Common causes and characteristics of adverse drug reactions in older adults: a retrospective studySpringer Science and Business Media LLC - Tập 21 Số 1 - 2020
Seong-Dae Woo, Ji‐Won Yoon, Go-Eun Doo, You‐Jin Park, Youngsoo Lee, So Hee Lee, Younghee Lee, Young-Min Ye
Abstract
Background
Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adults (≥65 years) in comparison to younger individuals (< 65 years).... hiện toàn bộ
Does antihypertensive treatment with renin-angiotensin system inhibitors prevent the development of diabetic kidney disease?Springer Science and Business Media LLC - Tập 16 - Trang 1-5 - 2015
Hiroki Miyazaki, Akira Babazono, Takumi Nishi, Toshiki Maeda, Takuya Imatoh, Masayoshi Ichiba, Hiroshi Une
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide. Renin-angiotensin system (RAS) inhibitors are the first-line treatment for diabetic patients with hypertension. However, whether RAS inhibitors prevent the development of DKD remains controversial. We conducted a retrospective cohort study quantifying the preventive effect of antihypertensive treatment with RA...... hiện toàn bộ
Comparison of two biosimilarity studies of FKB327 with the adalimumab reference product: randomized phase 1 studies of single-blind, single-dose subcutaneous injection in healthy Japanese male participantsSpringer Science and Business Media LLC - - 2022
Takuma Yonemura, Rie Yazawa, Miwa Haranaka, Kenichi Kazuki, Masayuki Takanuma, Takumi Kanzo, D. Stefanidis, Yasumasa Arai
Abstract
Background
FKB327 has been developed as a biosimilar of the adalimumab reference product (RP). We compared the pharmacokinetics (PK), safety, and immunogenicity of FKB327 with those of the adalimumab RP after a single dose by subcutaneous (SC) injection in Japanese male participants.... hiện toàn bộ