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Monocytic expression of CD14 and CD18, circulating adhesion molecules and inflammatory markers in women with diabetes mellitus and impaired glucose tolerance
Springer Science and Business Media LLC - Tập 47 - Trang 1948-1952 - 2004
L. Fogelstrand, J. Hulthe, L. M. Hultén, O. Wiklund, B. Fagerberg
Type 2 diabetes is a major risk factor for cardiovascular disease. Monocyte recruitment and inflammatory activation are crucial steps in the development of atherosclerosis and several receptors are involved in these processes. The aim of this study was to investigate levels of CD14 and the β2-integrin subunits CD11b and CD18 on monocytes from women with diabetes or impaired glucose tolerance. A po... hiện toàn bộ
Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes
Springer Science and Business Media LLC - Tập 55 - Trang 226-235 - 2011
N. Malandrino, W. C. Wu, T. H. Taveira, H. B. Whitlatch, R. J. Smith
Red blood cell distribution width (RDW) has been reported to be a risk marker of morbidity and mortality for cardiovascular disease in various study populations. However, no studies have investigated the relationship between RDW and diabetes complications. We therefore evaluated RDW as a marker of macrovascular and microvascular complications in a nationally representative sample of the adult diab... hiện toàn bộ
Type 2 diabetes impairs pulmonary function in morbidly obese women: a case–control study
Springer Science and Business Media LLC - Tập 53 - Trang 1210-1216 - 2010
A. Lecube, G. Sampol, X. Muñoz, C. Hernández, J. Mesa, R. Simó
To determine whether the presence of type 2 diabetes and the degree of metabolic control are related to reduced pulmonary function in obese individuals. Seventy-five morbidly obese women (25 with type 2 diabetes [cases]—and 50 without diabetes [controls]) with a history of non-smoking and without prior cardiovascular or respiratory disease were prospective recruited for a case–control study in the... hiện toàn bộ
Spatial distribution of early red lesions is a risk factor for development of vision-threatening diabetic retinopathy
Springer Science and Business Media LLC - Tập 60 - Trang 2361-2367 - 2017
Giovanni Ometto, Phil Assheton, Francesco Calivá, Piotr Chudzik, Bashir Al-diri, Andrew Hunter, Toke Bek
Diabetic retinopathy is characterised by morphological lesions related to disturbances in retinal blood flow. It has previously been shown that the early development of retinal lesions temporal to the fovea may predict the development of treatment-requiring diabetic maculopathy. The aim of this study was to map accurately the area where lesions could predict progression to vision-threatening retin... hiện toàn bộ
Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver
Springer Science and Business Media LLC - Tập 47 - Trang 1149-1156 - 2004
P. Iozzo, R. Lautamaki, F. Geisler, K. A. Virtanen, V. Oikonen, M. Haaparanta, H. Yki-Jarvinen, E. Ferrannini, J. Knuuti, P. Nuutila
We investigated the effect of elevated circulating NEFA on insulin-mediated hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male subjects. Studies were performed using positron emission tomography (PET) and [18F]-2-fluoro-2-deoxyglucose ([18F]FDG) during euglycaemic hyperinsulinaemia (0–120 min) and an Intralipid/heparin infusion (IL/Hep; −90–120 min). On a differ... hiện toàn bộ
DNA damage by the glycation products of glyceraldehyde 3-phosphate and lysine
Springer Science and Business Media LLC - Tập 37 - Trang 145-149 - 1994
E. A. Mullokandov, W. A. Franklin, M. Brownlee
In order to evaluate whether base modifications, apurinic/apyrimidinic site formation, strand breaks, or a combination of these lesions results from the interaction of glycation products with DNA, plasmid DNA was first reacted with these products, and then subjected to digestion with endonuclease III and endonuclease IV of Escherichia coli. Analysis of the differential effects of digestions with t... hiện toàn bộ
Elevated nocturnal NEFA are an early signal for hyperinsulinaemic compensation during diet-induced insulin resistance in dogs
Springer Science and Business Media LLC - Tập 58 - Trang 2663-2670 - 2015
Josiane L. Broussard, Cathryn M. Kolka, Ana V. B. Castro, Isaac Asare Bediako, Rebecca L. Paszkiewicz, Edward W. Szczepaniak, Lidia S. Szczepaniak, Kristen L. Knutson, Stella P. Kim, Richard N. Bergman
A normal consequence of increased energy intake and insulin resistance is compensatory hyperinsulinaemia through increased insulin secretion and/or reduced insulin clearance. Failure of compensatory mechanisms plays a central role in the pathogenesis of type 2 diabetes mellitus; consequently, it is critical to identify in vivo signal(s) involved in hyperinsulinaemic compensation. We have previousl... hiện toàn bộ
Insulin and insulin receptors in rodent brain
Springer Science and Business Media LLC - Tập 20 - Trang 268-273 - 1981
Jana Havrankova, M. Brownstein, J. Roth
While insulin effects on the central nervous system (CNS) mediated through hypoglycaemia are well known, direct insulin effects on the CNS remain controversial. Recently, we found insulin receptors in all areas of the rat brain, with highest concentrations in the olfactory bulb, cerebral cortex and hypothalamus; all areas involved in feeding. Insulin receptors in brain were, by multiple criteria, ... hiện toàn bộ
The use of B-type natriuretic peptide in the management of patients with diabetes and acute dyspnoea
Springer Science and Business Media LLC - Tập 49 - Trang 629-636 - 2006
C. Mueller, K. Laule-Kilian, A. Christ, A. P. Perruchoud
The aim of this study was to determine the impact of measurement of B-type natriuretic peptide (BNP) levels on the management of patients with diabetes presenting with acute dyspnoea. This study evaluated the subgroup of 103 patients with diabetes included in the B-type Natriuretic Peptide for Acute Shortness of Breath Evaluation (BASEL) study (n=452). Patients were randomly assigned to a diagnost... hiện toàn bộ
Observations on the structure and function of liver in indian diabetics
Springer Science and Business Media LLC - Tập 6 Số 1 - Trang 21-26 - 1970
H Vaishnava, Pooja Manchanda Gulati, V. N. Damodaran
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