Springer Science and Business Media LLC
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Fleroxacin Clinical Pharmacokinetics
Springer Science and Business Media LLC - Tập 22 - Trang 116-131 - 2012
Fleroxacin is a new member of the class of fluoroquinolones. The drug has good activity (i.e. minimum inhibitory concentrations at less than 2 mg/L against 90% of strains) against a wide range of Gram-positive and Gram-negative bacteria. High performance liquid chromatography is used to determine concentrations of fleroxacin and its metabolites in biological fluids. Absorption of orally ingested d......
Population Pharmacokinetic Analysis of Denosumab in Patients with Bone Metastases from Solid Tumours
Springer Science and Business Media LLC - Tập 51 - Trang 247-260 - 2012
Denosumab (XGEVA®; AMG 162) is a fully human IgG2 monoclonal antibody, which binds to the receptor activator of nuclear factor K-B ligand (RANKL) and prevents terminal differentiation, activation and survival of osteoclasts. We aimed to characterize the population pharmacokinetics of denosumab in patients with advanced solid tumours and bone metastases. A total of 14 228 free serum concentrations ......
Population Pharmacokinetic Modeling of Inebilizumab in Subjects with Neuromyelitis Optica Spectrum Disorders, Systemic Sclerosis, or Relapsing Multiple Sclerosis
Springer Science and Business Media LLC - Tập 61 - Trang 387-400 - 2021
Inebilizumab is a humanized, affinity-optimized, afucosylated immunoglobulin (Ig)-G1κ monoclonal antibody that binds to CD19, resulting in effective depletion of peripheral B cells. It is being developed to treat various autoimmune diseases, including neuromyelitis optica spectrum disorders (NMOSD), systemic sclerosis (SSc), and relapsing multiple sclerosis (MS). Pharmacokinetic data from a pivot......
Clinical Pharmacokinetics of Valproic Acid — 1988
Springer Science and Business Media LLC - Tập 15 - Trang 367-389 - 2012
Sodium valproate (valproic acid) has been widely used in the last decade and is now considered a relatively safe and effective anticonvulsant agent. Recently, several investigators have proposed its use in the treatment of anxiety, alcoholism and mood disorders, although these indications require further clinical studies. Valproic acid is available in different oral formulations such as solutions,......
Multicenter Population Pharmacokinetics and Exposure–Efficacy Analysis of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
Springer Science and Business Media LLC - Tập 62 - Trang 921-930 - 2023
Pirfenidone is an antifibrotic agent that has been proven to slow down the progression of idiopathic pulmonary fibrosis (IPF). This study aimed to characterize the population pharmacokinetics (PK) and exposure–efficacy analysis of pirfenidone in patients with IPF. Data from 10 hospitals with 106 patients were used to develop a population PK model. The annual decline in forced vital capacity (FVC) ......
Enalapril Clinical Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Relationships
Springer Science and Business Media LLC - Tập 25 - Trang 274-282 - 2012
The conventional pharmacokinetic profile of the angiotensin converting enzyme (ACE) inhibitor, enalapril, is a lipid-soluble and relatively inactive prodrug with good oral absorption (60 to 70%), a rapid peak plasma concentration (1 hour) and rapid clearance (undetectable by 4 hours) by de-esterification in the liver to a primary active diacid metabolite, enalaprilat. Peak plasma enalaprilat conce......
Clinical Pharmacokinetics of Commonly Used Anticancer Drugs
Springer Science and Business Media LLC - Tập 8 - Trang 202-232 - 2012
The quantitative aspects of drug disposition in man of the commonly used antineoplastic agents, including cyclophosphamide, the nitrosoureas, cisplatin, methotrexate, cytarabine, 5-fluorouracil, doxorubicin, daunorubicin, bleomycin, vincristine, vinblastine, and vindesine are reviewed. Although the pharmacokinetic behaviour of these drugs has been adequately described in man, the chemical reactivi......
Population Pharmacokinetic Modeling of Benralizumab in Adult and Adolescent Patients with Asthma
Springer Science and Business Media LLC - Tập 58 - Trang 943-958 - 2019
Benralizumab, an interleukin-5 receptor alpha–directed cytolytic anti-eosinophil monoclonal antibody, was recently approved as add-on maintenance treatment for patients aged 12 years and older with uncontrolled asthma with eosinophilic inflammation. Pharmacokinetic (PK) data from nine clinical trials for patients with asthma were pooled and analyzed to further characterize the PK of benralizumab a......
How to Use Warfarin Assays in Patient Management: Analysis of 437 Warfarin Measurements in a Clinical Setting
Springer Science and Business Media LLC - Tập 54 - Trang 517-525 - 2014
Approximately 50 % of inter-individual variation in warfarin dose requirements is attributed to the polymorphisms of cytochrome P450 (CYP) 2C9 (CYP2C9) and vitamin K epoxide reductase complex, subunit 1 (VKORC1) genotypes. What contributes to the remaining 50 % of variation remains unclear. The aim of this study is to assess the clinical usefulness of monitoring plasma warfarin concentrations. We ......
Tổng số: 2,492
- 1
- 2
- 3
- 4
- 5
- 6
- 10