Tigecycline for the Treatment of Severe and Severe Complicated Clostridium difficile InfectionSpringer Science and Business Media LLC - Tập 3 - Trang 321-331 - 2014
Nicholas S. Britt, Molly E. Steed, Emily M. Potter, Lisa A. Clough
Clostridium difficile infection (CDI) is a common cause of nosocomial diarrhea.
Metronidazole and vancomycin are the primary treatment options for CDI, but
increasing rates of antimicrobial resistance and severe, refractory disease have
prompted the need for alternative agents. Tigecycline has previously
demonstrated favorable in vitro activity against C. difficile isolates, but
clinical data on i... hiện toàn bộ
Building on Antimicrobial Stewardship Programs Through Integration with Electronic Medical Records: The Australian ExperienceSpringer Science and Business Media LLC - Tập 10 - Trang 61-73 - 2021
Kelly A. Cairns, Matthew D. M. Rawlins, Sean D. Unwin, Fiona F. Doukas, Rosemary Burke, Erica Tong, Andrew J. Henderson, Allen C. Cheng
Antimicrobial stewardship (AMS) is well established in Australian hospitals.
Electronic medical record (EMR) implementation has lagged in Australia, with two
Healthcare Information and Management Systems Society (HIMSS) Stage 6 hospitals
and one Stage 7 hospital as of September 2020. Specific barriers faced by AMS
teams with paper-based prescribing and medical records include real-time
identificat... hiện toàn bộ
Combined Bacterial Meningitis and Infective Endocarditis: When Should We Search for the Other When Either One is Diagnosed?Springer Science and Business Media LLC - Tập 11 - Trang 1521-1540 - 2022
Guillaume Béraud, Sarah Tubiana, Marie-Line Erpelding, Vincent Le Moing, Catherine Chirouze, Isabelle Gorenne, Pauline Manchon, Pierre Tattevin, Veronique Vernet, Emmanuelle Varon, Bruno Hoen, Xavier Duval
We aimed to describe patients with coexisting infective endocarditis (IE) and
bacterial meningitis (BM). We merged two large prospective cohorts, an IE cohort
and a BM cohort, with only cases of definite IE and community-acquired
meningitis. We compared patients who had IE and BM concurrently to patients with
IE only and BM only. Among the 1030 included patients, we identified 42 patients
with IE–... hiện toàn bộ
Societal Preferences for Meningococcal B Vaccination in Children: A Discrete Choice Experiment in SpainSpringer Science and Business Media LLC - Tập 12 - Trang 157-175 - 2022
Federico Martinón-Torres, Ángel Gil de Miguel, Jesús Ruiz-Contreras, Laura A. Vallejo-Aparicio, Andrea García, María C. Gonzalez-Inchausti, Eduardo de Gomensoro, Zeki Kocaata, Clara Gabás-Rivera, Marta Comellas, Miriam Prades, Luis Lizán
Immunization is the most effective strategy for the prevention of invasive
meningococcal disease caused by Neisseria meningitidis serogroup B (MenB);
however, parents need to weigh the risk–benefit and financial impact of
immunizing their children against MenB in the absence of a national immunization
program (NIP). This study aimed to explore societal preferences (of parents and
pediatricians) re... hiện toàn bộ
Therapeutic Drug Monitoring of Antifungal Drugs: Another Tool to Improve Patient Outcome?Springer Science and Business Media LLC - Tập 9 - Trang 137-149 - 2020
Antonio Vena, Patricia Muñoz, Miriam Mateos, Jesus Guinea, Alicia Galar, Federico Pea, Ana Alvarez-Uria, Pilar Escribano, Emilio Bouza
This study aimed to examine the relationship among adequate dose, serum
concentration and clinical outcome in a non-selected group of hospitalized
patients receiving antifungals. Prospective cross-sectional study performed
between March 2015 and June 2015. Dosage of antifungals was considered adequate
according to the IDSA guidelines, whereas trough serum concentrations
(determined with HPLC) were... hiện toàn bộ
A Needs Assessment for Infectious Diseases Consultation in Community HospitalsSpringer Science and Business Media LLC - Tập 12 - Trang 1725-1737 - 2023
Caitlyn M. Hollingshead, Ana E. Khazan, Justin H. Franco, Jacob A. Ciricillo, Michael N. Haddad, Julia T. Berry, Joel A. Kammeyer
Infectious diseases (ID) consultations have been demonstrated to improve patient
outcomes in the treatment of severe infections. However, ID consultation is
often unavailable to patients that live in rural communities. Little is known
regarding the treatment of infections in rural hospitals with no coverage from
an ID specialist. We characterized the outcomes of patients cared for in
hospitals wit... hiện toàn bộ
Assessment of Drug–Drug Interaction Risk Between Intravenous Fentanyl and the Glecaprevir/Pibrentasvir Combination Regimen in Hepatitis C Patients Using Physiologically Based Pharmacokinetic Modeling and SimulationsSpringer Science and Business Media LLC - Tập 12 Số 8 - Trang 2057-2070 - 2023
Mukherjee, Dwaipayan, Collins, Michelle, Dylla, Douglas E., Kaur, Jatinder, Semizarov, Dimitri, Martinez, Anthony, Conway, Brian, Khan, Tipu, Mostafa, Nael M.
An unsafe injection practice is one of the major contributors to new hepatitis C
virus (HCV) infections; thus, people who inject drugs are a key population to
prioritize to achieve HCV elimination. The introduction of highly effective and
well-tolerated pangenotypic direct-acting antivirals, including
glecaprevir/pibrentasvir (GLE/PIB), has revolutionized the HCV treatment
landscape. Glecaprevir i... hiện toàn bộ