Springer Science and Business Media LLC

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Role of Cytochrome P450 Activity in the Fate of Anticancer Agents and in Drug Resistance
Springer Science and Business Media LLC - Tập 44 - Trang 349-366 - 2012
Bertrand Rochat
Although activity of cytochrome P450 isoenzymes (CYPs) plays a major role in the fate of anticancer agents in patients, there are relatively few clinical studies that evaluate drug metabolism with therapeutic outcome. Nevertheless, many clinical reports in various non-oncology fields have shown the dramatic importance of CYP activity in therapeutic efficacy, safety and interindividual variability ...... hiện toàn bộ
Pharmacokinetics and Pharmacodynamics of Intravenous Inotropic Agents
Springer Science and Business Media LLC - Tập 43 - Trang 187-203 - 2012
Lasse A. Lehtonen, Saila Antila, Pertti J. Pentikäinen
Positive inotropic drugs have various mechanisms of action. Long-term use of cyclic adenosine monophosphate (cAMP)-dependent drugs has adverse effects on the prognosis of heart failure patients, whereas digoxin has neutral effect on mortality. There are, however, little data on the effects of intravenous inotropic drugs on the outcome of patients. Intravenous inotropic agents are used to treat car...... hiện toàn bộ
Phenytoin and Carbamazepine Serum Protein Binding in a Geriatric Patient Population
Springer Science and Business Media LLC - Tập 9 - Trang 92-93 - 2012
Peter Gal, Karen S. Oles, Wallace H. Baird
Fleroxacin Clinical Pharmacokinetics
Springer Science and Business Media LLC - Tập 22 - Trang 116-131 - 2012
Andreas E. Stuck, Donbosco K. Kim, Felix J. Frey
Fleroxacin is a new member of the class of fluoroquinolones. The drug has good activity (i.e. minimum inhibitory concentrations at less than 2 mg/L against 90% of strains) against a wide range of Gram-positive and Gram-negative bacteria. High performance liquid chromatography is used to determine concentrations of fleroxacin and its metabolites in biological fluids. Absorption of orally ingested d...... hiện toàn bộ
Population Pharmacokinetic Analysis of Denosumab in Patients with Bone Metastases from Solid Tumours
Springer Science and Business Media LLC - Tập 51 - Trang 247-260 - 2012
Leonid Gibiansky, Liviawati Sutjandra, Sameer Doshi, Jenny Zheng, Winnie Sohn, Mark C. Peterson, Graham R. Jang, Andrew T. Chow, Juan José Pérez-Ruixo
Denosumab (XGEVA®; AMG 162) is a fully human IgG2 monoclonal antibody, which binds to the receptor activator of nuclear factor K-B ligand (RANKL) and prevents terminal differentiation, activation and survival of osteoclasts. We aimed to characterize the population pharmacokinetics of denosumab in patients with advanced solid tumours and bone metastases. A total of 14 228 free serum concentrations ...... hiện toàn bộ
Successful Use of [14C]Paracetamol Microdosing to Elucidate Developmental Changes in Drug Metabolism
Springer Science and Business Media LLC - Tập 56 - Trang 1185-1195 - 2017
Miriam G. Mooij, Esther van Duijn, Catherijne A. J. Knibbe, Karel Allegaert, Albert D. Windhorst, Joost van Rosmalen, N. Harry Hendrikse, Dick Tibboel, Wouter H. J. Vaes, Saskia N. de Wildt
We previously showed the practical and ethical feasibility of using [14C]-microdosing for pharmacokinetic studies in children. We now aimed to show that this approach can be used to elucidate developmental changes in drug metabolism, more specifically, glucuronidation and sulfation, using [14C]paracetamol (AAP). Infants admitted to the intensive care unit received a single oral [14C]AAP microdose ...... hiện toàn bộ
Population Pharmacokinetic Modeling of Inebilizumab in Subjects with Neuromyelitis Optica Spectrum Disorders, Systemic Sclerosis, or Relapsing Multiple Sclerosis
Springer Science and Business Media LLC - Tập 61 - Trang 387-400 - 2021
Li Yan, Holly Kimko, Bing Wang, Daniel Cimbora, Eliezer Katz, William A. Rees
Inebilizumab is a humanized, affinity-optimized, afucosylated immunoglobulin (Ig)-G1κ monoclonal antibody that binds to CD19, resulting in effective depletion of peripheral B cells. It is being developed to treat various autoimmune diseases, including neuromyelitis optica spectrum disorders (NMOSD), systemic sclerosis (SSc), and relapsing multiple sclerosis (MS). Pharmacokinetic data from a pivot...... hiện toàn bộ
Clinical Pharmacology of Brigatinib: A Next-Generation Anaplastic Lymphoma Kinase Inhibitor
Springer Science and Business Media LLC - Tập 62 - Trang 1063-1079 - 2023
Neeraj Gupta, Michael J. Hanley, Robert J. Griffin, Pingkuan Zhang, Karthik Venkatakrishnan, Vikram Sinha
Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor designed to overcome mechanisms of resistance associated with crizotinib, is approved for the treatment of ALK-positive advanced or metastatic non-small cell lung cancer. After oral administration of single doses of brigatinib 30–240 mg, the median time to reach maximum plasma concentration ranged from 1 to 4 h. In patients w...... hiện toàn bộ
Clinical Pharmacokinetics of Valproic Acid — 1988
Springer Science and Business Media LLC - Tập 15 - Trang 367-389 - 2012
Gaetano Zaccara, Andrea Messori, Flavio Moroni
Sodium valproate (valproic acid) has been widely used in the last decade and is now considered a relatively safe and effective anticonvulsant agent. Recently, several investigators have proposed its use in the treatment of anxiety, alcoholism and mood disorders, although these indications require further clinical studies. Valproic acid is available in different oral formulations such as solutions,...... hiện toàn bộ
Clinical Significance of Pharmacokinetic Models of Hepatic Elimination
Springer Science and Business Media LLC - Tập 18 Số 1 - Trang 61-76 - 1990
Denis J. Morgan, Richard A. Smallwood
Tổng số: 2,492   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10