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Efficient and fast targeted production of murine models based on ENU mutagenesis
Springer Science and Business Media LLC - - 2005
Martin Augustin, Reinhard Sedlmeier, Thomas Peters, Ulrike Huffstadt, E. Kochmann, Daniel Simon, Michael Schöniger, S. Garke-Mayerthaler, Jürgen Laufs, Manuel Mayhaus, Silvia Isabel Rech Franke, Martin Klose, Anne Graupner, M. Kurzmann, Christian Zinser, Alexander Wolf, M. Voelkel, Max J. Kellner, Mogens Kilian, S. Seelig, Andrea Koppius, Andreas Teubner, Dirk Korthaus, Michael Nehls, Sigrid Wattler
An integrated cytogenetic, radiation-hybrid, and comparative map of dog Chromosome 5
Springer Science and Business Media LLC - Tập 12 - Trang 371-375 - 2001
Rachael Thomas, Matthew Breen, Panos Deloukas, Nigel G. Holmes, Matthew M. Binns
The development of a detailed genome map for the domestic dog (Canis familiaris, CFA) is a prerequisite for the continued use of this species as a model system for the study of inherited traits. We present an integrated cytogenetic, radiation-hybrid, and comparative map of dog Chromosome (Chr) 5 (CFA 5). The map comprises 14 gene markers, selected from loci previously mapped within the correspond...... hiện toàn bộ
Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome
Springer Science and Business Media LLC - Tập 17 - Trang 407-416 - 2006
A-Ri Cho, Kozue Uchio-Yamada, Takeshi Torigai, Tomomi Miyamoto, Ichiro Miyoshi, Junichiro Matsuda, Tsutomu Kurosawa, Yasuhiro Kon, Atsushi Asano, Nobuya Sasaki, Takashi Agui
The ICGN mouse is a model for nephrotic syndrome (NS) which presents with proteinuria, hyperlipidemia, and edema. In this study we attempted to identify the gene(s) responsible for NS. By analyzing albuminuria in 160 (ICGN × MSM)F1 × ICGN backcross progenies, we found that NS in the ICGN mouse is caused by more than one gene. We then performed a quantitative trait locus (QTL) analysis and detected...... hiện toàn bộ
Reference list
Springer Science and Business Media LLC - Tập 8 - Trang S420-S450 - 1998
A genome-wide survey on basic helix-loop-helix transcription factors in rat and mouse
Springer Science and Business Media LLC - Tập 20 - Trang 236-246 - 2009
X. Zheng, Y. Wang, Q. Yao, Z. Yang, K. Chen
The basic helix-loop-helix (bHLH) proteins play essential roles in a wide range of developmental processes in higher organisms. bHLH family members have been identified in over 20 organisms, including nematode, fruit fly, and human. Our study identified 114 rat and 14 additional mouse bHLH members in rat and mouse genomes, respectively. Phylogenetic analyses revealed that both rat and mouse had 49...... hiện toàn bộ
Characterization of the murine Hoxc-5 gene
Springer Science and Business Media LLC - Tập 7 - Trang 81-84 - 1996
A. M. C. Geada, P. L. Coletta, P. T. Sharpe
Genetic mapping near the myd locus on mouse Chromosome 8
Springer Science and Business Media LLC - - 1995
Karen Mills, Katherine D. Mathews, T Scherpbier-Heddema, Robert L. Schelper, R. Schmalzel, Holly L. Bailey, Joseph H. Nadeau, Kenneth H. Buetow, Jeffrey C. Murray
HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin
Springer Science and Business Media LLC - Tập 11 - Trang 1006-1015 - 2000
Vikramjit S. Chopra, Martina Metzler, Dita M. Rasper, Asa E.Y. Engqvist-Goldstein, Roshni Singaraja, Lu Gan, Keith M. Fichter, Krista McCutcheon, David Drubin, Donald W. Nicholson, Michael R. Hayden
Huntingtin-interacting protein 1 (HIP1) is a membrane-associated protein that interacts with huntingtin, the protein altered in Huntington disease. HIP1 shows homology to Sla2p, a protein essential for the assembly and function of the cytoskeleton and endocytosis in Saccharomyces cerevisiae. We have determined that the HIP1 gene comprises 32 exons spanning approximately 215 kb of genomic DNA and ...... hiện toàn bộ
Generation of a pseudogene during retroviral infection
Springer Science and Business Media LLC - Tập 6 - Trang 90-95 - 1995
M. B. L. Carlton, W. H. Colledge, M. J. Evans
During evolution, up to 10% of the mammalian genome may have arisen by rare retroposition events. This process involves reverse transcription of RNA intermediates that originate from retroviral and retrovial-like sequences, highly and middle repetitive DNA elements, and processed pseudogenes. The mechanism, and contemporary nature, for retrotransposition of the viral family and long interspersed e...... hiện toàn bộ
Genetic mapping of the choroideremia-like, rab escort protein-2 gene on mouse Chromosome 1
Springer Science and Business Media LLC - Tập 6 - Trang 488-489 - 1995
M. D. F. S. Barbosa, S. A. Johnson, K. Achey, M. J. Gutierrez, E. K. Wakeland, S. F. Kingsmore
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