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Role of the NLRP3 inflammasome in the transient release of IL-1β induced by monosodium urate crystals in human fibroblast-like synoviocytes
Springer Science and Business Media LLC - Tập 12 - Trang 1-9 - 2015
Shu-cong Zheng, Xiao-xia Zhu, Yu Xue, Li-hong Zhang, He-jian Zou, Jian-hua Qiu, Qiong Liu
To investigate whether monosodium urate (MSU) crystals induce interleukin (IL)-1β in human fibroblast-like synoviocytes (FLS), and whether the NLRP3 inflammasome is involved in the inflammatory mechanism. Human FLS isolated from explants of synovial tissue were stimulated with MSU crystals (0.001 to 0.5 mg/ml) for different time course (6 hours to 48 hours). The expressions of IL-1β, IL-6, TNF-α a...... hiện toàn bộ
The role of the purinergic P2X7 receptor in inflammation
Springer Science and Business Media LLC - Tập 4 - Trang 1-14 - 2007
Martin F Lister, John Sharkey, Deborah A Sawatzky, Joseph P Hodgkiss, Donald J Davidson, Adriano G Rossi, Keith Finlayson
The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three phases and harnessing the beneficial properties of inflammation whilst preventing its damaging effects, will undoubtedly lead to the advent of much needed therapies, particularly in chronic ...... hiện toàn bộ
Preclinical animal models of COPD
Springer Science and Business Media LLC - Tập 10 - Trang 1-1 - 2013
Ross Vlahos
Efficacy of probiotic Streptococcus thermophilus in counteracting TGF-β1-induced fibrotic response in normal human dermal fibroblasts
Springer Science and Business Media LLC -
Francesca Lombardi, Francesca Rosaria Augello, Serena Artone, Blerina Bahiti, Jenna Marie Sheldon, Maurizio Giuliani, Maria Grazia Cifone, Paola Palumbo, Benedetta Cinque
Abstract Background Abnormal and deregulated skin wound healing associated with prolonged inflammation may result in dermal fibrosis. Since the current therapeutic strategies revealed unsatisfactory, the investigation of alternative approaches such as those based on the use of specific probiotic str...... hiện toàn bộ
TGF-β gene polimorphisms as risk factors for asthma control among clinic patients
Springer Science and Business Media LLC - Tập 18 - Trang 1-12 - 2021
Panek Michał, Stawiski Konrad, Kuna Piotr
TGF-β and its receptors play a crucial role in asthma pathogenesis, bronchial hyperreactivity, and bronchial remodeling. Expression of isoforms 1–3 of TGFβ cytokine is influenced by tagging polymorphisms in the TGFβ1, TGFβ2 and TGFβ3 gene, and these SNPs may be associated with the risk of asthma development and severity as well as with other diseases. Polymorphic forms of TGF-β1, TGF-β2 and TGF-β3...... hiện toàn bộ
Hypercholesterolemia and microvascular dysfunction: interventional strategies
Springer Science and Business Media LLC - Tập 7 - Trang 1-10 - 2010
Phoebe A Stapleton, Adam G Goodwill, Milinda E James, Robert W Brock, Jefferson C Frisbee
Hypercholesterolemia is defined as excessively high plasma cholesterol levels, and is a strong risk factor for many negative cardiovascular events. Total cholesterol levels above 200 mg/dl have repeatedly been correlated as an independent risk factor for development of peripheral vascular (PVD) and coronary artery disease (CAD), and considerable attention has been directed toward evaluating mechan...... hiện toàn bộ
Does carbon monoxide treatment alter cytokine levels after endotoxin infusion in pigs? A randomized controlled study
Springer Science and Business Media LLC - Tập 5 - Trang 1-8 - 2008
Anna-Maja Åberg, Pernilla Abrahamsson, Göran Johansson, Michael Haney, Ola Winsö, Jan Erik Larsson
Carbon monoxide (CO) has recently been suggested to have anti-inflammatory properties, but data seem to be contradictory and species-specific. Thus, in studies on macrophages and mice, pretreatment with CO attenuated the inflammatory response after endotoxin exposure. On the other hand, human studies showed no effect of CO on the inflammatory response. Anti-inflammatory efficacy of CO has been sho...... hiện toàn bộ
Real-state of autophagy signaling pathway in neurodegenerative disease; focus on multiple sclerosis
Springer Science and Business Media LLC - Tập 17 - Trang 1-8 - 2020
Mehdi Hassanpour, Fateme Hajihassani, Amirataollah Hiradfar, Nasser Aghamohammadzadeh, Reza Rahbarghazi, Nasser Safaie, Mohammad Nouri, Yunes Panahi
The occurrence of neurodegenerative disease is increasingly raised. From physiopathological aspect, the emergence of auto-reactive antibodies against the nervous system antigens contributes to de-myelination in Multiple sclerosis (MS). These features cause the nervous system dysfunction. The follow-up of molecular alterations could give us a real-state vision about intracellular status during path...... hiện toàn bộ
E-selectin and vascular cell adhesion molecule-1 as biomarkers of 3-month outcome in cerebrovascular diseases
Springer Science and Business Media LLC - Tập 12 - Trang 1-9 - 2015
Sébastien Richard, Linnéa Lagerstedt, Pierre R. Burkhard, Marc Debouverie, Natacha Turck, Jean-Charles Sanchez
Inflammation is known to worsen cerebral damage at the acute phase of stroke. In this setting, cell adhesion molecules (CAMs) play a crucial role mediating migration of immune cells into the infarcted area. However, their value in long-term outcome prediction for patients with cerebrovascular diseases (CVD) is less described. Levels of four CAMs (E-selectin, P-selectin glycoprotein ligand-1, inter...... hiện toàn bộ
Relationship between vitamin D status and the inflammatory state in patients with chronic spontaneous urticaria
Springer Science and Business Media LLC - Tập 11 - Trang 1-5 - 2014
Alicja Grzanka, Edyta Machura, Bogdan Mazur, Maciej Misiolek, Jerzy Jochem, Jacek Kasperski, Alicja Kasperska-Zajac
Chronic spontaneous urticaria (CSU) is an immune-inflammatory disease, characterized by acute phase response (APR) and immune activation. There has been increasing evidence showing that vitamin D deficiency/insufficiency is associated with increased incidence and/or severity of immune-inflammatory disorders. To assess relationship between vitamin D status and C-reactive protein (CRP), a nonspecifi...... hiện toàn bộ
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