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Cornerstone program for transition-age youth with serious mental illness: study protocol for a randomized controlled trial
Springer Science and Business Media LLC - Tập 17 - Trang 1-13 - 2016
Michelle R. Munson, Andrea Cole, Victoria Stanhope, Steven C. Marcus, Mary McKay, James Jaccard, Shelly Ben-David
Transition-age youth have elevated rates of mental disorders, and they often do not receive services. This is a serious public health concern, as mental health conditions persist into adulthood. Continuing to engage this population has been a pervasive challenge for the mental health care system worldwide. Few mental health interventions have been developed for transition-age youth, and even fewer...... hiện toàn bộ
How informed is declared altruism in clinical trials? A qualitative interview study of patient decision-making about the QUEST trials (Quality of Life after Mastectomy and Breast Reconstruction)
Springer Science and Business Media LLC - Tập 17 - Trang 1-10 - 2016
Natalie Bidad, Lindsay MacDonald, Zoë E. Winters, Sarah J. L. Edwards, Marie Emson, Clare L. Griffin, Judith Bliss, Rob Horne
Randomised controlled trials (RCTs) often fail to recruit sufficient participants, despite altruism being cited as their motivation. Previous investigations of factors influencing participation decisions have been methodologically limited. This study evaluated how women weigh up different motivations after initially expressing altruism, and explored their understanding of a trial and its alternati...... hiện toàn bộ
Stopping guidelines for an effectiveness trial: what should the protocol specify?
Springer Science and Business Media LLC - Tập 17 - Trang 1-4 - 2016
Jon E. Tyson, Claudia Pedroza, Dennis Wallace, Carl D’Angio, Edward F. Bell, Abhik Das
Despite long-standing problems in decisions to stop clinical trials, stopping guidelines are often vague or unspecified in the trial protocol. Clear, well-conceived guidelines are especially important to assist the data monitoring committees for effectiveness trials. To specify better stopping guidelines in the protocol for such trials, the clinical investigators and trial statistician should care...... hiện toàn bộ
Organising Support for Carers of Stroke Survivors (OSCARSS): study protocol for a cluster randomised controlled trial, including health economic analysis
Springer Science and Business Media LLC - Tập 20 - Trang 1-11 - 2019
Emma Patchwood, Katy Rothwell, Sarah Rhodes, Evridiki Batistatou, Kate Woodward-Nutt, Yiu-Shing Lau, Gunn Grande, Gail Ewing, Audrey Bowen
Stroke often results in chronic disability, with partners and family members taking on the role of informal caregiver. There is considerable uncertainty regarding how best to identify and address carers’ needs. The Carer Support Needs Assessment Tool (CSNAT) is a carer-led approach to individualised assessment and support for caregiving that may be beneficial in palliative care contexts. CSNAT inc...... hiện toàn bộ
The effectiveness of different singly administered high doses of buprenorphine in reducing suicidal ideation in acutely depressed people with co-morbid opiate dependence: a randomized, double-blind, clinical trial
Springer Science and Business Media LLC - Tập 19 - Trang 1-8 - 2018
Jamshid Ahmadi, Mina Sefidfard Jahromi, Zahra Ehsaei
Buprenorphine is usually administered to treat opioid use disorder and pain syndromes. This research presents the first study regarding the effectiveness of different singly administered high doses of buprenorphine (a partial opioid agonist (of μ-opioid receptors), a potent opioid antagonist (of κ-receptors) and a partial agonist of nociception receptors) in reducing suicidal ideation in acutely d...... hiện toàn bộ
Gene therapy for lipid disorders
Springer Science and Business Media LLC - Tập 1 - Trang 1-8 - 2000
Masa-aki Kawashiri, Daniel J Rader
Lipid disorders are associated with atherosclerotic vascular disease, and therapy is associated with a substantial reduction in cardiovascular events. Current approaches to the treatment of lipid disorders are ineffective in a substantial number of patients. New therapies for refractory hypercholesterolemia, severe hypertriglyceridemia, and low levels of high-density lipoprotein cholesterol are ne...... hiện toàn bộ
Activity tracker-based intervention to increase physical activity in patients with type 2 diabetes and healthy individuals: study protocol for a randomized controlled trial
Springer Science and Business Media LLC - - 2022
Mareike Mähs, Jana Sabrina Pithan, I. Bergmann, Lars Gabrys, Johanna Graf, A. Hölzemann, Kristof Van Laerhoven, S. Otto-Hagemann, M. L. Popescu, L. Schwermann, Benjamin Wenz, I. Pahmeier, Andrea Teti
Abstract Background One relevant strategy to prevent the onset and progression of type 2 diabetes mellitus (T2DM) focuses on increasing physical activity. The use of activity trackers by patients could enable objective measurement of their regular physical activity in daily life and promote physical...... hiện toàn bộ
Debate: Subgroup analyses in clinical trials: fun to look at - but don't believe them!
Springer Science and Business Media LLC - Tập 1 - Trang 1-3 - 2000
Peter Sleight
Analysis of subgroup results in a clinical trial is surprisingly unreliable, even in a large trial. This is the result of a combination of reduced statistical power, increased variance and the play of chance. Reliance on such analyses is likely to be more erroneous, and hence harmful, than application of the overall proportional (or relative) result in the whole trial to the estimate of absolute r...... hiện toàn bộ
Video feedback intervention to enhance parental reflective functioning in primary caregivers of inpatient psychiatric children: protocol for a randomized feasibility trial
Springer Science and Business Media LLC - Tập 20 - Trang 1-10 - 2019
Fanny Leyton, Marcia Olhaberry, Rubén Alvarado, Graciela Rojas, Luis Alberto Dueñas, George Downing, Howard Steele
Children requiring hospitalization for psychiatric care have serious disorders, high use of psychotropic medication, and frequent readmissions. The development and implementation of therapies focused on incorporating primary caregivers or attachment figures is necessary for working with children with severe psychiatric disorders. Mentalization or parental reflective functioning (PRF) is the abilit...... hiện toàn bộ
Using a qualitative sub-study to inform the design and delivery of randomised controlled trials on medicinal cannabis for symptom relief in patients with advanced cancer
Springer Science and Business Media LLC - Tập 23 - Trang 1-16 - 2022
Rebecca E. Olson, Alexandra Smith, Georgie Huggett, Phillip Good, Morgan Dudley, Janet Hardy
Recruitment for randomised controlled trials in palliative care can be challenging; disease progression and terminal illness underpin high rates of attrition. Research into participant decision-making in medicinal cannabis randomised controlled trials (RCTs) is very limited. Nesting qualitative sub-studies within RCTs can identify further challenges to participation, informing revisions to study d...... hiện toàn bộ
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