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The replisome guides nucleosome assembly during DNA replication
Springer Science and Business Media LLC - Tập 10 Số 1 - 2020
Wenshuo Zhang, Jianxun Feng, Qing Li
AbstractNucleosome assembly during DNA replication is tightly coupled to ongoing DNA synthesis. This process, termed DNA replication-coupled (RC) nucleosome assembly, is essential for chromatin replication and has a great impact on both genome stability maintenance and epigenetic inheritance. This review discusses a set of recent findings regarding the role of replisome components contributing to ... hiện toàn bộ
Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction
Springer Science and Business Media LLC - Tập 9 - Trang 1-10 - 2019
Xiaoping Xie, Jin Jin, Lele Zhu, Zuliang Jie, Yanchuan Li, Baoyu Zhao, Xuhong Cheng, Pingwei Li, Shao-Cong Sun
TRAF3 is known as a central mediator of type I interferon (IFN) induction by various pattern recognition receptors, but the in vivo function of TRAF3 in host defense against viral infection is poorly defined due to the lack of a viable mouse model. Here we show that mice carrying conditional deletion of TRAF3 in myeloid cells or dendritic cells do not have a significant defect in host defense agai... hiện toàn bộ
WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome
Springer Science and Business Media LLC - Tập 14 - Trang 1-19 - 2024
Yuyao Tian, Sofie Lautrup, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Wai-Yee Chan
Metabolic dysfunction is one of the main symptoms of Werner syndrome (WS); however, the underlying mechanisms remain unclear. Here, we report that loss of WRN accelerates adipogenesis at an early stage both in vitro (stem cells) and in vivo (zebrafish). Moreover, WRN depletion causes a transient upregulation of late-stage of adipocyte-specific genes at an early stage. In an in vivo study, we gener... hiện toàn bộ
The expanding functions of thyroid hormone
Springer Science and Business Media LLC - Tập 7 - Trang 1-1 - 2017
Jiemin Wong, Shaochung Victor Hsia
Identification of target genes for spermatogenic cell-specific KRAB transcription factor ZFP819 in a male germ cell line
Springer Science and Business Media LLC - Tập 7 - Trang 1-15 - 2017
Sora Jin, Heejin Choi, Jun Tae Kwon, Jihye Kim, Juri Jeong, Jaehwan Kim, Seong Hyeon Hong, Chunghee Cho
Zfp819, a member of the Krüppel-associated box (KRAB) family, encodes a spermatogenic cell-specific transcription factor. Zfp819-overexpression induces apoptosis and inhibits proliferation in somatic cell lines. In the present study, we examined the cellular effects of Zfp819 in a male germ cell line (GC-2 cells). Overexpression of Zfp819 demonstrated an increase in the number of apoptotic cells, ... hiện toàn bộ
Chorionic villus-derived mesenchymal stem cell-mediated autophagy promotes the proliferation and invasiveness of trophoblasts under hypoxia by activating the JAK2/STAT3 signalling pathway
Springer Science and Business Media LLC - Tập 11 - Trang 1-13 - 2021
Yijing Chu, Chengzhan Zhu, Chongyu Yue, Wei Peng, Weiping Chen, Guifang He, Changchang Liu, Yang Lv, Guoqiang Gao, Ke Yao, Rendong Han, Xiaoyu Hu, Yan Zhang, Yuanhua Ye
Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. Several studies have revealed that human chorionic villous mesenchymal stem cells (CV-MSCs) could regulate trophoblasts function. To understand how human chorionic villous mesenchymal stem cells (CV-MSCs) regulate trophoblast function, we treated trophoblasts with CV-MSC supernatant under hypoxic conditions. Treatm... hiện toàn bộ
Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway
Springer Science and Business Media LLC - Tập 5 - Trang 1-14 - 2015
Susanna K. P. Lau, Ching-Wan Lam, Shirly O. T. Curreem, Kim-Chung Lee, Wang-Ngai Chow, Candy C. Y. Lau, Siddharth Sridhar, Sally C. Y. Wong, Paolo Martelli, Suk-Wai Hui, Kwok-Yung Yuen, Patrick C. Y. Woo
Burkholderia pseudomallei is an emerging pathogen that causes melioidosis, a serious and potentially fatal disease which requires prolonged antibiotics to prevent relapse. However, diagnosis of melioidosis can be difficult, especially in culture-negative cases. While metabolomics represents an uprising tool for studying infectious diseases, there were no reports on its applications to B. pseudomal... hiện toàn bộ
Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression
Springer Science and Business Media LLC - - 2016
Sidra Majaz, Zhangwei Tong, Kesong Peng, Wei Wang, Wenjing Ren, Ming Li, Kun Liu, Pingli Mo, Wengang Li, Chundong Yu
Upregulation of CKIP-1 inhibits high-glucose induced inflammation and oxidative stress in HRECs and attenuates diabetic retinopathy by modulating Nrf2/ARE signaling pathway: an in vitro study
Springer Science and Business Media LLC - - 2019
Lan Zhang, Jie Yu, Mingxia Ye, Hailan Zhao
Proteomic analysis of mismatch repair-mediated alkylating agent-induced DNA damage response
Springer Science and Business Media LLC - Tập 3 - Trang 1-14 - 2013
Xi Chen, Yong Zhao, Guo-Min Li, Lin Guo
Mediating DNA damage-induced apoptosis is an important genome-maintenance function of the mismatch repair (MMR) system. Defects in MMR not only cause carcinogenesis, but also render cancer cells highly resistant to chemotherapeutics, including alkylating agents. To understand the mechanisms of MMR-mediated apoptosis and MMR-deficiency-caused drug resistance, we analyze a model alkylating agent (N-... hiện toàn bộ
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