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5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages
Springer Science and Business Media LLC - Tập 19 - Trang 1-17 - 2022
Panqiao Liang, Linxin Wang, Sushan Yang, Xiping Pan, Jiashun Li, Yuehan Zhang, Yueyun Liang, Jing Li, Beixian Zhou
Acute lung injury (ALI) arises from sepsis or bacterial infection, which are life-threatening respiratory disorders that cause the leading cause of death worldwide. 5-Methoxyflavone, a methylated flavonoid, is gaining increased attention for its various health benefits. In the current study, we investigated the potential effects of 5-methoxyflavone against LPS-mediated ALI and elucidated the corre...... hiện toàn bộ
Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies
Springer Science and Business Media LLC - - 2020
Amandip Kaur, Paraskevi Goggolidou
AbstractDynamic interactions between the gastrointestinal epithelium and the mucosal immune system normally contribute to ensuring intestinal homeostasis and optimal immunosurveillance, but destabilisation of these interactions in genetically predisposed individuals can lead to the development of chronic inflammatory diseases. Ulcerative colitis is one of the main ...... hiện toàn bộ
Sensitivity of mice to lipopolysaccharide is increased by a high saturated fat and cholesterol diet
Springer Science and Business Media LLC - Tập 4 - Trang 1-11 - 2007
Hong Huang, Tongzheng Liu, Jane L Rose, Rachel L Stevens, Dale G Hoyt
It was hypothesized that a pro-atherogenic, high saturated fat and cholesterol diet (HCD) would increase the inflammatory response to E. coli endotoxin (LPS) and increase its concentration in plasma after administration to mice. C57Bl/6 mice were fed a HCD or a control diet (CD) for 4 weeks, and then treated with saline, 0.5, 1 or 2 mg LPS/kg, ip. Liver injury (alanine:2-oxoglutarate aminotransfer...... hiện toàn bộ
Downregulation of miR-223 promotes HMGB2 expression and induces oxidative stress to activate JNK and promote autophagy in an in vitro model of acute lung injury
Springer Science and Business Media LLC - Tập 18 - Trang 1-11 - 2021
Hao-Yu Tan, Bei Qing, Xian-Mei Luo, Heng-Xing Liang
Excessive autophagic activity in alveolar epithelial cells is one of the main causes of acute lung injury (ALI), but the underlying molecular mechanism has not been fully elucidated. Previous studies have shown that microRNAs (miRs) are involved in regulating autophagy in several diseases. This study aimed to determine the role of miR-223 in excessive autophagic activity in alveolar epithelial cel...... hiện toàn bộ
Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself
Springer Science and Business Media LLC - Tập 9 - Trang 1-5 - 2012
Michael Luong, Yanyu Zhang, Tim Chamberlain, Tianhui Zhou, Jill F Wright, Ken Dower, J Perry Hall
Toll-like receptor 4 (TLR4) is activated by bacterial endotoxin, a pathogen-associated molecular pattern (PAMP). It has been suggested that TLR4 can also be activated by damage-associated molecular pattern (DAMP) proteins such as HSP70. It remains a challenge to provide unequivocal evidence that DAMP proteins themselves play a role in TLR4 activation, as the DAMP proteins used are often contaminat...... hiện toàn bộ
Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways
Springer Science and Business Media LLC - Tập 8 - Trang 1-15 - 2011
Rachid Kacimi, Rona G Giffard, Midori A Yenari
We previously showed that microglia damage blood brain barrier (BBB) components following ischemic brain insults, but the underlying mechanism(s) is/are not well known. Recent work has established the contribution of toll-like receptor 4 (TLR4) activation to several brain pathologies including ischemia, neurodegeneration and sepsis. The present study established the requirement of microglia for li...... hiện toàn bộ
Mycobacterium leprae alters classical activation of human monocytes in vitro
Springer Science and Business Media LLC - Tập 13 - Trang 1-5 - 2016
Dorothy Fallows, Blas Peixoto, Gilla Kaplan, Claudia Manca
Macrophages play a central role in the pathogenesis of leprosy, caused by Mycobacterium leprae. The polarized clinical presentations in leprosy are associated with differential immune activation. In tuberculoid leprosy, macrophages show a classical activation phenotype (M1), while macrophages in lepromatous disease display characteristics of alternative activation (M2). Bacille Calmette-Guérin (BC...... hiện toàn bộ
Expression of AIM2 is high and correlated with inflammation in hepatitis B virus associated glomerulonephritis
Springer Science and Business Media LLC - Tập 10 Số 1 - 2013
Wenjun Du, Junhui Zhen, Zhaomin Zheng, Shumin Ma, Shijun Chen
Abstract Background & aims Innate immunity is the first line of defense against invasive microbial infection, and AIM2 plays an important role in this process by sensing double-stranded DNA viruses. However, the role of AIM2 in regulating the immune response to viruses in vivo, especially in ...... hiện toàn bộ
Can selenium supplementation modify oxidative stress in-vitro? A role for selenium supplementation in the prevention of cardiovascular disease
Springer Science and Business Media LLC - Tập 12 - Trang 1-2 - 2015
Dean Leighton, Marie Goua, Eimear Dolan, Katherine Burgess, Giovanna Bermano
Effects of long non-coding RNA Gm14461 on pain transmission in trigeminal neuralgia
Springer Science and Business Media LLC - - 2020
Mu Xu, Yi Yan, Mengye Zhu, Zhijian Wang, Xuexue Zhang, Daying Zhang
Abstract Background This study aims to investigate the role of long non-coding RNA Gm14461 in regulating pain transmission in trigeminal neuralgia (TN). The mouse TN model was produced by chronic constriction injury of the infraorbital nerve (CCI-ION). The values of mechanical withdrawal threshold (MWT) were measured to assess the...... hiện toàn bộ
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