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The replisome guides nucleosome assembly during DNA replication
Springer Science and Business Media LLC - Tập 10 Số 1 - 2020
Wenshuo Zhang, Jianxun Feng, Qing Li
AbstractNucleosome assembly during DNA replication is tightly coupled to ongoing DNA synthesis. This process, termed DNA replication-coupled (RC) nucleosome assembly, is essential for chromatin replication and has a great impact on both genome stability maintenance and epigenetic inheritance. This review discusses a set of recent findings regarding the role of repl...... hiện toàn bộ
Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction
Springer Science and Business Media LLC - Tập 9 - Trang 1-10 - 2019
Xiaoping Xie, Jin Jin, Lele Zhu, Zuliang Jie, Yanchuan Li, Baoyu Zhao, Xuhong Cheng, Pingwei Li, Shao-Cong Sun
TRAF3 is known as a central mediator of type I interferon (IFN) induction by various pattern recognition receptors, but the in vivo function of TRAF3 in host defense against viral infection is poorly defined due to the lack of a viable mouse model. Here we show that mice carrying conditional deletion of TRAF3 in myeloid cells or dendritic cells do not have a significant defect in host defense agai...... hiện toàn bộ
WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome
Springer Science and Business Media LLC - Tập 14 - Trang 1-19 - 2024
Yuyao Tian, Sofie Lautrup, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Wai-Yee Chan
Metabolic dysfunction is one of the main symptoms of Werner syndrome (WS); however, the underlying mechanisms remain unclear. Here, we report that loss of WRN accelerates adipogenesis at an early stage both in vitro (stem cells) and in vivo (zebrafish). Moreover, WRN depletion causes a transient upregulation of late-stage of adipocyte-specific genes at an early stage. In an in vivo study, we gener...... hiện toàn bộ
Chorionic villus-derived mesenchymal stem cell-mediated autophagy promotes the proliferation and invasiveness of trophoblasts under hypoxia by activating the JAK2/STAT3 signalling pathway
Springer Science and Business Media LLC - Tập 11 - Trang 1-13 - 2021
Yijing Chu, Chengzhan Zhu, Chongyu Yue, Wei Peng, Weiping Chen, Guifang He, Changchang Liu, Yang Lv, Guoqiang Gao, Ke Yao, Rendong Han, Xiaoyu Hu, Yan Zhang, Yuanhua Ye
Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. Several studies have revealed that human chorionic villous mesenchymal stem cells (CV-MSCs) could regulate trophoblasts function. To understand how human chorionic villous mesenchymal stem cells (CV-MSCs) regulate trophoblast function, we treated trophoblasts with CV-MSC supernatant under hypoxic conditions. Treatm...... hiện toàn bộ
Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression
Springer Science and Business Media LLC - - 2016
Sidra Majaz, Zhangwei Tong, Kesong Peng, Wei Wang, Wenjing Ren, Ming Li, Kun Liu, Pingli Mo, Wengang Li, Chundong Yu
Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models
Springer Science and Business Media LLC - Tập 13 - Trang 1-20 - 2023
Martina Lepore Signorile, Candida Fasano, Giovanna Forte, Katia De Marco, Paola Sanese, Vittoria Disciglio, Elisabetta Di Nicola, Antonino Pantaleo, Cristiano Simone, Valentina Grossi
Activation of the Wnt pathway has been linked to colorectal cancer (CRC). Previous reports suggest that Wnt3a can activate p38. Besides, p38α feeds into the canonical Wnt/β-catenin pathway by inhibiting GSK3β through phosphorylation. Recently, we identified p38α as a new druggable member of β-catenin chromatin-associated kinase complexes in CRC. The functional relationship between p38α and β-caten...... hiện toàn bộ
Lrp4 in hippocampal astrocytes serves as a negative feedback factor in seizures
Springer Science and Business Media LLC - - 2020
Zheng Yu, Meiying Zhang, Bin Luo, Hongyang Jing, Yue Yu, Shunqi Wang, Shunjing Luo
Abstract Background Epilepsy is characterized by the typical symptom of seizure, and anti-seizure medications are the main therapeutic method in clinical, but the effects of these therapy have not been satisfactory. To find a better treatment, it makes sense to further explore the regulatory mechani...... hiện toàn bộ
GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors
Springer Science and Business Media LLC - Tập 13 - Trang 1-18 - 2023
Hong Soon Kang, Sara A. Grimm, Raja Jothi, Pilar Santisteban, Anton M. Jetten
Loss of the transcription factor GLI-Similar 3 (GLIS3) function causes congenital hypothyroidism (CH) in both humans and mice due to decreased expression of several thyroid hormone (TH) biosynthetic genes in thyroid follicular cells. Whether and to what extent, GLIS3 regulates thyroid gene transcription in coordination with other thyroid transcriptional factors (TFs), such as PAX8, NKX2.1 and FOXE...... hiện toàn bộ
Epidermal growth factor receptor (EGFR) biology and Wnt developmental signaling highlight research endeavors of SCBA award winners
Springer Science and Business Media LLC - Tập 2 - Trang 1-2 - 2012
Kuan-Teh Jeang
This months Cell and Bioscience highlights review articles by Mien-Chie Hung on EGFR biology and Yingzi Yang on Wnt signaling. Dr. Hung was the 2011 Society of Chinese Bioscientists in America (SCBA) Presidential Award winner. Dr. Yang was the 2011 SCBA Outstanding Young Investigator Award winner.
Cell cycle regulators and bone: development and regeneration
Springer Science and Business Media LLC - Tập 13 Số 1
Alisha Shaikh, Austin A Wesner, Mohanad Abuhattab, Raman G. Kutty, Priyatha Premnath
AbstractCell cycle regulators act as inhibitors or activators to prevent cancerogenesis. It has also been established that they can play an active role in differentiation, apoptosis, senescence, and other cell processes. Emerging evidence has demonstrated a role for cell cycle regulators in bone healing/development cascade. We demonstrated that deletion of p21, a c...... hiện toàn bộ
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