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Cơ quản chủ quản: BioMed Central Ltd.
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NeurologyNeurology (clinical)
Phân tích ảnh hưởng
Các bài báo tiêu biểu
The role of inflammation in epileptogenesis
- 2020
AbstractEpilepsy is a chronic neurological disorder that has an extensive impact
on a patient’s life. Accumulating evidence has suggested that inflammation
participates in the progression of spontaneous and recurrent seizures.
Pro-convulsant incidences can stimulate immune cells, augment the release of
pro-inflammatory cytokines, elicit neuronal excitation as well as blood-brain
barrier (BBB) dysf...
Pathogenesis of seizures and epilepsy after stroke
Tập 4 Số 1
AbstractStroke is the most frequent cause of secondary epilepsy in the elderly.
The incidence of cerebral stroke is increasing with the extension of life
expectancy, and the prevalence of post-stroke epilepsy (PSE) is rising. There
are various seizure types after stroke, and the occurrence of epilepsy is
closely related to the type and location of stroke. Moreover, the clinical
treatment of post-s...
HMGB1, neuronal excitability and epilepsy
Tập 3 Số 1 - 2021
AbstractEpilepsy is a common neurological disease caused by synchronous firing
of hyperexcitable neurons. Currently, anti-epileptic drugs remain the main
choice to control seizure, but 30% of patients are resistant to the drugs, which
calls for more research on new promising targets. Neuroinflammation is closely
associated with the development of epilepsy. As an important inflammatory
factor, high...
Differential diagnosis between epileptic seizures and psychogenic nonepileptic seizures based on semiology
- 2019
Abstract Psychogenic nonepileptic seizures present as paroxysmal symptoms and
signs mimicking epileptic seizures. The gold standard test is the synchronous
recording by video, electrocardiogram and electroencephalogram. However, video
electroencephalogram is not available at many centers and not entirely
independent of semiology. Recent studies have focused on semiological
characteristics distingu...
The role of the TNFα-mediated astrocyte signaling pathway in epilepsy
- 2021
AbstractEpilepsy is a common disease in the central nervous system. There is
growing evidence that epilepsy is associated with glial cells, including
astrocytes. Tumor necrosis factor α (TNFα) is a “master regulator” of
proinflammatory cytokine production and is secreted by microglia and astrocytes.
TNFα secreted by microglia can activate astrocytes. Additionally, TNFα can
regulate neuron activit...
Long-term outcomes and prognosis factors of vagus nerve stimulation in patients with refractory epilepsy
Abstract Background Vagus nerve stimulation (VNS) is an effective treatment for
patients with refractory epilepsy, yet with varied predictive factors and
heterogeneous long-term outcomes. Adjustment of VNS parameters is critical for
obtaining favorable efficacy. In this study, we aimed to investigate the
long-term outcomes and the possible predictive factors of VNS in patients with
refractory epil...
Epilepsy control during an epidemic: emerging approaches and a new management framework
Tập 2 Số 1 - 2020
AbstractEpidemics are a big threat to world health. The ongoing pandemic of
corona virus disease 2019 (COVID-19) has caused a series of challenges to public
health. One such challenge is the management of chronic diseases such as
epilepsy during an epidemic event. Studies on this topic are rather limited and
the related medical practice is full of uncertainty. Here we review recent
development of ...
Effects of febrile seizures in mesial temporal lobe epilepsy with hippocampal sclerosis on gene expression using bioinformatical analysis
Tập 2 Số 1 - 2020
AbstractBackgroundTo investigate the effect of long-term febrile convulsions on
gene expression in mesial temporal lobe epilepsy with hippocampal sclerosis
(MTLE-HS) and explore the molecular mechanism of MTLE-HS.MethodsMicroarray data
of MTLE-HS were obtained from the Gene Expression Omnibus database.
Differentially expressed genes (DEGs) between MTLE-HS with and without febrile
seizure history w...
Arbovirus and seizures
- 2020
AbstractThe high prevalence and spread of arthropod-borne viruses (arboviruses)
make them an important cause of viral encephalitis in humans. Most epidemic
viral encephalitides have an etiology associated with arboviruses. Among various
arboviruses, the Japanese encephalitis virus, West Nile virus, Zika virus,
Dengue virus and Chikungunya virus can induce seizures. Arboviruses of the genus
Flavivi...
RHOBTB2 gene associated epilepsy and paroxysmal movement disorder: two cases report and literature review
Tập 3 Số 1 - 2021
Abstract Background RHOBTB2 gene is associated with developmental and epileptic
encephalopathy-64(DEE-64), which is characterized by epilepsy, developmental
delay, microcephaly, unspecific facial dysmorphism, and paroxysmal movement
disorders. Most previous studies showed that the phenotypes of RHOBTB2 gene
include developmental and epileptic encephalopathy(DEE) and DEE with paroxysmal
movement di...