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Role of the NLRP3 inflammasome in the transient release of IL-1β induced by monosodium urate crystals in human fibroblast-like synoviocytes
Springer Science and Business Media LLC - Tập 12 - Trang 1-9 - 2015
To investigate whether monosodium urate (MSU) crystals induce interleukin
(IL)-1β in human fibroblast-like synoviocytes (FLS), and whether the NLRP3
inflammasome is involved in the inflammatory mechanism. Human FLS isolated from
explants of synovial tissue were stimulated with MSU crystals (0.001 to 0.5
mg/ml) for different time course (6 hours to 48 hours). The expressions of
IL-1β, IL-6, TNF-α a...
The role of the purinergic P2X7 receptor in inflammation
Springer Science and Business Media LLC - Tập 4 - Trang 1-14 - 2007
The inflammatory process, orchestrated against a variety of injurious stimuli,
is composed of three inter-related phases; initiation, propagation and
resolution. Understanding the interplay between these three phases and
harnessing the beneficial properties of inflammation whilst preventing its
damaging effects, will undoubtedly lead to the advent of much needed therapies,
particularly in chronic ...
Preclinical animal models of COPD
Springer Science and Business Media LLC - Tập 10 - Trang 1-1 - 2013
Efficacy of probiotic Streptococcus thermophilus in counteracting TGF-β1-induced fibrotic response in normal human dermal fibroblasts
Springer Science and Business Media LLC -
Abstract Background Abnormal and deregulated skin wound healing associated with
prolonged inflammation may result in dermal fibrosis. Since the current
therapeutic strategies revealed unsatisfactory, the investigation of alternative
approaches such as those based on the use of specific probiotic strains could
provide promising therapeutic options. In this study, we aimed to evaluate
whether the ly...
TGF-β gene polimorphisms as risk factors for asthma control among clinic patients
Springer Science and Business Media LLC - Tập 18 - Trang 1-12 - 2021
TGF-β and its receptors play a crucial role in asthma pathogenesis, bronchial
hyperreactivity, and bronchial remodeling. Expression of isoforms 1–3 of TGFβ
cytokine is influenced by tagging polymorphisms in the TGFβ1, TGFβ2 and TGFβ3
gene, and these SNPs may be associated with the risk of asthma development and
severity as well as with other diseases. Polymorphic forms of TGF-β1, TGF-β2 and
TGF-β3...
Hypercholesterolemia and microvascular dysfunction: interventional strategies
Springer Science and Business Media LLC - Tập 7 - Trang 1-10 - 2010
Hypercholesterolemia is defined as excessively high plasma cholesterol levels,
and is a strong risk factor for many negative cardiovascular events. Total
cholesterol levels above 200 mg/dl have repeatedly been correlated as an
independent risk factor for development of peripheral vascular (PVD) and
coronary artery disease (CAD), and considerable attention has been directed
toward evaluating mechan...
Does carbon monoxide treatment alter cytokine levels after endotoxin infusion in pigs? A randomized controlled study
Springer Science and Business Media LLC - Tập 5 - Trang 1-8 - 2008
Carbon monoxide (CO) has recently been suggested to have anti-inflammatory
properties, but data seem to be contradictory and species-specific. Thus, in
studies on macrophages and mice, pretreatment with CO attenuated the
inflammatory response after endotoxin exposure. On the other hand, human studies
showed no effect of CO on the inflammatory response. Anti-inflammatory efficacy
of CO has been sho...
Real-state of autophagy signaling pathway in neurodegenerative disease; focus on multiple sclerosis
Springer Science and Business Media LLC - Tập 17 - Trang 1-8 - 2020
The occurrence of neurodegenerative disease is increasingly raised. From
physiopathological aspect, the emergence of auto-reactive antibodies against the
nervous system antigens contributes to de-myelination in Multiple sclerosis
(MS). These features cause the nervous system dysfunction. The follow-up of
molecular alterations could give us a real-state vision about intracellular
status during path...
E-selectin and vascular cell adhesion molecule-1 as biomarkers of 3-month outcome in cerebrovascular diseases
Springer Science and Business Media LLC - Tập 12 - Trang 1-9 - 2015
Inflammation is known to worsen cerebral damage at the acute phase of stroke. In
this setting, cell adhesion molecules (CAMs) play a crucial role mediating
migration of immune cells into the infarcted area. However, their value in
long-term outcome prediction for patients with cerebrovascular diseases (CVD) is
less described. Levels of four CAMs (E-selectin, P-selectin glycoprotein
ligand-1, inter...
Relationship between vitamin D status and the inflammatory state in patients with chronic spontaneous urticaria
Springer Science and Business Media LLC - Tập 11 - Trang 1-5 - 2014
Chronic spontaneous urticaria (CSU) is an immune-inflammatory disease,
characterized by acute phase response (APR) and immune activation. There has
been increasing evidence showing that vitamin D deficiency/insufficiency is
associated with increased incidence and/or severity of immune-inflammatory
disorders. To assess relationship between vitamin D status and C-reactive
protein (CRP), a nonspecifi...
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