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Clinical Pharmacokinetics of Nitroprusside, Cyanide, Thiosulphate and Thiocyanate
Springer Science and Business Media LLC - Tập 9 - Trang 239-251 - 2012
Sodium nitroprusside decomposes within a few minutes after intravenous infusion to form metabolites which are pharmacologically inactive but toxicologically important. Free cyanide, which represents 44% w/w of the sodium nitroprusside molar mass, is formed and must be detoxified in the body into thiocyanate using thiosulphate as substrate. Nitroprusside penetrates cell membranes slowly. At therape...... hiện toàn bộ
Clinical Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Anifrolumab
Springer Science and Business Media LLC - Tập 62 - Trang 655-671 - 2023
The type I interferon (IFN) signaling pathway is implicated in the pathogenesis of systemic lupus erythematosus (SLE). Anifrolumab is a monoclonal antibody that targets the type I IFN receptor subunit 1. Anifrolumab is approved in several countries for patients with moderate to severe SLE receiving standard therapy. The approved dosing regimen of anifrolumab is a 300-mg dose administered intraveno...... hiện toàn bộ
Population Pharmacokinetics of Sifalimumab, an Investigational Anti-Interferon-α Monoclonal Antibody, in Systemic Lupus Erythematosus
Springer Science and Business Media LLC - Tập 52 - Trang 1017-1027 - 2013
Sifalimumab is a fully human immunoglobulin G1κ monoclonal antibody that binds to and neutralizes a majority of the subtypes of human interferon-α. Sifalimumab is being evaluated as a treatment for systemic lupus erythematosus (SLE). The primary objectives of this analysis were (a) to develop a population pharmacokinetic model for sifalimumab in SLE; (b) to identify and quantitate the impact of pa...... hiện toàn bộ
Cardiopulmonary Bypass and the Pharmacokinetics of Drugs
Springer Science and Business Media LLC - Tập 17 - Trang 10-26 - 2012
Cardiopulmonary bypass is accompanied by profound changes in the organism that may alter the pharmacokinetics of drugs. Drug distribution can be altered, for example, by changes in blood flow and by haemodilution, with a decrease in protein binding; a decrease in the elimination of some drugs can be caused by impairment of renal or hepatic clearance, due, for example, to lowered perfusion and hypo...... hiện toàn bộ
Pharmacokinetic Optimisation of the Treatment of Deep Vein Thrombosis
Springer Science and Business Media LLC - Tập 32 - Trang 145-172 - 2012
The current treatment for deep vein thrombosis is a 5-to 10-day course of heparin followed by 3 to 6 months of oral anticoagulants. Both heparin and oral anticoagulants present a high inter- and intra-individual variability and require individualisation and monitoring of their dosage. The pharmacokinetic properties of heparin have been difficult to assess through the radiolabelling procedures typi...... hiện toàn bộ
Comprehensive Measurements of Intrauterine and Postnatal Exposure to Lamotrigine
Springer Science and Business Media LLC - Tập 58 - Trang 535-543 - 2018
The aim of this study was to measure and investigate correlations of lamotrigine concentrations in maternal as well as umbilical cord blood, amniotic fluid, and breast milk to account for the distribution of the drug. Concentrations of lamotrigine were measured in 19 mother–infant pairs at the time of delivery. To account for the penetration ratio into amniotic fluid, cord blood and breast milk, t...... hiện toàn bộ
Effects of Enterai Feeding on the Oral Bioavailability of Moxifloxacin in Healthy Volunteers
Springer Science and Business Media LLC - Tập 44 - Trang 969-976 - 2012
Background and objective: Moxifloxacin is a new generation fluoroquinolone antimicrobial agent used worldwide. In clinical practice in intensive care units, moxifloxacin may be frequently administered through a nasogastric feeding tube. In the absence of an oral liquid formulation and since the multivalent cations contained in enterai feeds may potentially impair absorption of mox...... hiện toàn bộ
Liraglutide 3.0 mg for Weight Management: A Population Pharmacokinetic Analysis
Springer Science and Business Media LLC - Tập 55 - Trang 1413-1422 - 2016
This analysis used a population pharmacokinetic approach to identify covariates that influence plasma exposure of liraglutide 3.0 mg, a glucagon-like peptide-1 (GLP-1) receptor agonist approved for weight management in overweight and obese individuals. Samples for pharmacokinetic analysis were drawn at weeks 2, 12 and 28 of the phase IIIa SCALE Obesity and Prediabetes (N = 2339) and SCALE Diabetes...... hiện toàn bộ
Disease-Induced Variations in Plasma Protein Levels
Springer Science and Business Media LLC - Tập 19 Số 2 - Trang 147-159 - 1990
Pharmacokinetic Factors in the Adverse Cardiovascular Effects of Antipsychotic Drugs
Springer Science and Business Media LLC - Tập 43 Số 1 - Trang 33-56 - 2004
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