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Real-world Management of CML: Outcomes and Treatment Patterns
Springer Science and Business Media LLC - Tập 18 - Trang 167-175 - 2023
Nicole Held, Ehab L. Atallah
Chronic myeloid leukemia (CML) is a disease that previously signified a poor prognosis, but treatment options and outcomes have improved over the last several decades. Despite this, challenges remain in optimal management in clinical practice, as the characteristics in trial populations differ from patients who are treated in a real-world setting. This review describes recent updates in real-world...... hiện toàn bộ
MRD in ALL: Optimization and Innovations
Springer Science and Business Media LLC - Tập 17 - Trang 69-81 - 2022
Eric Pierce, Benjamin Mautner, Joseph Mort, Anastassia Blewett, Amy Morris, Michael Keng, Firas El Chaer
Measurable residual disease (MRD) is an important monitoring parameter that can help predict survival outcomes in acute lymphoblastic leukemia (ALL). Identifying patients with MRD has the potential to decrease the risk of relapse with the initiation of early salvage therapy and to help guide decision making regarding allogeneic hematopoietic cell transplantation. In this review, we discuss MRD in ...... hiện toàn bộ
Novel Therapies in the Treatment of Adult Acute Lymphoblastic Leukemia
Springer Science and Business Media LLC - Tập 15 - Trang 294-304 - 2020
Alexander Gavralidis, Andrew M. Brunner
Acute lymphoblastic leukemia (ALL) is a rare hematologic malignancy. Advances in multi-agent chemotherapy have resulted in dramatic improvements in the number of pediatric cases that result in a cure; however, until recently, treatment options for older adults or patients with relapsed and refractory disease were extremely limited. This review seeks to describe in greater detail a number of emergi...... hiện toàn bộ
Treatment of MDS/MPN and the MDS/MPN IWG International Trial: ABNL MARRO
Springer Science and Business Media LLC - Tập 14 - Trang 543-549 - 2019
Andrew T. Kuykendall, Eric Padron
MDS/MPNs comprise a group of rare hematologic malignancies that balance features of myeloproliferation and bone marrow failure. Given overlapping clinical features and rarity of incidence, MDS/MPNs have long posed a diagnostic and therapeutic challenge. Herein, we sought to review recent advances in diagnosis and emerging therapeutic strategies and highlight the upcoming ABNL MARRO study which aim...... hiện toàn bộ
Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia
Springer Science and Business Media LLC - Tập 14 Số 2 - Trang 94-105 - 2019
Merli, Pietro, Algeri, Mattia, Del Bufalo, Francesca, Locatelli, Franco
The remarkable improvement in the prognosis of children with acute lymphoblastic leukemia (ALL) has been mainly achieved through the administration of risk-adapted therapy, including allogeneic hematopoietic stem cell transplantation (HSCT). This paper reviews the current indications to HSCT in ALL children, as well as the type of donor and conditioning regimens commonly used. Finally, it will foc...... hiện toàn bộ
Extranodal NK/T Cell Lymphoma, Nasal Type (ENKTL-NT): An Update on Epidemiology, Clinical Presentation, and Natural History in North American and European Cases
Springer Science and Business Media LLC - Tập 11 - Trang 514-527 - 2016
Bradley M. Haverkos, Zenggang Pan, Alejandro A. Gru, Aharon G. Freud, Rachel Rabinovitch, Meng Xu-Welliver, Brad Otto, Carlos Barrionuevo, Robert A. Baiocchi, Rosemary Rochford, Pierluigi Porcu
Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT) is an aggressive extranodal non-Hodgkin lymphoma most commonly occurring in East Asia and Latin America but with increasing incidence in the United States. Data on epidemiology, disease presentation, and outcome for European and North American (“Western”) cases are very limited. We review published landmark clinical studies on ENKTL-NT in the We...... hiện toàn bộ
“Antivirals” in the Treatment of Adult T Cell Leukaemia– Lymphoma (ATLL)
Springer Science and Business Media LLC - Tập 7 - Trang 267-275 - 2012
Paul A. Fields, Graham P. Taylor
Adult T cell leukaemia / lymphoma (ATLL) is a mature (post thymic) T cell lymphoma caused by the human T-lymphotropic virus type 1 (HTLV-1) infection. Overall survival in the aggressive subtypes (Acute Leukaemia and Lymphomatous) remains poor in part due to chemotherapy resistance. To improve treatment outcome for de novo disease, better induction therapies are required and since the pathogenic ag...... hiện toàn bộ
The Role of Autologous Transplantation in Hodgkin Lymphoma
Springer Science and Business Media LLC - Tập 6 - Trang 172-179 - 2011
Bastian von Tresckow, Andreas Engert
Between 80% and 90% of Hodgkin lymphoma (HL) patients can be cured with up-to-date combined-modality treatments, but patients with disease refractory to first-line therapy and those who relapse after first-line therapy still have a relatively poor prognosis. Dose intensification with stem cell support has been evaluated both to avoid relapses and to cure patients with refractory or relapsed diseas...... hiện toàn bộ
Circulating Tumor DNA in Lymphoma
Springer Science and Business Media LLC - Tập 17 - Trang 298-305 - 2022
Swetha Kambhampati, Jasmine Zain
Recent advances have been made in circulating tumor DNA (ctDNA), the method to minimally invasive detect lymphoma sensitively with tumor-derived DNA in the blood of patients with lymphomas. This article discusses these various methods of ctDNA detection and the clinical context in which they have been applied to for a variety of lymphoma subtypes. ctDNA has been applied to a variety of subtypes of...... hiện toàn bộ
Immunotherapeutic Approaches for Multiple Myeloma: Where Are We Now?
Springer Science and Business Media LLC - Tập 14 - Trang 1-10 - 2019
Myo Htut
The treatment landscape for multiple myeloma has evolved rapidly with the availability of multiple new drugs; however, although patient survival has improved, the disease remains incurable. Multiple myeloma is characterized by the unregulated growth of malignant plasma cells accompanied by immune dysfunction as well as disrupted immune surveillance mechanisms. Here, we analyze clinical modalities,...... hiện toàn bộ
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