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High levels of blood circulating immune checkpoint molecules in children with new-onset type 1 diabetes are associated with the risk of developing an additional autoimmune disease
Springer Science and Business Media LLC - Tập 65 - Trang 1390-1397 - 2022
Sara Bruzzaniti, Erica Piemonte, Enza Mozzillo, Dario Bruzzese, Maria Teresa Lepore, Fortunata Carbone, Paola de Candia, Rocky Strollo, Antonio Porcellini, Marco Marigliano, Claudio Maffeis, Maurizio Bifulco, Johnny Ludvigsson, Adriana Franzese, Giuseppe Matarese, Mario Galgani
We assessed the levels of blood circulating immune checkpoint molecules (ICMs) at diagnosis of type 1 diabetes, and determined their association with the risk of developing an additional autoimmune disorder over time. Children with new-onset type 1 diabetes (n = 143), without biological and/or clinical signs of additional autoimmune disorders, and healthy children (n = 75) were enrolled, and blood...... hiện toàn bộ
Hypomagnesaemia in IDDM patients with microalbuminuria and clinical proteinuria
Springer Science and Business Media LLC - Tập 37 - Trang 639-639 - 1994
J. C. Pickup
Introduction by workshop editors
Springer Science and Business Media LLC - Tập 10 - Trang 491-491 - 1974
Albert E. Renold, Albert Y. Chang, Walter A. Muller
Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells
Springer Science and Business Media LLC - Tập 64 - Trang 1422-1435 - 2021
Nima Purvis, Sweta Kumari, Dhananjie Chandrasekera, Jayanthi Bellae Papannarao, Sophie Gandhi, Isabelle van Hout, Sean Coffey, Richard Bunton, Ramanen Sugunesegran, Dominic Parry, Philip Davis, Michael J. A. Williams, Andrew Bahn, Rajesh Katare
Diabetes mellitus causes a progressive loss of functional efficacy in stem cells, including cardiac progenitor cells (CPCs). The underlying molecular mechanism is still not known. MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate genes at the post-transcriptional level. We aimed to determine if diabetes mellitus induces dysregulation of miRNAs in CPCs and to test if in vitro the...... hiện toàn bộ
A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of langerhans
Springer Science and Business Media LLC - Tập 21 - Trang 470-475 - 1981
A. M. Scott, I. Atwater, E. Rojas
A method has been developed for the simultaneous measurement of insulin release and electrical activity in single micro-dissected mouse islets of Langerhans. The effects of D-glucose have been studied in individual islets. Each islet was exposed to 0, 5.6, 11.1, 16.7, 22.2, 27.8 and 33.3 mmol/l glucose in a stepwise fashion. The minimum glucose concentration required to elicit spike activity is lo...... hiện toàn bộ
Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production
Springer Science and Business Media LLC - Tập 59 - Trang 1938-1947 - 2016
Francesca Semplici, Angeles Mondragon, Benedict Macintyre, Katja Madeyski-Bengston, Anette Persson-Kry, Sara Barr, Anna Ramne, Anna Marley, James McGinty, Paul French, Helen Soedling, Ryohsuke Yokosuka, Julien Gaitan, Jochen Lang, Stephanie Migrenne-Li, Erwann Philippe, Pedro L. Herrera, Christophe Magnan, Gabriela da Silva Xavier, Guy A. Rutter
Per-Arnt-Sim kinase (PASK) is a nutrient-regulated domain-containing protein kinase previously implicated in the control of insulin gene expression and glucagon secretion. Here, we explore the roles of PASK in the control of islet hormone release, by generating mice with selective deletion of the Pask gene in pancreatic beta or alpha cells. Floxed alleles of Pask were produced by homologous recomb...... hiện toàn bộ
Insulin resistance, compensatory hyperinsulinaemia, and coronary heart disease
Springer Science and Business Media LLC - - 1994
G. M. Reaven, A. Laws
Is fasting glucose sufficient to define diabetes? Epidemiological data from 20 European studies
Springer Science and Business Media LLC - Tập 42 - Trang 647-654 - 1999
The DECODE-study group on behalf of the European Diabetes Epidemiology Group
Aims/hypothesis. The World Health Organisation Consultation recommended new diagnostic criteria for diabetes mellitus including: lowering of the diagnostic fasting plasma glucose to 7.0 mmol/l and introduction of a new category: impaired fasting glycaemia. The diagnostic 2-h glucose concentrations for diabetes and for impaired glucose tolerance were unchanged. This study identifie...... hiện toàn bộ
Analysis of overlapping genetic association in type 1 and type 2 diabetes
Springer Science and Business Media LLC - Tập 64 Số 6 - Trang 1342-1347 - 2021
Jamie Inshaw, Carlo Sidore, Francesco Cucca, M. Irina Stefana, Crouch Djm., Mark McCarthy, Anubha Mahajan, John A. Todd
Abstract Aims/hypothesis Given the potential shared aetiology between type 1 and type 2 diabetes, we aimed to identify any genetic regions associated with both diseases. For associations where there is a shared signal and the allele that increases risk to one disease also increases risk to the other...... hiện toàn bộ
Endotrophin, a multifaceted player in metabolic dysregulation and cancer progression, is a predictive biomarker for the response to PPARγ agonist treatment
Springer Science and Business Media LLC - - 2017
Kai Sun, Jiyoung Park, Min Kim, Philipp E. Scherer
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