Non-alcoholic fatty liver is one of the most common comorbidities of diabetes. It can cause disturbance of glucose and lipid metabolism in the body, gradually develop into liver fibrosis, and even cause liver cirrhosis. Mangiferin has a variety of pharmacological activities, especially for the improvement of glycolipid metabolism and liver injury. However, its poor oral absorption and low bioavail... hiện toàn bộ
Chronic activation of heme free soluble guanylate cyclase leads to cardio-renal protection in experimental hypertension
Springer Science and Business Media LLC - Tập 14 - Trang 1-2 - 2013
Linda S Hoffmann, Axel Kretschmer, Bettina Lawrenz, Andreas Hucke, Berthold Hocher, Johannes-Peter Stasch
Inhaled Nitric Oxide: an sGC-dependent IOP lowering agent
Springer Science and Business Media LLC - Tập 16 - Trang 1-2 - 2015
Wolfgang S Lieb, Stefan Munster, Ana C Dordea, Sara Vandenwijngaert, Robert E Tainsh, Peter Brouckaert, Warren M Zapol, Emmanuel S Buys
Bilirubin potentiates etomidate-induced sedation by enhancing GABA-induced currents after bile duct ligation
Springer Science and Business Media LLC - Tập 24 - Trang 1-9 - 2023
Hao Gao, Qian Zhao, Jian-Gang Song, Guo-Xia Hu, Wei-Feng Yu, Ying-Fu Jiao, Jin-Chao Song
Our previous clinical trial showed that etomidate requirements to reach an appropriate level of anesthesia in patients with obstructive jaundice were reduced, which means that these patients are more sensitive to etomidate. However, the mechanism is still not completely clear. The present study was aimed to investigate the mechanism by which bilirubin facilitates etomidate induced sedation. A bile... hiện toàn bộ
Cohort protocol paper: The Pain and Opioids In Treatment (POINT) study
Springer Science and Business Media LLC - Tập 15 - Trang 1-9 - 2014
Gabrielle Campbell, Richard Mattick, Raimondo Bruno, Briony Larance, Suzanne Nielsen, Milton Cohen, Nicholas Lintzeris, Fiona Shand, Wayne D Hall, Bianca Hoban, Chyanne Kehler, Michael Farrell, Louisa Degenhardt
Internationally, there is concern about the increased prescribing of pharmaceutical opioids for chronic non-cancer pain (CNCP). In part, this is related to limited knowledge about the long-term benefits and outcomes of opioid use for CNCP. There has also been increased injection of some pharmaceutical opioids by people who inject drugs, and for some patients, the development of problematic and/or ... hiện toàn bộ
Amitraz poisoning: A case report of an unusual pesticide poisoning in Sri Lanka and literature review
Springer Science and Business Media LLC - Tập 18 - Trang 1-6 - 2017
Nilukshana Yogendranathan, Aruna Kulatunga, M. D. M. S. Wijayabandara, H. M. M. T. B. Herath, S. P. Pahalagamage
Amitraz is a pesticide used worldwide on animals and in agriculture. It contains triazapentadiene, which is a centrally acting alpha-2 adrenergic agonist. Amitraz poisoning is fairly uncommon in humans and occurs via oral, dermal or inhalational routes. Only a limited number of case reports of human intoxication have been published and most of them are of accidental ingestion by children. A twenty... hiện toàn bộ
Alternative splicing of α1 and β1 sGC genes is altered in aortic disease
Springer Science and Business Media LLC - Tập 14 - Trang 1-2 - 2013
Emil Martin, Eva Golunski, Iraida Sharina
Dipeptidyl peptidase 4 (DPP-4) inhibitors and cardiovascular outcomes in patients with type 2 diabetes mellitus (T2DM): a systematic review and meta-analysis
Springer Science and Business Media LLC - Tập 20 - Trang 1-9 - 2019
Dan Liu, Biao Jin, Wei Chen, Peng Yun
Dipeptidyl peptidase 4 (DPP-4) inhibitors are newer oral anti-diabetic agents which have been approved by the Food and Drug Administration for the treatment of patients with type 2 diabetes mellitus (T2DM). In this analysis, we aimed to systematically compare the cardiovascular outcomes associated with DPP-4 inhibitors versus non-DPP-4 inhibitor users. All English publications that compared the us... hiện toàn bộ
Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells
Springer Science and Business Media LLC - Tập 23 Số 1
Liu Hong, Sang Hoon Jeong, Hyejin Lee, Cherry Kim, Yoon Jeong Nam, JungHee Kang, Myeong Ok Song, Jin Young Choi, Jae‐Young Kim, Eun-Kee Park, Yongwook Baek, Ju Han Lee
Abstract Background Lung injury elicited by respiratory exposure to humidifier disinfectants (HDs) is known as HD-associated lung injury (HDLI). Current elucidation of the molecular mechanisms related to HDLI is mostly restricted to fibrotic and inflammatory lung diseases. In our previous report, we found that lung tumors were caused by intratracheal instillation of polyhexamethylene guanidine pho... hiện toàn bộ
Seasonal variation of heavy metals and metallothionein contents in Asian swamp eels, Monopterus albus (Zuiew, 1793) from Tumpat, Kelantan, Malaysia
Springer Science and Business Media LLC - Tập 20 - Trang 1-8 - 2019
Ai Yin Sow, Ahmad Ismail, Syaizwan Zahmir Zulkifli, Mohammad Noor Amal, Kamarul Hambali
Levels of toxic metal exposure in indigenous inhabitants are key bioindicators of the severity of environmental contamination. This study measured the seasonal variation of heavy metals and metallothionein (MT) contents in Asian swamp eels (Monopterus albus) from a paddy field situated in Tumpat, Kelantan, Malaysia, to identify prevalence, patterns and associations and togain insight on the suitab... hiện toàn bộ
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