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The impact of diabetes on heart failure: Opportunities for intervention
Springer Science and Business Media LLC - Tập 4 - Trang 70-77 - 2007
The pathophysiologic processes of diabetes mellitus and heart failure are likely interrelated. In particular, hyperglycemia and insulin resistance can induce myocardial contractile systolic and diastolic abnormalities at the cellular level. Furthermore, patients with heart failure and concomitant diabetes mellitus are more likely to have underlying comorbid conditions resulting in greater vulnerab......
Multiple renin-angiotensin-aldosterone-blocking agents in heart failure: How much is too much?
Springer Science and Business Media LLC - Tập 6 - Trang 112-116 - 2009
Angiotensin-converting enzyme inhibitors (ACE-Is) and β-adrenergic receptor blockers (BBs) have been effective in reducing cardiovascular morbidity and mortality in patients with heart failure (HF) and left ventricular systolic dysfunction (LVSD). Angiotensin receptor blockers and aldosterone blockers have also been shown to be effective. Although ACE-Is and BBs remain the therapies of choice for ......
Hospital to Home with Mechanical Circulatory Support
Springer Science and Business Media LLC - Tập 10 - Trang 212-218 - 2013
Mechanical circulatory support (MCS) is becoming the mainstay of therapy for patients with advanced heart failure, both for patients needing support as a bridge to transplantation and for those who require the device as a destination therapy. As more and more devices are implanted, there is a need to address effective discharge planning, arrange appropriate follow-up, anticipate and address compli......
Exploring the Microbiome in Heart Failure
Springer Science and Business Media LLC - Tập 13 - Trang 103-109 - 2016
Recent years have brought interesting insights into the human gut microbiota and have highlighted its increasingly recognized impact on cardiovascular (CV) diseases, including heart failure (HF). Changes in composition of gut microbiota, called dysbiosis, can trigger systemic inflammation, which is known to be involved in the pathophysiology of HF. Trimethylamine N-oxide (TMAO), which is derived f......
Impact of Loop Diuretic on Outcomes in Patients with Heart Failure and Reduced Ejection Fraction
Springer Science and Business Media LLC - Tập 19 - Trang 15-25 - 2022
Loop diuretics are the cornerstone of the treatment of congestion in heart failure patients. The manuscript aims to summarize the most updated information regarding the use of loop diuretics in heart failure. Diuretic response can be highly variable between patients and needs to be carefully evaluated during and after the hospitalization. Diuretic resistance can lead to residual congestion which a......
Thyroid Dysfunction and Heart Failure: Mechanisms and Associations
Springer Science and Business Media LLC - Tập 14 - Trang 48-58 - 2017
The purpose of this review is to provide an update on the current knowledge of the pathophysiology, the mechanisms, and the cardiovascular impact of the different stages of thyroid dysfunction (TD) in heart failure (HF) patients. The influence of thyroid hormones (THs) on the cardiovascular system involves the regulation of key processes related to maintenance of cardiac function; however, there a......
The Approach to the Psychosocial Evaluation of Cardiac Transplant and Mechanical Circulatory Support Candidates
Springer Science and Business Media LLC - Tập 16 - Trang 201-211 - 2019
We update evidence underlying the recommendations of a 2018 multi-society consensus report regarding the psychosocial evaluation of individuals for cardiothoracic transplantation and mechanical circulatory support (MCS). In the present review, we focus on heart transplantation and MCS. Expert opinion and new evidence support the inclusion of ten core content areas in the psychosocial evaluation. P......
Evaluation and Management of Left Ventricular Noncompaction Cardiomyopathy
Springer Science and Business Media LLC - Tập 12 - Trang 61-67 - 2014
Left ventricular (LV) noncompaction cardiomyopathy (LVNC) is a form of cardiomyopathy in which trabeculations fail to “compact” with the left ventricular endocardium during fetal cardiac development and is classically associated with subsequent impairment of LV function, significant mortality, ventricular dysrhythmias, and embolic phenomena. As awareness and medical imaging quality have improved, ......
Myocardial Fatigue at a Glance
Springer Science and Business Media LLC - Tập 20 Số 3 - Trang 191-193 - 2023
Expanding on the modern lexicon of heart failure (HF), the novel mechano-energetic concept of myocardial fatigue describes a transiently energy-depleted myocardium with impaired contractility and relaxation in the face of adverse haemodynamic load. It encompasses established concepts of ventricular-arterial decoupling, deranged cardiac energetics and impaired myocardial efficiency, offering an alt......
Mechanical approaches to alter remodeling
Springer Science and Business Media LLC - Tập 1 - Trang 14-18 - 2004
Regression of pathologic cardiac hypertrophy and dilation, so-called reverse remodeling, has emerged as an important therapeutic target in the treatment of dilated cardiomyopathies. Although pharmacologic therapies may promote regression of pathologic remodeling, the magnitude of reverse remodeling is usually small. In contrast, reverse remodeling associated with cardiovascular devices, as highlig......
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