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Update on microbicide research and development-seeking new HIV prevention tools for women
Springer Science and Business Media LLC - Tập 16 - Trang 1-6 - 2011
Women and girls are especially vulnerable to HIV infection in sub-Saharan Africa, and in some of those countries, prevalence among young women can be up to 3 times higher than among men of the same age. Effective HIV prevention options for women are clearly needed in this setting. Several ARV-based vaginal microbicides are currently in development for prevention of HIV transmission to women and ar......
Observation of the influences of diosgenin on aging ovarian reserve and function in a mouse model
Springer Science and Business Media LLC - Tập 22 - Trang 1-7 - 2017
The aim of this study was to investigate the impact of diosgenin, an important monomer of sapogenins in yams, on ovarian reserve in a natural aging mice model. This randomized controlled trial included 60 9-month-old C57 naturally aging female mice. Twenty-one mice were assigned to the dio group and were fed a single dose of diosgenin (200 mg/kg/day) suspended in 0.3% CMC. Twenty mice were assigne......
The low prevalence rate of vitamin E deficiency in urban adults of Wuhan from central China: findings from a single-center, cross-sectional studyAbstract
Background
Vitamin E is an essential nutrient in human body famous for its antioxidant and non-antioxidant functions. However, little is known about vitamin E deficiency status in urban adults of Wuhan from central China. Our aim is to describe the distribution of both circulating and lipid... ...
Springer Science and Business Media LLC -
Comorbidity in patients with Lichen sclerosus: a retrospective cohort study
Springer Science and Business Media LLC - Tập 28 - Trang 1-8 - 2023
Lichen sclerosus (LS) is a chronic lymphocyte mediated inflammatory mucocutaneous disease of unknown aetiology with a predilection for the anogenital region, and affecting both sexes. The disease is characterized by pain, intolerable itching and scarring. In late stages of LS, disfiguring scarring can drastically alter the structural anatomical architecture of the genitals. The association between......
Ingenol mebutate induces a tumor cell-directed inflammatory response and antimicrobial peptides thereby promoting rapid tumor destruction and wound healing
Springer Science and Business Media LLC - Tập 23 Số 1 - Trang 1-11 - 2018
Ingenol mebutat (IM)-gel is effective for the topical treatment of epithelial tumors, including actinic keratoses (AKs) or anogenital warts (AGW). AK patients treated with IM develop intensified inflammatory reactions on sights of prior clinical visible or palpable AKs as compared to the surrounding actinically damaged skin, suggesting the induction of a tumor cell-directed inflammation. AGW patie......
German-austrian recommendations for HIV1-therapy in pregnancy and in HIV1-exposed newborn - update 2008
Springer Science and Business Media LLC - Tập 14 Số 11 - 2009
Prognostic, diagnostic and clinicopathological roles of tsRNAs: a meta-analysis in breast cancer
Springer Science and Business Media LLC - Tập 29 - Trang 1-13 - 2024
Breast cancer (BC) is one of the most common malignancies in women and the leading cause of cancer-related death in women. The newly emerged non-coding RNAs tsRNAs (tRNA-derived small RNAs) play an important role in the occurrence and development of BC. The purpose of this study was to comprehensively evaluate the prognostic, diagnostic and clinicopathological roles of tsRNAs in BC. Through litera......
Increased CD44s and decreased CD44v6 RNA expression are associated with better survival in myxofibrosarcoma patients: a pilot studyAbstract
Background
New prognostic markers may be of value in determining survival and informing decisions of adjuvant treatment in the heterogeneous group of soft tissue sarcomas known as malignant fibrous sarcomas (MFS). Increased CD44 expression has been associated with a better outcome in can... ...
Springer Science and Business Media LLC - Tập 19 Số 1 - 2014
Cardiac autonomic control in adolescents with primary hypertension
Springer Science and Business Media LLC - Tập 14 - Trang 1-3 - 2009
Impairment in cardiovascular autonomic regulation participates in the onset and maintenance of primary hypertension. The aim of the present study was to evaluate cardiac autonomic control using long-term heart rate variability (HRV) analysis in adolescents with primary hypertension. Twenty two adolescent patients with primary hypertension (5 girls/17 boys) aged 14-19 years and 22 healthy subjects ......
A nomogram prediction model for hungry bone syndrome in dialysis patients with secondary hyperparathyroidism after total parathyroidectomy
Springer Science and Business Media LLC - - 2024
Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD). Hungry bone syndrome (HBS) after parathyroidectomy (PTX) is a serious complication, which can lead to diarrhea, convulsion, arrhythmia and even death. This study was aimed to determine the risk factors for HBS after PTX in dialysis patients with SHPT and construct a nomogram prediction model to predict t......
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