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Fleroxacin Clinical Pharmacokinetics
Springer Science and Business Media LLC - Tập 22 - Trang 116-131 - 2012
Andreas E. Stuck, Donbosco K. Kim, Felix J. Frey
Fleroxacin is a new member of the class of fluoroquinolones. The drug has good activity (i.e. minimum inhibitory concentrations at less than 2 mg/L against 90% of strains) against a wide range of Gram-positive and Gram-negative bacteria. High performance liquid chromatography is used to determine concentrations of fleroxacin and its metabolites in biological fluids. Absorption of orally ingested d...... hiện toàn bộ
Population Pharmacokinetic Analysis of Denosumab in Patients with Bone Metastases from Solid Tumours
Springer Science and Business Media LLC - Tập 51 - Trang 247-260 - 2012
Leonid Gibiansky, Liviawati Sutjandra, Sameer Doshi, Jenny Zheng, Winnie Sohn, Mark C. Peterson, Graham R. Jang, Andrew T. Chow, Juan José Pérez-Ruixo
Denosumab (XGEVA®; AMG 162) is a fully human IgG2 monoclonal antibody, which binds to the receptor activator of nuclear factor K-B ligand (RANKL) and prevents terminal differentiation, activation and survival of osteoclasts. We aimed to characterize the population pharmacokinetics of denosumab in patients with advanced solid tumours and bone metastases. A total of 14 228 free serum concentrations ...... hiện toàn bộ
Population Pharmacokinetic Modeling of Inebilizumab in Subjects with Neuromyelitis Optica Spectrum Disorders, Systemic Sclerosis, or Relapsing Multiple Sclerosis
Springer Science and Business Media LLC - Tập 61 - Trang 387-400 - 2021
Li Yan, Holly Kimko, Bing Wang, Daniel Cimbora, Eliezer Katz, William A. Rees
Inebilizumab is a humanized, affinity-optimized, afucosylated immunoglobulin (Ig)-G1κ monoclonal antibody that binds to CD19, resulting in effective depletion of peripheral B cells. It is being developed to treat various autoimmune diseases, including neuromyelitis optica spectrum disorders (NMOSD), systemic sclerosis (SSc), and relapsing multiple sclerosis (MS). Pharmacokinetic data from a pivot...... hiện toàn bộ
Clinical Pharmacokinetics of Valproic Acid — 1988
Springer Science and Business Media LLC - Tập 15 - Trang 367-389 - 2012
Gaetano Zaccara, Andrea Messori, Flavio Moroni
Sodium valproate (valproic acid) has been widely used in the last decade and is now considered a relatively safe and effective anticonvulsant agent. Recently, several investigators have proposed its use in the treatment of anxiety, alcoholism and mood disorders, although these indications require further clinical studies. Valproic acid is available in different oral formulations such as solutions,...... hiện toàn bộ
Multicenter Population Pharmacokinetics and Exposure–Efficacy Analysis of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
Springer Science and Business Media LLC - Tập 62 - Trang 921-930 - 2023
Peile Wang, Hui Li, Shanshan Chen, Han Xing, Jing Yang, Guojun Zhang, Xiaojian Zhang
Pirfenidone is an antifibrotic agent that has been proven to slow down the progression of idiopathic pulmonary fibrosis (IPF). This study aimed to characterize the population pharmacokinetics (PK) and exposure–efficacy analysis of pirfenidone in patients with IPF. Data from 10 hospitals with 106 patients were used to develop a population PK model. The annual decline in forced vital capacity (FVC) ...... hiện toàn bộ
Enalapril Clinical Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Relationships
Springer Science and Business Media LLC - Tập 25 - Trang 274-282 - 2012
Robert J. MacFadyen, Peter A. Meredith, Henry L. Elliott
The conventional pharmacokinetic profile of the angiotensin converting enzyme (ACE) inhibitor, enalapril, is a lipid-soluble and relatively inactive prodrug with good oral absorption (60 to 70%), a rapid peak plasma concentration (1 hour) and rapid clearance (undetectable by 4 hours) by de-esterification in the liver to a primary active diacid metabolite, enalaprilat. Peak plasma enalaprilat conce...... hiện toàn bộ
Clinical Pharmacokinetics of Commonly Used Anticancer Drugs
Springer Science and Business Media LLC - Tập 8 - Trang 202-232 - 2012
Frank M. Balis, John S. Holcenberg, W. Archie Bleyer
The quantitative aspects of drug disposition in man of the commonly used antineoplastic agents, including cyclophosphamide, the nitrosoureas, cisplatin, methotrexate, cytarabine, 5-fluorouracil, doxorubicin, daunorubicin, bleomycin, vincristine, vinblastine, and vindesine are reviewed. Although the pharmacokinetic behaviour of these drugs has been adequately described in man, the chemical reactivi...... hiện toàn bộ
How to Use Warfarin Assays in Patient Management: Analysis of 437 Warfarin Measurements in a Clinical Setting
Springer Science and Business Media LLC - Tập 54 - Trang 517-525 - 2014
Kyunghoon Lee, Hye In Woo, Oh Young Bang, Young-Keun On, June Soo Kim, Soo-Youn Lee
Approximately 50 % of inter-individual variation in warfarin dose requirements is attributed to the polymorphisms of cytochrome P450 (CYP) 2C9 (CYP2C9) and vitamin K epoxide reductase complex, subunit 1 (VKORC1) genotypes. What contributes to the remaining 50 % of variation remains unclear. The aim of this study is to assess the clinical usefulness of monitoring plasma warfarin concentrations. We ...... hiện toàn bộ
The Aging Liver
Springer Science and Business Media LLC - Tập 34 - Trang 359-373 - 2012
David G. Le Couteur, Allan J. McLean
A change in drug clearance with age is considered an important factor in determining the high prevalence of adverse drug reactions associated with prescribing medications for the elderly. Despite this, no general principles have been available to guide drug administration in the elderly, although a substantial body of clearance and metabolism data has been generated in humans and experimental anim...... hiện toàn bộ
Vancomycin
Springer Science and Business Media LLC - Tập 43 - Trang 417-440 - 2012
Matthijs de Hoog, Johan W. Mouton, John N. van den Anker
This review describes the use of vancomycin in neonates over the last three decades. Given the relation of late-onset neonatal septicaemia to outcome and the increase in coagulase-negative staphylococcal infection as causative organism, vancomycin remains an important antibacterial in the neonatal intensive care unit. The pharmacokinetic behaviour of vancomycin in neonates can be adequately descri...... hiện toàn bộ
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