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The Streptococcus virulence protein PepO triggers anti-tumor immune responses by reprograming tumor-associated macrophages in a mouse triple negative breast cancer model
Springer Science and Business Media LLC - Tập 13 - Trang 1-19 - 2023
The efficacy of current surgery and chemotherapy for triple negative breast cancer (TNBC) is limited due to heterogenous and immunosuppressive tumor microenvironment (TME). Tumor associated macrophages (TAMs), which are regarded as an M2 tumor-promoting phenotype, are crucial in the development of the immunosuppressive TME. Targeting TAM reprograming is a promising strategy in anti-tumor therapy s...... hiện toàn bộ
A review on hepatocyte nuclear factor-1beta and tumor
Springer Science and Business Media LLC - Tập 5 - Trang 1-8 - 2015
Hepatocyte nuclear factor-1beta (HNF1β) was initially identified as a liver-specific transcription factor. It is a homeobox transcription factor that functions as a homodimer or heterodimer with HNF1α. HNF1β plays an important role in organogenesis during embryonic stage, especially of the liver, kidney, and pancreas. Mutations in the HNF1β gene cause maturity-onset diabetes of the young type 5 (M...... hiện toàn bộ
Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models
Springer Science and Business Media LLC - Tập 13 - Trang 1-20 - 2023
Activation of the Wnt pathway has been linked to colorectal cancer (CRC). Previous reports suggest that Wnt3a can activate p38. Besides, p38α feeds into the canonical Wnt/β-catenin pathway by inhibiting GSK3β through phosphorylation. Recently, we identified p38α as a new druggable member of β-catenin chromatin-associated kinase complexes in CRC. The functional relationship between p38α and β-caten...... hiện toàn bộ
Methamphetamine facilitates HIV infection of primary human monocytes through inhibiting cellular viral restriction factors
Springer Science and Business Media LLC - Tập 11 - Trang 1-9 - 2021
Methamphetamine (METH), a potent addictive psychostimulant, is highly prevalent in HIV-infected individuals. Clinically, METH use is implicated in alteration of immune system and increase of HIV spread/replication. Therefore, it is of importance to examine whether METH has direct effect on HIV infection of monocytes, the major target and reservoir cells for the virus. METH-treated monocytes were m...... hiện toàn bộ
Comparative analysis of cellular expression pattern of schizophrenia risk genes in human versus mouse cortex
Springer Science and Business Media LLC - Tập 9 - Trang 1-8 - 2019
Schizophrenia is a common psychiatric disease with high hereditary. The identification of schizophrenia risk genes (SRG) has shed light on its pathophysiological mechanisms. Mouse genetic models have been widely used to study the function of SRG in the brain with a cell type specific fashion. However, whether the cellular expression pattern of SRG is conserved between human and mouse brain is not ...... hiện toàn bộ
Structure of noncoding RNA is a determinant of function of RNA binding proteins in transcriptional regulation
Springer Science and Business Media LLC - Tập 2 - Trang 1-8 - 2012
The majority of the noncoding regions of mammalian genomes have been found to be transcribed to generate noncoding RNAs (ncRNAs), resulting in intense interest in their biological roles. During the past decade, numerous ncRNAs and aptamers have been identified as regulators of transcription. 6S RNA, first described as a ncRNA in E. coli, mimics an open promoter structure, which has a large bulge w...... hiện toàn bộ
Activation of Akt protects cancer cells from growth inhibition induced by PKM2 knockdown
Springer Science and Business Media LLC - Tập 4 - Trang 1-5 - 2014
PKM2 is an attractive target for cancer therapy, however, for many cancer cells, PKM2 knockdown only leads to a modest impairment of survival and proliferation. It is not known whether PKM2 knockdown rewires cell signaling pathways in these “PKM2 knockdown resistant” cells, and whether the rewired pathways are needed for their survival. In present study, we investigated the effects of PKM2 knockdo...... hiện toàn bộ
The functions and mechanisms of prefoldin complex and prefoldin-subunits
Springer Science and Business Media LLC - Tập 10 - Trang 1-15 - 2020
The correct folding is a key process for a protein to acquire its functional structure and conformation. Prefoldin is a well-known chaperone protein that regulates the correct folding of proteins. Prefoldin plays a crucial role in the pathogenesis of common neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease). The important role of prefoldin in emerging f...... hiện toàn bộ
The crucial regulatory role of type I interferon in inflammatory diseases
Springer Science and Business Media LLC - Tập 13 - Trang 1-22 - 2023
Type I interferon (IFN-I) plays crucial roles in the regulation of inflammation and it is associated with various inflammatory diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and periodontitis, impacting people's health and quality of life. It is well-established that IFN-Is affect immune responses and inflammatory factors by regulating some signaling. However, cu...... hiện toàn bộ
DNA methylation modification is associated with gonadal differentiation in Monopterus albus
Springer Science and Business Media LLC - Tập 10 - Trang 1-11 - 2020
Both testis and ovary can be produced sequentially in an individual with the same genome when sex reversal occurs in the teleost Monopterus albus, and epigenetic modification is supposed to be involved in gonadal differentiation. However, DNA methylation regulation mechanism underlying the gonadal differentiation remains unclear. Here, we used liquid chromatography-electrospray ionization tandem m...... hiện toàn bộ
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