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Targeting Toll-Like Receptors for Cancer Therapy
Springer Science and Business Media LLC - Tập 13 - Trang 583-598 - 2018
The immune system encompasses a broad array of defense mechanisms against foreign threats, including invading pathogens and transformed neoplastic cells. Toll-like receptors (TLRs) are critically involved in innate immunity, serving as pattern recognition receptors whose stimulation leads to additional innate and adaptive immune responses. Malignant cells exploit the natural immunomodulatory funct......
Detection of HER2 Amplification in Circulating Tumor Cells of HER2-Negative Gastric Cancer Patients
Springer Science and Business Media LLC - Tập 12 - Trang 341-351 - 2017
A key to the successful use of targeted cancer therapy is the ability to preselect patients who are likely to benefit from the treatment according to molecular markers. Assessment for predicting therapy response is mostly done using tumor biopsies. However, these might not truly represent all of the patient’s malignant cells because of tumor heterogeneity and/or clonal evolution during disease pro......
Selective Oral MEK1/2 Inhibitor Pimasertib in Metastatic Melanoma: Antitumor Activity in a Phase I, Dose-Escalation Trial
Springer Science and Business Media LLC - Tập 16 - Trang 47-57 - 2020
Pimasertib is a selective, potent mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor. The aim of this study was to describe the efficacy, safety, and pharmacodynamics of pimasertib at pharmacologically active doses in a cohort of patients with locally advanced/metastatic melanoma from a first-in-human study of pimasertib. This was a phase I, open-label, two-part, dose-escalation study. Pa......
Prognostic and predictive biomarkers in renal cell carcinoma
Springer Science and Business Media LLC - - 2010
Controversial evaluation of EGFR protein and gene status in predicting response to anti-EGFR monoclonal antibodies in metastatic colorectal cancer: a case report and review of the literature
Springer Science and Business Media LLC - Tập 3 - Trang 127-130 - 2008
Clinical studies showed that only 10% of patients with metastatic colorectal cancer (mCRC) respond to treatment with the anti-epidermal growth factor receptor (EGFR) monoclonal antibodies panitumumab or cetuximab, regardless of the line of treatment. The current tool used to select patients, i.e. immunohistochemistry (IHC) evaluation of EGFR expression by EGFR pharmDx™ Kit, is not reliable in pred......
Imaging in targeted delivery of therapy to cancer
Springer Science and Business Media LLC - Tập 4 - Trang 201-217 - 2009
We review the current status of imaging as applied to targeted therapy with particular focus on antibody-based therapeutics. Antibodies have high tumor specificity and can be engineered to optimize delivery to, and retention within, the tumor. Whole antibodies can activate natural immune effector mechanisms and can be conjugated to β- and α-emitting radionuclides, toxins, enzymes, and nanoparticle......
Development of a Novel EGFR-Targeting Antibody-Drug Conjugate for Pancreatic Cancer Therapy
Springer Science and Business Media LLC - Tập 14 - Trang 93-105 - 2019
Overexpression of epidermal growth factor receptor (EGFR) is common in pancreatic cancer and associated with the poor prognosis of this malignancy. To develop anti-EGFR antibody–drug conjugates (ADCs) for use in a novel EGFR-targeting approach to treat pancreatic cancer. A humanized anti-EGFR monoclonal antibody (RC68) was generated by mouse immunization and complementary-determining region grafti......
Dinutuximab: Một Tổng Quan về Neuroblastoma Cao Nguy Cơ Dịch bởi AI
Springer Science and Business Media LLC - Tập 11 - Trang 247-253 - 2016
Dinutuximab (ch14.18; Unituxin™) là một kháng thể đơn dòng chimera giữa người và chuột, có khả năng liên kết với kháng nguyên glycolipid disialoganglioside, được biểu hiện mạnh mẽ trên bề mặt của các tế bào neuroblastoma. Thuốc tiêm tĩnh mạch này đã được phê duyệt tại EU và Mỹ như một liệu pháp kết hợp với yếu tố kích thích tụy bạch cầu – đại thực bào (GM-CSF), interleukin (IL)-2 và isotretinoin c......
#Dinutuximab #neuroblastoma #kháng thể đơn dòng #liệu pháp kết hợp #sống không sự kiện #sống toàn bộ.
Recommendations for the clinical and radiological evaluation of response to treatment in metastatic renal cell cancer
Springer Science and Business Media LLC - Tập 9 - Trang 9-24 - 2013
The evaluation of response to treatment is a critical step for determining the effectiveness of oncology drugs. Targeted therapies such as tyrosine kinase inhibitors and mammalian target of rapamycin inhibitors are active drugs in patients with metastatic renal cell carcinoma (mRCC). However, treatment with this type of drugs may not result in significant reductions in tumor size, so standard eval......
Recombinant TIMP-1-GPI inhibits growth of fibrosarcoma and enhances tumor sensitivity to doxorubicin
Springer Science and Business Media LLC - Tập 9 - Trang 251-261 - 2013
Fibrosarcomas show a high incidence of recurrence and general resistance to apoptosis. Limiting tumor regrowth and increasing their sensitivity to chemotherapy and apoptosis represent key issues in developing more effective treatments of these tumors. Tissue inhibitor of metalloproteinase 1 (TIMP-1) broadly blocks matrix metalloproteinase (MMP) activity and can moderate tumor growth and metastasis......
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