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Real-world Management of CML: Outcomes and Treatment Patterns
Springer Science and Business Media LLC - Tập 18 - Trang 167-175 - 2023
Nicole Held, Ehab L. Atallah
Chronic myeloid leukemia (CML) is a disease that previously signified a poor prognosis, but treatment options and outcomes have improved over the last several decades. Despite this, challenges remain in optimal management in clinical practice, as the characteristics in trial populations differ from patients who are treated in a real-world setting. This review describes recent updates in real-world...... hiện toàn bộ
MRD in ALL: Optimization and Innovations
Springer Science and Business Media LLC - Tập 17 - Trang 69-81 - 2022
Eric Pierce, Benjamin Mautner, Joseph Mort, Anastassia Blewett, Amy Morris, Michael Keng, Firas El Chaer
Measurable residual disease (MRD) is an important monitoring parameter that can help predict survival outcomes in acute lymphoblastic leukemia (ALL). Identifying patients with MRD has the potential to decrease the risk of relapse with the initiation of early salvage therapy and to help guide decision making regarding allogeneic hematopoietic cell transplantation. In this review, we discuss MRD in ...... hiện toàn bộ
Treatment of Childhood Acute Lymphoblastic Leukemia: Prognostic Factors and Clinical Advances
Springer Science and Business Media LLC - Tập 11 - Trang 385-394 - 2016
Lynda M. Vrooman, Lewis B. Silverman
While the majority of children and adolescents with newly diagnosed childhood acute lymphoblastic leukemia (ALL) will be cured, as many as 20 % of patients will experience relapse. On current treatment regimens, the intensity of upfront treatment is stratified based upon prognostic factors with the aim of improving cure rates (for those at the highest risk of relapse) and minimizing treatment-rela...... hiện toàn bộ
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Springer Science and Business Media LLC - Tập 2 - Trang 65-65 - 2007
Immunotherapies Old and New: Hematopoietic Stem Cell Transplant, Chimeric Antigen Receptor T Cells, and Bispecific Antibodies for the Treatment of Relapsed/Refractory Diffuse Large B Cell Lymphoma
Springer Science and Business Media LLC - - 2021
Anupama Doraiswamy, Mansi Shah, Rajat Bannerji
Novel Therapies in the Treatment of Adult Acute Lymphoblastic Leukemia
Springer Science and Business Media LLC - Tập 15 - Trang 294-304 - 2020
Alexander Gavralidis, Andrew M. Brunner
Acute lymphoblastic leukemia (ALL) is a rare hematologic malignancy. Advances in multi-agent chemotherapy have resulted in dramatic improvements in the number of pediatric cases that result in a cure; however, until recently, treatment options for older adults or patients with relapsed and refractory disease were extremely limited. This review seeks to describe in greater detail a number of emergi...... hiện toàn bộ
Treatment of MDS/MPN and the MDS/MPN IWG International Trial: ABNL MARRO
Springer Science and Business Media LLC - Tập 14 - Trang 543-549 - 2019
Andrew T. Kuykendall, Eric Padron
MDS/MPNs comprise a group of rare hematologic malignancies that balance features of myeloproliferation and bone marrow failure. Given overlapping clinical features and rarity of incidence, MDS/MPNs have long posed a diagnostic and therapeutic challenge. Herein, we sought to review recent advances in diagnosis and emerging therapeutic strategies and highlight the upcoming ABNL MARRO study which aim...... hiện toàn bộ
Standardizing the Initial Evaluation for Myelodysplastic Syndromes
Springer Science and Business Media LLC - Tập 8 - Trang 361-369 - 2013
Danielle Marshall, Gail J. Roboz
The myelodysplastic syndromes (MDS) pose a unique diagnostic challenge for clinicians and pathologists due to the clinicopathologic heterogeneity of the disease and overlapping features with other benign and malignant disorders. Currently, the initial evaluation of a patient with suspected MDS centers around a detailed medical history, review of the peripheral blood and bone marrow by an expert he...... hiện toàn bộ
Molecular Testing in Patients with Suspected Myelodysplastic Syndromes
Springer Science and Business Media LLC - Tập 11 - Trang 441-448 - 2016
Tamara K. Moyo, Michael R. Savona
Myelodysplastic syndromes (MDS) comprise a heterogeneous group of clonal hematologic malignancies characterized by a hypercellular bone marrow and morphologic dysplasia in one or more lineage (i.e., myeloid, erythroid, or megakaryocytic), presenting clinically with leukopenia, anemia, and/or thrombocytopenia and with a propensity to transform to acute myelogenous leukemia. Newer technologies such ...... hiện toàn bộ
Hydroxyurea: The drug of choice for polycythemia vera and essential thrombocythemia
Springer Science and Business Media LLC - Tập 1 - Trang 69-74 - 2006
David Dingli, Ayalew Tefferi
Hydroxyurea is an old drug that is often used to control essential thrombocythemia and polycythemia vera in patients with high-risk disease. It is usually well tolerated and cheap and has been proven effective in many studies for the prevention of thrombohemorrhagic complications associated with these disorders. However, many clinicians are reluctant to use it because of the perceived risk of prog...... hiện toàn bộ
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