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PET/CT imaging for tumour response assessment to immunotherapy: current status and future directions
Springer Science and Business Media LLC - Tập 4 - Trang 1-13 - 2020
Recent immunotherapeutic approaches have evolved as powerful treatment options with high anti-tumour responses involving the patient’s own immune system. Passive immunotherapy applies agents that enhance existing anti-tumour responses, such as antibodies against immune checkpoints. Active immunotherapy uses agents that direct the immune system to attack tumour cells by targeting tumour antigens. A......
Whole-body x-ray dark-field radiography of a human cadaver
Springer Science and Business Media LLC - Tập 5 - Trang 1-9 - 2021
Grating-based x-ray dark-field and phase-contrast imaging allow extracting information about refraction and small-angle scatter, beyond conventional attenuation. A step towards clinical translation has recently been achieved, allowing further investigation on humans. After the ethics committee approval, we scanned the full body of a human cadaver in anterior-posterior orientation. Six measurements......
Photon-counting detector CT-based virtual monoenergetic reconstructions: repeatability and reproducibility of radiomics features of an organic phantom and human myocardium
Springer Science and Business Media LLC - Tập 7 - Trang 1-11 - 2023
Photon-counting detector computed tomography (PCD-CT) may influence imaging characteristics for various clinical conditions due to higher signal and contrast-to-noise ratio in virtual monoenergetic images (VMI). Radiomics analysis relies on quantification of image characteristics. We evaluated the impact of different VMI reconstructions on radiomic features in in vitro and in vivo PCD-CT datasets.......
Effect of CT imaging on the accuracy of the finite element modelling in boneAbstract The finite element (FE) analysis is a highly promising tool to simulate the behaviour of bone. Skeletal FE models in clinical routine rely on the information about the geometry and bone mineral density distribution from quantitative computed tomography (CT) imaging systems. Several parameters in CT imaging have been reported to affect the accuracy of FE mod... ...
Springer Science and Business Media LLC - - 2020
Improved precision of noise estimation in CT with a volume-based approach
Springer Science and Business Media LLC - Tập 5 - Trang 1-7 - 2021
Assessment of image noise is a relevant issue in computed tomography (CT). Noise is routinely measured by the standard deviation of density values (Hounsfield units, HU) within a circular region of interest (ROI). We explored the effect of a spherical volume of interest (VOI) on noise measurements. Forty-nine chronic obstructive pulmonary disease patients underwent CT with clinical protocol (regul......
Multiparametric prostate MRI quality assessment using a semi-automated PI-QUAL software program
Springer Science and Business Media LLC - Tập 5 - Trang 1-8 - 2021
The technical requirements for the acquisition of multiparametric magnetic resonance imaging (mpMRI) of the prostate have been clearly outlined in the Prostate Imaging Reporting and Data System (PI-RADS) guidelines, but there is still huge variability in image quality among centres across the world. It has been difficult to quantify what constitutes a good-quality image, and a first attempt to add......
Multiparametric quantitative and texture 18F-FDG PET/CT analysis for primary malignant tumour grade differentiation
Springer Science and Business Media LLC - Tập 3 - Trang 1-8 - 2019
18F-FDG positron emission tomography/computed tomography (PET/CT) is a successfully used imaging modality in oncology. The aim of the study was to investigate a connection of epithelial tumour differentiation grade with both semiquantitative and quantitative metabolic PET data focusing on creation of multiparametric model of tumour grade prediction utilising both standardised uptake value-based an......
Shallow and deep learning classifiers in medical image analysis
Springer Science and Business Media LLC - - 2024
An increasingly strong connection between artificial intelligence and medicine has enabled the development of predictive models capable of supporting physicians’ decision-making. Artificial intelligence encompasses much more than machine learning, which nevertheless is its most cited and used sub-branch in the last decade. Since most clinical problems can be modeled through machine learning classi......
Experimental application of an automated alignment correction algorithm for geological CT imaging: phantom study and application to sediment cores from cold-water coral mounds
Springer Science and Business Media LLC - Tập 3 - Trang 1-8 - 2019
In computed tomography (CT) quality assurance, alignment of image quality phantoms is crucial for quantitative and reproducible evaluation and may be improved by alignment correction. Our goal was to develop an alignment correction algorithm to facilitate geological sampling of sediment cores taken from a cold-water coral mount. An alignment correction algorithm was developed and tested with a CT ......
Concentrations and pharmacokinetic parameters of MRI and SPECT hepatobiliary agents in rat liver compartments
Springer Science and Business Media LLC - Tập 5 - Trang 1-10 - 2021
In hepatobiliary imaging, systems detect the total amount of agents originating from extracellular space, bile canaliculi, and hepatocytes. They add in situ concentration of each compartment corrected by its respective volume ratio to provide liver concentrations. In vivo contribution of each compartment to liver concentration is inaccessible. Our aim was to quantify the compartmental distribution......
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